Tag: M.W=300-350

Su, Timothy A. published the artcileA Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals, Name: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Journal of the American Chemical Society (2018), 140(42), 13764-13774, database is CAplus and MEDLINE.

Copper deficiency is implicated in a variety of genetic, neurol., cardiovascular, and metabolic diseases. Current approaches for addressing copper deficiency rely on generic copper supplementation, which can potentially lead to detrimental off-target metal accumulation in unwanted tissues and subsequently trigger oxidative stress and damage cascades. Here we present a new modular platform for delivering metal ions in a tissue-specific manner and demonstrate liver-targeted copper supplementation as a proof of concept of this strategy. Specifically, we designed and synthesized an N-acetylgalactosamine-functionalized ionophore, Gal-Cu(gtsm), to serve as a copper-carrying “Trojan Horse” that targets liver-localized asialoglycoprotein receptors (ASGPRs) and releases copper only after being taken up by cells, where the reducing intracellular environment triggers copper release from the ionophore. We utilized a combination of bioluminescence imaging and inductively coupled plasma mass spectrometry assays to establish ASGPR-dependent copper accumulation with this reagent in both liver cell culture and mouse models with minimal toxicity. The modular nature of our synthetic approach presages that this platform can be expanded to deliver a broader range of metals to specific cells, tissues, and organs in a more directed manner to treat metal deficiency in disease.

Journal of the American Chemical Society published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C19H24BNO2, Name: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Henke, H. published the artcileHPLC of fatty acid esters of mono- and polyhydric alcohols. Part 1. Analytical separation, Category: esters-buliding-blocks, the publication is HRC & CC, Journal of High Resolution Chromatography and Chromatography Communications (1980), 3(2), 69-78, database is CAplus.

Fatty acid esters of monohydric alcs. and especially partial and full fatty acid esters of polyhydric alcs. can be separated and determined by high-pressure liquid chromatog. (HPLC) on LiChrosorb RP-8 with MeOH-H₂O. The Me esters of the fatty acids C_8:0 to C_22:0 and C_24:0, the iso-Pr, iso-Bu, n-hexyl-, and isooctyl esters of the even-numbered fatty acids C_8:0 to C_18:0, mono- and difatty acid esters of 1,3-bis-(2-hydroxyethyl)-5,5-dimethylhydantoin, mono-, di-, and triesters of trimethylolpropane as well as the tetraesters of pentaerythritol were separated quant.

HRC & CC, Journal of High Resolution Chromatography and Chromatography Communications published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamamoto, Tsuyoshi published the artcileSerial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides, SDS of cas: 10378-06-0, the publication is Bioorganic & Medicinal Chemistry (2016), 24(1), 26-32, database is CAplus and MEDLINE.

The targeting of abundant hepatic asialoglycoprotein receptors (ASGPR) with trivalent N-acetylgalactosamine (GalNAc) is a reliable strategy for efficiently delivering antisense oligonucleotides (ASOs) to the liver. The authors here exptl. demonstrate the high systemic potential of the synthetically-accessible, phosphodiester-linked monovalent GalNAc unit when tethered to the 5′-terminus of well-characterized 2′,4′-bridged nucleic acid (also known as locked nucleic acid)-modified apolipoprotein B-targeting ASO via a bio-labile linker. Quant. anal. of the hepatic disposition of the ASOs revealed that phosphodiester is preferable to phosphorothioate as an interunit linkage in terms of ASGPR binding of the GalNAc moiety, as well as the subcellular behavior of the ASO. The flexibility of this monomeric unit was demonstrated by attaching up to 5 GalNAc units in a serial manner and showing that knockdown activity improves as the number of GalNAc units increases. The authors’ study suggests the structural requirements for efficient hepatocellular targeting using monovalent GalNAc and could contribute to a new mol. design for suitably modifying ASO.

Bioorganic & Medicinal Chemistry published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C7H5Cl2NO, SDS of cas: 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ledauphin, Jerome published the artcileIdentification of Trace Volatile Compounds in Freshly Distilled Calvados and Cognac Using Preparative Separations Coupled with Gas Chromatography-Mass Spectrometry, Recommanded Product: Isobutyl palmitate, the publication is Journal of Agricultural and Food Chemistry (2004), 52(16), 5124-5134, database is CAplus and MEDLINE.

GC-MS using both electron impact and chem. ionization detection modes led to the determination of the volatile composition of 2 samples of freshly distilled Cognac and 2 samples of freshly distilled Calvados. A total of 169 volatile compounds were directly identified in dichloromethane extracts obtained by liquid-liquid extraction Trace compounds present in both spirits were characterized with the help of preparative separations In a 1st step, groups of compounds were separated by preparative GC, and the fractions were analyzed on a polar stationary phase by GC-MS. In a 2nd step, silica gel fractionation was used to sep. them by polarity. In 331 compounds, of which 162 can be considered as trace compounds, were characterized in both freshly distilled Cognac and Calvados. Of these, 39 are common to both spirits; 30 are specific to Cognac with numerous hexenyl esters and norisoprenoidic derivatives, whereas 93 are specific to Calvados with compounds such as unsaturated alcs., phenolic derivatives, and unsaturated aldehydes.

Journal of Agricultural and Food Chemistry published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Henke, H. published the artcilePreparative separations using Lobar LiChroprep columns, Recommanded Product: Isobutyl palmitate, the publication is Swiss Chem (1987), 9(7-8), 23-4, 26-8, 30, database is CAplus.

The title preparative chromatog. was used for separation of products from methanolysis of castor oil, reaction of p-C₆H₄(NCO)₂ with MeOH and Et₂NH, methanolysis of unsaturated fatty acids, butanolysis of aromatic polyesters, dimethylhydantoin ethoxylates and stearates, glycerides, phosphate esters, synthetic fiber nonionic emulsifiers, trimethylolpropane triesters, polyester and polyamide fiber extracts, and methanolyzed fiber preparations

Swiss Chem published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sobolevsky, Tim G. published the artcileSimultaneous determination of fatty, dicarboxylic and amino acids based on derivatization with isobutyl chloroformate followed by gas chromatography-positive ion chemical ionization mass spectrometry, Computed Properties of 110-34-9, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2004), 800(1-2), 101-107, database is CAplus and MEDLINE.

Gas chromatog.-mass spectrometry (GC-MS) with pos. ion chem. ionization (PICI) using isobutane as reagent gas was applied for anal. of isobutoxycarbonyl/isobutyl derivatives of 13 fatty, 6 dicarboxylic and 13 amino acids in a single run. For all investigated compounds (except several amino acids) the quasimol. ions [MH]⁺ were registered. Asparagine underwent fragmentation via decarboxylation followed by elimination of OC₄H₉ ([M-117]⁺), whereas serine and tyrosine produced the cluster ions [M + C₄H₉OCO]⁺. Estimated detection limits were 6-250 pg in the total ion current (TIC) mode and 3-10 times lower using the selected-ion monitoring (SIM) mode.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C4Br2N2O4S, Computed Properties of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reina, Jose J. published the artcileGlycosyl Aldehydes: New Scaffolds for the Synthesis of Neoglycoconjugates via Bioorthogonal Oxime Bond Formation, Formula: C14H19NO8, the publication is Synthesis (2018), 50(4), 831-845, database is CAplus.

The straightforward preparation of glycosyl neoconjugates by oxime (or hydrazone) bond formation represents a key bioorthogonal tool in chem. biol. However, when this strategy is employed by reacting the reducing end of the glycan moiety, the configuration and the stereochem. information is lost due to partial (or complete) opening of the glycan cyclic hemiacetal and the formation of the corresponding opened tautomers. We have completed the synthesis of a library of glycosyl aldehydes to be used as scaffold for the synthesis of neoglycoconjugates via oxime bond formation. These glycosyl aldehydes constitute a simple and accessible alternative to avoid loss of chiral information when conjugating, by oxime (or hydrazone) bonds, the aldehyde functionality present at the reducing end of natural carbohydrates.

Synthesis published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Formula: C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, Bin published the artcileA study on aromatic constituents of Pu-er tea by two different collection methods, Safety of Isobutyl palmitate, the publication is Xiangliao Xiangjing Huazhuangpin (2010), 17-23, database is CAplus.

Aromatic constituents of Pu-er tea was collected by two different methods: XAD-4 hydrophobic resin head space absorption and simultaneous distillation extraction, then the extracts were analyzed by GC-MS. There are difference between two extracts The two methods can be used in different fields.

Xiangliao Xiangjing Huazhuangpin published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C13H19Br2ClN2O, Safety of Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wei, Ping published the artcileGC-MS analysis of essential oil from flowers of Melia toosendan, Application In Synthesis of 110-34-9, the publication is Xibei Yaoxue Zazhi (2014), 29(3), 241-244, database is CAplus.

The aim is to analyze the chem. constituents of the essential oil from the fresh and the dried flowers of Melia toosendan. The chem. components of the essential oil were analyzed by GC-MS. 22 Peaks were separated totally, and 16 compounds were identified from the fresh flowers, which accounted for 72.73%. The oil contained mainly alkanes, also contained nitrogen and chlorine compounds 41 Peaks were separated totally, and 33 compounds were identified from the dried ones, which accounted for 80.49%. The oil contained mainly alc. and acid compounds, and didn’t contain nitrogen and chlorine compounds The relative content of each component was calculated by peak area normalization method. It was the first time to extract and analyze the essential oil from the dried and the fresh flowers of Melia toosendan.

Xibei Yaoxue Zazhi published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C4H4N2O2, Application In Synthesis of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ghaffari, Behnaz published the artcileSilyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis, Product Details of C15H18BF3O4, the publication is Journal of the American Chemical Society (2014), 136(41), 14345-14348, database is CAplus and MEDLINE.

Ir catalysts supported by ortho-(diisopropylsilyl)(di-p-tolylphosphino)benzene bidentate ligand that contains P- or N-donors, effects ortho-borylations for a range of substituted aromatics E.g., reaction of C₆H₅CO₂Me with bis(pinacolato)diboron (B₂pin₂) in the presence of 1.25 mol% [Ir(OMe)(cod)]₂/ 2.5 mol% (p-tol)₂PC₆H₄-2-(SiHⁱPr₂) in THF at 80° to give 72% yield of Me 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design.

Journal of the American Chemical Society published new progress about 1146214-86-9. 1146214-86-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester, name is Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate, and the molecular formula is C15H18BF3O4, Product Details of C15H18BF3O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics