Month: November 2022

Harahap, F. S. published the artcileComparison of the chemical compounds of malacca bark and malacca fruit (Phyllanthus emblica) with gas chromatography-mass spectrometer (GC-MS), SDS of cas: 627-93-0, the publication is Journal of Physics: Conference Series (2020), 072011, database is CAplus.

Malacca (Phyllanthus emblica) has a chem. that contains acids that are used to treat cancer. This research was aimed to compare the content of chem. compounds malacca stem with malacca fruit (Phyllanthus emblica) with multilevel extraction methods. Extraction of the stem and Malaca fruit was carried out by maceration and socletation using non-polar nhexane, semi-polar acetone, and polar methanol as solvent. Non-polar components were separated by the soxhlet extraction method using n-hexane solvent. The residue from the soxhlet extraction was then macerated using acetone solvent. Furthermore, the polar component was separated by maceration extraction method using ethanol as a solvent. The ethanol extract was then identified by chem. compounds with Gas Chromatog.-Mass Spectrometer (GC-MS). Chem. compounds identified with GC-MS showed extracts on stem balakka contain the compound succinic acid di-Me ester, di-Me pentanedioate, and di-Me adipate, while extracts on malacca fruit contain the compound succinic acid di-Me ester, di-Me pentanedioate, di-Me adipate, Me adipate, 1,3-Dioxolane-4-methanol.

Journal of Physics: Conference Series published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, SDS of cas: 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Derakhshani, Afshin published the artcileThe expression pattern of VISTA in the PBMCs of relapsing-remitting multiple sclerosis patients: A single-cell RNA sequencing-based study, Computed Properties of 624-49-7, the publication is Biomedicine & Pharmacotherapy (2022), 112725, database is CAplus and MEDLINE.

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). Dysregulated immune responses have been implicated in MS development. Growing evidence has indicated that inhibitory immune checkpoint mols. can substantially regulate immune responses and maintain immune tolerance. V-domain Ig suppressor of T cell activation (VISTA) is a novel inhibitory immune checkpoint mol. that can suppress immune responses; however, its expression pattern in the peripheral blood mononuclear cells (PBMCs) of relapsing-remitting multiple sclerosis (RRMS) has not thoroughly been studied. Herein, we evaluated Vsir expression in PBMCs of RRMS patients and characterized the expression pattern of the Vsir in the PBMCs of MS patients. Besides, we investigated the effect of fingolimod, IFNβ-1α, glatiramer acetate (GA), and di-Me fumarate (DMF) on Vsir expression in PBMCs of RRMS patients. Our results have shown that Vsir expression is significantly downregulated in the PBMCs of patients with RRMS. Besides, the single-cell RNA sequencing results have demonstrated that Vsir expression is downregulated in classical monocyte, intermediate monocytes, non-classical monocytes, myeloid DCs (mDC), Plasmacytoid dendritic cells (pDCs), and naive B-cells of PBMCs of MS patients compared to the control. In addition, DMF, IFNβ-1α, and GA have significantly upregulated Vsir expression in the PBMCs of RRMS patients. Collectively, the current study has shed light on Vsir expression in the PBMCs of MS patients; however, further studies are needed to elucidate the significance of VISTA in the mentioned immune cells.

Biomedicine & Pharmacotherapy published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Computed Properties of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Azizi, Najmedin published the artcileVersatile and large-scale synthesis of functional dithiocarbamates in water, COA of Formula: C12H17NS2, the publication is Synthetic Communications (2011), 41(1), 94-99, database is CAplus.

Structural diversity is possible in direct access to functional dithiocarbamates based on a highly efficient and simple one-pot reaction of CS₂, amines, and alkyl halides in nearly quant. yields in water.

Synthetic Communications published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, COA of Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Azizi, Najmedin published the artcileStraightforward and Highly Efficient Catalyst-Free One-Pot Synthesis of Dithiocarbamates under Solvent-Free Conditions, HPLC of Formula: 3052-61-7, the publication is Organic Letters (2006), 8(23), 5275-5277, database is CAplus and MEDLINE.

A highly efficient and simple synthesis of dithiocarbamates, e.g. I, based on the one-pot reaction of amines, CS₂, and alkyl halides without using a catalyst under solvent-free conditions, is reported. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochem. industries.

Organic Letters published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Turgis, R. published the artcileKetone functionalized task specific ionic liquids for selective tantalum extraction, Application of 3-Acetyldihydrofuran-2(3H)-one, the publication is Separation and Purification Technology (2018), 174-182, database is CAplus.

A novel family of ketone functionalized task specific ionic liquids (TSILs) was designed for the selective extraction of tantalum from sulfuric acid medium. We report the synthesis of functionalized hydrophobic ionic liquids based on piperidium, imidazolium or pyridinium cations bearing ketone moieties and their application in the liquid/liquid extraction of Ta(V). Recovery processes for Ta after extraction were performed and the recyclability of the TSIL was demonstrated. An eco-friendly process based on a TSIL was proposed for the extraction and stripping of tantalum from sulfuric acidic medium. Such system can be used as an alternative to the methyl-iso-Bu ketone (MIBK) which is the most commonly used extractant for the separation and purification of niobium and tantalum by solvent extraction

Separation and Purification Technology published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C9H9F5Si, Application of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gold, Ralf published the artcileLong-term safety and efficacy of dimethyl fumarate for up to 13 years in patients with relapsing-remitting multiple sclerosis: Final ENDORSE study results, Computed Properties of 624-49-7, the publication is Multiple Sclerosis Journal (2022), 28(5), 801-816, database is CAplus and MEDLINE.

Di-Me fumarate (DMF) demonstrated favorable benefit-risk in relapsing-remitting multiple sclerosis (RRMS) patients in phase-III DEFINE and CONFIRM trials, and ENDORSE extension. The main aim of this study is assessing DMF safety/efficacy up to 13 years in ENDORSE. Randomized patients received DMF 240 mg twice daily or placebo (PBO; Years 0-2), then DMF (Years 3-10; continuous DMF/DMF or PBO/DMF); maximum follow-up (combined studies), 13 years. By Jan. 2020, 1736 patients enrolled/dosed in ENDORSE (median follow-up 8.76 years (ENDORSE range: 0.04-10.98) in DEFINE/CONFIRM and ENDORSE); 52% treated in ENDORSE for ≥6 years. Overall, 551 (32%) patients experienced serious adverse events (mostly multiple sclerosis (MS) relapse or fall; one progressive multifocal leukoencephalopathy); 243 (14%) discontinued treatment due to adverse events (4% gastrointestinal (GI) disorders). Rare opportunistic infections, malignancies, and serious herpes zoster occurred, irresp. of lymphocyte count. For DMF/DMF (n = 501), overall annualized relapse rate (ARR) remained low (0.143 (95% confidence interval (CI), 0.120-0.169)), while for PBO/DMF (n = 249), ARR decreased after initiating DMF and remained low throughout (ARR 0-2 years, 0.330 (95% CI, 0.266-0.408)); overall ARR (ENDORSE, 0.151 (95% CI, 0.118-0.194)). Over 10 years, 72% DMF/DMF and 73% PBO/DMF had no 24-wk confirmed disability worsening. Sustained DMF safety/efficacy was observed in patients followed up to 13 years, supporting DMF’s pos. benefit/risk profile for long-term RRMS treatment.

Multiple Sclerosis Journal published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Computed Properties of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kot, David published the artcileExtraction of stabilizers from polymers: Separation of oligomeric hindered amine light stabilizers and phenolic antioxidants from polyolefins using liquid chromatography and high-temperature solid-phase extraction, Safety of Tris(2,4-di-tert-butylphenyl) phosphite, the publication is Journal of Separation Science (2021), 44(12), 2408-2417, database is CAplus and MEDLINE.

The extraction of different stabilizers from a polymer matrix and the subsequent separation of said stabilizers is one of the most important as well as challenging undertakings in polymer chem. A multitude of stabilizers exists, each of which may be hard to extract, be difficult if not impossible to sep. from other stabilizers or necessitate very selected and time-consuming intermediate stages for separation Certain polymer matrixes even pose addnl. challenges, such as polyolefins being only soluble at elevated temperatures One of the most well-established approaches for the extraction of stabilizers is Soxhlet extraction However, even this highly successful approach shows only limited success with regard to the extraction of the ever more relevant oligomeric stabilizers or the extraction of multiple stabilizers in a one-shot approach. Moreover, performing Soxhlet extractions often necessitates ≥24 h. For these reasons, alternative approaches for the extraction of stabilizers from polymers are highly sought after. An approach with enormous potential is solid-phase extraction, which allows the selective retention and enrichment of stabilizers. Herein, the very first application of high-temperature solid-phase extraction for the extraction of stabilizers from polyolefin matrixes is described; as with other extraction techniques, the identification and quantification of the stabilizers is then allowed. At temperatures of 140-160°C, it was possible to adsorb common polyolefin stabilizers selectively on a silica solid phase from their polyolefin matrix. To predict high-temperature solid-phase extraction test conditions, first LC tests are necessary, offering an elegant approach for the separation of polyolefins from oligomeric stabilizers, which was not achievable until now.

Journal of Separation Science published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Safety of Tris(2,4-di-tert-butylphenyl) phosphite.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rauscher, Stefan published the artcileEffects of dodecyl acetate and Z-10-tridecenyl acetate on attraction of Eupoecilia ambiguella males to the main sex pheromone component, Z-9-dodecenyl acetate, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate, the publication is Journal of Chemical Ecology (1984), 10(2), 253-64, database is CAplus and MEDLINE.

Attraction of E. ambiguella males to Z-9-dodecenyl acetate (Z9-12:Ac) [16974-11-1], alone and in combination with dodecyl acetate (12:Ac) [112-66-3] or Z-10-tridecenyl acetate (Z10-13:Ac) [64437-24-7] was tested in both wind-tunnel and field experiments In the laboratory, response to Z9-12:Ac reached a distinct dosage optimum at which attraction was nearly as good as to live females. Addition of 12:Ac, a minor component of female glands and effluvia, had no effect at low doses of Z9-12:Ac and only marginally improved attraction at the optimum. However, inclusion of 12:Ac with an overdose of Z9-12:Ac, fully restored activity. In the field, Z9-12:Ac alone was not very attractive at any dose; catches markedly increased by adding 12:Ac and climbed with increasing dose of each compound ≤10 mg. Optimum ratio of Z9-12:Ac to 12:Ac was 1:1-1:5. Z10-13:Ac, had the same effect as 12:Ac in the laboratory and the field, but was effective at a lower dose. In the field, inclusion of the synergist permits use of high cap loads to attract more males, perhaps from greater distances.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Buser, Hans Rudolf published the artcileDetermination of double bond position in mono-unsaturated acetates by mass spectrometry of dimethyl disulfide adducts, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate, the publication is Analytical Chemistry (1983), 55(6), 818-22, database is CAplus.

Forty-seven model compounds (decenyl to octadecenyl acetates) in nanogram quantities were reacted with Me₂S₂ and the derivatives analyzed by high-resolution gas chromatog. and electron-impact mass spectrometry. The derivatives yield easily recognizable mol. ions. Cleavage between the sulfur-substituted carbons leads to key fragments which allow a determination of the position of the double bond in the original mono-unsaturated acetate. The procedure is applied in the identification of mono-unsaturated acetates in pheromone extracts of two moth species.

Analytical Chemistry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guerin, P. M. published the artcileThe sex pheromone of Adoxophyes orana. Preliminary findings from a reinvestigation, Safety of (Z)-Dodec-9-en-1-yl acetate, the publication is Colloques – Institut National de la Recherche Agronomique (1982), 267-9, database is CAplus.

Mixtures including minor components of the pheromone blend of A. orana were more attractive to males than mixtures containing only the 2 main components, (Z)-9- and (Z)-11-tetradecenylacetates. The minor components principally responsible appeared to be (Z)-9- and (Z)-11-tetradecenyl alcs. and (E)-11-tetradecenylacetate. The 2 main components were effective over a wide range of ratios, and a considerable age-dependent variation was observed in the ratio of these 2 isomers in females.

Colloques – Institut National de la Recherche Agronomique published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Safety of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics