Adding a certain compound to certain chemical reactions, such as: 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 884497-46-5, Computed Properties of C8H8FNO2
Step C. Methyl 3-(dibenzylamino)-5-fluorobenzoate. To a solution of methyl 3-amino-5- fluorobenzoate (440 mg, 2.6 mmol) in dry DMF ( 10 mL) was added NaH ( 1 87 mg, 7.8 mmol) portionwise, followed by addition of benzyl bromide (1 . 1 g, 6.5 mmol). The reaction mixture was stirred at 40 C for 16 hr and concentrated. The resulting residue was purified by column chromatography to give the desired product. MS: 350 (M+ l )+.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding; WO2015/10297; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics