On February 5, 2021, Yang, Xiaobao; Jiang, Biao; Song, Xiaoling; Sun, Ning; Ren, Chaowei; Sun, Renhong; Qu, Xiaojuan; Liu, Haixia; Qiu, Xing published a patent.Category: esters-buliding-blocks The title of the patent was Diastereoselective preparation of (aryl)amides derivatives as antitumor agents for EGFR degradation. And the patent contained the following:
The present invention relates to the diastereoselective preparation of (aryl)amides derivatives as antitumor agents for EGFR degradation In particular, (aryl)amide derivatives I [wherein, EGFR binders can bind to EGFR protein; ULM is II; wherein, A is selected from -CH2-, -(C=O)-; B, X, Y, and Z are each independently selected from CH and N; R is -S-, -SO-, -NH-, etc., or not present; D is -(C=O)-, or D does not exist; or, ULM is III, wherein, Z is selected from -(C=O)-, or Z does not exist; or, ULM is IV, wherein, A is selected from -CH2-, -NR’-, -O-, -S-, -(C=O)-, wherein R’ is selected from H, linear or branched C1-C10 alkyl or C3-C10 cycloalkyl; B is -(C=O)-, or B does not exist; D1, D2, D3, D4, D5, D6, D7, D8 are each independently selected from F, Cl, Br, etc.; LIN represents a linking group connected to EGFR binders and ULM through covalent bonds.] bifunctional compound or a pharmaceutically acceptable salt, isomer, prodrug, polymorph or solvate thereof were prepared The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Category: esters-buliding-blocks
The Article related to aryl amide derivative preparation antitumor agent egfr degradation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics