Reference of 5941-55-9, The chemical industry reduces the impact on the environment during synthesis 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, I believe this compound will play a more active role in future production and life.
To a mixture of 5-amino-1H-pyrazole-4-carbonitrile (10.00 g, 92.51 mmol) in DMF (350.00mL) was added ethyl (E)-3-ethoxyacrylate (13.34 g, 92.51 mmol) and Cs2CO3 (60.38 g, 185.02mmol). The mixture was stirred at 100C for 2 hrs. After LCMS showed the reaction was complete, the reaction mixture was cooled to 25C, then added to water (300 mL), acidified by HC1 (1 M) till pH = 4, then filtered. The filter cake was dried in vacuum to give 5-hydroxypyrazolo[1,5- ajpyrimidine-3-carbonitrile (10.00 g, yield: 67.5 1%) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl (E)-3-Ethoxyacrylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; WENGLOWSKY, Steven, Mark; MIDUTURU, Chandrasekhar, V.; BIFULCO, Neil, Jr; KIM, Joseph, L.; (91 pag.)WO2017/87778; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics