Month: October 2022

Ramachandran, P. Veeraraghavan; Otoo, Barnabas published the artcile< Irreversible aldolization of ketones with bisdicyclohexylboron enediolates>, Reference of 94-02-0, the main research area is hydroxy acid preparation diastereoselective; ketone bisdicyclohexylboron enolate irreversible aldolization.

Reversible addition of ketone enolborinates to ketones RCOR1 (R = Et, 4-bromophenyl, cyclohexyl, etc.; R1 = H, chloromethyl, Ph, 3-ethoxy-3-oxoprop-1-en-1-yl, etc.) and the aldolization of ketones with bisboron enediolates derived from carboxylic acids R2CH2C(O)OH (R2 = Me, Cl, ph, etc.) proceed without difficulty. A variety of α,β,β-trisubstituted-β-hydroxy acids syn/anti-RC(OH)(R1)CH(R2)C(O)OH have been thus synthesized in good to excellent yields and diastereoselectivities.

Tetrahedron Letters published new progress about Aldol condensation (irreversible). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Reference of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Duan, Ju; Wang, Wenting; Zou, Degui; Liu, Jing; Li, Na; Weng, Junying; Xu, Li-ping; Guan, Ying; Zhang, Yongjun; Zhou, Pengfei published the artcile< Construction of a Few-Layered COF@CNT Composite as an Ultrahigh Rate Cathode for Low-Cost K-Ion Batteries>, Category: esters-buliding-blocks, the main research area is covalent organic framework carbon nanotube potassium ion battery cathode; cathode materials; covalent organic frameworks; few-layered; potassium-ion batteries; ultrahigh rate performance.

Potassium-ion batteries (PIBs) are attracting great interest for large-scale energy storage owing to the abundant resources and low redox potential of K+/K. However, the large volume changes and slow kinetics caused by the larger ionic radius of K+ for cathode materials remain a critical challenge for PIBs. Herein, we construct few-layered covalent organic frameworks integrated with carboxylated carbon nanotubes (DAAQ-COF@CNT) as cathode materials for PIBs. The synthesized DAAQ-COF@CNT features numerous active sites, a stable conductive framework, and an appropriate surface area with nanopores, which can render high elec. conductivity, shorten the ion/electron diffusion distance, and accelerate K+ diffusion. In consequence, the DAAQ-COF@CNT delivers a high reversible capacity of 157.7 mAh g-1 at 0.1 A g-1, an excellent rate capability of 111.2 mAh g-1 at 1 A g-1, and a long cycling stability of 77.6% capacity retention after 500 cycles at 0.5 A g-1. The integrated characterization of ex situ XPS, Fourier transform IR spectroscopy, and theor. simulation discloses that the storage mechanism of DAAQ-COF@CNT is based on the reversible reaction between electroactive C=O groups and K+ during two successive steps. This work provides a promising high-performance cathode material for PIBs and encourages the development of new types of covalent organic frameworks for PIBs.

ACS Applied Materials & Interfaces published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Hua; Liu, Liangliang; Liu, Xiao; Jia, Yu; Zhang, Peng; Zhang, Yong published the artcile< Greatly promoted oxygen reduction reaction activity of solid catalysts by regulating the stability of superoxide in metal-O2 batteries>, Application of C19H34O2, the main research area is superoxide solid catalyst stability oxygen battery reduction reaction activity.

Oxygen reduction reactions (ORRs) with one- or two-electron-transfer pathways are the essential process for aprotic metal-oxygen batteries, in which the stability of superoxide intermediates/products (O2-, LiO2, NaO2, etc.) mainly dominates the ORR activity/stability and battery performance. However, little success in regulating the stability of the superoxides has been achieved due to their highly reactive characteristics. Herein, we identified and modulated the stability of superoxides by introducing anthraquinone derivatives as cocatalysts which functioned as superoxide trapper adsorbing the superoxides generated via surface-mediated ORR and then transferring them from the solid catalyst surface into electrolyte. Among the studied trappers, 1,4-difluoroanthraquinone (DFAQ) with electron-withdrawing groups showed the highest adsorption towards superoxides and could efficiently stabilize LiO2 in electrolyte, which greatly promoted the surface-mediated ORR rate and stability. This highlighted the magnitude of adsorption between the trapper and LiO2 on the ORR activity/stability. Using an aprotic Li-O2 battery as a model metal-O2 battery, the overall performance of the cell with DFAQ was substantially improved in terms of cell capacity, rate capability and cyclic stability. These results represent a significant advance in the understanding of ORR mechanisms and promoting the performance of metal-O2 batteries.

Science China Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lan; Xian, Yan-Fang; Hu, Zhen; Loo, Steven King Fan; Ip, Siu Po; Chan, Wood Yee; Lin, Zhi-Xiu; Wu, Justin Che Yuen published the artcile< Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis>, Synthetic Route of 112-63-0, the main research area is Chinese herbal formula exptl model atopic dermatitis; Atopic dermatitis; Chinese herbal formula; Epidermal barrier; NF-κB pathway; Skin inflammation; Th1/Th2 balance.

Atopic dermatitis (AD) is a skin inflammatory disease characterized by erythema, eruption, lichenification and pruritus. Shi Zhen Formula (SZF), an empirical Chinese herbal preparation, has clin. efficacy in relieving the symptoms of AD patients. However, the underlying mol. mechanisms of SZF remained unclear. We aimed to investigate the anti-AD effects of SZF and elucidate its underlying mol. mechanisms using in vitro and in vivo models of AD. High-performance liquid chromatog. anal. was performed for quality control of SZF extract The anti-inflammatory effect of SZF was investigated through evaluating the levels of nitric oxide (NO), chemokines and pro-inflammatory cytokines in the lipopolysaccharide (LPS) stimulated RAW264.7 cells. AD-like skin lesions in female BALB/c mice were induced by 2,4-dinitrochlorobenzene (DNCB). SZF (3.15, 6.30 and 9.45 g/kg) and dexamethasone (5 mg/kg) were administered by gavage daily for 15 consecutive days. The body weight, skin thickness, skin dermatitis severity and scratching behaviors were recorded throughout the study. Histol. anal., reverse transcription-quant. polymerase chain reaction (RT-PCR), western blot (WB) and ELISA anal. were used to illuminate the mol. targets associated with the anti-AD effects of SZF. SZF markedly decreased the epidermal thickening and infiltration of mast cells in the ears and dorsal skin of the 2,4-dinitrochlorobenzene (DNCB)-treated mice. SZF not only suppressed the levels of IgE (IgE), histamine, thymic stromal lymphopoietin (TSLP) and IL-4 in the serum but also suppressed the over-production of IL-4 and IL-6 and gene expressions of IL-4, IL-13, IL-31 and TSLP in the dorsal skin. Moreover, SZF improved epidermal barrier by increasing the protein expressions of filaggrin, involucrin and loricrin and inhibited the activation of NF-κB p65 pathway in the dorsal skin of the DNCB-treated mice. SZF alleviates DNCB induced AD-like skin lesions in mice through regulating Th1/Th2 balance, improving epidermal barrier and inhibiting skin inflammation. Our research findings provide scientific footing on the use of this Chinese herbal formula for the treatment of AD.

Journal of Ethnopharmacology published new progress about Atopic dermatitis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Dong; Chen, Ying-Chun; Wang, Qi-Wei; Cun, Ling-Feng; Zhu, Jin; Deng, Jin-Gen published the artcile< Asymmetric Direct Vinylogous Michael Reaction of Activated Alkenes to Nitroolefins Catalyzed by Modified Cinchona Alkaloids>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is malononitrile alkylidene stereoselective vinylogous Michael addition nitroalkene cinchona alkaloid; alkylidene malononitrile nitroalkyl asym synthesis.

The first organocatalytic and asym. direct vinylogous Michael reaction of electron-deficient alkylidene malononitriles, e.g. I (X = CH2, O, S), as the nucleophilic species with nitroalkenes RCH:CHNO2 (R = Ph, 4-MeOC6H4, 4-ClC6H4, 2-furyl, 2-thienyl, etc.) has been reported. The novel transformations exhibit exclusive γ-selectivity and high diastereo- and enantioselectivity and afford the multifunctional products with two vicinal chiral centers, e.g. II, in 85-95% yields.

Organic Letters published new progress about Alkenes, electron-deficient Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yin, Jiameng; Lin, Yajun; Fang, Weiwei; Zhang, Xin; Wei, Jie; Hu, Gang; Liu, Pu; Niu, Jie; Guo, Jun; Zhen, Yongzhan; Li, Jian published the artcile< Tetrandrine citrate suppresses breast cancer via depletion of glutathione peroxidase 4 and activation of nuclear receptor coactivator 4-mediated ferritinophagy>, Application In Synthesis of 347174-05-4, the main research area is tetrandrine citrate glutathione peroxidase nuclear receptor coactivator breast cancer; breast cancer; ferroptosis; glutathione peroxidase 4; nuclear receptor coactivator 4; tetrandrine citrate.

Tetrandrine citrate (TetC), a novel tetrandrine salt with high water solubility, demonstrates a potent antitumor activity in chronic myeloid leukemia. Studies have indicated an important role of ferroptosis in breast cancer (BC). However, whether TetC inhibits BC progression via ferroptosis has never been explored. In the present study, we showed that TetC had a significant inhibitory effect on the proliferation and migration of MCF7 and MDA-MB-231 cells. Then, we combined TetC with different inhibitors to determine which form of cell death could be driven by TetC. MTT assay showed that ferrostatin (Fer-1) demonstrated the most potent effect on improving TetC-induced cell death in contrast to other inhibitors. TetC was also shown to significantly increase the mRNA level of prostaglandinendoperoxide synthase 2 (Ptgs2), a ferroptosis marker. Further studies showed that TetC significantly suppressed the expression of glutathione peroxidase 4 (GPX4) and ferritin heavy chain 1 (FTH1) but increased the expression of nuclear receptor coactivator 4 (NCOA4) in MCF7 and MDA-MB-231 cells even in the presence of erastin or Ras-selective lethal 3 (RSL3). Collectively, we showed novel data that ferroptosis was a major form of TetC-induced cell death. Moreover, TetC-induced ferroptotic cell death was achieved via suppressing GPX4 expression and activating NCOA4-mediated ferritinophagy in BC cells.

Frontiers in Pharmacology published new progress about Autophagosome. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polonski, Tadeusz published the artcile< Chiroptical properties and molecular geometry of substituted succinic anhydrides and imides>, Computed Properties of 617-55-0, the main research area is CD succinic anhydride succinimide conformation; mol mechanic succinic anhydride succinimide; UV spectra succinic anhydride succinimide; solvent effect CD anhydride imide.

UV and CD spectra have been measured for several α-substituted succinic anhydrides and imides. The Cotton effect signs corresponding to the two n-π* electronic transitions can be explained with the octant rule. The strong substituent and solvent dependence of the spectra is a result of the equilibrium between two skewed conformers of the five-membered ring. The geometry and relative energies of the conformers were found from mol. mechanics (MM2) calculations

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Circular dichroism. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Computed Properties of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amburgey-Peters, Judith C.; Haynes, LeRoy W. published the artcile< The addition of bromine to 1,2-diphenylethene>, Reference of 112-63-0, the main research area is chem education bromination diphenylethene pyridinium bromide perbromide bromine solvent.

The bromination of 1,2-diphenylethene, using a variety of solvents and brominating agents, can be used in both introductory and advanced organic chem. courses. The reactions can be used to illustrate the effects of changing solvents and reagents, as well as to reveal interesting aspects of organic reaction mechanisms. Experiments were carried out involving the addition of two brominating agent, pyridinium bromide perbromide (PBPB) and bromine to (Z)-1,2-diphenylethene (cis-stilbene) in the presence of different solvents, such as glacial acetic acid and dichloromethane. Bromine in glacial acetic acid gave an acceptable yield of d,l-1,2-dibromo-1,2-diphenylethane (d,l-DBDPE) than does PBPB in glacial acetic acid, and that even bromine in dichloromethane yields about 45% of d,l-DBDPE. A 49% of the d,l product was recovered by evaporating completely the dichloromethane.

Journal of Chemical Education published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Yang; Yang, Huailei; Shan, Baiyu; Fang, Kuo; Li, Mingyu; Wang, Fang; Bao, Huiwei published the artcile< Simultaneous Determination of Seven Active Components in Desheng Pills by High-performance Liquid Chromatography>, Application In Synthesis of 112-63-0, the main research area is Desheng pill paeoniflorin costunolide high performance liquid chromatog.

Desheng pills (DSP) consist of six traditional Chinese medicine. This preparation is used fornourishing blood, eliminating stasis, soothing liver and regulating menstruation, and can also be used to treat menoxenia and dysmenorrhea caus ed by qi stagnation and blood stasis. Objective: In this paper, an accurate and sensitive high-performance liquid chromatog.-diode array detector (HPLC-DAD) method was developed and validated for simultaneous determination of seven active components (gallic acid, paeoniflorin, costunolide, dehydrocostuslactone, rutin, leonurine hydrochloride and ferulic acid) in the traditional Chinese formula-Desheng pills. The seven analytes were separated on Agilent ZORBAX SB-C18 column (250mmx 4.6mm, 5μm) maintained at the temperature of 30. Gradient elution was performed with the mobile phase of methanol (A)-0.1% phosphoric acid solution (B) at the flow rate of 1.0mL·min-1. The anal. was carried out at the wavelength of 225 nm, 256 nm, 277 nm and 320 nm with an injection volume of 10μL. The measured seven components showed good linear relationships within their own concentration ranges along with coefficients of determination ≥0.9996. The limits of detection and quantitation of all analytes were in the range of 0.19-13.51μg/mL and 0.59-40.93μg/mL, resp. Average recoveries ranged from 98.82% to 102.01% with RSDs of 1.47%-1.99%. The content of tested components was in the range of 0.053-0.421 mg/g. Conclusion: The proposed method was found to be sensitive, accurate and reproducible, which provided an effective quant. anal. method for quality control of Desheng pills.

Current Pharmaceutical Analysis published new progress about Chinese medicine (Desheng pill). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Durie, Karson; Yatvin, Jeremy; McNitt, Christopher D.; Reese, R. Alexander; Jung, Calvin; Popik, Vladimir V.; Locklin, Jason published the artcile< Multifunctional Surface Manipulation Using Orthogonal Click Chemistry>, COA of Formula: C9H3F5O2, the main research area is reactive surface morphol polypentafluorophenyl acrylate brush click aminolysis.

Polymer brushes are excellent substrates for the covalent immobilization of a wide variety of mols. due to their unique physicochem. properties and high functional group d. By using reactive microcapillary printing, poly(pentafluorophenyl acrylate) brushes with rapid kinetic rates toward aminolysis can be partially patterned with other click functionalities such as strained cyclooctyne derivatives and sulfonyl fluorides. This trireactive surface can then react locally and selectively in a one pot reaction via three orthogonal chemistries at room temperature: activated ester aminolysis, strain promoted azide-alkyne cycloaddition, and sulfur(VI) fluoride exchange, all of which are tolerant of ambient moisture and oxygen. Furthermore, we demonstrate that these reactions can also be used to create areas of morphol. distinct surface features on the nanoscale, by inducing buckling instabilities in the films and the grafting of nanoparticles. This approach is modular, and allows for the development of highly complex surface motifs patterned with different chem. and morphol.

Langmuir published new progress about 1,3-Dipolar cycloaddition reaction. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics