Osawa, Tsutomu; Kizawa, Tomoko; Takano, Fumika; Ikeda, Shinji; Kitamura, Takayuki; Inoue, Yoshihisa; Borovkov, Victor published an article in 2014, the title of the article was Catalytic Enantiodifferentiating Hydrogenation with Commercial Nickel Powders Chirally Modified by Tartaric Acid and Sodium Bromide.Formula: C5H10O3 And the article contains the following content:
The chirally modified nickel catalysts for the enantiodifferentiating hydrogenation of β-ketoesters are prepared conventionally by immersing hydrogen-activated metallic nickel into an aqueous solution of enantiopure tartaric acid, in which the preactivation of nickel is essential. Herein, we revealed that even com. available nickel powders without any pretreatment can catalyze the enantiodifferentiating hydrogenation of β-ketoesters to give the corresponding β-hydroxyesters in quant. yield and high enantioselectivity (up to 91%) under optimized conditions. The immediate use of com. available nickel powders and the reproducible high chem. and optical yields not only expand the scope of heterogeneous asym. catalysis but also pave the way for the practical application and industrial use of chirally modified nickel catalysts. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Formula: C5H10O3
The Article related to methyl hydroxybutyrate enantioselective synthesis, ketoester hydrogenation tartaric acid modified nickel sodium bromide, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Formula: C5H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics