Tag: M.W=250-300

Cai, Yuanhong; Tan, Donghang; Zhang, Qiqi; Lv, Wenxin; Li, Qingjiang; Wang, Honggen published the artcile< Synthesis of difluoromethylated benzylborons via rhodium(I)-catalyzed fluorine-retainable hydroboration of gem-difluoroalkenes>, Related Products of 112-63-0, the main research area is rhodium catalyzed fluorine retainable hydroboration gem fluoroalkene; fluoromethylated benzylborane preparation.

The synthesis of borylated organofluorines is of great interest due to their potential values as synthons in modular construction of F-containing mols. Reported herein is a Rh-catalyzed hydroboration of aryl gem-difluoroalkenes leading to α-difluoromethylated benzylborons. The use of cationic Rh catalyst and a biphosphine ligand with large bite angle was crucial for reactivity by offering good regioselectivity and diminishing the undesired β-F elimination. Preliminary derivatizations of the products were conducted to showcase the utility of this protocol.

Chinese Chemical Letters published new progress about Boranes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (difluoromethylated benzylborons). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghaffari, Behnaz; Preshlock, Sean M.; Plattner, Donald L.; Staples, Richard J.; Maligres, Peter E.; Krska, Shane W.; Maleczka, Robert E.; Smith, Milton R. published the artcile< Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis>, Related Products of 112-63-0, the main research area is ortho silylphosphinylbenzene tethered iridium cyclooctadiene preparation catalyst orthoborylation; crystal structure ortho silylphosphinylbenzene tethered iridium cyclooctadiene; mol structure ortho silylphosphinylbenzene tethered iridium cyclooctadiene.

Ir catalysts supported by ortho-(diisopropylsilyl)(di-p-tolylphosphino)benzene bidentate ligand that contains P- or N-donors, effects ortho-borylations for a range of substituted aromatics E.g., reaction of C6H5CO2Me with bis(pinacolato)diboron (B2pin2) in the presence of 1.25 mol% [Ir(OMe)(cod)]2/ 2.5 mol% (p-tol)2PC6H4-2-(SiHiPr2) in THF at 80° to give 72% yield of Me 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (benzamides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamaguchi, Akihiro; Okazaki, Mitsuo published the artcile< Modified wittig reaction. II. Preparation of α-bromo-4-nitrostilbenes and diphenylacetylenes>, Application In Synthesis of 112-63-0, the main research area is stilbene halo nitro; halonitrostilbene preparation Wittig; nitrohalostilbene preparation Wittig; Wittig aldehyde halobenzylphosphonate; aromatic aldehyde Wittig reaction; phosphonate haloenzyl Wittig reaction; arylnitrophenylacetylene preparation Wittig.

α-Bromo-4-nitrostilbenes and diphenylacetylenes were prepared by a modified Wittig reaction. Diethyl α-bromo-p-nitrobenzylphosphonate (I) was obtained quant. by bromination of diethyl p-nitrobenzylphosphonate. Treatment of I with aromatic aldehydes in the presence of an equivalent amount of Na alkoxide in alc. at room temperature gave the corresponding α-bromo-4-nitrostilbenes in good yield. The use of two equivalent base gave diphenylacetylenes. Similarly, the reaction of α-iodo-p-nitrobenzylphosphonate with aromatic aldehydes was investigated.

Nippon Kagaku Kaishi published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramchandani, Shanaya; Mohan, Chakrabhavi Dhananjaya; Mistry, Jenaifer Rustom; Su, Qi; Naz, Irum; Rangappa, Kanchugarakoppal S.; Ahn, Kwang Seok published the artcile< The multifaceted antineoplastic role of pyrimethamine against human malignancies>, SDS of cas: 112-63-0, the main research area is review cancer chronic lymphocytic leukemia pyrimethamine anticancer drug; MAPK; STAT3; apoptosis; cancer; drug repurposing; pyrimethamine.

A review. Cancer accounted for nearly 10 million deaths in 2020 and is the second leading cause of death worldwide. The chemotherapeutic agents that are in clin. practice possess a broad range of severe adverse effects towards vital organs which emphasizes the importance of the discovery of new therapeutic agents or repurposing of existing drugs for the treatment of human cancers. Pyrimethamine is an antiparasitic drug used for the treatment of malaria and toxoplasmosis with a well-documented excellent safety profile. In the last 5 years, numerous efforts have been made to explore the anticancer potential of pyrimethamine in in vitro and in vivo preclin. models and to repurpose it as an anticancer agent. The studies have demonstrated that pyrimethamine inhibits oncogenic proteins such as STAT3, NF-κB, DX2, MAPK, DHFR, thymidine phosphorylase, telomerase, and many more in a different types of cancer models. Moreover, pyrimethamine has been reported to work in synergy with other anticancer agents, such as temozolomide, to induce apoptosis of tumor cells. Recently, the results of phase-1/2 clin. trials demonstrated that pyrimethamine administration reduces the expression of STAT3 signature genes in tumor tissues of chronic lymphocytic leukemia patients with a good therapeutic response. In the present article, we have reviewed most of the published articles related to the antitumor effects of pyrimethamine in malignancies of breast, liver, lung, skin, ovary, prostate, pituitary, and leukemia in in vitro and in vivo settings. We have also discussed the pharmacokinetic profile and results of clin. trials obtained after pyrimethamine treatment. From these studies, we believe that pyrimethamine has the potential to be repurposed as an anticancer drug.

IUBMB Life published new progress about Animal gene, DHFR Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vidomanova, Eva; Majercikova, Zuzana; Dibdiakova, Katarina; Pilchova, Ivana; Racay, Peter; Hatok, Jozef published the artcile< The effect of temozolomide on apoptosis-related gene expression changes in glioblastoma cells.>, Synthetic Route of 112-63-0, the main research area is apoptosis; glioblastoma; temozolomide gene expression..

BACKGROUND: Glioblastoma (GB) is the most common and biologically the most aggressive primary brain tumor of the central nervous system (CNS) in adults. Standard treatment for newly diagnosed GB consists of surgical resection, radiotherapy, and chemotherapy with temozolomide (TMZ). Despite numbers of studies, a resistance to chemotherapy is the major obstacle to successful GB treatment. OBJECTIVES: The aim of our study was to detect the sensitivity of glioblastoma T98G cells to TMZ treatment and subsequently to determine the expression changes of apoptosis-associated genes in glioblastoma cells. MATERIAL AND METHODS: The human glioblastoma cell line (T98G) was treated with specified concentrations of TMZ during different time periods. Their viability was measured by colorimetric MTT assay and the activation of the apoptotic pathway was determined by measuring the caspase 3/7 activity. Commercial pre-designed microfluidic array was used to quantify expression of human apoptosis-associated genes. RESULTS: The untreated control of T98G cell line against human brain total RNA standards reported significant changes in several apoptotic genes expression levels. We identified also a deregulation in geneexpression levels between the TMZ treated and untreated T98G cells associated with apoptotic pathways. After 48 hours of exposure of T98G cells to TMZ, we observed a significant deregulation ofseven genes: BBC3, BCL2L1, RIPK1, CASP3, BIRC2, CARD6 and DAPK1. These results can contribute to the importance of apoptosis in glioblastoma cells metabolism and effect of TMZ treatment. CONCLUSIONS: Identification of apoptotic gene panel in T98G cell line could help to improve understanding of brain tumor cells metabolism. Recognizing of the pro-apoptotic and anti-apoptotic genes expression changes could contribute to clarify the sensitivity to TMZ therapy and molecular base in healthy and tumor cells (Tab. 1, Fig. 2, Reference 48).

Bratislavske lekarske listy published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copcu, Burcu; Sayin, Koray; Karakas, Duran published the artcile< Investigations substituent effect on structural, spectral and optical properties of phenylboronic acids>, Related Products of 112-63-0, the main research area is phenylboronic acid substituent effect spectral optical property.

Ortho- and para-substituent arylboronic acid are investigated. Geometric structure and structural properties of these compounds are done. IR and NMR spectrum are calculated for the spectral characterizations. Contour diagram of frontier MOs which are HOMO and LUMO is calculated and mol. electrostatic potential (MEP) map of them are obtained to evaluate the electronic properties and to determine the active site on the mols. Non-linear optical (NLO) properties are investigated. UV-VIS spectrum of studied compounds is calculated and the wavelength of main band is examined Then, some quantum chem. parameters which are total static dipole moment, the average linear polarizability, the anisotropy of the polarizability and first hyperpolarizability are calculated and it was found that B3 is the best NLO material for applications.

Journal of Molecular Structure published new progress about Anisotropy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Le; Ma, Yong; Gu, Yuting; Yuan, Xuzhou; He, Ying; Li, Xinjian; Zhao, Liang; Peng, Yang; Deng, Zhao published the artcile< Ru-Embedded Highly Porous Carbon Nanocubes Derived from Metal-Organic Frameworks for Catalyzing Reversible Li2O2 Formation>, Category: esters-buliding-blocks, the main research area is ruthenium porous carbon nanocube catalyst lithium oxygen battery; Li−O2 batteries; metal−organic frameworks; oxygen catalyst; porous carbon; ruthenium nanoparticles.

Rechargeable lithium-oxygen batteries (LOBs) have attracted increasing attention due to their high energy d. but highly rely on the development of efficient oxygen catalysts for reversible Li2O2 deposition/decomposition Herein, highly porous carbon nanocubes with a sp. surface area up to 1600 m2 g-1 are synthesized and utilized to tightly anchor Ru nanoparticles for using as the oxygen-cathode catalyst in LOBs, achieving a low charge/discharge potential gap of only 0.75 V, a high total discharge capacity of 17,632 mA h g-1, and a superb cycling performance of 550 cycles at 1000 mA g-1. Comprehensive ex situ and operando characterizations unravel that the outstanding LOB performance is ascribed to the highly porous catalyst structure embedding rich active sites that synergistically function in reducing overpotentials, suppressing parasitic reactions, accommodating reaction products, and promoting mass and charge transportation.

ACS Applied Materials & Interfaces published new progress about Adsorption (isotherm). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xing; Xu, Wenqing; Yuan, Wenhua; Liu, Kangkang; Zhou, Jian; Shan, Guorong; Bao, Yongzhong; Pan, Pengju published the artcile< Separate crystallization and melting of polymer blocks and hydrogen bonding units in double-crystalline supramolecular polymers>, Application In Synthesis of 112-63-0, the main research area is crystallization melting polymer block supramol.

End functionalization of oligomers by the multiple H-bonding units is a feasible way to prepare the supramol. polymers (SMPs). The crystallization of oligomer blocks and H-bonding units can lead to form the complicated double crystalline structure in SMPs; such double crystalline behavior and its correlation with the phys. properties are of fundamental importance for the processing and applications of SMPs. Herein, we choose the oligomeric polycaprolactone (PCL) end-functionalized by the self-complementary quadruple H-bonding 2-ureido-4-pyrimidinone (UPy) units (named as U-PCL) as the model double crystalline SMPs and investigate their crystalline structure, crystallization kinetics, thermally induced structural evolution, and structure-property relationships. The U-PCLs display the similar composition-dependent crystallization and melting behavior as the double crystalline block copolymers. The U-PCLs with short, medium-length, and long PCL blocks crystallize in the UPy crystals, UPy/PCL mixed crystals, and PCL crystals, resp. Melting temperature of UPy crystals decreases and their melting peak disappears as the UPy content of U-PCLs decreases. UPy units and PCL blocks are microphase-separated in the U-PCLs, despite the absence of long-range ordered phase structure. Dual shape memory effects capable of switching at the body temperature were realized based on the double crystalline nature of U-PCLs by using UPy crystals as the phys. crosslinkers and PCL blocks as the switching segments.

Polymer published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hafner, Andreas; Filipponi, Paolo; Piccioni, Lorenzo; Meisenbach, Mark; Schenkel, Berthold; Venturoni, Francesco; Sedelmeier, Joerg published the artcile< A Simple Scale-up Strategy for Organolithium Chemistry in Flow Mode: From Feasibility to Kilogram Quantities>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is scale strategy organolithium chem feasibility kilogram.

A platform for conducting organolithium chem. in continuous flow mode, covering the scales from medicinal chem. to later phase process development, is described. The use of this flow setup, which mimics the concept of flash chem. on scale, was demonstrated by the exemplary, large-scale preparation of (4-fluoro-2-(trifluoromethyl)phenyl)boronic acid following a reaction sequence of halogen/lithium exchange, borylation, and semibatch workup. Also, the key factors and corresponding practical assessments required for the streamlined and seamless scale-up from laboratory environment to higher productivity are highlighted.

Organic Process Research & Development published new progress about Apparatus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pongmuksuwan, Pornlada; Harnnarongchai, Wanlop published the artcile< Synthesis and characterization of soft polyurethane for pressure ulcer prevention>, Quality Control of 112-63-0, the main research area is pressure ulcer prevention polyurethane preparation.

A series of super-soft polyurethanes was prepared by synthesizing lightly crosslinked polyurethane with low isocyanate:hydroxyl ([NCO]:[OH]) molar ratios. The starting materials were polymeric isocyanate (pMDI), polypropylene glycol (PPG), and 1,1,1-tris(hydroxymethyl)propane (TMP). The effects of the [NCO]:[OH] molar ratio and concentrations of the crosslinking agent TMP on the crosslink d. and the thermal, dynamic-mech., and mech. properties of the polyurethanes were determined In addition, TMP generates chem. and phys. crosslinks within polyurethane; therefore, data calculated using the Flory-Rehner equation and the rubber elasticity were compared. The success of the reaction between pMDI and PPG was confirmed using Fourier-transform IR spectroscopy. The synthesized polyurethanes exhibited a mixing phase between soft and hard segments. The addition of TMP increased the crosslinking d., resulting in increased glass transition temperature, tensile properties, and hardness; however, the pressure distribution was suppressed. The synthesized polyurethane showed effective properties for pressure ulcer relief applications.

Polymer Testing published new progress about Crosslinking agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics