Zhang, Qi; Chiou, Mong-Feng; Ye, Changqing; Yuan, Xiaobin; Li, Yajun; Bao, Hongli published an article in 2022, the title of the article was Radical 1,2,3-tricarbofunctionalization of α-vinyl-β-ketoesters enabled by a carbon shift from an all-carbon quaternary center.Quality Control of Methyl 2-cyclopentanonecarboxylate And the article contains the following content:
An intermol., radical 1,2,3-tricarbofunctionalization of α-vinyl-β-ketoesters I (R = Me, Et, Bn; R1 = H, OMe; R2 = H, Me, OMe; R3 = H, F, OMe; R4 = H, Cl, Ph, etc.; R5 = R6 = H, Me) and Et 1-ethenyl-2-oxocyclohexane-1-carboxylate, Et 1-ethenyl-2-oxocycloheptane-1-carboxylate to achieve the goal of building mol. complexity via the one-pot multifunctionalization of alkenes R7CCS(O)2R8 (R7 = Ph, 4-chlorophenyl, thiophen-3-yl, etc.; R8 = CF3, C4F9) have been reported. This reaction allows the expansion of the carbon ring by a carbon shift from an all-carbon quaternary center, and enables further C-C bond formation on the tertiary carbon intermediate with the aim of reconstructing a new all-carbon quaternary center. The good functional group compatibility ensures diverse synthetic transformations of this method. Exptl. and theor. studies reveal that the excellent diastereoselectivity should be attributed to the hydrogen bonding between the substrates and solvent. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Quality Control of Methyl 2-cyclopentanonecarboxylate
The Article related to tetrahydronaphthalenone preparation diastereoselective dft, vinylketoester alkene intermol radical tricarbofunctionalization, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Naphthalenes and other aspects.Quality Control of Methyl 2-cyclopentanonecarboxylate
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