Month: December 2022

Leite, Victor S. A. published the artcileUntargeted Metabolomics Reveals Metabolic Changes Linked to Bulb Purpling in Garlic (Allium sativum L.), Application of Methyl octanoate, the main research area is Allium bulb purpling metabolomics metabolism.

Garlic (Allium sativum L.) is a vegetable known worldwide, mainly for its characteristic aroma and flavor and for exhibiting several medicinal properties. This culture has significant economic and social relevance in the world agricultural scenario. Most of the garlic production is sold in fresh bulbs, where for some countries the more purple skin bulbs are more valued in the market. However, there is still no consensus about the factors that intensify the purple color of the garlic bulbs. Here, we employed gas chromatog.-mass spectrometry-based untargeted metabolomics to study the metabolome of dark and light purple garlics. Multivariate statistical anal. revealed distinct metabolite signatures between these garlic groups. As metabolic changes play an important factor in changes in the phenotype of cells or an organism, this report presents a fundamental approach for supporting garlic producers in understanding the factors that intensify the purplish color of garlic bulbs, paving the way for safer garlic production with dark purple bulbs. In addition, the medicinal properties of dark purple garlic were greater than that of the light purple garlic, presenting greater abundance in organosulfur compounds Overall, the data suggest that some organic acid and fatty acids such as malonic acid and docosanoic acid are the key differentiating factors between dark and light purple garlics.

ACS Food Science & Technology published new progress about Allium sativum. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Application of Methyl octanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anastasiou, Ioanna A. published the artcileIn vitro data of current therapies for SARS-CoV-2, Quality Control of 55981-09-4, the main research area is review therapy SARS CoV 2; ACE2 receptor; SARS-CoV-2 (COVID-19); VeroE6 Cells; in vitro studies; therapies; vaccines.

Background: In Dec. 2019, a new coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), emerged from China, causing pneumonia outbreaks first in the Wuhan region and then spread worldwide. Due to a lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the most efficient tool to find a therapeutic solution Objectives: The aim of this study was to summarize in vitro data of current agents used for the management of SARS-CoV-2 all over the world. Methods: A literature search of articles from Jan. 2000 until Apr. 2020 was performed using MEDLINE, EMBASE and the Cochrane Library to assess in vitro data of current or putative therapies for SARS-CoV-2. Results: Although in vitro studies are scarce, data regarding chloroquine, hydroxychloroquine, remdesivir, nitazoxanide, teicoplanin, ivermectin, lopinavir, homoharringtonine, and emetine seem promising. Conclusion: Scientists all over the world should work together and increase their efforts in order to find feasible and efficient solutions against this new global viral threat.

Current Medicinal Chemistry published new progress about Allium sativum. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Quality Control of 55981-09-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sulejmani, Erhan published the artcileA comparative study of compositional, antioxidant capacity, ACE-inhibition activity, RP-HPLC peptide profile and volatile compounds of herbal artisanal cheeses, SDS of cas: 111-11-5, the main research area is Origanum artisanal cheese hexanal ACE inhibitor antioxidant RP HPLC.

The effect of aromatic herbs on the RP-HPLC peptide profile, angiotensin I-converting enzyme-inhibitory (ACE-i) activity, antioxidant capacity and volatile compounds in artisanal cheeses was investigated. Three representative artisanal cheeses (white brined, beaten and Kashkaval cheeses) were produced using aromatic herbs (Mentha longifolia, Origanum vulgare, Thymus longicaulis, Alium sativum, Petroselinum crispum, Capsicum annuum). Compared with control group, herbal cheeses (except white cheese with garlic and parsley) revealed a significant increase in antioxidant activity. The highest ACE-i activity was noticed in 60 days of ripening with a mean value of 98.72% in goat beaten cheese and 97.78% in Kashkaval cheese enriched with peppers. One hundred and one volatile compounds, mainly acids, esters and alcs., were identified in significantly higher amounts in cheeses made with herbs and contributed to the development of the overall aroma perception.

International Dairy Journal published new progress about Allium sativum. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, SDS of cas: 111-11-5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sulejmani, Erhan published the artcileA comparative study of compositional, antioxidant capacity, ACE-inhibition activity, RP-HPLC peptide profile and volatile compounds of herbal artisanal cheeses, Related Products of esters-buliding-blocks, the main research area is Origanum artisanal cheese hexanal ACE inhibitor antioxidant RP HPLC.

The effect of aromatic herbs on the RP-HPLC peptide profile, angiotensin I-converting enzyme-inhibitory (ACE-i) activity, antioxidant capacity and volatile compounds in artisanal cheeses was investigated. Three representative artisanal cheeses (white brined, beaten and Kashkaval cheeses) were produced using aromatic herbs (Mentha longifolia, Origanum vulgare, Thymus longicaulis, Alium sativum, Petroselinum crispum, Capsicum annuum). Compared with control group, herbal cheeses (except white cheese with garlic and parsley) revealed a significant increase in antioxidant activity. The highest ACE-i activity was noticed in 60 days of ripening with a mean value of 98.72% in goat beaten cheese and 97.78% in Kashkaval cheese enriched with peppers. One hundred and one volatile compounds, mainly acids, esters and alcs., were identified in significantly higher amounts in cheeses made with herbs and contributed to the development of the overall aroma perception.

International Dairy Journal published new progress about Allium sativum. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Gui Min published the artcileTwo-membrane air fresheners for continuous non-energized perfume delivery, Formula: C9H10O2, the main research area is two membrane air freshener nonenergized perfume delivery.

We have developed two-membrane air fresheners for continuous non-energized air freshener perfume delivery with significantly superior delivery consistency over a conventional membrane air freshener. In this study, a model perfume is used to investigate the conventional air freshener as functions of temperature and air velocity. The release rate of the conventional air freshener varies greatly from its initial use to its end-of-life under a fixed ambient condition. In order to regulate the evaporation rates of the volatile compounds, the new air freshener consisting of an inner membrane and an outer membrane. The outer membrane is used as the regulation membrane to create a vapor reservoir between the inner wet membrane and the outer membrane so that the vapor generated from the inner membrane can be regulated. Comparing the conventional air freshener to the new air freshener, the outer membrane impregnated with polyethylene glycol (PEG) shows significantly better consistency of perfume delivery rates under different air velocities and temperatures In addition, a model has been employed to predict the perfume release from the conventional air freshener. The perfume release from the newly developed air fresheners is regulated by vapor transport through the outer membrane which may be predicted through the Knudsen flow or solution diffusion model.

Journal of Membrane Science published new progress about Air (velocity). 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Formula: C9H10O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yasuno, Takumi published the artcileFullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease, COA of Formula: C4H8O3, the main research area is pyridinium fullerene preparation dual inhibitor HIV reverse transcriptase protease; piperidinium fullerene preparation dual inhibitor HIV reverse transcriptase protease; proline fullerene preparation dual inhibitor HIV reverse transcriptase protease; Fullerene; HIV protease; HIV reverse transcriptase.

In the present study, we newly synthesized three types of novel fullerene derivatives: pyridinium-type derivatives, piperidinium-type derivatives, and proline-type derivatives Among the assessed compounds, some were found to inhibit both HIV reverse transcriptase and HIV protease (HIV-PR), with IC50 values in the low micromolar range being observed Regarding HIV-PR inhibition activity, proline-type derivatives, bearing an alkyl chain between the hydroxylmethylcarbonyl (HMC) moiety and pyrrolidine ring, were more potent than other derivatives This result might indicate that connecting HMC moieties with proline-type fullerene derivatives through properly sized alkyl chain leads to improved HIV-PR inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, COA of Formula: C4H8O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sillapachaiyaporn, Chanin published the artcileHIV-1 Protease and Reverse Transcriptase Inhibitory Activities of Curcuma aeruginosa Roxb. Rhizome Extracts and the Phytochemical Profile Analysis: In Vitro and In Silico Screening, Application In Synthesis of 71617-10-2, the main research area is Curcuma aeruginosa human immunodeficiency virus type 1 protease inhibitor; ADMET analysis; AIDS; Curcuma aeruginosa Roxb.; HIV-1 protease inhibitor; HIV-1 reverse transcriptase inhibitor; drug discovery; immunodeficiency virus; virtual screening.

Human immunodeficiency virus type-1 (HIV-1) infection causes acquired immunodeficiency syndrome (AIDS). Currently, several anti-retroviral drugs are available, but adverse effects of these drugs have been reported. Herein, we focused on the anti-HIV-1 activity of Curcuma aeruginosa Roxb. (CA) extracted by hexane (CA-H), Et acetate (CA-EA), and methanol (CA-M). The in vitro HIV-1 protease (PR) and HIV-1 reverse transcriptase (RT) inhibitory activities of CA extracts were screened. CA-M potentially inhibited HIV-1 PR (82.44%) comparable to Pepstatin A (81.48%), followed by CA-EA (67.05%) and CA-H (47.6%), resp. All extracts exhibited moderate inhibition of HIV-1 RT (64.97 to 76.93%). Besides, phytochem. constituents of CA extracts were identified by GC-MS and UPLC-HRMS. Fatty acids, amino acids, and terpenoids were the major compounds found in the extracts Furthermore, drug-likeness parameters and the ability of CA-identified compounds on blocking of the HIV-1 PR and RT active sites were in silico investigated. Dihydroergocornine, 3β,6α,7α-trihydroxy-5β-cholan-24-oic acid, and 6β,11β,16α,17α,21-Pentahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide showed strong binding affinities at the active residues of both HIV-1 PR and RT. Moreover, antioxidant activity of CA extracts was determined CA-EA exhibited the highest antioxidant activity, which pos. related to the amount of total phenolic content. This study provided beneficial data for anti-HIV-1 drug discovery from CA extracts

Pharmaceuticals published new progress about AIDS (disease). 71617-10-2 belongs to class esters-buliding-blocks, name is Isopentyl 3-(4-methoxyphenyl)acrylate, and the molecular formula is C15H20O3, Application In Synthesis of 71617-10-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phiri, Sydney published the artcileFermented cereal-based Munkoyo beverage: Processing practices, microbial diversity and aroma compounds, Computed Properties of 123-29-5, the main research area is Munkoyo fermented cereal beverage microbial diversity aroma compound.

Fermented cereal-based foods play a crucial role in attaining food and nutrition security for resource-poor populations in sub-Saharan Africa. These products are widely produced by spontaneous fermentation using of cereal grains as raw material. Lactic acid bacteria dominate the fermentation process and lead to a low pH of around 4, which suppresses the growth of pathogenic bacteria, thereby increasing the shelf-life and safety of the food. In four regions of Zambia, we surveyed processing practices and consumption patterns of a spontaneously fermented cereal-based beverage called Munkoyo, commonly produced in Zambia and the Democratic Republic of Congo. Characterization of the bacterial communities of over 90 samples with 16S amplicon sequencing on DNA extracted from the entire bacterial community revealed six dominant families, namely Streptococcaceae, Leuconostocaceae, Enterobacteriaceae, Lactabacillales, Bacillaceae and Aeromonadaceae, and a Shannon index of up to 1.18 with an effective number of 3.44 bacterial species. Bacterial communities that underlie the fermentation in Munkoyo differ in their composition for the different regions using common processing steps, suggesting that different combinations of bacteria can be used to achieve successful Munkoyo fermentation Anal. of aroma profiles in 15 different samples from two different Provinces showed that aldehydes, esters, organic acids, alkanes, alkenes and alcs. dominated.

PLoS One published new progress about Aeromonadaceae. 123-29-5 belongs to class esters-buliding-blocks, name is Ethyl nonanoate, and the molecular formula is C11H22O2, Computed Properties of 123-29-5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zarini, Daniele published the artcileAre In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?, COA of Formula: C7H12O3, the main research area is toxicity electronic cigarette liquid QSAR model.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Chemical Research in Toxicology published new progress about Acute toxicity. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, COA of Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zarini, Daniele published the artcileAre In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?, SDS of cas: 140-11-4, the main research area is toxicity electronic cigarette liquid QSAR model.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Chemical Research in Toxicology published new progress about Acute toxicity. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, SDS of cas: 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics