Month: October 2022

Majumdar, Krishna C.; Kundu, Anup K. published the artcile< Pyridine hydrobromide perbromide mediated regioselective heterocyclization of ortho-cyclohexenyl phenols>, Computed Properties of 112-63-0, the main research area is pyridine hydrobromide perbromide cyclization cyclohexenylphenol preparation.

A series of 2,6-methano-1-benzoxecin derivatives was prepared in almost quant. yields by regioselective heterocyclization of 2-(2-cyclohexen-1-yl)phenols. The structures of one of the 2,5-methano-1-benzoxecins thus prepared was determined by the synthesis of a mercury compound from the intermediate 2-(2-cyclohexen-1-yl)-4-methoxyphenol. The cyclization of 2-chloro-6-(2-cyclohexen-1-yl)phenol failed and yielded a ring-brominated product instead.

Canadian Journal of Chemistry published new progress about Cyclization, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Song; Ren, Fang-Yu; Xie, Wei-Hang; He, Liang-Nian; Li, Hong-Ru published the artcile< Heterogeneous esterification of ricinoleic acid with polyol for the synthesis of polyol ricinoleates as biomass-based lubricant base oil>, Related Products of 112-63-0, the main research area is ricinoleic acid polyol ricinoleats biomass lubricant base oil esterification.

Bio-derived lubricants, especially those derived from vegetable oils, are considered to be promising alternatives to mineral oil-based lubricants due to the features of sustainability and environmental friendliness. In this work, the polyol ricinoleates were prepared by esterification of ricinoleic acid with trimethylolpropane (TMP), neopentyl glycol (NPG) and pentaerythritol (PE) resp. using Lewis acidic stannous oxide as an efficient heterogeneous catalyst, affording the polyol ricinoleates up to 99.7% yield. Remarkably, the solid catalyst was readily recovered and reused at least for five cycles without significant loss of activity. The resulting polyol ricinoleates products were structurally characterized by Fourier transform IR spectroscopy (FT-IR), 1H NMR, 13C NMR, electrospray ionization mass spectra (ESI-MS); and were stable below 300°C through thermogravimetric anal. (TGA). Furthermore, the physicochem. and lubricating properties of as-synthesized polyol esters were also evaluated including viscosity at 40 and 100°C, viscosity index (VI), pour point and flash point, thermal stability and wear scar diameter To our delight, the performance indicators of the target products were comparable or better than the com. lubricants, showing their potential as lubricant base oil. This work represents an alternative access to useful lubricant products via effective and selective conversion of non-edible vegetable oil.

Journal of the American Oil Chemists’ Society published new progress about Base oils. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Frymark, Justyna; Zabiszak, Michal; Grajewski, Jakub; Hnatejko, Zbigniew; Kolodynska, Dorota; Kaczmarek, Malgorzata T.; Jastrzab, Renata published the artcile< Excess of polyamine as a factor influencing the mode of coordination in the Eu(III)/α-hydroxy acid/spermine system>, Synthetic Route of 112-63-0, the main research area is europium complexation hydroxy acid spermine excess polyamine spectroscopy.

The complexes of europium(III) ions in binary and ternary systems with α-hydroxy acids and biogenic amine – spermine were investigated. Studies have been performed in aqueous solution using the potentiometric method with computer anal. of the data. Anal. of the equilibrium constants of the reactions and spectroscopic data have allowed us to determine the type of coordination and effectiveness of the carboxyl groups in the process of complex formation in the systems studied. Furthermore, the results confirmed the occurrence of non-covalent interactions of protonated spermine with coordinated α-hydroxy acid. The effect of biogenic polyamine concentration was clearly confirmed, and their influence on the stability and coordination mode of ternary complexes was found.

Polyhedron published new progress about Circular dichroism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Yuan; Chen, Li; Ding, Deping; Li, Ziheng; Cheng, Li; You, Qiuyun; Zhang, Shunbo published the artcile< Cyanidin-3-O-glucoside inhibits the β-catenin/MGMT pathway by upregulating miR-214-5p to reverse chemotherapy resistance in glioma cells>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyanidin 3 glucoside anticancer agent mRNA glioma.

Overcoming resistance to alkylating agents has important clin. significance in glioma. Cyanidin-3-O-glucoside (C3G) has a tumor-suppressive effect on tumor cells. However, whether it plays a role in temozolomide resistance in glioma is still unclear. We constructed a TMZ-resistant LN-18/TR glioma cell line, observed the effect of C3G on TMZ resistance in this cell line, and explored the role of miR-214-5p in chemoresistance. Results showed that β-catenin and MGMT were significantly upregulated in LN-18/TR cells. C3G upregulated miR-214-5p and enhanced the cytotoxic effect of temozolomide on LN-18/TR cells. Contrarily, C3G downregulated β-catenin and MGMT. Moreover, the miR-214-5p mimic downregulated β-catenin and MGMT in LN-18/TR cells, whereas the miR-214-5p inhibitor had the opposite effect; the miR-214-5p inhibitor significantly blocked the C3G-induced downregulation of β-catenin and MGMT. C3G or the miR-214-5p mimic enhanced temozolomide-induced apoptosis in LN-18/TR cells, whereas the miR-214-5p inhibitor blocked this effect. Furthermore, C3G or miR-214-5p agomir combined with TMZ significantly inhibited the growth of LN-18/TR tumors. Collectively, our research discovered the potential signaling mechanism associated with C3G-mediated suppression of TMZ resistance in LN-18/TR cells through miR-214-5p, which can facilitate the treatment of MGMT-induced resistance in glioma cells.

Scientific Reports published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (CTNNB1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perlow, Haley K.; Yaney, Alexander; Yang, Michael; Klamer, Brett; Matsui, Jennifer; Raval, Raju R.; Blakaj, Dukagjin M.; Arnett, Andrea; Beyer, Sasha; Elder, James B.; Ammirati, Mario; Lonser, Russell; Hardesty, Douglas; Ong, Shirley; Giglio, Pierre; Pillainayagam, Clement; Goranovich, Justin; Grecula, John; Chakravarti, Arnab; Gondi, Vinai; Brown, Paul D.; Palmer, Joshua D. published the artcile< Dose-escalated accelerated hypofractionation for elderly or frail patients with a newly diagnosed glioblastoma>, Application of C19H34O2, the main research area is glioblastoma cancer diagnosis hypofractionation temozolomide MGMT methylation drug toxicity; Elderly; Frail; Glioblastoma; Hypofractionation; Radiation.

The standard of care for elderly glioblastoma patients is 40 Gy in 15 fraction radiotherapy with temozolomide (TMZ). However, this regimen has a lower biol. equivalent dose (BED) compared to the Stupp regimen of 60 Gy in 30 fractions. We hypothesize that accelerated hypofractionated radiation of 52.5 Gy in 15 fractions (BED equivalent to Stupp) will have superior survival compared to 40 Gy in 15 fractions. Elderly patients (≥ 65 years old) who received hypofractionated radiation with TMZ from 2010 to 2020 were included in this anal. Overall survival (OS) and progression free survival were defined as the time elapsed between surgery/biopsy and death from any cause or progression. Baseline characteristics were compared between patients who received 40 and 52.5 Gy. Univariable and multivariable analyses were performed. Sixty-six newly diagnosed patients were eligible for anal. Thirty-nine patients were treated with 40 Gy in 15 fractions while twenty-seven were treated with 52.5 Gy in 15 fractions. Patients had no significant differences in age, sex, methylation status, or performance status. OS was superior in the 52.5 Gy group (14.1 mo) when compared to the 40 Gy group (7.9 mo, p = 0.011). Isoeffective dosing to 52.5 Gy was shown to be an independent prognostic factor for improved OS on multivariable anal. Isoeffective dosing to 52.5 Gy in 15 fractions was associated with superior OS compared to standard of care 40 Gy in 15 fractions. These hypothesis generating data support accelerated hypofractionation in future prospective trials.

Journal of Neuro-Oncology published new progress about Alopecia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Massey, Richard S.; Murray, Jacob; Collett, Christopher J.; Zhu, Jiayun; Smith, Andrew D.; O’Donoghue, AnnMarie C. published the artcile< Kinetic and structure-activity studies of the triazolium ion-catalysed benzoin condensation>, Category: esters-buliding-blocks, the main research area is benzaldehyde triazolium catalyst preparation benzoin condensation reaction kinetics.

Steady-state kinetic and structure-activity studies of a series of six triazolium-ion pre-catalysts 2a-2f were investigated for the benzoin condensation. These data provide quant. insight into the role of triazolium N-aryl substitution under synthetically relevant catalytic conditions in a polar solvent environment. Kinetic behavior was significantly different to that previously reported for a related thiazolium-ion pre-catalyst 1, with the observed leveling of initial rate constants to νmax at high aldehyde concentrations for all triazolium catalysts. Values for νmax for 2a-2f increase with electron withdrawing N-aryl substituents, in agreement with reported optimal synthetic outcomes under catalytic conditions, and vary by 75-fold across the series. The leveling of rate constants supports a change in rate-limiting step and evidence supports the assignment of the Breslow-intermediate forming step to the plateau region. Correlation of νmax reaction data yielded a pos. Hammett ρ-value (ρ = +1.66) supporting the build up of electron d. adjacent to the triazolium N-Ar in the rate-limiting step favored by electron withdrawing N-aryl substituents. At lower concentrations of aldehyde, both Breslow-intermediate and benzoin formation are partially rate-limiting.

Organic & Biomolecular Chemistry published new progress about Benzoin condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sankpal, Mrunali Mohan published the artcile< Determination of phytoconstituents in Annona reticulata Linn. Methanolic leaf extract using GCMS>, Quality Control of 112-63-0, the main research area is phytoconstituent Methanolic leaf extract Annona reticulata.

The present investigation was carried out for the qual. screening of major phytochem. groups and to identify specific bioactive compounds present in the methanolic leaf extracts of Annona reticulata Linn. The qual. screening of phytochem. groups was done using the standard procedures described in Exptl. Phytopharmacognosy and the identification of bioactive compounds by using GC-MS anal. The qual. phytochem. screening revealed the presence of phenolics, flavonoids, alkaloids, tannins, glycosides, terpenoids and carbohydrates. The GC-MS anal. identified 33 phytocompounds of which most of them were reported to have important biol. activities. The study confirmed the medicinal property of Annona reticulata Linn. and suggest that further research works are to be carried out for the utilization of the active principles for future drug developments.

World Journal of Pharmaceutical Research published new progress about Alkaloids Role: ANT (Analyte), PAC (Pharmacological Activity), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Jun; Qiu, Xiaoyong; Yan, Bin; Xie, Lei; Yang, Jingqi; Xu, Haolan; Deng, Yonghong; Chen, Lingyun; Wang, Xiaogang; Zeng, Hongbo published the artcile< Robust polymer nanofilms with bioengineering and environmental applications via facile and highly efficient covalent layer-by-layer assembly>, Synthetic Route of 71195-85-2, the main research area is polymer nanofilm bioengineering cell adhesion surface hydrophobicity.

This work reports novel, robust, multifunctional covalent-bonded polymer nanofilms based on highly efficient spin-assisted layer-by-layer (LbL) assembly, with a wide range of engineering and bioengineering applications. An active-ester block copolymer, polypentafluorophenylacrylate-block-polystyrene (PPFPA-b-PS), and an amine-rich polymer, branched polyethyleneimine (PEI), were chosen as model polymers. The as-prepared nanofilms show switchable hydrophobicity with controllable thickness. Nanomech. tests demonstrate that the surface adhesion between the PPFPA-b-PS and PEI layers facilitates excellent film stability under different solvent conditions. Robust and centimeter-scale freestanding nanofilms with good transparency and excellent flexibility could be readily obtained by peeling the films from their silicon substrates without using a sacrifice layer. More importantly, the multi-layer nanofilms containing free pentafluorophenol groups or amine groups can be readily functionalized further to tailor the properties of the films for various applications. As a proof of concept, a multi-layer nanofilm with free ester groups was modified with rhodamine-6G hydrazone and tested as a H+ sensor. The free amine groups in the polymer nanofilms show strong interactions with perfluorooctanoic acid for achieving high surface hydrophobicity. The polymer nanofilms also show exceptional tunable cell-attachment behavior by switching the outmost layer between PPFPA-b-PS and PEI, demonstrating great potential for biomedical applications.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Adhesion, physical (surface). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Synthetic Route of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kunz, Roxanne K.; Rumfelt, Shannon; Chen, Ning; Zhang, Dawei; Tasker, Andrew S.; Buerli, Roland; Hungate, Randall; Yu, Violeta; Nguyen, Yen; Whittington, Douglas A.; Meagher, Kristin L.; Plant, Matthew; Tudor, Yanyan; Schrag, Michael; Xu, Yang; Ng, Gordon Y.; Hu, Essa published the artcile< Discovery of amido-benzisoxazoles as potent c-Kit inhibitors>, Category: esters-buliding-blocks, the main research area is benzisoxazole preparation cKit inhibitor SAR.

Deregulation of the receptor tyrosine kinase c-Kit is associated with an increasing number of human diseases, including certain cancers and mast cell diseases. Interference of c-Kit signaling with multi-kinase inhibitors has been shown clin. to successfully treat gastrointestinal stromal tumors and mastocytosis. Targeted therapy of c-Kit activity may provide therapeutic advantages against off-target effects for non-oncol. applications. A new structural class of c-Kit inhibitors is described, including in vitro c-Kit potency, kinase selectivity, and the observed binding mode.

Bioorganic & Medicinal Chemistry Letters published new progress about c-Kit proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Nan-Nan; Zhao, Ying; Guo, Yue-Yue; Zhang, Zhi-Hui; Gao, Lan; Yu, De-Xin; Xu, De-Xiang; Xu, Shen published the artcile< Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury>, Synthetic Route of 347174-05-4, the main research area is mitochondria reactive oxygen species ferroptosis lipopolysaccharide acute kidney injury; Acute kidney injury; Ferroptosis; Mitochondria-derived reactive oxygen species; Mitochondria-targeted antioxidants.

Our earlier studies indicated that reactive oxygen species (ROS) were involved in lipopolysaccharide (LPS)-induced acute kidney injury (AKI). The present study aimed to explore the role of mitochondria-derived ROS on renal cell ferroptosis during LPS-induced AKI. Male CD-1 mice were i.p. injected with LPS (2.0 mg/kg). Renal MDA and 4HNE residue, two markers of lipid peroxidation, were increased in LPS-exposed mice. Oxidized lipids were detected in LPS-treated human HK-2 cells. In vivo, ferroptosis-characteristic ultrastructure changes, including cell volume reduction, nuclear pyknosis and smaller mitochondria, were shown in renal cortex. In vitro, abnormal alteration of mitochondrial membrane potential was observed in LPS-treated human HK-2 cells. Ferrostatin-1, a specific inhibitor of ferroptosis, attenuated LPS-evoked renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage and renal cell death. Mechanistically, mitochondria-derived ROS were elevated in LPS-stimulated HK-2 cells. MitoQ, a mitochondria-targeted antioxidant, almost completely scavenged LPS-stimulated mitochondrial ROS in human HK-2 cells. Moreover, pretreatment with MitoQ attenuated LPS-induced GSH depletion and lipid peroxidation in mouse kidney. Finally, pretreatment with MitoQ alleviated LPS-induced renal cell death and AKI. Taken together, these results suggest that mitochondria-derived ROS contribute, at least partially, to renal cell ferroptosis during LPS-induced AKI. Mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.

International Immunopharmacology published new progress about Acute kidney injury. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Synthetic Route of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics