Month: November 2022

On May 6, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 8, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 22, 2010, Sugita, Kazuyuki; Ota, Masahiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or their pharmacol. acceptable salts], etc., were prepared For example, reaction of Et [(trans)-7-chloro-5-[3-methoxy-2-(trifluoromethyl)phenyl]-2-thioxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetate (preparation given) with NH2NH2·H2O followed by cyclization with trifluoroacetic anhydride, separation using chiral HPLC and hydrolysis afforded (4R,6R)-I. In squalene synthase inhibition assays, the IC50 value of (4R,6R)-I was 0.88 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. Pharmaceutical composition comprising (4R,6R)-I is disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2015, Leslie, G.; Rutter, A.; Pollard, A.; Davis, J.; Matovic, D. published an article.Reference of (Trimethoxymethyl)benzene The title of the article was The effects of weathering on the pyrolysis of low-carbon fuels: Railway ties and asphalt shingles. And the article contained the following:

Creosote-treated wooden railway ties and roofing asphalt shingles are discarded in large quantities and may be significant sources of energy; however, they may have rotted or oxidized, and the chem. changes that result from such weathering could affect their behavior as a fuel or pyrolysis feedstock. Such changes in railway tie wood, and roofing asphalt shingles were studied by identifying isothermal 250 and 550 °C pyrolysis products (pyrolyzates) with pyrolysis-gas chromatog./mass spectrometry (py-GC/MS). Poplar wood pyrolysis was also studied and compared to existing literature to establish a reference scenario; identified poplar wood pyrolyzates assisted in the anal. of railway tie and asphalt shingle pyrolyzates. Poplar pyrolyzates included the products of polysaccharide ring-breaking and lignin pyrolysis, confirming one of the two competing low-temperature pyrolysis models. Railway tie pyrolyzates showed few signs of bacterial degradation or oxidation, indicating that the tie considered here did not undergo extensive weathering. Roofing asphalt pyrolyzates included many carbonyl, hydroxyl, and ether functionalized cyclic species, as well as sulfur dioxide; these pyrolyzates indicate extensive and preferential oxidation of cyclic carbon and sulfur. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Reference of (Trimethoxymethyl)benzene

The Article related to weathering waste fuel railway tie asphalt shingle pyrolysis, Electrochemical, Radiational, and Thermal Energy Technology: Energy Sources and other aspects.Reference of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 3, 1998, Hardy, Jean-claude; Bouquerel, Jean; Nemecek, Patrick; Aloup, Jean-claude; Mignani, Serge; Peyronel, Jean-francois published a patent.Application of 141940-37-6 The title of the patent was Preparation of 2-iminothiazolo[5,4,3-ij]quinolines and analogs as glutamatergic antagonists. And the patent contained the following:

Title compounds [I; R1 = H or alkyl; R6 = fluoroalkyl, -alkoxy, -alkylthio; R7 = H or alkyl, CH2OH, CH2NH2, alkylsulfonylmethyl, etc. only when Z = CH2CH2; Z = CH2CH2, CH(OH)CF2, COCH2, SO0-2CH2, etc.; Z1 = S or Se] were prepared Thus, 4-(F3CO)C6H4NH2 was cyclocondensed with HOCH(CH2OH)2 and the hydrogenated product cyclocondensed with KCNS to give I (R2 = R7 = H, R6 = OCF3, Z = CH2CH2, Z1 = S). Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6

The Article related to iminothiazoloquinoline preparation glutamatergic antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 2, 2021, Zhou, Haibing; Wu, Shuwen; Xu, Zhichao published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of oseltamivir PROTAC compound and application in anti-influenza virus drugs. And the patent contained the following:

The present invention relates to the preparation of oseltamivir PROTAC compound and application in antiinfluenza virus drugs. In particular, oseltamivir PROTAC compound I and II, wherein ( E3 ligase = VHL or CRBN ligand; linker = alkylene or alkoxy) was prepared The compound provided by the invention can effectively degrade influenza virus neuraminidase so as to exert the activity of inhibiting influenza virus replication, not only has the inhibitory activity on wild strain influenza virus, but also has a good inhibitory effect on oseltamivir-resistant strains, and has low toxicity on cells, the compound of the present invention, or a pharmacol. or physiol. acceptable salt thereof, can be used for the preparation of a medicament against influenza virus. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0

The Article related to oseltamivir protac compound preparation antiinfluenza virus, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 4, 1999, Hardy, Jean-Claude; Bouquerel, Jean; Nemecek, Patrick; Peyronel, Jean-Francois published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of thiazolobenzazepines and analogs as anticonvulsants and glutamate antagonists. And the patent contained the following:

Title compounds [I; R2 = H or alkyl; R6R3 = (CH2)4, (CH2)3CO, (CH2)3O, etc.; R7 = polyfluoroalkyl(oxy); Z = S or Se] were prepared Thus, N-protected Et 2-amino-5-trifluoromethoxybenzoate was N-alkylated by Br(CH2)3CO2Et and the product cyclized to give, in 3 addnl. steps, benzazepine II which was cyclocondensed with KSCN to give I [R2 = H, R6R3 = CH(OH)(CH2)3, R7 = OCF3, Z = S]. Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolobenzazepine preparation anticonvulsant glutamate antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2017, Tzanetis, Konstantinos F.; Posada, John A.; Ramirez, Andrea published an article.Application In Synthesis of (Trimethoxymethyl)benzene The title of the article was Analysis of biomass hydrothermal liquefaction and biocrude-oil upgrading for renewable jet fuel production: The impact of reaction conditions on production costs and GHG emissions performance. And the article contained the following:

This paper shows a detailed anal. of a biomass HTL process by considering changes in three main reaction variables (i.e. catalysts (water, Na2CO3(aqueous), and Fe(aqueous)), temperature (280-340°C), and catalysts/biomass mass ratio (0-0.33 kg catalysts/kg biomass)), and by assessing their influence on the techno-economic and GHG emissions performance. This anal. is based on Aspen Plus simulations, process economics and life-cycle GHG assessment on SimaPro (using Ecoinvent 2.2). Results showed that the lowest production cost for biocrude oil is achieved when HTL is performed at 340°C with Fe as catalyst (450 euro/tbiocrude-oil or 13.6 euro/GJbiocrude-oil). At these conditions, the biocrude oil produced has an oxygen content of 16.6 wt% and a LHV of 33.1 MJ/kgbiocrude-oil. When the hydrotreatment and hydrogen generation units are included, the total production costs was 1040 euro/tupgraded-oil or 0.8 euro/Lupgraded-oil. After fractionation, the estimated production cost was 1086 euro/tbiojet-fuel or 25.1 euro/GJbiojet-fuel. This value is twice the com. price of fossil jet fuel. However, the allocated life cycle GHG emissions for renewable jet fuel were estimated at 13.1 kgCO2-eq./GJbiojet-fuel, representing only 15% the GHG emission of fossil jet fuel and therefore, indicating a significant potential on GHG emission reduction The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application In Synthesis of (Trimethoxymethyl)benzene

The Article related to renewable jet fuel ghg biocrude oil biomass hydrothermal liquefaction, Electrochemical, Radiational, and Thermal Energy Technology: Energy Sources and other aspects.Application In Synthesis of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2018, Durak, Halil; Genel, Yasar published an article.Quality Control of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Hydrothermal conversion of biomass (Xanthium strumarium) to energetic materials and comparison with other thermochemical methods. And the article contained the following:

In the present study, the biomass was converted into liquid and solid residues by using hydrothermal liquefaction method at 250, 300 and 350°C with (FeCl3, NaOH) and without catalyst. The resultant products were examined using GC-MS, FT-IR, 1H NMR, SEM, and elemental anal. methods. According to the performed analyses, the highest liquid product yield (total bio-oil) was found to be 38.08% at 300°C by using FeCl3 as catalyst. In the experiments carried out at 350°C, the highest HHV value was found to be 32.35 MJ kg-1 by using NaOH catalyst. The energy values of products obtained at the end of experiments were compared to the values obtained from pyrolysis and supercritical liquefaction method, and it was determined that the liquid products having higher level of energy value were achieved by using hydrothermal liquefaction method. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to xanthium strumarium hydrothermal conversion process subcritical liquefaction, biofuels, biofuels (bio-oil), biomass, biomass pyrolysis fuel oils, charcoal role: spn (synthetic preparation), prep (preparation) (biochar), liquefaction, thermochemical liquefaction, xanthium strumarium and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 8, 2004, Polisetti, Dharma Rao; Kodra, Janos Tibor; Lau, Jesper; Bloch, Paw; Valcarce-Lopez, Maria Carmen; Blume, Niels; Guzel, Mustafa; Santhosh, Kalpathy Chidambareswaran; Mjalli, Adnan M. M.; Andrews, Robert Carl; Subramanian, Govindan; Ankersen, Michael; Vedso, Per; Murray, Anthony; Jeppesen, Lone published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of thiazolyl aryl ureas as activators of glucokinase. And the patent contained the following:

The title compounds [I; A1 = arylene, heteroarylene, fused cycloalkylarylene, etc.; L1 = a bond, O, S, SO, etc.; G1 = alkyl, cycloalkyl, cycloalkylalkylene, etc.; L2 = a bond, alkylene, alkenylene, etc.; L3 = CO, COCO, COCH2CO, SO2; R1 = alkyl, alkenyl, alkynyl, etc.; G2 = heteroaryl, fused heterocyclylheteroaryl, cycloalkylheteroaryl, etc.] which are activators of glucokinase and may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial (no data), were prepared and formulated. Thus, reacting 2-phenoxyaniline with 2-aminothiazole and 1,1′-carbonyldiimidazole afforded 95% the urea II. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolyl aryl urea preparation formulation glucokinase activator antidiabetic and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics