Tag: M.W=250-300

Hu, Mengyan; Liu, Peirong; Lu, Shuxian; Wang, Zhihao; Lyu, Zhaojie; Liu, Hongkai; Sun, Yuhong; Liu, Feng; Tian, Jing published the artcile< Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is naoxintong cardiomyopathy zebrafish transcriptome profile; Cardiomyopathy; HEG1; Naoxintong (NXT); Transcriptome; Zebrafish.

Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure. Naoxintong (NXT), as a traditional Chinese Medicine (TCM) preparation, is widely used in the treatment of cardiovascular diseases, including cardiomyopathy, while its underlying mechanism has not been fully elucidated. The purpose of this study is to investigate the therapeutic effect of NXT on cardiomyopathy and its mol. mechanism in zebrafish model. The zebrafish cardiomyopathy model was established using terfenadine (TFD) and treated with NXT. The therapeutic effect of NXT on cardiomyopathy was evaluated by measuring the heart rate, the distance between the sinus venosus and bulbus arteriosus (SV-BA), the pericardial area, and the blood flow velocity of zebrafish. Then, the zebrafish hearts were isolated and collected; transcriptome anal. of NXT on cardiomyopathy was investigated. Moreover, the heg1 mutant of zebrafish congenital cardiomyopathy model was used to further validate the therapeutic effect of NXT on cardiomyopathy. Addnl., UPLC anal. combined with the zebrafish model investigation was performed to identify the bioactive components of NXT. In the TFD-induced zebrafish cardiomyopathy model, NXT treatment could significantly restore the cardiovascular malformations caused by cardiac dysfunction. Transcriptome and bioinformatics analyses of the TFD and TFD + NXT treated zebrafish developing hearts revealed that the differentially expressed genes were highly enriched in biol. processes such as cardiac muscle contraction and heart development. As a cardiac development protein associated with cardiomyopathy, HEG1 had been identified as one of the important targets of NXT in the treatment of cardiomyopathy. The cardiovascular abnormalities of zebrafish heg1 mutant could be recovered significantly from NXT treatment, including the expanded atrial cavity and blood stagnation. qRT-PCR anal. further showed that NXT could restore cardiomyopathy phenotype in zebrafish through HEG1-CCM signaling. Among the seven components identified in NXT, paeoniflorin (PF) and salvianolic acid B (Sal B) were considered to be the main bioactive ones with myocardial protection. NXT presented myocardial protective effect and could restore myocardial injury and cardiac dysfunction in zebrafish; the action mechanism was involved in HEG1-CCM signaling.

Chinese Medicine (London, United Kingdom) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (NEXN). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karolak, Aleksandra; Levatic, Jurica; Supek, Fran published the artcile< A framework for mutational signature analysis based on DNA shape parameters>, Synthetic Route of 112-63-0, the main research area is DNA sequence mutational signature oligonucleotides mutagenesis.

The mutation risk of a DNA locus depends on its oligonucleotide context. In turn, mutability of oligonucleotides varies across individuals, due to exposure to mutagenic agents or due to variable efficiency and/or accuracy of DNA repair. Such variability is captured by mutational signatures, a math. construct obtained by a deconvolution of mutation frequency spectra across individuals. There is a need to enhance methods for inferring mutational signatures to make better use of sparse mutation data (e.g., resulting from exome sequencing of cancers), to facilitate insight into underlying biol. mechanisms, and to provide more accurate mutation rate baselines for inferring pos. and neg. selection. We propose a conceptualization of mutational signatures that represents oligonucleotides via descriptors of DNA conformation: base pair, base pair step, and minor groove width parameters. We demonstrate how such DNA structural parameters can accurately predict mutation occurrence due to DNA repair failures or due to exposure to diverse mutagens such as radiation, chem. exposure, and the APOBEC cytosine deaminase enzymes. Furthermore, the mutation frequency of DNA oligomers classed by structural features can accurately capture systematic variability in mutagenesis of >1,000 tumors originating from diverse human tissues. A nonneg. matrix factorization was applied to mutation spectra stratified by DNA structural features, thereby extracting novel mutational signatures. Moreover, many of the known trinucleotide signatures were associated with an addnl. spectrum in the DNA structural descriptor space, which may aid interpretation and provide mechanistic insight. Overall, we suggest that the power of DNA sequence motif-based mutational signature anal. can be enhanced by drawing on DNA shape features.

PLoS One published new progress about B-cell lymphoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sekeroglu, Zulal Atli; Sekeroglu, Vedat; Kucuk, Nihan published the artcile< Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells>, Product Details of C19H34O2, the main research area is breast carcinoma proliferation apoptosis migration reverse transcriptase inhibitor; apoptosis; breast cancer; migration; proliferation; reverse transcriptase inhibitors.

High telomerase activity in human breast cancer is associated with aggressive tumors resulting in decreased survival. In the present study, we examined the effects of 4 reverse transcriptase inhibitors (RTIs), used for the treatment of HIV; Abacavir (AC), Lamivudine (LV), Stavudine (SV), and Tenofovir (TF) on proliferation, apoptosis, and migration in the normal human mammary epithelial cell line, hTERT-HME1, and the human breast cancer cell line, MCF-7. Cells were treated with AC, LV, SV, or TF alone or in combination with paclitaxel (PAC), a known drug used to treat breast cancer. Conduct of the thiazolyl blue tetrazolium bromide assay demonstrated that AC, SV, and TF had stronger cytotoxic effects on MCF-7 cells than in hTERT-HME1 cells. The combined treatment of RTIs and PAC caused high rates of cell death in MCF-7 and low rates of cell death in HTERT-HME1 by apoptosis. The percentages of apoptotic cells in the treatment of AC and SV in combination with PAC for 48 and 72 h were higher than PAC. Significantly increased apoptosis and decreased migration levels were found in MCF-7 cells treated with AC and co-treatment of AC+PAC or SV+PAC than HME1 cells. These treatments can also prevent migration capacity more than PAC. Therefore, a combination strategy based on telomerase inhibitors such as AC or SV and anticancer drugs may be more effective in the treatment of certain breast cancers.

International Journal of Toxicology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giordano, Claudio; Coppi, Laura published the artcile< Br3- vs Br2: opposite diastereoselectivity in the bromination of enantiomerically pure ketals>, HPLC of Formula: 112-63-0, the main research area is stereochem bromination ketal bromine onium tribromide.

For the first time it has been shown that different halogenating species (Br3- vs. Br2, SO2Cl2 and ICl) provide opposite high diastereofacial selectivity in the functionalization of chiral auxiliary bound alkenes. The stereochem. outcome of the bromination of ketal I (n = 1; R = H), precursor of a single geometry constrained enol ether I (n = 0), with Br3- in different solvents is reported and compared with that with Br2. Thus, up to 99% of I (R = Br) was obtained in the bromination of I (R = H) with tetraalkylammonium tribromides, while the diastereomeric product was formed in up to 99% yield, when I (R = H) was brominated with Br2 in THF.

Journal of Organic Chemistry published new progress about Bromination, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tong, Guanghu; Zhu, Bo; Lee, Richmond; Yang, Wenguo; Tan, Davin; Yang, Caiyun; Han, Zhiqiang; Yan, Lin; Huang, Kuo-Wei; Jiang, Zhiyong published the artcile< Highly Enantio- and Diastereoselective Allylic Alkylation of Morita-Baylis-Hillman Carbonates with Allyl Ketones>, Reference of 112-63-0, the main research area is enantioselective diastereoselective allylic alkylation MBH carbonate allyl ketone; Morita Baylis Hillman carbonate enantioselective diastereoselective allylic alkylation; regioselective allylic alkylation MBH carbonate allyl ketone.

The asym. allylic alkylation of Morita-Baylis-Hillman (MBH) carbonates with allyl ketones has been developed. The α-regioselective alkylation adducts, containing a hexa-1,5-diene framework with important synthetic value, were achieved in up to 83% yield, >99% ee, and 50:1 dr by using a com. available Cinchona alkaloid as the catalyst (e.g., I + II → III). From the allylic alkylation adduct, a cyclohexene bearing two adjacent chiral centers was readily prepared (III → IV).

Journal of Organic Chemistry published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Algahtani, Mohammad; Natarajan, Umamaheswari; Alhazzani, Khalid; Alaseem, Ali; Rathinavelu, Appu published the artcile< Evaluation of anti-angiogenic agent F16 for targeting glioblastoma xenograft tumors>, Synthetic Route of 112-63-0, the main research area is glioblastoma multiforme VEGFR F16 antiangiogenic antitumor; Anti-angiogenic; Anti-tumor; F16; Glioblastoma; TMZ; VEGFR-2; Xenograft.

Glioblastoma Multiforme (GBM) is one of the most aggressive and lethal types of all cancers, with an average 5-yr survival rate of 5%. Since GBM tumors are highly vascularized tumors, and their growth is angiogenesis-dependent, antagonizing tumor angiogenesis by using angiogenesis inhibitors were considered as one of the promising approaches. In this context, intensive preclin. evaluation of a novel small mol. named F16 has exhibited potent anti-angiogenic and anti-tumor activities by selectively antagonizing Vascular Endothelial Growth Factor Receptor (VEGFR). Also, recent pharmacokinetic evaluation of F16 with tissue distribution anal. has shown that this mol. is transported across the blood-brain barrier (BBB) and accumulates in the brain regions with no signs of neurotoxicity. Therefore, further studies were conducted to determine the efficacy of F16 in delaying glioblastoma progression via inhibiting tumor angiogenesis. Our in vitro studies have clearly demonstrated the ability of F16 to inhibit migration and invasion of U87MG cells and also confirmed a potent cytotoxic effect against these cells in comparison to Temozolomide (TMZ). Our in vivo studies with the s.c. implanted (s.c.) xenograft tumor model and in vitro studies have clearly demonstrated the ability of F16 to delay tumor growth and inhibit migration and invasion.

Cancer Genetics published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheng, Meixiong; Wang, Qi; Chen, Longyi; Zhao, Dongdong; Tang, Jian; Xu, Jianguo; He, Zongze published the artcile< LncRNA UCA1/miR-182-5p/MGMT axis modulates glioma cell sensitivity to temozolomide through MGMT-related DNA damage pathways>, HPLC of Formula: 112-63-0, the main research area is temozolomide anticancer agent UCA1 MGMT miR1825p glioma viability glioblastoma; Glioblastoma (GBM); LncRNA UCA1; MGMT; Temozolomide (TMZ); miR-182-5p.

Glioblastoma (GBM) is the most malignant subtype of gliomas. GBM resistance to temozolomide (TMZ) remains a huge challenge. O6-methylguanine-DNA methyltransferase (MGMT) is mainly responsible for repairing DNA alkylation damage caused by alkylating drugs such as TMZ; therefore, it has been regarded as the major cause of the resistance to TMZ. Hematoxylin and eosin (H&E) and immunohistochem. (IHC) staining were performed in tissue sections. LncRNA urothelial cancer-associated 1 (UCA1) knockdown was conducted via the transfection of the plasmid containing small interfering RNA (siRNA) targeting lncRNA UCA1. Cell viability and apoptosis were examined using MTT assay and flow cytometry. Nude mouse tumorigenicity assay was performed to detect tumor formation in vivo. MGMT expression and lncRNA UCA1 expression were increased in high-grade glioma tissues and cells. UCA1 knockdown in glioma cells enhanced TMZ efficacies in affecting glioma cell viability, cell apoptosis, MGMT protein level, and DNA damage markers in vitro, as well as tumorigenesis in vivo. Moreover, miR-182-5p targeted UCA1 and MGMT; miR-182-5p inhibited MGMT expression. Similar to UCA1 knockdown, miR-182-5p overexpression also promoted TMZ effects on glioma cell phenotype, MGMT expression level, and the levels of DNA damage markers. Under TMZ treatment, the efficacies of UCA1 knockdown in MGMT expression level and glioma cell sensitivity to TMZ were notably reversed after miR-182-5p overexpression. Taken together, we demonstrate the lncRNA UCA1/miR-182-5p/MGMT axis modulates glioma cell sensitivity to TMZ via MGMT-related DNA damage pathways.

Human Pathology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Saadi, Abdulaziz A. published the artcile< Understanding the Influence of Electron-Donating and Electron-Withdrawing Substituents on the Anticorrosive Properties of Imidazole: A Quantum-Chemical Approach>, Electric Literature of 112-63-0, the main research area is imidazole substituent effect protonation mol structure HOMO LUMO.

The nature and position of electron-donating and electron-withdrawing substituents are believed to play a major role on the corrosion inhibition properties in small organic mols. In this study, the substituent effect on the imidazoles anticorrosive properties has been explored theor. using the d. functional theory performed at the B3LYP/6-311++G(d,p) level. A wide spectrum of substituents including NH2, COOH, I, Br, Cl, F, CN, F, OH, OCH3, NO2, C6H5 and SH groups has been explored in the aqueous medium, and the different possible substitution positions have been investigated. Frontier MOs and quantum-chem. reactivity descriptors were calculated for the neutral and protonated forms of imidazole derivative While the energy gaps, electronegativity and global hardness values showed a very good agreement with the corrosion inhibition performance reported from previous exptl. work for imidazoles, the electrophilicity and mol. volume parameters were found less consistent. This study concluded that the amino and nitro groups, in particular those at C2 and C4 positions, exhibit prominent corrosion inhibition performance. The electron-releasing Ph and methoxy substituents could also play a potential role in enhancing the anticorrosive properties of imidazole.

Arabian Journal for Science and Engineering published new progress about Atomic charge. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alizadeh, Nima; Barde, Mehul; Minkler, Michael; Celestine, Asha-Dee; Agrawal, Vinamra; Beckingham, Bryan; Auad, Maria L. published the artcile< High-fracture-toughness acrylic-polyurethane-based graft-interpenetrating polymer networks for transparent applications>, Formula: C19H34O2, the main research area is fracture toughness acrylic polyurethane graft interpenetrating polymer network.

Transparent materials with robust mech. properties are essential for numerous applications and require careful manipulation of polymer chem. Here, polyurethane (PU) and acrylic-based copolymers out of styrene were utilized to synthesize transparent PU-acrylic graft-interpenetrating polymer networks (graft-IPNs) for the first time. In these materials, PU imparts greater flexibility, while the acrylic copolymer increases rigidity and glass transition temperature of the graft-IPNs. Kinetics of the graft-IPN synthesis was monitored using Fourier transform IR spectroscopy and 1H NMR spectroscopy through the conversion of the isocyanate group. System compatibility, degree of phase separation and material transparency were evaluated using transmission electron microscopy and UV-visible spectroscopy. Overall, higher compatibility is observed at a higher percentage of styrene in the acrylate copolymer. The thermomech. properties of the IPNs were quantified using dynamic mech. anal. to assess the effect of the acrylic copolymer content on fracture toughness of the resulting graft-IPNs. The high fracture toughness of the graft-IPNs, coupled with excellent transparency, demonstrates the potential of these systems for high-performance applications. 2020 Society of Industrial Chem.

Polymer International published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Yuxiao; Li, Xiaojun; Wang, Xiaoting; Zhang, Lu; Guan, Jiaqi published the artcile< Network pharmacological prediction and molecular docking analysis of the combination of Atractylodes macrocephala Koidz. and Paeonia lactiflora Pall. in the treatment of functional constipation and its verification>, HPLC of Formula: 112-63-0, the main research area is Atractylodes Paeonia mol docking analysis functional constipation; coupling of AMK and PLP; functional constipation; mechanism; network pharmacology.

We aimed to reveal the mechanism of functional constipation in the treatment of Atractylodes macrocephala Koidz. (AMK) and Paeonia lactiflora Pall. The main active ingredients of AMK and PLP were screened by the Traditional Chinese Medicine Systems Pharmacol. (TCMSP) platform. A database of functional constipation targets was established by GeneCard and OMIM. An “”ingredient-target”” network map was constructed with Cytoscape software (version 3.7.1), and mol. docking anal. was performed on the components and genes with the highest scores. The rats in the normal group were given saline, and those in the other groups were given 10 mg/kg diphenoxylate once a day for 14 days. The serum and intestinal tissue levels of adenosine monophosphate (cAMP), protein kinase A (PKA), and adenylyl cyclase (AC) of the rats and aquaporin (AQP)1, AQP3, and AQP8 were measured. AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation. After treatment with AMK, PLP, or mosapride, the serum and intestinal tissue levels of AC, cAMP, and PKA were significantly downregulated. Groups receiving AMK and PLP or mosapride exhibited a reduction in the level of AQP1, AQP3, and AQP8 to varying degrees. Mol. docking anal. revealed that AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation. Studies have confirmed that AMK and PLP can also affect AC, cAMP, and PKA. AC, cAMP, and PKA in model rats were significantly downregulated. AQP expression is closely related to AC, cAMP, and PKA. AMK and PLP can reduce the expression of AQP1, AQP3, and AQP9 in the colon of constipated rats.

Animal Models and Experimental Medicine published new progress about Aquaporin 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics