Tag: M.W=250-300

Li, Wenbiao; Jiang, Shangxu; Xie, Yuan; Yan, Xiaoqing; Zhao, Fugang; Pang, Xinchang; Zhang, Kai; Jia, Zhongfan published the artcile< Anthraquinone-Catalyzed TEMPO Reduction to Realize Two-Electron Energy Storage of Poly(TEMPO-methacrylate)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is anthraquinone catalyzed reduction electron energy storage poly methacrylate.

2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) functional polymers are a type of organic electroactive material featuring a two-electron redox process. However, the electrochem. reduction of TEMPO (TEMPO•/-) is rarely adopted for energy storage due to its slow reaction kinetics. Here, we report using anthraquinone (AQ) as an organic redox mediator to promote TEMPO reduction kinetics. The catalytic effect of AQ is verified by electrochem. in situ FTIR spectroscopy in a model three-electrode system and further evidenced by cyclic voltammetry and chronoamperometry, providing a turnover frequency of 69 h-1. To exemplify the AQ catalytic effect in energy storage performance, we incorporate AQ groups into a typical TEMPO polymer (i.e., poly(TEMPO-methacrylate), PTMA). The AQ-catalyzed TEMPO reduction and AQ/carbon π-π interaction synergistically reduce the heterogeneous charge transfer resistance and accelerate the kinetics of the TEMPO•/- process in the PTMA electrode. The half-cell tests of the AQ functional PTMA show two prominent discharge plateaus with an initial capacity of 174 mAh g-1 and a 0.18% capacity loss per cycle. Moreover, the discharge capacity based on the TEMPO•/- couple is about 85 mAh g-1, 30% higher than that of the pristine PTMA. This new strategy could be widely applied to various organic redox systems to enhance their electrochem. kinetics and particularly improve the energy storage performance of organic polymer redox materials.

ACS Energy Letters published new progress about Carbon black Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de Souza, I.; Monteiro, L. K. S.; Guedes, C. B.; Silva, M. M.; Andrade-Tomaz, M.; Contieri, B.; Latancia, M. T.; Mendes, D.; Porchia, B. F. M. M.; Lazarini, M.; Gomes, L. R.; Rocha, C. R. R. published the artcile< High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation>, Computed Properties of 112-63-0, the main research area is .

Abstract: Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance. NRF2 is an important transcript factor involved in chemotherapy resistance due to its protective role in the transcription of genes involved in cellular detoxification and prevention of cell death processes, such as ferroptosis. However, the relation between NRF2 and iron-dependent cell death in glioma is still poorly understood. Therefore, in this study, we analyzed the role of NRF2 in ferroptosis modulation in glioblastoma cells. Two human glioblastoma cell lines (U251MG and T98G) were examined after treatment with TMZ, ferroptosis inducers (Erastin, RSL3), and ferroptosis inhibitor (Ferrostatin-1). Our results demonstrated that T98G was more resistant to chemotherapy compared to U251MG and showed elevated levels of NRF2 expression. Interestingly, T98G revealed higher sensitivity to ferroptosis, and significant GSH depletion upon system xc- blockage. NRF2 silencing in T98G cells (T98G-shNRF2) significantly reduced the viability upon TMZ treatment. On the other hand, T98G-shNRF2 was resistant to ferroptosis and reverted intracellular GSH levels, indicating that NRF2 plays a key role in ferroptosis induction through GSH modulation. Moreover, silencing of ABCC1, a well-known NRF2 target that diminishes GSH levels, has demonstrated a similar collateral sensitivity. T98G-siABCC1 cells were more sensitive to TMZ and resistant to Erastin. Furthermore, we found that NRF2 pos. correlates with ABCC1 expression in tumor tissues of glioma patients, which can be associated with tumor aggressiveness, drug resistance, and poor overall survival. Altogether, our data indicate that high levels of NRF2 result in collateral sensitivity on glioblastoma via the expression of its pro-ferroptotic target ABCC1, which contributes to GSH depletion when the system xc- is blocked by Erastin. Thus, ferroptosis induction could be an important therapeutic strategy to reverse drug resistance in gliomas with high NRF2 and ABCC1 expression.

Cell Death & Disease published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prabhu, C.; Rajasekar, V.; Prakash, T. published the artcile< Characterisation and assessment of physicochemical properties of grapeseed methyl ester using predictive correlations and ASTM standards for CI engine application>, Electric Literature of 112-63-0, the main research area is grape seed methyl ester physicochem property CI engine application.

In the present work, a detailed investigation of the physio-chem. characteristics of grapeseed Me ester (GSME) obtained from winery biomass waste has been carried out to evaluate its suitability as an energy alternate, for CI engines. GSME was subjected to Gas chromatog. and mass spectrometry anal. from which fatty acids compositions were determined followed by other interpretations such as carbon number, number of double bonds, etc. Two different predictive correlations were identified from the literature for predicting the properties that are considered important, for using GSME as a fuel. The predicted properties of GSME are compared with the exptl. results obtained through standard ASTM procedures, for diesel, neat grapeseed oil (GSO) and GSME, resp. Further, the influence of the structural and compositional characteristics of GSME on the physicochem. properties like d., kinematic viscosity, lower calorific value, etc. has been evaluated and found to be closer to diesel.

Nature, Environment and Pollution Technology published new progress about Cetane number. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Danyi; Yuan, Li; Liang, Guozheng; Gu, Aijuan published the artcile< Self-Healable and Remoldable Transparent Polyurethane Film with High Dielectric Constant from the Synergistic Effect between Lithium Salt and Ionic Liquid>, Application of C19H34O2, the main research area is self healable remoldable transparent polyurethane dielec lithium ionic liquid.

The rapid development of new-generation flexible touch display panels puts forward more requirements on the overlays, not only including colorlessness and transparency but also having self-healing and remolding abilities as well as high dielec. constant Herein, new self-healable and remoldable polyurethane films (PULEx) with high dielec. constant were developed through building of reversible crosslinked networks with special synergistic effect between lithium salt and ionic liquid The integrated performance of PULEx was systematically investigated. Results show that as the loadings of lithium salt and ionic salt increase, films show increased dielec. constant and self-healing ability. The film with suitable composition (PULE7.5) has the best comprehensive performance; its dielec. constants (104-106 Hz) range from 9.6 to 6.1, which are comparable to those of glass (commonly used overlay for rigid capacitive touchscreen panels). The construction of reversible covalent crosslinking endows PULE7.5 with good mech. strength, high self-healing efficiency after complete fracture (92.7%), and high recovery of mech. properties after remolding (91.8%). In addition, the colorless PULE7.5 has high transparency (90.7% transmittance at 550 nm) and can freely convert among three shapes of bending, scrolling, and S-shape, showing great prospects in fabricating flexible display devices. The mechanism behind these outstanding integrated performances of PULE films is investigated through correlation with structures.

Industrial & Engineering Chemistry Research published new progress about Dielectric constant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lange, Heiko; Bergander, Klaus; Froehlich, Roland; Kehr, Seda; Nakamura, Shuichi; Shibata, Norio; Toru, Takeshi; Hoppe, Dieter published the artcile< Highly enantioselective reactions of configurationally labile epimeric diamine complexes of lithiated S-benzyl thiocarbamates>, Product Details of C19H34O2, the main research area is enantioselective reaction configuration labile epimeric diamine complex lithiation benzylthiocarbamate.

Substitution reactions that employ primary-carbamoyl-protected arylmethanethiols are described. The enantio-determination step was found to occur in the post-deprotonation step as a dynamic thermodn. resolution with a chiral bis(oxazoline) ligand. The configurationally labile lithium complexes were trapped with various electrophiles to yield different substitution products in good to excellent yields and enantiomeric excesses. The absolute configurations of the substitution products were determined, and the stereochem. pathway of the substitution reaction was elucidated for different classes of electrophiles. The temperature-dependent epimerization process was monitored by 1H and 6Li NMR spectroscopy.

Chemistry – An Asian Journal published new progress about Absolute configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamane, Daisuke; Hayashi, Yuri; Matsumoto, Moe; Nakanishi, Hiroki; Imagawa, Haruka; Kohara, Michinori; Lemon, Stanley M.; Ichi, Ikuyo published the artcile< FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication>, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is HCV replication FADS fatty acid desaturation ferroptosis cellular sensitivity; FADS2; Mead acid; direct-acting antivirals; ferroptosis; hepatitis C virus; lipid peroxidation; polyunsaturated fatty acid.

The metabolic oxidative degradation of cellular lipids severely restricts replication of hepatitis C virus (HCV), a leading cause of chronic liver disease, but little is known about the factors regulating this process in infected cells. Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2). Genetic depletion and ectopic expression experiments show FADS2 is a key determinant of cellular sensitivity to ferroptosis. Inhibiting FADS2 markedly enhances HCV replication, whereas the ferroptosis-inducing compound erastin alters conformation of the HCV replicase and sensitizes it to direct-acting antiviral agents targeting the viral protease. Our results identify FADS2 as a rate-limiting factor in ferroptosis, and suggest the possibility of pharmacol. manipulating the ferroptosis pathway to attenuate viral replication.

Cell Chemical Biology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boyer, Paul L.; Rehm, Catherine A.; Sneller, Michael C.; Mican, JoAnn; Caplan, Margaret R.; Dewar, Robin; Ferris, Andrea L.; Clark, Patrick; Johnson, Adam; Maldarelli, Frank; Hughes, Stephen H. published the artcile< A combination of amino acid mutations leads to resistance to multiple nucleoside analogs in reverse transcriptases from HIV-1 subtypes B and C>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is abacavir azidothymidine zidovudine antiviral agent drug resistance HIV1 infection.

Resistance to anti-HIV drugs has been a problem from the beginning of antiviral drug treatments. The recent expansion of combination antiretroviral therapy worldwide has led to an increase in resistance to antiretrovirals; understanding the mechanisms of resistance is increasingly important. In this study, we analyzed reverse transcriptase (RT) variants based on sequences derived from an individual who had low-level rebound viremia while undergoing therapy with abacavir, azidothymidine (AZT) (zidovudine), and (-)-L-2,3-dideoxy-3-thiacytidine (3TC) (lamivudine). The RT had mutations at positions 64, 67, 70, 184, and 219 and a threonine insertion after amino acid 69 in RT. The virus remained partially susceptible to the nucleoside RT inhibitor (NRTI) regimen. We show how these mutations affect the ability of NRTIs to inhibit DNA synthesis by RT. The presence of the inserted threonine reduced the susceptibility of the RT mutant to inhibition by tenofovir.

Antimicrobial Agents and Chemotherapy published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagner, Peter J.; Meador, Michael A.; Zhou, Boli; Park, Bong Ser published the artcile< Photocyclization of α-(o-tolyl)acetophenones: triplet and 1,5-biradical reactivity>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is photocyclization tolylacetophenone mechanism stereochem; biradical intermediate tolylacetophenone photocyclization; safety bromine addition DMF.

Several ring-substituted α-(o-tolyl)acetophenones undergo photocyclization to 2-indanol derivatives in high quantum efficiency in solution and in high chem. yield as solids. The mechanism for reaction involves triplet state δ-hydrogen atom abstraction that generates 1,5-biradicals. Quenching studies indicate that the n,π* excited triplets of these ketones react, with rate constants >108 s-1. Variations in triplet reactivity are ascribed to conformational equilibrium that populate reactive and unreactive geometries to different extents. The α-aryl ring eclipses the carbonyl in the lowest energy geometry, from which the most favorable geometry for reaction can be reached by small bond rotations. α-(2,4,6-Triisopropylphenyl)acetophenone forms the relatively long lived enol as well as indanol in solvent-dependent ratios; deuterium labeling indicates that the 1,5-biradical disproportionates to form enol. This does not happen with α-mesitylacetophenone, so its 54% cyclization quantum efficiency is ascribed to an internal triplet quenching that competes with hydrogen abstraction. This internal quenching is presumed to be of the charge-transfer type and does not appear to lead directly to 1,5-biradicals. 1-Methyl-2-phenyl-2-indanol is formed from α-(o-ethylphenyl)acetophenone with a Z/E ratio of 20:1 in benzene and 2:1 in methanol. The 1,5-biradical intermediates were characterized by flash spectroscopy; they have lifetimes between 15 and 45 ns, with those derived from α-(o-isopropylphenyl) ketones being twice as long-lived as those derived from α-(o-methylphenyl) ketones, and show only a small solvent dependence. Biradical lifetimes and the diastereoselectivity of cyclization are interpreted in terms of biradical intersystem crossing occurring preferentially along the reaction coordinate for cyclization, such that the two processes effectively occur concurrently. The applicability of this concept to other biradicals is discussed. Authors counsel caution in addition of Br2 to DMF.

Journal of the American Chemical Society published new progress about Abstraction reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de la Osa, Clara; Perez-Lopez, Jesus; Feria, Ana-Belen; Baena, Guillermo; Marino, Daniel; Coleto, Inmaculada; Perez-Montano, Francisco; Gandullo, Jacinto; Echevarria, Cristina; Garcia-Maurino, Sofia; Monreal, Jose A. published the artcile< Knock-down of phosphoenolpyruvate carboxylase 3 negatively impacts growth, productivity, and responses to salt stress in sorghum (Sorghum bicolor L.)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Sorghum root leaf growth nitrate reductase citrate synthase; Sorghum bicolor ; RNA interference; central metabolism; phosphoenolpyruvate carboxylase; productivity; salt stress; stomata.

Phosphoenolpyruvate carboxylase (PEPC) is a carboxylating enzyme with important roles in plant metabolism Most studies in C4 plants have focused on photosynthetic PEPC, but less is known about non-photosynthetic PEPC isoenzymes, especially with respect to their physiol. functions. In this work, we analyzed the precise roles of the sorghum (Sorghum bicolor) PPC3 isoenzyme by the use of knock-down lines with the SbPPC3 gene silenced (Ppc3 lines). Ppc3 plants showed reduced stomatal conductance and plant size, a delay in flowering time, and reduced seed production In addition, silenced plants accumulated stress indicators such as Asn, citrate, malate, and sucrose in roots and showed higher citrate synthase activity, even in control conditions. Salinity further affected stomatal conductance and yield and had a deeper impact on central metabolism in silenced plants compared to wild type, more notably in roots, with Ppc3 plants showing higher nitrate reductase and NADH-glutamate synthase activity in roots and the accumulation of mols. with a higher N/C ratio. Taken together, our results show that although SbPPC3 is predominantly a root protein, its absence causes deep changes in plant physiol. and metabolism in roots and leaves, neg. affecting maximal stomatal opening, growth, productivity, and stress responses in sorghum plants. The consequences of SbPPC3 silencing suggest that this protein, and maybe orthologs in other plants, could be an important target to improve plant growth, productivity, and resistance to salt stress and other stresses where non-photosynthetic PEPCs may be implicated.

Plant Journal published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yu; Xi, Hui; Fu, Yingjie; Li, Peng; Sun, Shihao; Zong, Yongli published the artcile< Effects of Organic Acids on the Release of Fruity Esters in Water: An Insight at the Molecular Level>, Computed Properties of 112-63-0, the main research area is ester organic acid mol interaction hydrogen bond; aroma release; density functional theory; esters; intermolecular interaction; odour detection threshold; organic acids.

It is well known that organic acids (OAs) could affect the flavor of fruit juices and beverages. However, the mol. mechanism of aroma release is still unclear. In this study, the effects of citric acid (CA), L-(-)-malic acid (MA) and L-lactic acid (LA) on the release of six selected esters and their sensory perception were investigated by means of HS-GC-MS analyses and odor detection threshold determination, resp. Meanwhile, the d. functional theory (DFT) calculation was employed to explore the interaction modes between esters and OAs. HS-GC-MS analyses showed that the concentration and the type of OAs regulated the release of esters. The results were basically consistent with the detection threshold change of those esters. The DFT calculation suggested that the main intermol. interaction was hydrogen bonds, and several esters could form a ternary ring structure with OAs through hydrogen bonds. The interactions can induce the different release behaviors of esters in OAs water solution The number of carboxyl functional groups in OAs and the spatial conformation of esters appeared to influence the magnitude of the interaction. The above results demonstrated the mechanism of OAs affecting the release of esters and indicated a possible flavor control way by using different OAs and OA concentrations

Molecules published new progress about Esters Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics