Tag: M.W=250-300

Khatua, Hillol; Das, Sandip Kumar; Roy, Satyajit; Chattopadhyay, Buddhadeb published the artcile< Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is manganese catalyst tetrazole click denitrogenative annulation; nitrogen heterocycle disubstituted triazole triazolopyridine preparation; 1,3-cycloaddition; catalysis; click chemistry; denitrogenative annulation; manganese.

A general catalytic method using a Mn-porphyrin-based catalytic system is reported that enables two different reactions (click reaction and denitrogenative annulation) and affords two different classes of nitrogen heterocycles, 1,5-disubstituted 1,2,3-triazoles (with a pyridyl motif) and 1,2,4-triazolo-pyridines. Mechanistic studies suggest that although the click reaction likely proceeds through an ionic mechanism, which is different from the traditional click reaction, the denitrogenative annulation reaction likely proceeds via an electrophilic metallonitrene intermediate rather than a metalloradical intermediate. Collectively, this method is highly efficient and offers several advantages over other methods. For example, this method excludes a multi-step synthesis of the N-heterocyclic mols. described and produces only environmentally benign N2 gas a byproduct.

Angewandte Chemie, International Edition published new progress about Click chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iwashima, Makoto; Kinsho, Takeshi; Smith, Amos B. III published the artcile< A caveat on the Sharpless asymmetric dihydroxylation>, Application of C19H34O2, the main research area is vinyl C glycoside stereoselective dihydroxylation; alditol; Sharpless stereoselective hydroxylation olefin sugar.

Sharpless asym. dihydroxylation (AD) of the homochiral synthetic intermediates 2a-c gave anomalous results: pairs of pseudoenantiomeric reagents, expected to generate complementary diastereomer ratios characteristic of double diastereoselection, instead generally furnished indistinguishable product mixtures AD reactions of related monosubstituted olefins failed to pinpoint the structural features responsible for the unexpected behavior.

Tetrahedron Letters published new progress about Alditols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Chun-Ling; Lu, Weihui; Qiu, Feifei; Li, Dan; Liu, Huazhen; Zheng, Fang; Zhang, Qunfang; Chen, Yuchao; Lu, Chuanjian; Li, Bin; Dai, Zhenhua published the artcile< Paeoniflorin ameliorates murine lupus nephritis by increasing CD4+Foxp3+ Treg cells via enhancing mTNFα-TNFR2 pathway>, Reference of 112-63-0, the main research area is paeoniflorin immunosuppressant antiinflammatory agent TNF alpha TNFR2 lupus nephritis; Lupus nephritis; Macrophage; Paeoniflorin; TNF-α /TNFR2; Treg.

Treg cells are essential for re-establishing self-tolerance in lupus. However, given that direct Treg therapies may be inadequate to control autoimmunity and inflammation, a strategy of inducing or expanding endogenous Treg cells in vivo may be a good option. Macrophages are main tissue-infiltrating cells and play a role in promoting Treg differentiation while paeoniflorin (PF), a monoterpene glycoside, exhibits anti-inflammatory and immunoregulatory effects. Here, we studied the effects of PF on CD4+FoxP3+ Treg frequency and the potential mechanisms involving M2 macrophages. We demonstrated that PF ameliorated lupus nephritis in lupus-prone B6/gld mice by reducing urinary protein, serum creatinine and anti-dsDNA levels, diminishing renal cellular infiltration, improving renal immunopathol. and downregulating renal gene and protein expressions of key cytokines, including IFN-γ, IL-6, IL-12 and IL-23. PF also lowered the percentage of CD44highCD62Llow effector T cells while augmenting CD4+FoxP3+ Treg frequency in B6/gld mice. Importantly, PF increased TNFR2 expression on CD4+FoxP3+ Tregs, but not CD4+FoxP3- T cells, in vivo and in vitro. Furthermore, we found that CD206+ subset of F4/80+CD11b+ macrophages expressed a higher level of mTNF-α than their CD206- counterparts while PF increased mTNF-α expression on CD206+ macrophages in vitro and in vivo. In vitro studies showed that mTNF-α+ M2 macrophages were more potent in inducing Treg differentiation and proliferation than their mTNF-α- counterparts, whereas the effects of mTNF-α+ M2 macrophages were largely reversed by separation of M2 macrophages using a transwell or TNFR2-blocking Ab in the culture. Finally, PF also promoted in vitro Treg generation induced by M2 macrophages. Thus, we demonstrated that mTNFα-TNFR2 interaction is a new mechanism responsible for Treg differentiation mediated by M2 macrophages. We provided the first evidence that PF may be used to treat lupus nephritis.

Biochemical Pharmacology (Amsterdam, Netherlands) published new progress about Antinuclear antibodies Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Min; Zhang, Haifeng; Zhang, Yameng; Fan, Jinting; Zhu, Jinhao; Gu, Xinyue; Li, Zhonghui; Zhang, Chengyang; Liu, Zhen; Li, Yuebai; Zang, Mingxi; Jin, Ge; Li, Guoping; Mi, Yang published the artcile< Berberine modulates macrophage activation by inducing glycolysis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is TNFalpha berberine macrophage activation glycolysis endotoxic shock.

Classical activation of macrophage and monocyte differentiation induced by β-glucan is accompanied with metabolic change in glucose. However, the role of the metabolic rewiring in monocyte/macrophage activation remains elusive. In this study, we show that berberine induces aerobic glycolysis by blocking the tricarboxylic acid cycle and modulates cytokine responses in bone marrow-derived macrophages (BMDMs) from mice and human PBMC. 13-Methyberberine had activities on glucose metabolism and BMDM activation similar to those of berberine, whereas other tested derivatives lost both activities. Glucose transporter (GLUT)1 expression and total cellular hexokinase activity increased gradually in BMDMs in the presence of berberine. In the contrast, LPS upregulated GLUT1 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) levels in 6 h. Extracellular glucose levels and replacing glucose with galactose in culture medium affected the cytokine secretion of BMDMs. Berberine alleviated enteritis of Salmonella typhimurium infection and protected mice against endotoxic shock. In mice i.p. injected with LPS, the increase of serum TNF-α and the drop of blood glucose were attenuated by berberine treatment. These data together demonstrated that macrophage activation was closely related with glucose metabolism

Journal of Immunology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Azawi, Anas; Cenev, Zoran; Tupasela, Topi; Peng, Bo; Ikkala, Olli; Zhou, Quan; Jokinen, Ville; Franssila, Sami; Ras, Robin H. A. published the artcile< Tunable and Magnetic Thiol-ene Micropillar Arrays>, Electric Literature of 112-63-0, the main research area is superhydrophobic micopillar thiol; microdroplet transport; micromanipulation; self-assembly; superhydrophobicity; thiol-ene elastomers.

Tunable and responsive surfaces offer routes to multiple functionalities ranging from superhydrophobic surfaces to controlled adhesion. Inspired by cilia structure in the respiratory pathway, magnetically responsive periodic arrays of flexible and magnetic thiol-ene micropillars are fabricated. Omnidirectional collective bending of the pillar array in magnetic field is shown. Local non-contact actuation of a single pillar is achieved using an electromagnetic needle to probe the responsiveness and the elastic properties of the pillars by comparing the effect of thiol-ene crosslinking d. to pillar bending. The suitable thiol-ene components for flexible and stiff magnetic micropillars and the workable range of thiol-to-allyl ratio are identified. The wettability of the magnetic pillars can be tailored by chem. and topog. modification of the pillar surface. Low-surface-energy self-assembled monolayers are grafted by UV-assisted surface activation, which is also used for surface topog. modification by covalent bonding of micro- and nanoparticles to the pillar surface. The modified thiol-ene micopillars are resistant to capillarity-driven collapse and they exhibit low contact angle hysteresis, allowing water droplet motion driven by repeated bending and recovery of the magnetic pillars in an external magnetic field. Transport of polyethylene microspheres is also demonstrated.

Macromolecular Rapid Communications published new progress about Contact angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Wyk, Hedwig M.; Schoeman, Dewald; Kwembeya, Ezekeil; Hans, Renate H.; Pool, Edmund J.; Louw, Stefan published the artcile< In vitro acetylcholinesterase inhibitory activity and chemical composition of the dichloromethane extracts of the leaves and inflorescences of the tumbleweed, Trachyandra laxa (N.E.Br.) Oberm. var. rigida (Suesseng.) Roessl>, Reference of 112-63-0, the main research area is Trachyandra laxa acetylcholinesterase inhibitor chem composition dichloromethane leaf tumbleweed.

Trachyandra laxa, which belongs to the family Asphodelaceae, is a poisonous geophyte, often consumed by livestock, particularly when pastures are poor. Ingestion of T. laxa by livestock causes paresis and paralysis of the animals. However, the chem. composition of this plant has never been studied before and its toxic components are still unknown. In this study, an acetylcholinesterase (AChE) inhibition assay of different extracts of the parts of Trachyandra laxa (N.E.Br.) Oberm. var. rigida (Suesseng.) Roessl. revealed that the DCM extracts possess the highest AChE inhibitory activity. In addition, using qual. phytochem. tests, it was determined that all the plant parts contain polyphenols and tannins, while only the leaves contain flavonoids. Saponins were detected in all plant parts, except in the flowers and anthraquinones were detected in all plant parts expect the roots. Using GC-MS anal., 13 volatile constituents were identified in the DCM extracts of the leaves and inflorescences, including α,β-unsaturated lactones, carboxylic acids and esters, a diterpenoid, phytol, and a phytosterol, β-sitosterol. Of particular interest are the α,β-unsaturated lactones, which were identified as dihydroactinidiolide (DHA) and its hydroxylated analog, hydroxy-DHA, as well as phytol, a diterpenoid. DHA and phytol have been reported to possess potent AChE inhibition activity. It is therefore plausible that these compounds and potentially also hydroxy-DHA could contribute to the AChE inhibitory activity of the DCM extracts, and thus the neurotoxicity of T. laxa var. rigida.

South African Journal of Botany published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saima, Yasmin; Khamarui, Saikat published the artcile< MnVI-NP-Catalyzed Generation of Nitrile Oxides: Easy Access to Isoxazolines and Isoxazoles via Stereoselective 1,3-Dipolar Cycloaddition Reactions>, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is aldoxime alkene manganese catalyst chemoselective regioselective diastereoselective dipolar cycloaddition; isoxazole preparation; alkyne aldoxime manganese catalyst chemoselective regioselective diastereoselective dipolar cycloaddition; isoxazoline preparation.

The versatility and effectiveness of Mn(VI)-nanoparticles as a catalyst is examined for the generation of nitrile oxides from aldoximes and subsequent 1,3-dipolar cycloaddition reactions. This synthetic protocol features fast reaction convergence under benign reaction conditions, operational simplicity, and the use of inexpensive precursors; it avoids the use of acids or bases. The strategy offers excellent chemo-, regio-, and diastereoselectivity in the 1,3-dipolar cycloaddition reaction of in situ-generated nitrile oxides with alkenes and alkynes.

SynOpen published new progress about 1,3-Dipolar cycloaddition catalysts. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiong, Xingquan; Yi, Chao; Han, Qian; Shi, Lin; Li, Sizhong published the artcile< I2/ionic liquid as a highly efficient catalyst for per-O-acetylation of sugar under microwave irradiation>, COA of Formula: C19H34O2, the main research area is peracetylated sugar iodine ionic liquid microwave irradiation.

A practical and highly efficient approach was developed to synthesize peracetylated sugar derivatives using a recyclable iodine/PEG400-based ionic liquid catalyst (I2/IL). The peracetylated sugars were readily obtained in a few minutes in excellent yields (90%-99%, 13 examples)on a multi-gram scale (50.0 mmol) by the reaction of sugar and acetic anhydride under microwave irradiation in the absence of a volatile organic solvent. The desired product was easily obtained by simple extraction with toluene from the reaction mixture, and I2/ILs could be readily recovered and reused at least six times without obvious loss in the yield. When the scale of the per-O-acetylation reaction was increased to 50.0 mmol, the desired product was still obtained in 90%yield after five recycles.

Cuihua Xuebao published new progress about Acetylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Le, Xuyen H.; Lee, Chun Pong; Monachello, Dario; Millar, A. Harvey published the artcile< Metabolic evidence for distinct pyruvate pools inside plant mitochondria>, HPLC of Formula: 112-63-0, the main research area is Arabidopsis mitochondria pyruvate citrate AlaAT NADME.

The majority of the pyruvate inside plant mitochondria is either transported into the matrix from the cytosol via the mitochondria pyruvate carrier (MPC) or synthesized in the matrix by alanine aminotransferase (AlaAT) or NAD-malic enzyme (NAD-ME). Pyruvate from these origins could mix into a single pool in the matrix and contribute indistinguishably to respiration via the pyruvate dehydrogenase complex (PDC), or these mols. could maintain a degree of independence in metabolic regulation. Here we demonstrate that feeding isolated mitochondria with uniformly labeled 13C-pyruvate and unlabeled malate enables the assessment of pyruvate contribution from different sources to intermediate production in the tricarboxylic acid cycle. Imported pyruvate was the preferred source for citrate production even when the synthesis of NAD-ME-derived pyruvate was optimized. Genetic or pharmacol. elimination of MPC activity removed this preference and allowed an equivalent amount of citrate to be generated from the pyruvate produced by NAD-ME. Increasing the mitochondrial pyruvate pool size by exogenous addition affected only metabolites from pyruvate transported by MPC, whereas depleting the pyruvate pool size by transamination to alanine affected only metabolic products derived from NAD-ME. PDC was more membrane-associated than AlaAT and NAD-ME, suggesting that the phys. organization of metabolic machinery may influence metabolic rates. Together, these data reveal that the respiratory substrate supply in plants involves distinct pyruvate pools inside the matrix that can be flexibly mixed on the basis of the rate of pyruvate transport from the cytosol. These pools are independently regulated and contribute differentially to organic acid export from plant mitochondria.

Nature Plants (London, United Kingdom) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yanfei; Wu, Yunyan; Yuan, Guangfeng; Hao, Leiduan; Gao, Xiang; Yang, Zhenzhen; Yu, Bo; Zhang, Hongye; Liu, Zhimin published the artcile< Azole-Anion-Based Aprotic Ionic Liquids: Functional Solvents for Atmospheric CO2 Transformation into Various Heterocyclic Compounds>, Reference of 112-63-0, the main research area is cyclic carbonate quinazoline dione benzimidazolone benzothiazoline preparation; azole anion aprotic ionic liquid carbon dioxide; atmospheric chemistry; azoles; carbon dioxide; heterocyclic compounds; ionic liquids.

Herein, azole-anion-based aprotic ionic liquids (ILs) were synthesized by the deprotonation of weak proton donors (e.g., 2-methylimidazole, 4-methylimidazole, and 2,4-dimethylimidazole) with tetrabutylphosphonium hydroxide, [Bu4P][OH]. These ILs, such as [Bu4P][2-MIm], could activate atm. CO2 through the formation of carbamates. The resultant carbamate intermediates could further react with various types of substrate, including propargylic alcs., 2-aminobenzonitriles, ortho-phenylenediamines, and 2-aminothiophenol, thereby producing α-alkylidene cyclic carbonates, quinazoline-2,4(1H,3H)-diones, benzimidazolones, and benzothiazoline, resp., in moderate-to-good yields. The transformation of CO2 at atm. pressure was achieved, and this method is expected to open up new routes for the synthesis of various oxygen-containing heterocyclic compounds under metal-free conditions.

Chemistry – An Asian Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics