Associations between phthalic acid esters in household dust and childhood asthma in Shanghai, China was written by Zhang, Jialing;Sun, Chanjuan;Lu, Rongchun;Zou, Zhijun;Liu, Wei;Huang, Chen. And the article was included in Environmental Research in 2021.Reference of 84-61-7 This article mentions the following:
Phthalic acid esters (PAEs) have a neg. impact on human health and are widely distributed in China. As part of the China, Children, Home, Health (CCHH) study, we investigated the associations between childhood asthmatic symptoms and PAEs in settled house dust in Shanghai, China. We found that di-2-ethylhexyl phthalate (DEHP), di-Bu phthalate (DBP), and diisobutyl phthalate (DiBP) were abundant in the indoor environment. A total of 27% of children suffered from diagnosed asthma. The Mann-Whitney U test and multiple logistic regression were used to obtain the associations between PAEs and childhood asthmatic symptoms. Stratification anal. was performed to reveal the influence of gender on the associations between PAE exposure and target symptoms. Compared with low concentrations of PAEs, high concentrations of high mol. weight PAEs (HMW-PAEs) were significantly associated with childhood diagnosed asthma (adjusted odds ratios (AORs) > 1, P < 0.05). Moreover, significantly neg. associations were found between high concentrations of DiBP and current cough (AORs<1, P < 0.05). All significantly pos. associations were observed among girls, and most of the associations of di-Me phthalate (DMP) and di-Et phthalate (DEP) exposure with the studied symptoms among girls were higher than those among boys. Exposure to PAEs may be a risk factor for asthmatic symptoms in children, especially in girls. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Reference of 84-61-7).
Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 84-61-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics