Tag: M.W=300-350

Kuruvilla, Sibu P. published the artcileEffect of N-acetylgalactosamine ligand valency on targeting dendrimers to hepatic cancer cells, COA of Formula: C14H19NO8, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2018), 545(1-2), 27-36, database is CAplus and MEDLINE.

The display of N-acetylgalactosamine (NAcGal) ligands has shown great potential in improving the targeting of various therapeutic mols. to hepatocellular carcinoma (HCC), a severe disease whose clin. treatment is severely hindered by limitations in delivery of therapeutic cargo. We previously used the display of NAcGal on generation 5 (G5) polyamidoamine (PAMAM) dendrimers connected through a poly(ethylene glycol) (PEG) brush (i.e. G5-cPEG-NAcGal; monoGal) to effectively target hepatic cancer cells and deliver a loaded therapeutic cargo. In this study, we were interested to see if tri-valent NAcGal ligands (i.e. NAcGal₃) displayed on G5 dendrimers (i.e. G5-cPEG-NAcGal₃; triGal) could improve their ability to target hepatic cancer cells compared to their monoGal counterparts. We therefore synthesized a library of triGal particles, with either 2, 4, 6, 8, 11, or 14 targeting branches (i.e. cPEG-NAcGal₃) attached. Conventional flow cytometry studies showed that all particle formulations can label hepatic cancer cells in a concentration-dependent manner, reaching 90-100% of cells labeled at either 285 or 570 nM G5, but interestingly, monoGal labeled more cells at lower concentrations To elucidate the difference in internalization of monoGal vs. triGal conjugates, we turned to multi-spectral imaging flow cytometry and quantified the amount of internalized (I) vs. surface-bound (I⁰) conjugates to determine the ratio of internalization (I/I⁰) in all treatment groups. Results show that regardless of NAcGal valency, or the d. of targeting branches, all particles achieve full internalization and diffuse localization throughout the cell (I/I⁰ âˆ?3.0 for all particle compositions). This indicates that while tri-valent NAcGal is a promising technique for targeting nanoparticles to hepatic cancer cells, mono-valent NAcGal is more efficient, contrary to what is observed with small mols.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, COA of Formula: C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kuruvilla, Sibu P. published the artcileN-Acetylgalactosamine-Targeted Delivery of Dendrimer-Doxorubicin Conjugates Influences Doxorubicin Cytotoxicity and Metabolic Profile in Hepatic Cancer Cells, HPLC of Formula: 10378-06-0, the publication is Advanced Healthcare Materials (2017), 6(5), n/a, database is CAplus and MEDLINE.

This study describes the development of targeted, doxorubicin (DOX)-loaded generation 5 (G5) polyamidoamine dendrimers able to achieve cell-specific DOX delivery and release into the cytoplasm of hepatic cancer cells. G5 is functionalized with poly(ethylene glycol) (PEG) brushes displaying N-acetylgalactosamine (NAcGal) ligands to target hepatic cancer cells. DOX is attached to G5 through one of two aromatic azo-linkages, L3 or L4, achieving either P1 ((NAcGal_β-PEGc)_16.6-G5-(L3-DOX)_11.6) or P2 ((NAcGal_β-PEGc)_16.6-G5-(L4-DOX)_13.4) conjugates. After confirming the conjugatesâ€?biocompatibility, flow cytometry studies show P1/P2 achieve 100% uptake into hepatic cancer cells at 30-60 × 10^-9 M particle concentration This internalization correlates with cytotoxicity against HepG2 cells with 50% inhibitory concentration (IC₅₀) values of 24.8, 1414.0, and 237.8 × 10^-9 M for free DOX, P1, and P2, resp. Differences in cytotoxicity prompted metabolomics anal. to identify the intracellular release behavior of DOX. Results show that P1/P2 release alternative DOX metabolites than free DOX. Stable isotope tracer studies show that the different metabolites induce different effects on metabolic cycles. Namely, free DOX reduces glycolysis and increases fatty acid oxidation, while P1/P2 increase glycolysis, likely as a response to high oxidative stress. Overall, P1/P2 conjugates offer a platform drug delivery technol. for improving hepatic cancer therapy.

Advanced Healthcare Materials published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, HPLC of Formula: 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Medina, Scott H. published the artcileTargeting Hepatic Cancer Cells with PEGylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands, Recommanded Product: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Advanced Healthcare Materials (2013), 2(10), 1337-1350, database is CAplus and MEDLINE.

Poly(amidoamine) (PAMAM) dendrimers are branched water-soluble polymers defined by consecutive generation numbers (Gn) indicating a parallel increase in size, mol. weight, and number of surface groups available for conjugation of bioactive agents. In this article, we compare the biodistribution of N-acetylgalactosamine (NAcGal)-targeted [¹⁴C]₁-G5-(NH₂)₅-(Ac)₁₀₈-(NAcGal)₁₄ particles to non-targeted [¹⁴C]₁-G5-(NH₂)₁₂₇ and PEGylated [¹⁴C]₁-G5-(NH₂)₄₄-(Ac)₇₃-(PEG)₁₀ particles in a mouse hepatic cancer model. Results show that both NAcGal-targeted and non-targeted particles are rapidly cleared from the systemic circulation with high distribution to the liver. However, NAcGal-targeted particles exhibited 2.5-fold higher accumulation in tumor tissue compared to non-targeted ones. In comparison, PEGylated particles showed a 16-fold increase in plasma residence time and a 5-fold reduction in liver accumulation. These results motivated us to engineer new PEGylated G5 particles with PEG chains anchored to the G5 surface via acid-labile cis-aconityl linkages where the free PEG tips are functionalized with NAcGal or SP94 peptide to investigate their potential as targeting ligands for hepatic cancer cells as a function of sugar conformation (α vs. β), ligand concentration (100-4000 nM), and incubation time (2 and 24 h) compared to fluorescently (Fl)-labeled and non-targeted G5-(Fl)₆-(NH₂)₁₂₂ and G5-(Fl)₆-(Ac)₁₀₇-(cPEG)₁₅ particles. Results show G5-(Fl)₆-(Ac)₁₀₇-(cPEG[NAcGal_β])₁₄ particles achieve faster uptake and higher intracellular concentrations in HepG2 cancer cells compared to other G5 particles while escaping the non-specific adsorption of serum protein and phagocytosis by Kupffer cells, which make these particles the ideal carrier for selective drug delivery into hepatic cancer cells.

Advanced Healthcare Materials published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Recommanded Product: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Koike, Kenzo published the artcileSubstrate specificity of regiospecific desaturation of aliphatic compounds by a mutant Rhodococcus strain, Recommanded Product: Isobutyl palmitate, the publication is Bioscience, Biotechnology, and Biochemistry (2000), 64(5), 1064-1066, database is CAplus and MEDLINE.

Substrate specificity of cis-desaturation of aliphatic compounds by resting cells of a mutant, Rhodococcus sp. strain KSM-MT66, was examined Among substrates tested, the rhodococcal cells were able to convert n-alkanes (C13-C19), 1-chloroalkanes (C16 and C18), Et fatty acids (C14-C17) and alkyl (C1-C4) esters of palmitic acid to their corresponding unsaturated products of cis configuration. The products from n-alkanes and 1-chloroalkanes had a double bond mainly at the 9th carbon from their terminal Me groups, and the products from acyl fatty acids had a double bond mainly at the 6th carbon from their carbonyl carbons.

Bioscience, Biotechnology, and Biochemistry published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Perl Molnar, Ibolya published the artcileEsterification of carboxylic acids with butanol in aqueous solutions for their gas chromatographic analysis, Recommanded Product: Isobutyl palmitate, the publication is Magyar Kemiai Folyoirat (1985), 91(10), 459-73, database is CAplus.

Carboxylic acids (C₁-C₂₀ fatty, C₂-C₇ aliphatic di, and aromatic di- and polycarboxylic acids) were esterified with BuOH/H₂SO₄ and the products analyzed by gas chromatog. The efficiency of the esterification was improved by using anhydrous Na₂SO₄.

Magyar Kemiai Folyoirat published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Xiao-hui published the artcileSeparation of activated compounds from Synechococcus sp. and the bioactivity study, SDS of cas: 110-34-9, the publication is Tianran Chanwu Yanjiu Yu Kaifa (2013), 25(1), 12-16, 70, database is CAplus.

Marine microalga Synechococcus was one of Cyanobacteria. In order to investigate the bioactivity components of Synechococcus, three organic solvents, including petroleum ether, Et acetate and n-butanol, were used to extract the ethanol extract of Synechococcus, resp., and three kinds of organic phase crude extracts were obtained. Then the antibiosis and antioxidant activities of crude extracts were detected. The chem. components of crude extracts were analyzed by GC-MS chromatogram, and 20 components of petroleum ether phase and n-butanol phase were determined, resp. The activity tracking results showed that the best antibacterial and antioxidant effects of crude extracts were observed in petroleum ether phase, followed by Et acetate phase and n-butanol phase. The aqueous extracts had no bioactivities. Subsequently, silica gel column chromatog., gel Sephadex LH-20 chromatog. and preparative thin layer chromatog. were used to sep. and purify the compounds from petroleum ether phase, and a monomeric compound was obtained, the structure of compound was elucidated as β-sitosterol by the means of ¹H NMR, ¹³C NMR etc. spectrum technol.

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C7H13BrSi, SDS of cas: 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Knothe, Gerhard published the artcileKinematic viscosity of biodiesel fuel components and related compounds. Influence of compound structure and comparison to petrodiesel fuel components, Application In Synthesis of 110-34-9, the publication is Fuel (2005), 84(9), 1059-1065, database is CAplus.

Biodiesel, defined as the mono-alkyl esters of vegetable oils and animal fats is an alternative diesel fuel that is steadily gaining attention and significance. One of the most important fuel properties of biodiesel and conventional diesel fuel derived from petroleum is viscosity, which is also an important property of lubricants. Ranges of acceptable kinematic viscosity are specified in various biodiesel and petrodiesel standards In this work, the kinematic viscosity of numerous fatty compounds as well as components of petrodiesel were determined at 40 °C (ASTM D445) as this is the temperature prescribed in biodiesel and petrodiesel standards The objective is to obtain a database on kinematic viscosity under identical conditions that can be used to define the influence of compound structure on kinematic viscosity. Kinematic viscosity increases with chain length of either the fatty acid or alc. moiety in a fatty ester or in an aliphatic hydrocarbon. The increase in kinematic viscosity over a certain number of carbons is smaller in aliphatic hydrocarbons than in fatty compounds The kinematic viscosity of unsaturated fatty compounds strongly depends on the nature and number of double bonds with double bond position affecting viscosity less. Terminal double bonds in aliphatic hydrocarbons have a comparatively small viscosity-reducing effect. Branching in the alc. moiety does not significantly affect viscosity compared to straight-chain analogs. Free fatty acids or compounds with hydroxy groups possess significantly higher viscosity. The viscosity range of fatty compounds is greater than that of various hydrocarbons comprising petrodiesel. The effect of dibenzothiophene, a sulfur-containing compound found in petrodiesel fuel, on viscosity of toluene is less than that of fatty esters or long-chain aliphatic hydrocarbons. To further assess the influence of the nature of oxygenated moieties on kinematic viscosity, compounds with 10 carbons and varying oxygenated moieties were investigated. A reversal in the effect on viscosity of the carboxylic acid moiety vs. the alc. moiety is noted for the C10 compounds compared to unsaturated C18 compounds Overall, the sequence of influence on kinematic viscosity of oxygenated moieties is COOH≈C-OH>COOCH₃≈C=O>C-O-C> no oxygen.

Fuel published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Application In Synthesis of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Szlag, Victoria M. published the artcileSERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers, Product Details of C14H19NO8, the publication is ACS Sensors (2016), 1(7), 842-846, database is CAplus.

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrixes: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme’s detection limit was well below that of the predicted oral exposure limit. Theor. predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermol. interactions.

ACS Sensors published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C7H6O3, Product Details of C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fan, Chunying published the artcileChemical compositions and copper(II) adsorption properties of sequentially extracted humic substances, including different humin fractions, Recommanded Product: Isobutyl palmitate, the publication is Fresenius Environmental Bulletin (2018), 27(10), 6485-6499, database is CAplus.

Humin (HU) is the least understood humic substance (HS) fractions due to its close associations with soil mineral colloids. Here, humic acid (HA), fulvic acid (FA), HU, iron-bound HU (HUi), claybound HU (HUc) and residual HU (HUr) were sequentially extracted from an Alfisol of northeast China. Elemental anal., solid-state carbon-13 cross-polarization magic-angle-spinning NMR (13C CPMAS NMR) spectroscopy and pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS) were used to characterize HS fractions. The adsorption isotherms of Cu(II) on HS fractions were obtained using batch equilibrium method. Among these HS fractions, HA contained higher proportion of phenols, whereas HUc exhibited higher proportion of aliphatic hydrocarbons. For the different HU fractions, n-alkanes/n-alkenes were particularly abundant in HUc, whereas polysaccharides were abundant in HUr. The adsorption of Cu(II) on HS fractions well fitted both Freundlich and Langmuir equations. The maximum amounts of Cu(II) adsorbed was FA > HUi > HA > HUc > HU > HUr, which was pos. correlated with their O/C ratio and carbonyl C whereas neg. correlated with C/N ratio (p < 0.01). The results suggested that HU is highly heterogeneous in terms of their chem. compositions and plays important role in controlling the behavior and fate of Cu(II) in the environment.

Fresenius Environmental Bulletin published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Milovanovic, Dusan published the artcileRisk assessment approach for prioritizing danube basin-specific pollutants: a case study in the novi sad region, Recommanded Product: Isobutyl palmitate, the publication is Polish Journal of Environmental Studies (2019), 28(6), 4297-4309, database is CAplus.

The aim of this work was to determine the most relevant pollutants in Danube surface water and wastewater in the city of Novi Sad, and to conduct a risk assessment approach on substances for the optimization of future monitoring programs. According to the requirements of Serbian law, obligatory and operating monitoring was focused on physico-chem. and biol. parameters while the expanded monitoring programs have not been applied – often due to practical circumstances. Novi Sad, with a population of more than 300.000 inhabitants, does not have a wastewater treatment plant, and about 2 m3 of wastewater is discharged directly to the Danube river every day. Screening analyses of the water within the Danube basin around city of Novi Sad included more than 300 different organic substances, while target anal. was conducted for all WFD pollutants. The methodol. for generating the list of priority substances was applied for the first time in the Danubian region around the city of Novi Sad. By applying the prioritization procedure, 86 organic substances were determined in screening analyses and 27 substances obtained within target analyses were identified as the most relevant. In addition, seasonal variation anal. was conducted to determine the occurrence trends of specific compounds in different seasons.

Polish Journal of Environmental Studies published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics