13412-12-9, name is Methyl 3-(methylamino)but-2-enoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 3-(methylamino)but-2-enoate
General procedure: 1195 mg (9.25 mmol 1 eq.) 1 and 1000 mg (9.25 mmol 1 eq.) 1,4-benzoquinone is solved in 12 mL nitromethane. The mixture is left for 24 hrs (no stirring). Crystals of product precipitate. They were filtered, washed with nitromethane and recrystallized from EtOAc. Rf in PE+EtOAc 2+1: 0.2. Yellow solid, yield: 1300 mg, 64 %. Compound described in 2.
The synthetic route of 13412-12-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Schaefer, Anja; Burstein, Ethan S.; Olsson, Roger; Bioorganic and Medicinal Chemistry Letters; vol. 24; 8; (2014); p. 1944 – 1947;,
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