On April 27, 2020, Gilbert, Nicolas; Ricard, Simon; Bergeron, Jodrey; Lambolez, Pierre; Daoust, Benoit published an article.Name: Methyl 2-cyclopentanonecarboxylate The title of the article was Synthesis of Exo- and Endocyclic Enamides Through Copper-Catalyzed Regioselective Intramolecular N-Halovinylation. And the article contained the following:
Cross-couplings between amides and 1,2-dihaloalkenes are an efficient and straightforward way to access β-haloenamides which, in turn, can be functionalized into complex, stereodefined enamide motifs. However, the intramol. version of these cross-couplings, leading to cyclic β-haloenamides, was not formally studied. The authors report a study of factors affecting the efficiency of the reaction and its selectivity between potential exo and endo cyclization products. Exo/endo selectivity is largely determined by ring strain, whether it arises from the size of the resulting ring or from the structure of the starting compound, but selectivity can also be modulated by varying reaction conditions. Finally, resulting β-haloenamides readily undergo transition metal-catalyzed reactions, making this sequence a viable way to access highly functionalized cyclic enamides. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Name: Methyl 2-cyclopentanonecarboxylate
The Article related to enamide exo endocycle preparation copper catalyst regioselective intramol halovinylation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Name: Methyl 2-cyclopentanonecarboxylate
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