The chemical industry reduces the impact on the environment during synthesis Methyl 2-(3-fluorophenyl)acetate. I believe this compound will play a more active role in future production and life.
Synthetic Route of 64123-77-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.
Example 21: (R)-3-[l-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-l-(5-phenyl- [l,3,4]oxadiazol-2-ylmethyl)-l-azonia-bicyclo[2.2.2]octane chloride a) 2-But-3-enyl-2-(3-fluoro-phenyl)-hex-5-enoic acid methyl ester (3-Fluoro-phenyl)-acetic acid methyl ester (4.30 g) was dissolved in tetrahydrofuran (20 mL) and cooled to -78C. Lithium zs(trimethylsilyl)amide (25.6 mL, IM THF solution) was added and the solution was stirred for 30 minutes. 4-Bromo-but-l-ene (2.60 mL) was added and the reaction was allowed to warm to room temperature and stirred for an hour. The reaction was again cooled to -78C. Lithium zs(trimethylsilyl)amide (25.6 mL, IM THF solution) was added and the solution was stirred for 30 minutes. 4-Bromo-l-butene (2.60 mL) was added and the reaction was allowed to warm to room temperature and stirred for an hour. The reaction was again cooled to -78C and further aliquots of Lithium zs(trimethylsilyl)amide (25.6 mL, IM THF solution) and 4-bromo-l-butene (2.60 mL) were added following the procedure outlined above. After stirring overnight, water (20 mL) was added and the reaction mixture extracted with diethyl ether (2 x 60 mL). The combined organic extracts were dried with magnesium sulfate and evaporated. The resulting liquid was purified by column chromatography on silica eluting with ethyl acetate / iso hexane (1 / 99) to afford the sub-titled compound (5.0 g).m/e 277 [M+H]+
The chemical industry reduces the impact on the environment during synthesis Methyl 2-(3-fluorophenyl)acetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ARGENTA DISCOVERY Ltd.; FORD, Rhonan; WO2009/139709; (2009); A1;,
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