On April 30, 2018, Osawa, Tsutomu; Wakasugi, Masahiro; Kizawa, Tomoko; Borovkov, Victor; Inoue, Yoshihisa published an article.Reference of (R)-Methyl 3-hydroxybutanoate The title of the article was Enantio-differentiating hydrogenation of alkyl 3-oxobutanoates over tartaric acid-modified Ni catalyst: Enthalpy-entropy compensation effect as a tool for elucidating mechanistic features. And the article contained the following:
The enantio-differentiating hydrogenations of a series of alkyl 3-oxobutanoates were carried out at the temperatures ranging from 333 to 393K over the (R,R)-tartaric acid-modified Ni catalyst prepared from com. available Ni powder to achieve high enantiomeric excesses of 91-94%. It was demonstrated that the enantio-selectivity was not a simple function of the reaction temperature, being enhanced in the low temperature region to reach a maximum at 363-373K and then decreased at higher temperatures Nevertheless, all the differential enthalpies and entropies of activation calculated from the enantiomer ratios in the low and high temperature regions compensated with each other, indicating the same enantio-differentiation mechanism over the entire temperature range. A plausible enantio-differentiation mechanism explaining the effects of hydrogenation temperature on the enantio-selectivity is proposed. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Reference of (R)-Methyl 3-hydroxybutanoate
The Article related to alkyl oxobutanoate hydrogenation mechanism kinetics thermodn, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Reference of (R)-Methyl 3-hydroxybutanoate
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