Tag: M.W=300-400

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18281-05-5, name is Ethyl icosanoate, A new synthetic method of this compound is introduced below., Computed Properties of C22H44O2

EXAMPLE 111 (+-)-cis,trans-2-[[[[(4-octadecyltetrahydrofuran-2-yl)methoxy]carbonyl]amino]methyl]pyridine Following the procedure described in example 9, but using in place of the compound prepared in example 4b, (+-)-cis,trans-(4-octadecyltetrahydrofuran-2-yl)methanol obtained as in example 70c starting from ethyl eicosanate, the title compound was obtained as a colourless oil and in quantitative yield. Rf: 0.24 (silicagel, hexane:ethyl acetate 1:1); IR (film) v: 3317, 3050, 2913, 2846, 1714, 1588, 1566, 1463, 1211 cm-1; 1 H-NMR (90 MHz, CDCl3) delta: 0.87 (m, 3H), 1.0-2.6 (complex signal, 36 H), 3.40 (m, 1H), 4.08 (m, 4H), 4.50 (d, J=5.4 Hz, 2 H), 5.96 (m, NH), 7.28 (m, 2H), 7.64 (t of d, Ja=7.6 Hz, Jb=1.8 Hz, 1H), 8.51 (d, J=4.6 Hz, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; J Uriach & Cia S.A.; US4997843; (1991); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 125483-57-0, name is Benzyl 1-aminocyclobutanecarboxylate 4-methylbenzenesulfonate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

This compound (2.58 g; 0.00686 moles) was reacted with [(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-(4-methylsulfonyl-phenyl)]-butanoic acid (2 g; 0.0049 moles) in a way similar to that described in example 1. A crude (2.9 g) was obtained and crystallized, first, from acetonitrile and, then, from ethanol giving 1[(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-(4-methylsulfonyl-phenyl)-butanoyl]-amino-1-cyclobutanecarboxylic acid benzyl ester (1.74 g; 50% yield) as a white crystalline solid with m.p. 163-165 C. 1 H–NMR (200 MHz, CD3 OD-TMS): delta (ppm): 7.85-7.45 (m, 4H), 7.36-7.18 (m, 10H); nuA =5.15-nuB =5.11 (ABq, JAB =12.4 Hz, 2H); nuA =4.95-nuB =4.88 (ABq, JAB =12.6 Hz, 2H); 4.24 (m, 1H); 3.99 (d,1H, J=2.7 Hz); 3.06 (s, 3H); 3.08-2.84 (m, 2H); 2.68-2.46 (m, 2H); 2.35-2.15 (m, 2H); 2.04-1.84 (m, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zambon Group, S.p.A.; US5145872; (1992); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 179688-27-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 179688-27-8 name is Ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 113 N’-[2-Carbethoxy-4,5-bis(2-methoxyethoxy)phenyl]-N,N-dimethylformamidine To a stirred solution of 15.7 g (50 mmol) of ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate (Pfizer patent WO 96130347) in 50 ml of DMF at 0 C. was added phosphorous oxychloride (5.6 ml, 60 mmol) during 15 m. The resulting solution was heated at 55 C. for 45 m, cooled, diluted with methylene chloride, and treated at 0 C. with 200 ml of N/i sodium hydroxide during 2 m. The organic layer was separated and washed at 0 C. with water. The solution was dried and evaporated with added toluene present to give 18.4 g of amber oil; NMR (CDCl3) delta 3.02 (s, Me2 N).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate, and friends who are interested can also refer to it.

Reference:
Patent; American Cyanamid Company; US6002008; (1999); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 581065-95-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of (VI-6), obtained above (1.4 g) in methylene chloride (10 mL) was added TFA (5 mL). The mixture was stirred at RT for an hour. The volatiles were removed in vacuo to yield crude product (VI-7) as its TFA salt (1.6 g) as yellow oil, which was used for the next step without further purification. ESI m/z: 266 (M + H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; REGENERON PHARMACEUTICALS, INC.; HAN, Amy; OLSON, William; MURPHY J., Andrew; (393 pag.)WO2018/89373; (2018); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 581065-95-4, A common heterocyclic compound, 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, molecular formula is C15H31NO6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 23-3 (33mg, 0.102 mmol), compound 12-7 (40 mg, 0.051 mmol) and 54 mu^ of diisopropylethylamine in 1 mL of DMF was added 38 mg of HATU. The reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was purified by HPLC to give 52 mg of compound 23-4. MS (ESI) m/z 525[M+2H], 1049[M+H].

The synthetic route of 581065-95-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMBRX, INC.; MIAO, Zhenwei; ATKINSON, Kyle, C.; BIROC, Sandra; BUSS, Timothy; COOK, Melissa; KRAYNOV, Vadim; MARSDEN, Robin; PINKSTAFF, Jason; SKIDMORE, Lillian; SUN, Ying; SZYDLIK, Angieszka; VALENTA, Ianina; WO2012/166560; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 502764-52-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 502764-52-5 name is Diethyl dithieno[3,2-b:2′,3′-d]thiophene-2,6-dicarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

152.0 g (0.446 mol) of the compound represented by the formula 3-c obtained from the above reaction formula 17 and 2.3 L of tetrahydrofuran were added to a 5 L round bottom flask, and then 95.5 g (2,277 mol) of lithium hydroxide was dissolved in 2.3 L of water, The reaction mixture was stirred for 30 minutes and then refluxed for 6 hours. After the temperature was lowered to room temperature, 3 L of 1 N hydrochloric acid was poured, and the solid was filtered, washed with methanol and dried to obtain 112.0 g (88.2%) of the compound represented by the formula 3-d.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl dithieno[3,2-b:2′,3′-d]thiophene-2,6-dicarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; SFC Ltd.; Che Jong-tae; Jeong Seong-uk; Park Seok-bae; Kang Yeong-jin; Ryu Yeon-gwon; (45 pag.)KR101791161; (2017); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2915-53-9, name is Dioctyl maleate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2915-53-9, SDS of cas: 2915-53-9

(iii) Preparation of Hexyl/Octyl Sulphosuccinate Hexyl/octyl maleate/fumarate (50 g, 0.16 mole) was dissolved in methylated spirit (100 ml) and the pH of the mixture was adjusted to about 7.5 with sodium carbonate. The mixture was stirred under reflux for 5 hours with a solution of sodium metabisulphite (60 g) in water (160 ml) in a 3-necked round bottom flask fitted with stirrer and condenser. The hot solution was filtered and set to crystallise. The crude crystals were filtered off, dried and extracted with boiling ethanol. The residual inorganics were filtered off. Evaporation of the filtrate yielded the product as a glassy solid (20 g) which failed to recrystallise from acetone or ethanol. This material contained 92percent detergent-active material and 1.5percent non-detergent organic matter. It had infra-red peaks at 1735 cm-1 (C=O) and 1210-1240 cm-1 (SO3 Na) and was also identified by 1 H NMR.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dioctyl maleate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lever Brothers Company; US4434091; (1984); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 581065-95-4,Some common heterocyclic compound, 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, molecular formula is C15H31NO6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 2-{3-[(2-{5-[(3a5,45,6aR)-2-oxo-hexahydro- 1 H-thieno[3,4-d]i midazolidin-4- yl]pentanamido}ethyl)carbamoyl]-5-[3, 5-bis(carboxymethoxy)phenyl]phenoxy}acetic acid(Preparation 5, 20.0 mg, 29.0 pmol) dissolved in DMF (500 pL) was added HATU (44.0 mg,116 pmol) and DIPEA (40.5 pL, 232 pmol). After 1 minute tert-butyl 1-amino-3,6,9,12- tetraoxapentadecan-15-oate (35.0 pL, 116 pmol) was added and the reaction was stirred at room temperature under nitrogen for 3 hours. The reaction was concentrated in vacuo and purified using reverse phase column chromatography (Biotage SP1, 4 g, 0-18 column, elutingwith 5-40% MeCN in water with 0.1% NH3) to afford the title compound as a colourless oil (30.9 mg, 67%).LCMS Method B: Rt = 2.96 mins, ES MS mlz 599.7 [M+H]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, its application will become more common.

Reference:
Patent; CENTAURI THERAPEUTICS LIMITED; PICKFORD, Christopher; WATSON, Christine; GLOSSOP, Melanie; (189 pag.)WO2017/60729; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 581065-95-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

00345] tert- butyl 2-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)oxy)acetate (0775) (0.06rng, 0.13mmol) was dissolved in 1 ml. TFA. The solution was stirred at room temperature for 2 hours. Then the mixture was concentrated under reduced pressure to afford solid product, which was used in the following synthesis without further purification. Then the product from last step (0.043g, 0.13mmol) was mixed with HATH (0.099g, 0.26mmol) in 2mL DMF with the presence of EtsN (9luL, G.65mrnol). The mixture was stirred for lOmin before amino PEG-4-i-butyl ester (0.042g, O.lSmmol) was added. The reaction was stirred at room temperature for 5 hours. The mixture was next subjected to direct preparative HPLC purification to afford 97mg product (>100%) LCMS (ESI) m/z 580.22 (show as free acid instead of t-butyl ester) [(M+H)+; calcd for C^TTfiNsOii : 636.28]

The synthetic route of tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BUHRLAGE, Sara; ANDERSON, Kenneth C.; HIDESHIMA, Teru; GRAY, Nathanael S.; LIU, Xiaoxi; (137 pag.)WO2019/118728; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179688-27-8, name is Ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate, A new synthetic method of this compound is introduced below., Formula: C15H23NO6

Compound (v) (171.1g), formamidine acetate (79.8 g) was dissolved in n-butanol (1027mL), and nitrogen at elevatedTemperature to 80 C for 5 hours, the reaction was complete by HPLC. Spin dry n-butanol, was added 1711g of isopropyl acetate heated to reflux for 1Hours, cooled to _5 C for 4 hours. Filtered, 50 C and dried under blast (vi) (164.0g), yield 98%, purity>95%. NMR data identified compound (vi) as follows

The synthetic route of 179688-27-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Apeloa Kangyu Pharmaceutical Co.,Ltd; Shanghai Yuyuan Bio-Pharma Co. Ltd; FENG, LICHUN; LI, QIEQIE; (11 pag.)CN103709110; (2016); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics