On April 5, 2022, Wang, Yonggang; Lin, Zhaiwei; Hu, Shuanghua published a patent.Safety of Ethyl 3-fluoro-2-methylbenzoate The title of the patent was Preparation of pyridazinone derivatives and its application thereof. And the patent contained the following:
The present invention relates to the preparation of pyridazinone derivatives and its application thereof. In particular, pyridazinone derivative I (wherein, R1 is H, optionally substituted phosphate group or -C(=O)Y1, -C(=O)-O-Y1, -(CH2)-O-(C=O)-Y1, (CH2)- O-(C=O)-O-Y1, -(CHCH3)-O-(C=O)-Y1 and -(CHCH3)-O-(C=O)-O-Y1; Y1 is optionally substituted C1-10 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted aryl, etc.; R2 and R3 can be optionally independently H, C1-6 alkyl, -C(O)-C1-6 alkyl, halogen, -CF3, -CN, etc.; R4 is (R7)(R8)CH- (here, R7 and R8 are are optionally substituted aryl, and optionally substituted heteroaryl; wherein the substituents are independent C1-6 alkyl, -C(O)- C1-6 alkyl, etc.)). Further, (or II (here, R9, R10 are optionally substituted aryl, and optionally substituted heteroaryl; wherein the substituents are independent C1-6 alkyl, -C(O)- C1-6 alkyl, C1-6 haloalkyl, halogen, -CF3, etc.; R11 is H, C1-3 alkyl, C1-3 haloalkyl or C1-3 alkoxy); R7 and R8 can be linked to form a ring structure III (where n and m can be independently 0-3, Q is CR*R**, NR*, O, S, SO, SO2; R* and R** are independently H and optionally substituted C1-6 alkyl); R5 and R6 are independently selected from F, CH3 and CF3, and R5 and R6 are not selected as CH3 at the same time) and its pharmaceutically acceptable salts, solvates, hydrates, N-oxides, polycrystals, prodrugs, co-crystals, tautomers, stereoisomers or their mixtures, isotopically labeled derivatives were prepared The inventive compounds of the present invention can be used as anti-influenza drugs having CEN (cap-dependent endonuclease) inhibition. The experimental process involved the reaction of Ethyl 3-fluoro-2-methylbenzoate(cas: 114312-57-1).Safety of Ethyl 3-fluoro-2-methylbenzoate
The Article related to pyridopyridazine dione derivative preparation antiinfluenza drug, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Safety of Ethyl 3-fluoro-2-methylbenzoate
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