In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks
To a solution of 4-(adamantan-1-yl)phenol(0.8 g, 3.50 mmol) in N,N-dimethylformamide(8 mL) was added anhydrous potassium carbonate(1.45 g, 10.51 mmol) and methyl 2-bromo-2-methylpropanoate(1.15 g, 7.0 mmol), and stirred at room temperature for 12 hours. The reaction mixture was diluted with ethyl acetate and washed with aqueous sodium bicarbonate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was filtered and evaporated under reduced pressure to afford a crude solid, which was purified by silica gel column chromatography to give methyl 2-(4-(adamantan-1-yl)phenoxy)-2-methylpropanoate as colorless oil(1.1 g, 94.1% yield). [288] 1H-NMR (MeOH-d4, 500 MHz) delta 7.21 (2H, d, aromatic-H), 6.75 (2H, d, aromatic-H), 3.73 (3H, s, OCH3), 2.05 (3H, brs, adamantyl-H), 1.88 (6H, m, adamantyl-H), 1.77 (6H, m, adamantyl-H), 1.52 (6H, s, (CH3)2).
The synthetic route of 23426-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; LEE, Kyeong; WON, Mi-Sun; KIM, Hwan-Mook; PARK, Song-Kyu; LEE, Ki-Ho; LEE, Chang-Woo; KIM, Bo-Kyung; BAN, Hyun-Seung; CHUNG, Kyung-Sook; RAVI, Naik; CHOI, Hyun-Kyung; WO2013/48164; (2013); A1;,
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