Tag: M.W=300-400

Electric Literature of 18013-97-3, These common heterocyclic compound, 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The inventive diindenothiophene derivatives can be produced by any of the methods that are conventionally known to persons having ordinary skill in the art. For instance, the above-mentioned compound of formula (2) can be prepared by a method comprising the following steps:

Statistics shows that Diethyl 2,5-dibromoterephthalate is playing an increasingly important role. we look forward to future research findings about 18013-97-3.

Reference:
Patent; ETERNAL CHEMICAL CO., LTD.; US2010/168444; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 859299-66-4, name is Dimethyl 4,5-dibromophthalate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 859299-66-4, SDS of cas: 859299-66-4

S01: The 4.7g (0.21mol) of sodium was slowly added to 50mL (0.48mol) of sodium ethoxide prepared in absolute ethanol; the ethanol was added to 60mL of sodium propionate and 52.8g (0.15mol) 5, 6- dibromo phthalate mixed solution of dimethyl, raised to 80 and stirred for 4 hours to give a pale yellow viscous paste; then use the atmospheric distillation paste methanol , ethanol, methyl propionate was removed, and then subjected to suction filtration residue was washed with petroleum ether to give 40.5g of a pale yellow solid after vacuum drying.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dimethyl 4,5-dibromophthalate, and friends who are interested can also refer to it.

Reference:
Patent; Technical Institute of Physics and Chemistry, CAS; Zhang, Xiaolong; Chen, Dongyang; Zheng, Caijun; (15 pag.)CN105693608; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 153559-48-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153559-48-9, name is Methyl 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Firstly weighing (20.4 mg, 0 . 15 mmol),photocatalyst Ir[dF(CF3)ppy]2(dtbbpy)PF6(2.3 mg, 0.002 mmol), K2HPO4(7.0 Mg, 0 . 04 mmol),and Ph3P (31.5 mg, 0.12 mmol)are added to a reaction tube, pumping air through the vacuum line three times, in the argon atmosphere, adding DCM/H2O (2.0 ml, 4:1 v/v), then carefully added (36.2 Mg, 0.1 mmol),then put into 5W blue LEDs lamp irradiation, react at room temperature for 48 h.Add 20 ml water, and the DCM extraction (3x 10 ml) the aqueous phase, combined with the organic phase. The organic phase by absolute Na2SO4 after drying and steaming and to remove the solvent, dry sample, column chromatography (300 – 400 item of chromatographic analysis silica gel) (petroleum ether – ethyl acetate) to obtain the product 34.2 mg, Yield 71%.

The synthetic route of Methyl 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing University; Xie Jing; Zhang Muliang; (58 pag.)CN108912042; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 18014-00-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2.59 g of compound 2 and 880 mg of 2,5-dibromoterephthalate were dissolved in 100 mL of freshly distilled tolueneMouth,Then, 400 mg of Pd (PPh3) 4 and 330 mg of CuI were added thereto under a nitrogen atmosphere,Heated to reflux for 8-12 hours. After completion of the reaction, the mixture was cooled to room temperature, the reaction solution was poured into water,Extracted with toluene twice, the organic phase was combined, dried, filtered and spin dried to obtain the crude product,The resulting crude product was purified by silica gel column to give 996 mg of compound 3 (84%).

The synthetic route of Dimethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hefei exciton Energy Technology Co., Ltd.; Ding, Jun; (21 pag.)CN106188091; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18014-00-1, Recommanded Product: 18014-00-1

A degassed solution of 157.6 g (400 mmol) of diethyl dibromoterephthalate and 36.7 g (220 mmol) of carbazole in 1 l of 1,2-dichlorobenzene is saturated with N2 for 1 h. Then, firstly 20 g (314 mmol) of copper powder, then 18 g (67 mmol) of 18-crown-6 are added to the solution, and 177 g (850 mmol) of potassium carbonate as the solid are subsequently added. The reaction mixture is heated at 170 C. for 18 h. After cooling to room temperature, 1 l of water is carefully added. The organic phase is washed with 4×50 ml of H2O and dried over MgSO4, and the solvents are removed in vacuo. The pure product is obtained by recrystallisation. The yield is 83 g (177 mmol), corresponding to 81% of theory

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Merck Patent GmbH; Parham, Amir Hossain; Pflumm, Christof; US2013/26422; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate, A new synthetic method of this compound is introduced below., Recommanded Product: 18014-00-1

Carbazole (6.68 g, 0.04 mol),Methyl 2,5-dibromo-1,4-terephthalate (10.48 g, 0.02 mol),O-dichlorobenzene (15ml),Potassium carbonate (5.52 g, 0.04 mol),18-crown-6 (1.07g, 4mmol),Cuprous iodide (0.76g, 4mmol)Mix in a dry single-mouth bottle (50ml),Under the protection of nitrogen atmosphere,Heating to 150 C, stirring and refluxing reaction for 18h ~ 36h,After cooling, suction filtration,Washed with dichloromethane,After rotary evaporation to remove the volatile solvent in the filtrate,Separation by column chromatography,Wet loading,Using petroleum ether/ethyl acetate (6:1) as the eluent,The yellow-green solid product (7.76 g, 14.8 mmol) was obtained.The yield is 74%;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing University of Posts and Telecommunications; Qian Yan; Wang Yingnan; Ye Jingfang; Mi Baoxiu; Gao Zhiqiang; Yi Mingdong; Zhang Guangwei; Xie Linghai; (10 pag.)CN110054581; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 581065-95-4, A common heterocyclic compound, 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, molecular formula is C15H31NO6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(4) 50g of the amino end product obtained in step (3) was added to 100ml of 3M hydrochloric acid,The temperature was raised to 60 C and stirred for 8h.The reaction is over,Adjust PH neutral,Then spin dry,Suction filtration,The filtrate was dried over anhydrous sodium sulfate,Spin dry,35 g of pure product was obtained.NMR data are as follows:

The synthetic route of 581065-95-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Deng Zeping; Li Hu; Cheng Jia; (8 pag.)CN107235848; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 111-61-5, name is Ethyl stearate, A new synthetic method of this compound is introduced below., Formula: C20H40O2

General procedure: To a solution of 100 mg of compound 3 (55 mumol, 1 equiv) in 2 ml of corresponding fatty ester (excess), 100 mg of Lipozyme was added. The reaction was set under rotary evaporator at 50 C during 8 to 14 hours depending on the corresponding fatty ester. Lipozyme was filtered, and the solution was purified directly on silica gel (from pure EtOAc to EtOAc/MeOH 4:1(v/v)), giving white solid. Yields: 4 (80mg): 74%, 5 (75mg): 68%, 6 (72mg): 64%, 7 (69mg): 60%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Miao, Yong; Djedani-Pilard, Florence; Bonnet, Vronique; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2654 – 2657;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 205448-64-2, name is Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate, A new synthetic method of this compound is introduced below., Safety of Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate

After heating biphenylphenoxybenzene (360 mL) to 175 C, Compound 3 (30 g, 89.47 mmol, 1 eq) was added portionwise at 175 C over 20 min. Stirring was continued at 175 C for another 2 h. The reaction mixture was cooled to room temperature (l6C), and petroleum ether (500 mL) was added. The resulting solid was filtered, and the filter cake washed with 100 mL of methyl tertiary butyl ether, dried under vacuum, and purified by flash silica gel chromatography (ISCO; 120 g SepaFlash Silica Flash Column, Eluent of 0-10% CH30H/CH2Cl2 50 mL/min) to give Compound 4 as a yellow solid (6 g, 27.3% yield). NMR (400 MHz, DMSO-d6) delta 11.70 (br s, 1H), 8.43 (s, 1H), 7.86 (br d, 1H), 7.02 (s, 1H), 5.99 (d, 1H), 3.89 (s, 3H), 3.81 (s, 3H); MS (El) for C12H11NO4, found 233.9 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; EXELIXIS, INC.; BANNEN, Lynne Canne; BUI, Minna; JIANG, Faming; WANG, Yong; XU, Wei; (235 pag.)WO2019/148043; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 581065-95-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, This compound has unique chemical properties. The synthetic route is as follows.

Example 9: Preparation of Compounds 10a and 10b [00172] Compound 8 (1.0 g, 1.97 mmol) was dissolved in DMF (25 mL) and Et3N (1.37 mL, 9.87 mmol) and cooled to 0 C. Then TSTU (593 mg, 1.97 mmol) was added and the reaction was stirred at 0 C for 30 minutes. A solution of the appropriate pegylated amine (2.07 mmol) in chloroform (10 mL) was added dropwise at 0 C and the reaction was allowed to warm to room temperature and stir for 12 hours. The reaction was concentrated and the -Bu ester of lOa/lOb was purified by silica gel chromatography (acetonitrile/methanol). The purified -Bu ester of lOa/lOb was dissolved in dichloro methane (20 mL) and TFA (5 mL) was added at 0 C. The reaction was stirred at room temperature overnight. The reaction was concentrated and dried under reduced pressure to give pure lOa/lOb.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BIOTIUM, INC.; MAO, Fei; MCGARRAUGH, Patrick, Gordon; MADRID, Alexis, Spain; LEUNG, Wai-Yee; ROBERTS, Lori, M.; (104 pag.)WO2016/69922; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics