Tag: M.W=250-300

Karapanayiotis, Thanasis; Bowen, Richard D. published the artcile< Differentiation of ionized benzimidazole from its isomeric α-distonic ion by collision-induced dissociation and neutralization-reionization mass spectrometry>, Computed Properties of 112-63-0, the main research area is benzimidazole radical cation distonic tautomer CID NR mass spectra.

Ionized benzimidazole and its isomeric α-distonic ion (or ionized ylide) have been examined by recording their metastable ion, collision-induced dissociation and neutralization-reionization mass spectra. These tautomers may be distinguished by careful consideration of key features of the collision-induced dissociation spectra, with or without prior neutralization and reionization. Formation of doubly-charged ions by charge stripping occurs preferentially when the α-distonic ion is subjected to collision. This α-distonic ion survives neutralization and reionization, thus establishing that the corresponding ylide is stable on the microsecond time frame. The effects of benzannulation on the ease of differentiation of classical and distonic radical cations derived from biol. important heterocycles are considered.

European Journal of Mass Spectrometry published new progress about Collision-induced dissociation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ozen, Tevfik; Demirtas, Ibrahim published the artcile< Comparison of the chemical composition and bioactive properties of extracts prepared from the mature Turkish and Brazilian banana peels>, Application In Synthesis of 112-63-0, the main research area is Brazilian Turkish banana peel extract chem composition bioactive property.

The banana (Musa sp.) plant grows in tropical and subtropical regions. The fruit of the banana is eaten and the peel of the banana is discarded. In this study, chem. analyzes (HPLCTOF/MS ve GC-MS) and biochem. activities (antioxidant and antimicrobial) of Et acetate (Ea) and methanol/chloroform (Me/Ch) extracts prepared from banana peel (Bbp) grown in Brazil and banana peel (Tbp) grown in Turkey were investigated. Cetene, 4-hydroxybenzoic, palmitic, linoleic, stearic, gentisic and syringic acid are the most abundant compounds in the extracts The total antioxidant activity of Tbp-Ea (A0.5: 36.84 μg/mL), inhibition of lipid peroxidation of Bbp-Ea (IC50: 3.22 μg/mL), reducing power of Tbp-Me/Ch (A0.5: 4.96 μg/mL), DPPH• scavenging activity of Bbp-Ea (IC50: 8.54 μg/mL), metal chelating activity of Tbp-Ea (IC50: 16.54 μg/mL) and H2O2 scavenging activity of Tbp-Me/Ch (IC50: 0.36 μg/mL) were found the most effective. It was exhibited that extracts were effective against gramneg. and gram-pos. bacteria. In conclusion, the phytochem. and biochem. results of the TbP and Bbp extracts will contribute further pharmacol., biochem. and pharmacol. investigations.

International Journal of Chemistry and Technology (Kilis, Turkey) published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Ani, Mena; Elemam, Noha Mousaad; Hundt, Jennifer Elisabeth; Maghazachi, Azzam A. published the artcile< Drugs for multiple sclerosis activate natural killer cells: do they protect against COVID-19 infection?>, COA of Formula: C19H34O2, the main research area is review human covid19 virus natural killer cell; COVID-19; NK cells; multiple sclerosis.

A review. COVID-19 infection caused by the newly discovered coronavirus severe acute respiratory distress syndrome virus-19 (SARS-CoV-2) has become a pandemic issue across the globe. There are currently many investigations taking place to look for specific, safe and potent anti-viral agents. Upon transmission and entry into the human body, SARS-CoV-2 triggers multiple immune players to be involved in the fight against the viral infection. Amongst these immune cells are NK cells that possess robust antiviral activity, and which do not require prior sensitization. However, NK cell count and activity were found to be impaired in COVID-19 patients and hence, could become a potential therapeutic target for COVID-19. Several drugs, including glatiramer acetate (GA), vitamin D3, di-Me fumarate (DMF), monomethyl fumarate (MMF), natalizumab, ocrelizumab, and IFN-β, among others have been previously described to increase the biol. activities of NK cells especially their cytolytic potential as reported by upregulation of CD107a, and the release of perforin and granzymes. In this review, we propose that such drugs could potentially restore NK cell activity allowing individuals to be more protective against COVID-19 infection and its complications.

Infection and Drug Resistance published new progress about COVID-19. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Almoshari, Yosif; Iqbal, Haroon; Razzaq, Anam; Ali Ahmad, Khalil; Khan, Muhammad Khalid; Saeed Alqahtani, Saad; Hadi Sultan, Muhammad; Ali Khan, Barkat published the artcile< Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy>, Computed Properties of 112-63-0, the main research area is curcumin temozolomide anticancer agent colon cancer; Nanocubosomes; colon cancer; curcumin; temozolomide; therapy.

Current research aimed to develop nanocubosomes co-loaded with dual anticancer drugs curcumin and temozolomide for effective colon cancer therapy. Drugs co-loaded nanocubosomal dispersion was prepared by modified emulsification method using glyceryl monooleate (GMO), pluronic F127 and bovine serum albumin (BSA) as a lipid phase, surfactant, and stabilizer, resp. The resulting nanocubosomes were characterized by measuring hydrodynamic particle size, particle size distribution (PSD), drug loading capacity (DL), encapsulation efficiency (EE), colloidal stability and drug release profile. We also physiochem. characterized the nanocubosomes by transmission electron microscopy (TEM), Fourier transform IR (FTIR), and x-rays diffraction (XRD) for their morphol., polymer drug interaction and its nature, resp. Further, the in-vitro cell-uptake, mechanism of cell-uptake, in-vitro anti-tumor efficacy and apoptosis level were evaluated using HCT-116 colon cancer cells. The prepared nanocubosomes exhibited a small hydrodynamic particle size (PS of 150 ± 10 nm in diameter) with nearly cubic shape and appropriate polydispersity index (PDI), enhanced drug loading capacity LC of 6.82 ± 2.03% (Cur) and 9.65 ± 1.53% (TMZ), high entrapment efficiency EE of 67.43 ± 2.16% (Cur) and 75.55 ± 3.25% (TMZ), pH-triggered drug release profile and higher colloidal stability in various physiol. medium. Moreover, the nanocubosomes showed higher cellular uptake, in-vitro cytotoxicity and apoptosis compared to free drugs, curcumin and temozolomide, most likely because its small particle size. In addition, BSA-stabilized nanocubosomes were actively taken by aggressive colon cancer cells that over-expressed the albumin receptors and utilized BSA as nutrient source for their growth. In short, this study provides a new and simple strategy to improve the efficacy and simultaneously overawed the adaptive treatment tolerance in colon cancer.

Drug Delivery published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xi, Yumeng; Su, Bo; Qi, Xiaotian; Pedram, Shayun; Liu, Peng; Hartwig, John F. published the artcile< Application of Trimethylgermanyl-Substituted Bisphosphine Ligands with Enhanced Dispersion Interactions to Copper-Catalyzed Hydroboration of Disubstituted Alkenes>, Product Details of C19H34O2, the main research area is germanyl bisphosphine ligand preparation copper catalyzed hydroboration disubstituted alkene; free energy olefin hydrocupration germanyl bisphosphine ligand transition state.

The authors report the incorporation of large substituents based on heavy main group elements that are atypical in ligand architectures to enhance dispersion interactions and, thereby, enhance enantioselectivity. Specifically, the authors prepared the chiral biaryl bisphosphine ligand (TMG-SYNPHOS) containing 3,5-bis(trimethylgermanyl)phenyl groups on P and applied this ligand to the challenging problem of enantioselective hydrofunctionalization reactions of 1,1-disubstituted alkenes. Indeed, TMG-SYNPHOS forms a Cu complex that catalyzes hydroboration of 1,1-disubstituted alkenes with high levels of enantioselectivity, even when the two substituents are both primary alkyl groups. Cu catalysts bearing ligands possessing germanyl groups were much more active for hydroboration than one derived from DTBM-SEGPHOS, a ligand containing 2,5-di-tert-Bu groups and widely used for Cu-catalyzed hydrofunctionalization. This observation led to the identification of DTMGM-SEGPHOS, a bisphosphine ligand bearing 3,5-bis(trimethylgermanyl)-4-methoxyphenyl groups as the substituents on the P, as a new ligand that forms a highly active catalyst for hydroboration of unactivated 1,2-disubstituted alkenes, a class of substrates that has not readily undergone Cu-catalyzed hydroboration previously. Computational studies revealed that the enantioselectivity and catalytic efficiency of the germanyl-substituted ligands is higher than that of the silyl and tert-Bu substituted analogs because of attractive dispersion interactions between the bulky trimethyl-germanyl groups on the ancillary ligand and the alkene substrate and that Pauli repulsive interactions tended to de-crease enantioselectivity.

Journal of the American Chemical Society published new progress about Cupration (hydrocupration, mechanism). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Jianjian; Wang, Bo; Hao, Aiyou; Xing, Pengyao published the artcile< Arene-perfluoroarene interaction induced chiroptical inversion and precise ee% detection of chiral acids in a benzimidazole-involved ternary coassembly>, HPLC of Formula: 112-63-0, the main research area is pyrenecarboxylate octafluoronaphthalene hydrogen bond chiral recognition CD.

Flexible regulation of chirality and handedness of chiral functional materials and quant. sensing of natural chiral compounds remains a considerable challenge. Herein, an achiral fluorescent 1-pyrenecarboxylic acid-benzimidazole derivative (PBI) was synthesized and its chiroptical properties upon coassembly with chiral acids (TA and MA) and octafluoronaphthalene (OFN) through hydrogen bonds between benzimidazole and chiral acids as well as an arene-perfluoroarene (AP) interaction between a pyrene moiety and OFN were systemically studied. The binary assemblies of PBI/TA and PBI/MA displayed opposite chiroptical properties including CD and circularly polarized luminescence (CPL) signals. Interestingly, the handedness of CPL was further inverted in ternary assemblies due to the synergistic effect of the AP interaction and hydrogen bonds. Besides, the highly accurate chiral sensing of chiral acids via binary assemblies was successfully achieved with a high correlation coefficient This work provides a simple method for regulating the handedness of chiroptical active materials and quant. sensing of chiral acids through orthogonal multiple component coassemblies.

Nanoscale published new progress about Binary systems. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ye, Yang; Li, Xue; Feng, Guoquan; Ma, Ying; Ye, Fen; Shen, Haijun; Sun, Kang; Lu, Rongzhu; Miao, Shuhan published the artcile< 3,3'-Diindolylmethane induces ferroptosis by BAP1-IP3R axis in BGC-823 gastric cancer cells>, Formula: C15H22N2O2, the main research area is BAP1 IP3R anticancer agent gastric cancer.

To investigate the effect and potential mechanism of 3,3-diindolylmethane (DIM) on ferroptosis against gastric cancer, cells proliferation, lipid reactive oxygen species (ROS) and GSH level were measured in the BGC-823 gastric cancer cells after DIM treatment. Western blotting was used to detect the expression of SLC7A11, GPX4, IP3R and BAP1. Results showed that DIM could induce ferroptosis in the BGC-823 gastric cancer cells via upregulating lipid-ROS level and decreasing GSH generation. Besides, DIM also significantly reduced the protein level of SLC7A11 and GPX4, which was an important regulator of ferroptosis. In addition, DIM promoted the protein level of BAP1 and IP3R in a concentration-dependent manner in the BGC-823 gastric cancer cells. The knockdown of BAP1 could reduce IP3R level and DIM-induced ferroptosis of gastric cancer cells. Taken together, these results indicated that DIM could induce ferroptosis to exert anti-cancer effects via BAP1-IP3R axis, suggesting its effective therapeutic potential in gastric cancer.

Anti-Cancer Drugs published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fuladi, Shadi; Gholivand, Hamed; Ahmadiparidari, Alireza; Curtiss, Larry A.; Salehi-Khojin, Amin; Khalili-Araghi, Fatemeh published the artcile< Multicomponent Phase Separation in Ternary Mixture Ionic Liquid Electrolytes>, SDS of cas: 112-63-0, the main research area is phase separation mixture ionic liquid solvent lithium salt MD.

We investigate the phase behavior of ternary mixtures of ionic liquid, organic solvent, and lithium salt by mol. dynamics simulations. We find that at room temperature, the electrolyte separates into distinct phases with specific compositions; an ion-rich domain that contains a fraction of solvent mols. and a second domain of pure solvent. The phase separation is shown to be entropy-driven and is independent of lithium salt concentration Phase separation is only observed at microsecond time scales and greatly affects the transport properties of the electrolyte.

Journal of Physical Chemistry B published new progress about Diffusion (of Li+). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brera, Carlo; Debegnach, Francesca; Minardi, Valentina; Pannunzi, Elena; De Santis, Barbara; Miraglia, Marina published the artcile< Immunoaffinity column cleanup with liquid chromatography for determination of aflatoxin B1 in corn samples: interlaboratory study>, Quality Control of 112-63-0, the main research area is aflatoxin corn immunoaffinity cleanup LC interlaboratory calibration.

An interlaboratory study was conducted to evaluate the effectiveness of an immunoaffinity column cleanup liquid chromatog. (LC) method for the determination of aflatoxin B1 levels in corn samples, enforced by European Union legislation. A test portion was extracted with methanol-water (80 + 20); the extract was filtered, diluted with phosphate-buffered saline solution, filtered on a microfiber glass filter, and applied to an immunoaffinity column. The column was washed with deionized water to remove interfering compounds, and the purified aflatoxin B1 was eluted with methanol. Aflatoxin B1 was separated and determined by reversed-phase LC with fluorescence detection after either pre- or postcolumn derivatization. Precolumn derivatization was achieved by generating the trifluoroacetic acid derivative, used by 8 laboratories The postcolumn derivatization was achieved either with pyridinium hydrobromide perbromide, used by 16 laboratories, or with an electrochem. cell by the addition of bromide to the mobile phase, used by 5 laboratories The derivatization techniques used were not significantly different when compared by the Student’s t-test; the method was statistically evaluated for all the laboratories Five corn sample materials, both spiked and naturally contaminated, were sent to 29 laboratories (22 Italian and 7 European). Test portions were spiked with aflatoxin B1 at levels of 2.00 and 5.00 ng/g. The mean values for recovery were 82% for the low level and 84% for the high contamination level. Based on results for spiked samples (blind pairs at 2 levels) as well as naturally contaminated samples (blind pairs at 3 levels), the values for relative standard deviation for repeatability (RSDr) ranged from 9.9 to 28.7%. The values for relative standard deviation for reproducibility (RSDR) ranged from 18.6 to 36.8%. The method demonstrated acceptable within- and between-laboratory precision for this matrix, as evidenced by the HorRat values.

Journal of AOAC International published new progress about Calibration, interlaboratory. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prehal, Christian; Samojlov, Aleksej; Nachtnebel, Manfred; Lovicar, Ludek; Kriechbaum, Manfred; Amenitsch, Heinz; Freunberger, Stefan A. published the artcile< In situ small-angle X-ray scattering reveals solution phase discharge of Li-O2 batteries with weakly solvating electrolytes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is small angle X ray scattering lithium air battery electrolyte; Li-air battery; disproportionation; oxygen reduction; small-angle X-ray scattering.

Electrodepositing insulating lithium peroxide (Li2O2) is the key process during discharge of aprotic Li-O2 batteries and determines rate, capacity, and reversibility. Current understanding states that the partition between surface adsorbed and dissolved lithium superoxide governs whether Li2O2 grows as a conformal surface film or larger particles, leading to low or high capacities, resp. However, better understanding governing factors for Li2O2 packing d. and capacity requires structural sensitive in situ metrologies. Here, we establish in situ small- and wide-angle X-ray scattering (SAXS/WAXS) as a suitable method to record the Li2O2 phase evolution with at. to submicrometer resolution during cycling a custom-built in situ Li-O2 cell. Combined with sophisticated data anal., SAXS allows retrieving rich quant. structural information from complex multiphase systems. Surprisingly, we find that features are absent that would point at a Li2O2 surface film formed via two consecutive electron transfers, even in poorly solvating electrolytes thought to be prototypical for surface growth. All scattering data can be modeled by stacks of thin Li2O2 platelets potentially forming large toroidal particles. Li2O2 solution growth is further justified by rotating ring-disk electrode measurements and electron microscopy. Higher discharge overpotentials lead to smaller Li2O2 particles, but there is no transition to an electronically passivating, conformal Li2O2 coating. Hence, mass transport of reactive species rather than electronic transport through a Li2O2 film limits the discharge capacity. Provided that species mobilities and carbon surface areas are high, this allows for high discharge capacities even in weakly solvating electrolytes. The currently accepted Li-O2 reaction mechanism ought to be reconsidered.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Battery capacity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics