On April 11, 2013, Boss, Christoph; Brotschi, Christine; Heidmann, Bibia; Sifferlen, Thierry; Williams, Jodi T. published a patent.Reference of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the patent was Preparation of diazabicyclononane derivatives for use as orexin receptor antagonists. And the patent contained the following:
Title compounds I [A = (un)substituted Ph or heteroaryl; B = (un)substituted heteroaryl; X = CH2 or O], and their pharmaceutically acceptable salts, are prepared and disclosed as orexin receptor antagonists. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in OX1 receptor assays, e.g., II demonstrated an IC50 value of 8 nM. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Reference of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
The Article related to diazabicyclononane derivative preparation orexin receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Reference of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
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