On February 18, 2022, Lin, Zhaiwei; Cui, Baicheng published a patent.Formula: C10H11FO2 The title of the patent was Preparation of pyridazinone derivatives and its application as anti-influenza drugs with CEN inhibitory effect. And the patent contained the following:
The present invention relates to the preparation of pyridazinone derivatives and its application as anti-influenza drugs with CEN inhibitory effect. In particular, the pyridazinone derivative I (wherein, R1 = H or -C(=O)Y1, -C(=O)-O-Y1, -(CH2)-O-(C=O)-Y1 etc.; Y1 = optionally substituted C1-10 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted aryl, -C(R* )2NHR** etc., and each R* and R** = independently hydrogen or optionally substituted C1-6 alkyl; R2 and R3 = independently H, D, C1-6 alkyl, -C(O)- C1-6 alkyl, halogen, -OR* etc.; R2 and R3 can be connected to form a ring to form an optionally substituted cycloalkyl, an optionally substituted heterocyclyl and an optionally substituted cycloalkenyl; R* and R** = independently H and optionally substituted C1-6 alkyl; q = 0-6). Further, (R4 = R6 and R7 substituted isobutane, where R6 and R7 are optionally substituted aryl groups and optionally substituted heteroaryl groups; wherein the substituents are independently C1-6 alkyl, -CN, -COOR* etc., where R* and R** = independently H, D and optionally substituted C1-6 alkyl; q = 0-6; R6 and R7 can be linked to form a compound II (wherein, m and n = independently 0-3, Q = CR*R**, NR*, O, S, SO, SO2; R* and R** = independently H, D and optionally substituted C1-6 alkyl); R5 = optionally substituted cycloalkyl, optionally substituted heterocyclyl and optionally substituted cycloalkenyl, such as a 6-membered ring, the ring may be carbocycle or O, N containing heterocycle) or its pharmaceutically acceptable salts, solvates, including hydrates, polymorphs, prodrugs, co-crystals, tautomers, stereoisomers were prepared The inventive compounds can be used as anti-influenza drugs having CEN inhibitory action. The experimental process involved the reaction of Ethyl 3-fluoro-2-methylbenzoate(cas: 114312-57-1).Formula: C10H11FO2
The Article related to pyridazinone derivative preparation antiinfluenza drug cen inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Formula: C10H11FO2
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