Tag: M.W=250-300

Li, Zhijun; Bao, Haiying published the artcile< Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic>, Product Details of C19H34O2, the main research area is Inonotus hepatic carcinoma petroleum ether extract amino acid antitumor; Anti-tumor; Inonotus hispidus petroleum-ether-extract (IPE); Mechanisms; Serum metabonomic; UPLC-MS/MS.

The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear. This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics. The model of H22 tumor-bearing mice was constructed according to the histopathol. data and biochem. parameters, while the serum metabolomics was analyzed by non-targeted ultra-high performance liquid chromatog. and high-resolution mass spectrometry (UPLC-MS/MS) to study the potential anti-tumor mechanisms of IPE. These results indicated that IPE has significant anti-tumor effect on H22 tumor-bearing mice and no obvious adverse reactions were observed After the intervention of IPE, the biosynthesis of cortisol and corticosterone as the metabolics in the downstream of steroid biosynthesis pathway and the biosynthesis of succinate, fumarate and malate as the metabolics in the downstream of tricarboxylic acid cycle pathway were inhibited; but the metabolic pathways of the amino acids as tryptophan, lysine degradation, alanine, aspartate and glutamate and other amino acid were activated. IPE has significant anti-tumor effect in H22 tumor-bearing mice, and the anti-tumor activity of IPE is main through the regulation of energy, amino acids, and steroid hormone biosynthesis pathways expression.

Journal of Ethnopharmacology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (metabolism). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mahankali, Kiran; Gottumukkala, Sundeep Varma; Masurkar, Nirul; Thangavel, Naresh Kumar; Jayan, Rahul; Sawas, Abdulrazzag; Nagarajan, Sudhan; Islam, Mahbubul Md; Arava, Leela Mohana Reddy published the artcile< Unveiling the Electrocatalytic Activity of 1T'-MoSe2 on Lithium-Polysulfide Conversion Reactions>, Computed Properties of 112-63-0, the main research area is unveiling electrocatalytic molybdenum selenide lithium polysulfide conversion reaction; 2D material; electrocatalysis; lithium−sulfur; phase transformation; transition metal dichalcogenide.

The dissolution of intermediate lithium polysulfides (LiPS) into an electrolyte and their shuttling between the electrodes have been the primary bottlenecks for the commercialization of high-energy d. lithium-sulfur (Li-S) batteries. While several two-dimensional (2D) materials have been deployed in recent years to mitigate these issues, their activity is strictly restricted to their edge-plane-based active sites. Herein, for the first time, we have explored a phase transformation phenomenon in a 2D material to enhance the number of active sites and electrocatalytic activity toward LiPS redox reactions. Detailed theor. calculations demonstrate that phase transformation from the 2H to 1T’ phase in a MoSe2 material activates the basal planes that allow for LiPS adsorption. The corresponding transformation mechanism and LiPS adsorption capabilities of the as-formed 1T’-MoSe2 were elucidated exptl. using microscopic and spectroscopic techniques. Further, the electrochem. evaluation of phase-transformed MoSe2 revealed its strong electrocatalytic activity toward LiPS reduction and their oxidation reactions. The 1T’-MoSe2-based cathode hosts for sulfur later provide a superior cycling performance of over 250 cycles with a capacity loss of only 0.15% per cycle along with an excellent Coulombic efficiency of 99.6%.

ACS Applied Materials & Interfaces published new progress about Battery electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lahuta, Leslaw Bernard; Szablinska-Piernik, Joanna; Glowacka, Katarzyna; Stalanowska, Karolina; Railean-Plugaru, Viorica; Horbowicz, Marcin; Pomastowski, Pawel; Buszewski, Boguslaw published the artcile< The Effect of Bio-Synthesized Silver Nanoparticles on Germination, Early Seedling Development, and Metabolome of Wheat (Triticum aestivum L.)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Triticum aestivum silver nanoparticle germination early seedling development metabolome; ROS; metabolic profiles; seedling; silver nanoparticles; wheat.

Changes in the metabolome of germinating seeds and seedlings caused by metal nanoparticles are poorly understood. In the present study, the effects of bio-synthesized silver nanoparticles ((Bio)Ag NPs) on grains germination, early seedlings development, and metabolic profiles of roots, coleoptile, and endosperm of wheat were analyzed. Grains germinated well in (Bio)Ag NPs suspensions at the concentration in the range 10-40 mg/L. However, the growth of coleoptile was inhibited by 25%, regardless of (Bio)Ag NPs concentration tested, whereas the growth of roots gradually slowed down along with the increasing concentration of (Bio)Ag NPs. The deleterious effect of Ag NPs on roots was manifested by their shortening, thickening, browning of roots tips, epidermal cell death, progression from apical meristem up to root hairs zone, and the inhibition of root hair development. (Bio)Ag NPs stimulated ROS production in roots and affected the metabolic profiles of all tissues. Roots accumulated sucrose, maltose, 1-kestose, phosphoric acid, and some amino acids (i.e., proline, aspartate/asparagine, hydroxyproline, and branched-chain amino acids). In coleoptile and endosperm, contrary to roots, the concentration of most metabolites decreased. Moreover, coleoptile accumulated galactose. Changes in the concentration of polar metabolites in seedlings revealed the affection of primary metabolism, disturbances in the mobilization of storage materials, and a translocation of sugars and amino acids from the endosperm to growing seedlings.

Molecules published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kolar, David; Kleteckova, Lenka; Skalova, Katerina; Brozka, Hana; Kalous, Martin; Vales, Karel published the artcile< Glycolytic and Krebs cycle enzymes activity in rat prefrontal cortex, hippocampus, and striatum after single and repeated NMDA inhibition by MK-801>, Synthetic Route of 112-63-0, the main research area is MK801 NMDA antagonist glycolytic Krebs cycle enzyme schizophrenia brain; Citrate synthase; Energy metabolism; Hexokinase; Lactate dehydrogenase; Malate dehydrogenase; Schizophrenia.

Psychosis is a state of altered thoughts which often accompanies schizophrenia. It was suggested that changes in energetic metabolism accompany psychosis and post-psychosis states. Here, author use the N-methyl–aspartate (NMDA) receptor antagonist MK-801 to exptl. induce psychosis-like behavior in rats. Author addressed an effect of single and repeated (5x) MK-801 application (0.3 mg/kg; i.p.) on the energy metabolism in homogenates and crude mitochondrial fraction (CMF) of the striatum (STR), prefrontal cortex (PFC), and the hippocampus (HIP) of the adult male Wistar rat (n = 39). In each brain region, author assessed activity of glycolytic (hexokinase (HK) and lactate dehydrogenase (LDH)) and Krebs cycle enzymes (citrate synthase (CS) and malate dehydrogenase (MDH)) 2 h and 3 days (3d) after the last MK-801 application together with relative respiratory rates assessment in tissue homogenate. In STR, a single MK-801 application led to a decrease in the LDH (p = 0.0035) and the increase of the MDH (p = 0.0043) activities following 3d. Therein, repeated MK-801 doses evoked increased LDH (p = 0.0204) and CS (p = 0.0019) activities in the homogenate 2 h and increased HK (p = 0.0007) 3d after the last application. Elevated HK activity within CMF was observed after 3d (p = 0.0054). In PFC, repeated MK-801 application decreased HK activity in the homogenate 3d after the final application (p = 0.0234). Correspondingly, PFC HK activity in CMF of repeated administration samples dropped (p = 0.003). In HIP, repeated MK-801 administration led to increased respiration of SDH (p = 0.0475) only 2 h after the last application and decreased CS activity (p = 0.0160) was observed 3d after the last application. Author result indicate a progressive metabolic dysregulation of glycolytic and Krebs cycle enzymes following repeated inhibition of NMDA receptors activity in a region-specific manner. Energetic alterations may form a basis for persisting cognitive problems during and following a psychosis in schizophrenia patients.

NeuroToxicology published new progress about Brain corpus striatum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Otsuji, Yoshio; Koda, Yoshiki; Kubo, Masaru; Furukawa, Masaaki; Imoto, Eiji published the artcile< Reactivities of the heterocyclic compounds. VI. Application of the Hammett equation to pyridine compounds>, Product Details of C19H34O2, the main research area is .

5-Ethylpyridine-2-carboxylic acid (I) (12 g.) dissolved in 100 ml. AcOH and 10 g. H2SO4, 11 g. CrO3 added at 15°, and the product purified through the Cu salt gave 42% 5-acetylpyridine-2-carboxylic acid (II), m. 179-80°. Et ester of II was prepared similarly in 72% yield, b5 143-5°; 2,4-dinitrophenylhydrazone m. 226°. H2O2 (30%) (20 ml.) added to 50 ml. H2SO4 at 0-5° and 5 g. 2-aminopyridine-5-carboxylic acid in 50 ml. H2SO4 added gave after 2 days 63% 2-nitropyridine-5-carboxylic acid (III), m. 187-8°. Compounds used in this study were picolinic acid (IV), I, 5-iodo-2-carboxylic acid, II, nicotinic acid, and their Et esters, 2-methylpyridine-5-carboxylic acid, 2-chloropyridine-5-carboxylic acid, and III. The hydrolysis rates of Et 5-substituted pyridine-2-carboxylates at 25° were studied and found to be linear with Hammett σp values except for Et ester of II. Deviation of the Ac group was attributed to enolization and ionization when the Ac group was attached to an electron-drawing group. ρ was obtained as 1.56 and the small ρ was attributed to the electronegativity of N. Hydrolysis rate of 3 Et pyridinecarboxylates was in good agreement with the π-electron distribution. Dissociation constants of 5-substituted pyridine-2-carboxylic acids (V) and 2-substituted pyridine-5-carboxylic acids (VI) were obtained. V gave always higher pKa than VI, indicating that IV and its derivatives existed as zwitterions. The Hammett equation was also applicable to the dissociation and ρ was obtained as 2.31 and 1.60 for V and VI, resp., while substituted benzoic acids had 1.60 under the similar conditions. Greater ρ than that expected from ester hydrolysis must be attributed to the existence of a zwitterion of which H+ on N influences the σ values. From the ρ value the ratio of zwitterion in V was estimated as 30% in 50% EtOH. The σ value was corrected by use of the above zwitterion content and better linear correlation was obtained.

Nippon Kagaku Zasshi published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bristow, Tony; Harrison, Mark; Sims, Martin published the artcile< The application of gas chromatography/atmospheric pressure chemical ionisation time-of-flight mass spectrometry to impurity identification in Pharmaceutical Development>, Synthetic Route of 112-63-0, the main research area is gas chromatog atm pressure impurity pharmaceutical development.

Accurate mass measurement (used to determine elemental formulas) is an essential tool for impurity identification in pharmaceutical development for process understanding. Accurate mass liquid chromatog./mass spectrometry (LC/MS) is used widely for these types of analyses; however, there are still many occasions when gas chromatog. (GC)/MS is the appropriate technique. Therefore, the provision of robust technol. to provide accurate mass GC/MS (and GC/MS/MS) for this type of activity is essential. In this report we describe the optimization and application of a newly available atm. pressure chem. ionization (APCI) interface to couple GC to time-of-flight (TOF) MS. To fully test the potential of the new interface the APCI source conditions were optimized, using a number of standard compounds, with a variety of structures, as used in synthesis at AstraZeneca. These compounds were subsequently analyzed by GC/APCI-TOF MS. This study was carried out to evaluate the range of compounds that are amenable to anal. using this technique. The range of compounds that can be detected and characterized using the technique was found to be extremely broad and include apolar hydrocarbons such as toluene. Both protonated mols. ([M + H]+) and radical cations (M+.) were observed in the mass spectra produced by APCI, along with addnl. ion signals such as [M + H + O]+. The technique has been successfully applied to the identification of impurities in reaction mixtures from organic synthesis in process development. A typical mass accuracy of 1-2 mm/zunits (m/z 80-500) was achieved allowing the reaction impurities to be identified based on their elemental formulas. These results clearly demonstrate the potential of the technique as a tool for problem solving and process understanding in pharmaceutical development. The reaction mixtures were also analyzed by GC/electron ionization (EI)-MS and GC/chem. ionization (CI)-MS to understand the capability of GC/APCI-MS relative to these two firmly established techniques. Copyright © 2010 John Wiley & Sons, Ltd.

Rapid Communications in Mass Spectrometry published new progress about Drugs. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Han; Xu, Qiong; Li, Hui; Liu, Jian; Liu, Xianxiang; Huang, Geng; Yin, Dulin published the artcile< Catalytic Transfer Hydrogenation of Ethyl Levulinate to γ-Valerolactone Over Ni Supported on Equilibrium Fluid-Catalytic-Cracking Catalysts>, SDS of cas: 112-63-0, the main research area is catalytic transfer hydrogenation ethyl levulinate gamma valerolactone.

Nickel supported on equilibrium fluid-catalytic-cracking catalysts (Ni/E-cats) were prepared by a simple grinding-pyrolysis method and employed for the transfer hydrogenation of Et levulinate (EL) to γ-valerolactone (GVL). 96.2% selectivity of GVL and 90.3% conversion of EL were obtained at 180°C for 6 h over 30-Ni/E-cat. Through XRD, N2 adsorption-desorption, NH3-TPD and SEM anal., the high activity of the 30-Ni/E-cat catalyst was attributed to its dispersed Ni metal active centers and available acidic sites. Catalytic probe test revealed that metal and acid sites of Ni/E-cat played a synergistic catalytic role in the synthesis of GVL in 2-propanol, where Ni metal sites contribute to the hydrogenation of ketone group in EL, and acid sites of E-cat promoted the lactonization of intermediate ethyl- or iso-Pr 4-hydroxyvalerate. Two reaction pathways and synergistic mechanism were proposed in this catalytic system. Moreover, Ni/E-cat catalyst exhibited good stability up to four cycles without obvious loss of catalytic activity.

Catalysis Letters published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasulov, N. Sh.; Goyushov, R. D.; Bairamov, G. M.; Guseinov, S. A. published the artcile< Monoalkyl hexahydroterephthalates>, Formula: C19H34O2, the main research area is hexahydroterephthalate monoalkyl ester; terephthalate hexahydro diacid chloride esterification.

The title esters were obtained in high yield (≤65%) from the esterification of hexahydroterephthalic diacid chloride with ROH (R = Me, Et, Pr).

Azerbaidzhanskii Khimicheskii Zhurnal published new progress about Esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Congxiao; Liu, Chao; Chen, Jun; Jiang, Han; Zhang, Wei; Yang, Lili; Li, Xueda; Li, Zixiang; Peng, Lijing; Hu, Xiaokun; Sun, Peng published the artcile< Effect of neoadjuvant iodine-125 brachytherapy upon resection of glioma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is neoadjuvant iodine125 brachytherapy glioma resection; Combination therapy; Glioma; Neoadjuvant 125I brachytherapy; Surgical resection; Tumor shrinkage.

A more extensive surgical resection of glioma contributes to improved overall survival (OS) and progression-free survival (PFS). However, some patients miss the chance of surgical resection when the tumor involves critical structures. The present study aimed to assess the feasibility of neoadjuvant 125I brachytherapy followed by total gross resection for initially inoperable glioma. Six patients diagnosed with inoperable glioma due to invasion of eloquent areas, bihemispheric diffusion, or large tumor volume received 125I brachytherapy. Surgical resection was performed when the tumor shrank, allowing a safe resection, assessed by the neurosurgeons. Patients were followed up after surgery. Shrinkage of the tumor after adjuvant 125I brachytherapy enabled a total gross resection of all six patients. Four patients were still alive at the last follow-up, with the longest survival time of more than 50 mo, two of which returned to everyday life with a KPS of 100. Another two patients had neurol. injuries with KPSs of 80 and 50, resp. One patient with grade II glioma died 34 mo, and another with grade IV glioma died 40 mo after the combined therapy. In the present study, the results demonstrated that 125I brachytherapy enabled a complete resection of patients with initially unresectable gliomas. The 125I brachytherapy may offer a proper neoadjuvant therapy method for glioma.

BMC Cancer published new progress about Brachytherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinet, Julien; Treguier, S.; Levasseur-Garcia, C.; Calmon, A.; Violleau, F. published the artcile< Iodine and Peroxide Index Rapid Determination by Mid- and Near-infrared Spectroscopy in Ozonated Sunflower Oil and Ozonated Fats>, Product Details of C19H34O2, the main research area is iodine peroxide index IR spectroscopy ozonated sunflower oil fat.

Ozone can react with fatty species such as vegetable oils to form oxidized compounds with interesting antibacterial activity. The iodine and peroxide indexes of these ozonated products are two crucial antibacterial characteristics. Currently, these two parameters are determined by chem. methods, which is disadvantageous because it requires long handling time, sample destruction and the use of toxic products. Spectroscopic analyses coupled with chemometric evaluations have already shown their usefulness for characterizing virgin oils via rapid, chem.-free methods. In addition, IR spectroscopy is widely used to characterize ozonated compounds The present study evaluates the possibility of coupling IR spectroscopy with chem. analyses of ozonated compounds We subjected 187 fat samples of varying compositions to different ozonation conditions to determine their chem. parameters. We analyzed the samples by IR spectroscopy and modeled the results by combining chem. data with spectral anal. The model results are quantified by the coefficient of determination R2, the root-mean-square error, and the residual predictive deviation (RPD). The model produces RPDs greater than 3.5 for the mid-IR spectral range, which means that they may be used to estimate indexes. In addition, with RPDs between 2 and 3, partial least squares near-IR models demonstrate a capacity for rough screening of ozonated fats.

Ozone: Science & Engineering published new progress about Corn oil Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics