Synthesis of pH-Responsive Multilayer Micelles for Sustained Release of Folic Acid was written by Zhai, Cuiping;Wang, Pan;Liu, Xuejun. And the article was included in Polymer-Plastics Technology and Engineering in 2016.Electric Literature of C14H12S2 This article mentions the following:
Two novel triblock copolymers poly(hydroxypropyl acrylate)-b-poly (Me methacrylate)-b-poly(N,N-dimethylaminoethyl methacrylate) and poly(hydroxypropyl acrylate)-b-poly(Me methacrylate)-b-poly(acrylic acid) were successfully synthesized. In acetone media, using the electrostatic interactions between N,N-dimethylaminoethyl methacrylate and acrylic acid units, they could form spherically shaped multilayer micelles with pH-responsive, and have a mean diameter around 110 nm. The critical micelle concentration of it was determined to be 2.42 mg/L. In vitro release experiments, the folic acid-loaded micelles exhibited sustained release behavior and the drug release rate was affected by the pH value of release media. These results indicate that the multilayer micelles may serve as a novel intelligent drug delivery system. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Electric Literature of C14H12S2).
Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C14H12S2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics