Tag: M.W=250-300

Pinnell, Robert P.; Huyser, Earl S.; Kleinberg, Jacob published the artcile< Reactions of trichloromethanesulfonyl bromide with some hydrocarbons>, Electric Literature of 112-63-0, the main research area is .

Trichloromethanesulfonyl bromide reacts with cyclohexane, cyclopentane, and PhMe under the influence of light to yield the expected bromohydrocarbons, CHCl3, and SO2. The competitive bromination of cyclohexane and PhMe strongly suggests that the Cl3C· radical is involved in H abstraction from the hydrocarbons. This is in sharp contrast to the previously reported reactions of trichloromethanesulfonyl chloride with hydrocarbons, in which Cl3CSO2·is apparently the H abstractor. Peroxide- or light-induced decomposition of trichloromethanesulfonyl bromide into CBrCl3 and SO2 is proposed to account for the behavior of this material with hydrocarbons.

Journal of Organic Chemistry published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jung, Cheolsoo; Jikei, Mitsutoshi; Kakimoto, Masa-aki published the artcile< Synthesis of polyimide possessing NLO chromophore and properties of Langmuir-Blodgett films>, Category: esters-buliding-blocks, the main research area is polyimide nonlinear optical chromophore.

Newly synthesized polyimide possessing NLO chromophore as a side chain has a good solubility and is stable to 320°. Polyimide Langmuir-Blodgett (LB) films were prepared by the precursor method. The differences of multilayer structure between the precursor and the polyimide LB films were analyzed by means of ellipsometry.

Journal of Photopolymer Science and Technology published new progress about Fluoropolymers, polyimide- Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hollenhorst, Marie A.; Clardy, Jon; Walsh, Christopher T. published the artcile< The ATP-Dependent Amide Ligases DdaG and DdaF Assemble the Fumaramoyl-Dipeptide Scaffold of the Dapdiamide Antibiotics>, Formula: C12H24N2O4, the main research area is DdaG DdaF ATP dependent amide ligase assembly dapdiamide antibiotic.

The enzymes DdaG and DdaF, encoded in the Pantoea agglomerans dapdiamide antibiotic biosynthetic gene cluster, when expressed in Escherichia coli, form the tandem amide bonds of the dapdiamide scaffold at the expense of ATP cleavage. DdaG uses fumarate, 2,3-diaminopropionate (DAP), and ATP to make fumaroyl-AMP transiently on the way to the Nβ-fumaroyl-DAP regioisomer. Then DdaF acts as a second ATP-dependent amide ligase, but this enzyme cleaves ATP to ADP and Pi during amide bond formation. However, DdaF will not accept Nβ-fumaroyl-DAP; the enzyme requires the fumaroyl moiety to be first converted to the fumaramoyl half-amide in Nβ-fumaramoyl-DAP. DdaF adds Val, Ile, or Leu to the carboxylate of fumaramoyl-DAP to make dapdiamide A, B, or C, resp. Thus, to build the dapdiamide antibiotic scaffold, amidation must occur on the fumaroyl-DAP scaffold, after DdaG action but before DdaF catalysis. This is an unusual instance of two ligases acting sequentially in untemplated amide bond formations using attack of substrate carboxylates at Pα (AMP-forming) and then at Pγ (ADP-forming) of ATP co-substrates.

Biochemistry published new progress about Antibiotics (dapdiamides). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Formula: C12H24N2O4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Leboho, Tlabo C.; van Vuuren, Sandy F.; Michael, Joseph P.; de Koning, Charles B. published the artcile< The acid-catalyzed synthesis of 7-azaindoles from 3-alkynyl-2-aminopyridines and their antimicrobial activity>, SDS of cas: 112-63-0, the main research area is azaindole derivative preparation antibacterial antifungal.

The synthesis of 7-azaindoles from 3-alkynyl-2-aminopyridines using acidic conditions, namely, a mixture of trifluoroacetic acid (TFA) and trifluoroacetic anhydride (TFAA), is described. This methodol. resulted in the synthesis of fifteen 7-azaindoles, with most containing substituents at the 2- and 5-positions. The majority of these were tested for antimicrobial activity against a range of bacteria and yeasts. The 7-azaindoles displayed the best activity against the yeasts, particularly against Cryptococcus neoformans, where activities as low as 3.9 μg ml-1 were observed

Organic & Biomolecular Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Raina, Shilpa; Sharma, Vikas; Sheikh, Zahid Nabi; Kour, Navneet; Singh, Shashank K.; Zari, Ali; Zari, Talal A.; Alharby, Hesham F.; Hakeem, Khalid Rehman published the artcile< Anticancer Activity of Cordia dichotoma against a Panel of Human Cancer Cell Lines and Their Phytochemical Profiling via HPLC and GCMS>, Synthetic Route of 112-63-0, the main research area is Cordia anticancer agent HPLC GCMS cancer; C. dichotoma; GCMS; HPLC; ROS; anticancer; apoptosis.

The current study was conducted to examine the in vitro anticancer potential of Cordia dichotoma (bark, leaves, pulp and seed). The plant material was collected from UT of J&K and methodical bioassays were carried out on ten human cancer cell lines Michigan Cancer Foundation-7 (MCF-7), M.D. Anderson-Metastatic Breast (MDA-MB-231), Neuroblastoma-2a (N2A), SH-SY5Y, U-251, HCT-116, SW-620, A-549, MIA PaCa-2, Panc-1 from five different origins (breast, CNS, colon, lung, pancreas) resp. Methanolic extracts were produced and fractions were then obtained from the extracts and evaluated for cytotoxicity. Mechanistic assays, HPLC, and GCMS profiling were performed on the highest active fraction. The Sulforhodamine B (SRB) assay determined the in vitro cytotoxicity. The findings revealed that the bark portion had in vitro cytotoxicity against the A-549 human lung cancer cell line. To our knowledge, this is the first study to show that the plant’s bark has anticancer properties and induced chromatin condensation, confirmed cell death via ROS generation, and significantly decreased colony formation in A-549 cell line from lung origin in a dose-dependent manner. Furthermore, HPLC and GCMS investigations indicated the presence of a number of bioactive mols. such as gallic acid (144,969.86) uV*sec, caffeic acid (104.26) uV*sec, ferulic acid (472.87) uV*sec, vanillic acid (13,775.39) uV*sec, palmitic acid (18.34%), cis vaccenic acid (28.81%), etc. and one of the compounds was reported for the first time from the bark. As a result of its promising efficacy, it may become an essential cancer chemopreventive or chemotherapeutic medication for patients with lung carcinoma.

Molecules published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hassler, Carla; Zhang, Yanan; Gilmour, Brian; Graf, Tyler; Fennell, Timothy; Snyder, Rodney; Deschamps, Jeffrey R.; Reinscheid, Rainer K.; Garau, Celia; Runyon, Scott P. published the artcile< Identification of Neuropeptide S Antagonists: Structure-Activity Relationship Studies, X-ray Crystallography, and in Vivo Evaluation>, Formula: C19H34O2, the main research area is diphenyltetrahydro oxazolo pyrazinone derivative preparation structure neuropeptide S antagonist.

Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-ones were synthesized and evaluated for antagonist activity at the neuropeptide S receptor. The absolute configuration was determined by chiral resolution of the key synthetic intermediate, followed by anal. of one of the individual enantiomers by X-ray crystallog. The R isomer was then converted to a biol. active compound (34) that had a Ke of 36 nM. The most potent compound displayed enhanced aqueous solubility compared with the prototypical antagonist SHA-68 and demonstrated favorable pharmacokinetic properties for behavioral assessment. In vivo anal. in mice indicated a significant blockade of NPS induced locomotor activity at an i.p. dose of 50 mg/kg. This suggests that analogs having improved drug-like properties will facilitate more detailed studies of the neuropeptide S receptor system.

ACS Chemical Neuroscience published new progress about Central nervous system agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Wei; Wang, Xiao-Ye; Li, Jing; Li, Zhi-Ting; Yan, Yu-Kun; Wang, Wei; Pei, Jian published the artcile< A photoconductive charge-transfer crystal with mixed-stacking donor-acceptor heterojunctions within the lattice>, HPLC of Formula: 112-63-0, the main research area is pyrene butyl viologen donor acceptor charge transfer complex photoconductivity.

A pyrene derivative as the donor and a butyl-viologen as the acceptor were used to construct a novel charge-transfer cocrystal consisting of mixed-stacking structure and having switchable photoconductivity stemming from the donor-acceptor heterojunctions within the lattice.

Chemical Communications (Cambridge, United Kingdom) published new progress about Electron acceptors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sorrenti, Valeria; Vanella, Luca; Platania, Chiara Bianca Maria; Greish, Khaled; Bucolo, Claudio; Pittala, Valeria; Salerno, Loredana published the artcile< Novel heme oxygenase-1 (HO-1) inducers based on dimethyl fumarate structure>, Application of C19H34O2, the main research area is unsaturated dicarbonyl compound preparation heme oxygenase docking; HO-1 inducers; LX-2 cells; dimethyl fumarate (DMF); heme oxygenase (HO); hepatic fibrosis.

Novel heme oxygenase-1 (HO-1) inducers based on di-Me fumarate (DMF) structure I [R = H, 4-Me, 2-CO2H, etc.; R1 = Me, Ph, 4-ClC6H4, etc.; X = O, NH; Y = a bond, CH2, CH2CH2, CH2CH2CH2] were reported in this paper. These compounds were obtained by modification of the DMF backbone. Particularly, maintaining the α, β-unsaturated dicarbonyl function as the central chain crucial for HO-1 induction, different substituted or unsubstituted Ph rings are introduced by means of an ester or amide linkage. Sym. and asym. derivatives were synthesized. All compounds were tested on a human hepatic stellate cell line LX-2 to assay their capacity for modifying HO-1 expression. Compounds I [R = H, R1 = Ph, X = O, Y = null; R = 4-Cl, R1 = 4-ClC6H4, X = O, Y = null; R = H, R1 = Ph, X = NH, Y = CH2] stand out for their potency as HO-1 inducers, being 2-3 fold more active than DMF, and for their ability to reverse reactive oxygen species (ROS) production mediated using palmitic acid (PA). These properties, coupled with a low toxicity toward LX-2 cell lines, made these compounds potentially useful for treatment of diseases in which HO-1 overexpression may counteract inflammation, such as hepatic fibrosis. Docking studies showed a correlation between predicted binding free energy and exptl. HO-1 expression data. These preliminary results might support the development of new approaches in the management of liver fibrosis.

International Journal of Molecular Sciences published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hegde, Guruprasad S.; Sundara, Ramaprabhu published the artcile< Entropy Stabilized Oxide Nanocrystals as Reaction Promoters in Lithium-O2 Batteries>, Category: esters-buliding-blocks, the main research area is lithium peroxide nanocrystal secondary battery electrochem performance.

Charge transport limitations at the Li2O2 discharge product-electrode interfaces hinder the rechargeability of Li-O2 batteries. Herein, we introduce entropy stabilized oxides (ESO) as reaction promoters in pos. electrodes that can facilitate charge transport by reducing the binding energy of the intermediates. In this work, we developed a rock-salt type entropy stabilized oxide. We show that the rock salt phase transforms into a pure, equimolar, quinary spinel on heat treatment. A Li-O2 battery with the developed ESOs at the pos. electrode is cycled with an areal capacity of 1 mAh cm-2 at a current rate of 0.25 mA cm-2 to study its role as a reaction promoter. The surface, bulk, and morphol. characterization are carried out for both materials. The presence of multiple cations and defects on the surface of the ESO is found to benefit the discharge product oxidation and improve the cyclic stability.

Batteries & Supercaps published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Chengwei; Ji, Chong-Lei; Hong, Xin; Szostak, Michal published the artcile< Palladium-Catalyzed Decarbonylative Borylation of Carboxylic Acids: Tuning Reaction Selectivity by Computation>, Application of C19H34O2, the main research area is palladium catalyst decarbonylative borylation carboxylic acid mol modeling; carboxylic acids; computational chemistry; decarbonylation; regioselectivity; transition-metal catalysis.

Decarbonylative borylation of carboxylic acids is reported. Carbon electrophiles are generated directly after reagent-enabled decarbonylation of the in situ accessible sterically-hindered acyl derivative of a carboxylic acid under catalyst controlled conditions. The scope and the potential impact of this method are demonstrated in the selective borylation of a variety of aromatics (>50 examples). This strategy was used in the late-stage derivatization of pharmaceuticals and natural products. Computations reveal the mechanistic details of the unprecedented C-O bond activation of carboxylic acids. By circumventing the challenging decarboxylation, this strategy provides a general synthetic platform to access arylpalladium species for a wide array of bond formations from abundant carboxylic acids. The study shows a powerful combination of experiment and computation to predict decarbonylation selectivity.

Angewandte Chemie, International Edition published new progress about Boronic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics