Tag: M.W=250-300

Luo, Guanglin; Chen, Ling; Burton, Catherine R.; Xiao, Hong; Sivaprakasam, Prasanna; Krause, Carol M.; Cao, Yang; Liu, Nengyin; Lippy, Jonathan; Clarke, Wendy J.; Snow, Kimberly; Raybon, Joseph; Arora, Vinod; Pokross, Matt; Kish, Kevin; Lewis, Hal A.; Langley, David R.; Macor, John E.; Dubowchik, Gene M. published the artcile< Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors>, Synthetic Route of 112-63-0, the main research area is preparation isonicotinamide brain glycogen synthase kinase inhibitor antitumor neoplasm; crystal structure.

GSK-3 is a serine/threonine kinase that has numerous substrates. Many of these proteins are involved in the regulation of diverse cellular functions, including metabolism, differentiation, proliferation, and apoptosis. Inhibition of GSK-3 may be useful in treating a number of diseases including Alzheimer’s disease (AD), type II diabetes, mood disorders, and some cancers, but the approach poses significant challenges. Here, the authors present a class of isonicotinamides, e.g. I [R = F, Cl] that are potent, highly kinase-selective GSK-3 inhibitors, the members of which demonstrated oral activity in a triple-transgenic mouse model of AD. The remarkably high kinase selectivity and straightforward synthesis of these compounds bode well for their further exploration as tool compounds and therapeutics.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zahedifar, Mahboobeh; Es-haghi, Ali; Zhiani, Rahele; Sadeghzadeh, Seyed Mohsen published the artcile< Synthesis of benzimidazolones by immobilized gold nanoparticles on chitosan extracted from shrimp shells supported on fibrous phosphosilicate>, Category: esters-buliding-blocks, the main research area is chitosan fibrous phosphosilicate supported gold nanocatalyst preparation surface area; phenylenediamine carbon dioxide reusable gold nanocatalyst carbonylation; benzimidazolone preparation green chem.

The synthesis of benzimidazolones from o-phenylenediamines and carbon dioxide in the presence of gold nanoparticles supported on a composite material based on microcrystalline chitosan from shrimp shells and fibrous phosphosilicate (CS-FPS/Au) was demonstrated. The results showed that the gold nanoparticles were stable with the P, N and O atoms of CS-FPS. The morphol. and structure of FPS led to a higher catalytic activity. The CS-FPS/Au NPs were thoroughly characterized using TEM, FESEM, TGA, FTIR and BET.

RSC Advances published new progress about Aromatic diamines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Qiong; Cao, Hui; Xu, Wengang; Li, Jing; Zhou, Qi; Tao, Weijian; Zhu, Haiming; Cao, Xingzhong; Zhong, Linxin; Lu, Jiong; Peng, Xinwen; Wu, Jie published the artcile< Vacancy engineered polymeric carbon nitride nanosheets for enhanced photoredox catalytic efficiency>, Related Products of 112-63-0, the main research area is carbon nitride nanosheet photoredox catalytic efficiency.

Polymeric carbon nitrides (PCNs) have emerged as promising heterogeneous photocatalysts for organic transformations as they are metal-free, inexpensive, and possess tunable bandgaps, with excellent chem. stability and photo-stability. However, current application of PCNs in organic synthesis is rather limited to several well-established materials, which limits the scope of reaction patterns and efficiency. We herein report the synthesis and fabrication of two PCN nanosheets by incorporating nanostructure construction, element doping, and vacancy engineering into one hybrid platform. The heteroatom doped PCN nanosheets with vacancies feature highly porous structures with extremely large substrate-catalyst interface areas and enhanced charge separation The generated heterogeneous catalysts demonstrate impressive photoredox catalytic performances in a variety of organic transformations (e.g., defluoroborylation; [2+2] cycloaddition; C-N, C-S, C-O cross-couplings; and an unprecedented regioselective hydrosilylation), providing efficiencies comparable to reported optimized homogeneous catalysts and exceeding those with commonly utilized PCNs.

Cell Reports Physical Science published new progress about Band gap. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramadoss, Velayudham; Alonso-Castro, Angel Josabad; Campos-Xolalpa, Nimsi; Solorio-Alvarado, Cesar R. published the artcile< Protecting-Group-Free Total Synthesis and Biological Evaluation of 3-Methylkealiiquinone and Structural Analogues>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is methylkealiiquinone synthesis antitumor.

The modular protecting-group-free total synthesis of 3-methylkealiiquinone (I), an analog of the marine alkaloid kealiiquinone, was accomplished in seven steps. A regioselectively constructed functionalized arylbenzimidazolone moiety and di-Me squarate were used as the only two building blocks. A thermal ring expansion via 6π-conrotatory ring closure to build the quinone fragment gave rise to the desired linear analog of the natural compound along with a nondescribed structurally attractive angular naphtho[1,2-d]imidazole regioisomer. The IC50 values for the compounds were determined on three cancer cell lines.

Journal of Organic Chemistry published new progress about Alkaloids Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses) (imidazole). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Xinwei; Li, Xiao; Zhu, Yanbo; Gao, YingYing; Xu, Liping published the artcile< Paeoniflorin upregulates mitochondrial thioredoxin of Schwann cells to improve diabetic peripheral neuropathy indicated by 4D label-free quantitative proteomics>, Application of C19H34O2, the main research area is .

Diabetic peripheral neuropathy (DPN) is a diabetic complication characterized by demyelination. The pathogenesis of DPN has not been fully elucidated, thus lacking therapies. In the current study, we aimed to confirm whether paeoniflorin (PF) could improve DPN by upregulating mitochondrial thioredoxin (Trx2) based on 4D Label-free proteomic experiments of Schwann cells (SCs) mitochondria. Firstly, PF increased the expression of mitochondrial processing peptidase α (Pmpca) and small ubiquitin-related modifier 1 (Sumo1) to increase mitochondrial protein processing of Trx2. Then, PF increased the protein expression of Trx reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), which belong to mitochondrial Trx systems. Accordingly, PF decreased mitochondrial reactive oxygen species (ROS) while increasing mtDNA and mitochondrial membrane potential to improve mitochondria function under high glucose environment. Furthermore, total glucosides of paeony capsules (TGP), containing more than 90% PF, increased the Trx2, TrxR2, and Prx3 levels in sciatic nerve of DPN rats, thus reducing demyelination as well as improving mech. pain threshold, thermal pain threshold, motor nerve conduction velocity (MNCV), and sensor nerve conduction velocity (SNCV). Overall, these results suggest that PF could provide protection for DPN by upregulating Trx2.

Oxidative Medicine and Cellular Longevity published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Xin; Cui, Lijuan; Zhang, Yushan; Guo, Chao; Deng, Lijiao; Wen, Zhitong; Lu, Zhihong; Shi, Xiaoyuan; Xing, Haojie; Liu, Yunfeng; Zhang, Yi published the artcile< Screening for potential therapeutic agents for non-small cell lung cancer by targeting ferroptosis>, COA of Formula: C15H22N2O2, the main research area is NSCLC ferroptosis therapeutic agent screening target.

Ferroptosis is a form of non-apoptotic and iron-dependent cell death originally identified in cancer cells. Recently, emerging evidence showed that ferroptosis-targeting therapy could be a novel promising anti-tumor treatment. However, systematic analyses of ferroptosis-related genes for the prognosis of non-small cell lung cancer (NSCLC) and the development of antitumor drugs exploiting the ferroptosis process remain rare. This study aimed to identify genes related to ferroptosis and NSCLC and to initially screen lead compounds that induce ferroptosis in tumor cells. We downloaded mRNA expression profiles and NSCLC clin. data from The Cancer Genome Atlas database to explore the prognostic role of ferroptosis-related genes. Four prognosis-associated ferroptosis-related genes were screened using univariate Cox regression anal. and the lasso Cox regression anal., which could divide patients with NSCLC into high- and low-risk groups. Then, based on differentially expressed risk- and ferroptosis-related genes, the neg. correlated lead compound flufenamic acid (FFA) was screened through the Connective Map database. This project confirmed that FFA induced ferroptosis in A549 cells and inhibited growth and migration in a dose-dependent manner through CCK-8, scratch, and immunofluorescence assays. In conclusion, targeting ferroptosis might be a therapeutic alternative for NSCLC.

Frontiers in Molecular Biosciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (CISD1). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, COA of Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhihua; Zhu, Guofeng; Sheng, Chunpeng; Lei, Jianwei; Song, Sihui; Zhu, Jianming published the artcile< Hispidulin Enhances Temozolomide (TMZ)-Induced Cytotoxicity against Malignant Glioma Cells In Vitro by Inhibiting Autophagy.>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Temozolomide (TMZ), an oral alkylating agent, is the widely used first-line chemotherapeutic reagent for glioma in clinical practice. However, TMZ-induced autophagy is another cellular process favoring glioma cell survival. This study aimed to explore whether hispidulin can facilitate TMZ-induced cell death of glioma. The MTT assay showed that coadministration with hispidulin and TMZ could significantly decrease the viability of glioma U87MG cells. Meanwhile, hispidulin administration was also observed to promote TMZ-induced apoptosis. Furthermore, additional hispidulin treatment further elevated TMZ-induced expression of Bax, cleaved-caspase-9, and cleaved-caspase-3 protein but decreased Bcl-2 protein expression in U87MG cells. We also observed that hispidulin suppressed TMZ-induced autophagy to promote apoptosis, as showed by decreased AVOs and LC3B-I/II protein expression. These results collectively suggested that the combination of hispidulin and TMZ could improve the antitumor efficiency of TMZ against malignant gliomas.

Computational intelligence and neuroscience published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schoene, Jens; Gazzi, Thais; Lindemann, Peter; Christmann, Mathias; Volkamer, Andrea; Nazare, Marc published the artcile< Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors>, Computed Properties of 112-63-0, the main research area is nitrogen heterocycle indazole synthesis SGK1 Tie2 SRC kinase; docking; drug design; focused library; kinase inhibition; nitrogen heterocycles; scaffolds.

The broader and systematic application of a novel scaffold is often hampered by the unavailability of a short and reliable synthetic access. We investigated a new strategy for the design and synthesis of an array of N2-substituted aza-2H-indazole derivatives as potential kinase inhibitors. Guided by a rational ligand alignment approach to qualify the so-far underrepresented aza-2H-indazole scaffold, indazoles were connected at the N2 position with a Ph spacer and an arylsulfonamide or amide linkage. Initial profiling against a panel of 30 kinases confirmed the in silico predicted selectivity bias. A synthesized focused library of 52 different aza-2H-indazole derivatives showed good initial selective inhibition against SGK1, Tie2, and SRC kinases, with the best representatives having IC50 values in the range of 500 nM. In a comparative computational study, these data were analyzed and rationalized in light of docking studies.

ChemMedChem published new progress about Drug targets. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamazaki, Shigeo; Nagaya, Shoko; Saito, Katsunori; Tanimura, Takenori published the artcile< Enantiomeric separation of underivatized aliphatic β-amino alcohols by ligand-exchange chromatography using barbital as an additive to the mobile phase>, Reference of 112-63-0, the main research area is enantiomer separation aliphatic amino alc HPLC; ligand exchange chromatog amino alc enantiomer; barbital additive HPLC mobile phase; copper additive HPLC mobile phase; HPLC amino alc enantiomer; liquid chromatog amino alc enantiomer.

Underivatized aliphatic β-amino alcs. with a secondary alc. moiety were separated into enantiomers by HPLC using octadecylsilanized silica coated with N-n-dodecyl-L-hydroxyproline as the stationary phase and an aqueous solution containing copper(II) and barbital as the mobile phase.

Journal of Chromatography A published new progress about Amino alcohols Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amey, Ronald L.; Martin, J. C. published the artcile< Synthesis and reactions of stable alkoxyaryltrifluoroperiodinanes. A ""tamed"" analog of iodine pentafluoride for use in oxidations of amines, alcohols, and other species>, Synthetic Route of 112-63-0, the main research area is iodinane per alkoxyaryl trifluoro; periodinane alkoxyaryl trifluoro; oxidation periodinane alc amine; iodine pentafluoride analog; benziodoxole preparation reaction.

Stable alkoxyaryltrifluoroperiodinanes I and II were prepared by oxidation of the resp. parent iodo alcs. 5,2-MeIC6H3C(CF3)2OH and 2-IC6H4CMe2OH with excess CF3OF. The stability and low reactivity of I and II are ascribed to the strong stabilizing influence of the 5-membered ring. The reaction of I with Me3SiCl gives the corresponding iodine(III) species, III, and chlorine. I is hydrolyzed with aqueous base to give a species thought to be iodinane oxide (IV). I is a selective reagent for the oxidation of primary and secondary amines or alcs. bearing α hydrogens to the corresponding aldehyde or ketone. In contrast to iodine pentafluoride, I does not further oxidize the product aldehydes to acids. tert-Butylamine is oxidized by I to give 1,1,1′,1′-tetramethylazoethane. PhMgBr reacts with I to give PhF. Possible mechanisms for these selective oxidations are discussed. It is suggested that the stabilizing structural features of I make it a tamed analog of IF5.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics