5,6,7-Trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase was written by Perner, Richard J.;Gu, Yu-Gui;Lee, Chih-Hung;Bayburt, Erol K.;McKie, Jeffery;Alexander, Karen M.;Kohlhaas, Kathy L.;Wismer, Carol T.;Mikusa, Joe;Jarvis, Michael F.;Kowaluk, Elizabeth A.;Bhagwat, Shripad S.. And the article was included in Journal of Medicinal Chemistry in 2003.Safety of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:
The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel non-nucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogs that are potent inhibitors of adenosine kinase with in vivo analgesic activity. Compounds thus prepared and tested included 5,6-bis(3-fluoro-4-methylphenyl)-7-(2-thienyl)pyrido[2,3-d]pyrimidin-4-amine hydrochloride, 5-(4-bromo-2-thienyl)-6-(3,4-dimethoxyphenyl)-7-(2-thienyl)pyrido[2,3-d]pyrimidin-4-amine hydrochloride, 5-(3-bromophenyl)-7-[6-(4-morpholinyl)-3-pyridinyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amine hydrochloride, etc. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Safety of Ethyl 2-(4-fluorophenyl)acetate).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Ethyl 2-(4-fluorophenyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics