Copper-mediated etherification of arenes with alkoxysilanes directed by an (2-aminophenyl)pyrazole group was written by Selvakumar, Jayaraman;Grandhi, Gowri Sankar;Sahoo, Harekrishna;Baidya, Mahiuddin. And the article was included in RSC Advances in 2016.Quality Control of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:
An efficient copper-mediated etherification of inert C-H bonds of (hetero)arenes with reagent-amounts of alkoxysilanes and alkanols was developed using (2-aminophenyl)pyrazole (2-APP) as a removable directing group. The reaction was scalable, rapidly proceeded under an open atm., and tolerated diverse functional groups to provide alkyl aryl ethers in high yields (up to 87%). As an application, the formal synthesis of anti-emetic drug metoclopramide was accomplished. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Quality Control of Methyl 2-methoxy-4-methylbenzoate).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 2-methoxy-4-methylbenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics