On October 29, 2015, Lim, Yeon-Hee; Guo, Zhuyan; Ali, Amjad; Edmondson, Scott D.; Liu, Weiguo; Gallo-Etienne, Gioconda V.; Wu, Heping; Gao, Ying-Duo; Stamford, Andrew M.; Yu, Younong; Kevin, Nancy J.; Anand, Rajan; Sha, Deyou; Neelamkavil, Santhosh F.; Hussain, Zahid; Kumar, Puneet; Moningka, Remond; Duffy, Joseph L.; Xu, Jiayi; Jiang, Yu; Sone, Hiroki; Chakrabarti, Anjan published a patent.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of spiropyridooxazinepyrrolidine compounds as factor XIa inhibitors. And the patent contained the following:
The invention provides a compounds of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective factor XIa inhibitors or dual inhibitors of factor XIa and plasma kallikrein. Compounds of formula I wherein Y1 – Y4 are independently CR4 and N; Z is S, SO, SO2 and CO; L is a bond, CONH, NHCO, etc.; M is (un)substituted aryl, heteroaryl, CH2, etc.; R1a is H, halo, CN, etc.; R1b is H, CN, OH, etc.; R2 is H, CN, halo, etc.; each R3 is independently H, halo, CN, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). Example compounds of the invention were tested in an assay to measure effectiveness as inhibitors of human factor XIa and plasma kallikrein. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to spiropyridooxazinepyrrolidine compound preparation factor xia inhibitor kallikrein therapy, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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