Tag: M.W=250-300

Nogales-Delgado, Sergio; Encinar Martin, Jose Maria published the artcile< Cardoon biolubricant through double transesterification: Assessment of its oxidative, thermal and storage stability>, Electric Literature of 112-63-0, the main research area is cardoon biolubricant transesterification oxidation thermal storage stability.

Biolubricants could be a suitable replacement for industrial lubricants, due to their good performance and environmental-friendly quality, showing better flash and combustion points. However, depending on the raw material, the quality of biolubricants can vary, especially concerning oxidative and storage stability. The aim of this research work was to assess the stability of cardoon biolubricant, paying attention to oxidation and thermal and storage stability (by using the Rancimat method, thermogravimetry and viscosity during storage, resp.). The high linoleic acid content in cardoon oil (exceeding 25%) could influence the low oxidative stability of cardoon biolubricant (3 h), implying changes in quality parameters during storage (viscosity increased above 15% and viscosity index decreased about 23%). Thus, the use of antioxidants is advisable to keep its properties over time.

Materials Letters published new progress about Artichoke. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhiyong; Guan, Qian; Xu, Haiyan; Lei, Tingzhou; Lin, Lu; Wang, Zhiwei; He, Xiaofeng; Zhu, Jinling published the artcile< Study on the formation of ethyl levulinate from wheat straw based on a model compound>, Application In Synthesis of 112-63-0, the main research area is ethyl levulinate wheat straw glucose microcrystalline cellulose.

Glucose and microcrystalline cellulose were selected as model compounds to investigate the formation of Et levulinate (EL). Optimal glucose and microcrystalline cellulose transformation conditions resulted in yields of 41.05 weight% and 38.56 weight% for EL, 0.73 weight% and 2.63 weight% for ethyl-glucoside (EG), 0.42 weight% and 0.36 weight% for 5-hydroxymethylfurfural (HMF), and 2.18 weight% and 2.16 weight% for 5-ethoxy Me furfural (EMF), resp. Increasing the reaction time and temperature resulted in an optimized yield of EL. These increases also resulted in decreased EG and EMF yield, and the change trend of HMF was not significant. EMF, HMF, and EG are intermediates in the formation of EL. Finally, we concluded that biomass conversion occurs first through cellulose degradation to glucose followed by the production of EG through alcoholysis and hydrolysis and dehydration of the reaction products to produce EL.

Journal of Biobased Materials and Bioenergy published new progress about Liquefaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alanazi, Rahmah; Nakatogawa, Hirokazu; Wang, Haitao; Ji, Delphine; Luo, Zhengwei; Golbourn, Brian; Feng, Zhong-Ping; Rutka, James T; Sun, Hong-Shuo published the artcile< Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo.>, Synthetic Route of 112-63-0, the main research area is TRPM7; carvacrol; drug target; glioblastoma; in vivo; ion channels.

Glioblastoma (GBM) is the most prevalent and aggressive type of primary human brain tumours originating in the central nervous system. Despite the fact that current treatments involve surgery, chemotherapy (Temozolomide), and radiation therapy, the prognosis for patients diagnosed with GBM remains extremely poor. The standard treatment is not only unable to completely eradicate the tumour cells, but also tumour recurrence after surgical resection presents a major challenge. Furthermore, adjuvant therapies including radiation and chemotherapy have high cytotoxicity which causes extensive damage to surrounding healthy tissues and treatment is usually halted before GBM is fully eradicated. Finally, most GBM cases demonstrate temozolomide resistance, a common reason for GBM treatment failure. Therefore, there is an urgent need to develop a suitable alternative therapy that targets GBM specifically and has low cytotoxicity for healthy cells. We previously reported that transient receptor potential melastatin 7 (TRPM7) channels are aberrantly upregulated in GBM, and inhibition of TRPM7 reduced GBM cellular functions including proliferation, migration, and invasion. This suggests TRPM7 is a potential therapeutic target for GBM treatment. In this study, we investigated the effects of the TRPM7 inhibitor, carvacrol, on human GBM cell lines U87 and U251 in vivo. With the use of a flank xenograft GBM mouse model, we demonstrated that carvacrol significantly reduced the tumour size in both mice injected with U87 and U251 cells, decreased p-Akt protein level and increased p-GSK3β protein levels. Therefore, these results suggest that carvacrol may have therapeutic potential for GBM treatment.

The European journal of neuroscience published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xuejing; Deng, Xingwang; Coyne, Anthony G.; Srinivasan, Rajavel published the artcile< meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation>, HPLC of Formula: 112-63-0, the main research area is meta nitroarene regioselective preparation; arene borylation nitration tandem iridium catalyst copper; C−H borylation; copper catalysis; nitration; nitro(hetero)arenes; one-pot reactions.

The meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C-H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes RNO2 [R = 4,5-di-ClC6H3, 3,4-di-BrC6H3, 5-Cl-3-pyridyl, etc.] in a one-pot fashion was reported. The reaction tolerated a wide array of ortho/para-directing groups, such as -F, -Cl, -Br, -CH3, -Et, -iPr -OCH3 and -OCF3. It also provided regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives The application of this method was demonstrated in the late-stage modification of complex mols. and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, showed that the nitro product obtained by this strategy could also be directly converted to the aniline or hindered amine through Baran’s amination protocol.

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Lijsebetten, Filip; De Bruycker, Kevin; Winne, Johan M.; Du Prez, Filip E. published the artcile< Masked Primary Amines for a Controlled Plastic Flow of Vitrimers>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is masked primary amine controlled plastic flow vitrimer.

We present a simple method for increasing the reprocessability of vinylogous urethane (VU) vitrimers while decreasing the possibility of creep deformation at lower temperatures In particular, varying amounts of triethylenetetramine were added as a comonomer to the curing VU formulation to ensure that all of the primary amines reacted to form enaminone cross-links, resulting in a network without reactive primary amine chain-ends. As a result, transamination was significantly slowed down because secondary amines are much less reactive to VU exchange. On the other hand, at higher temperatures, pendent primary amines can be released via a dynamic, endothermic exchange with a nearby less-reactive secondary amine, thereby (re)activating material flow. As a result, ambivalent viscoelastic behavior could be achieved without depolymerization by dynamically releasing pendent primary amines from vinylogous urethane polymer chains. Through careful comonomer selection, VU vitrimers with low viscosity at processing temperatures and at the same time high viscosity at service temperatures could be prepared without the use of catalysts or additives, leveraging the synergistic effects of mildly reactive functionalities through neighboring group participation.

ACS Macro Letters published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhanjiang; Shen, Guang; Yang, Yihua; Li, Cui; Chen, Xiaoying; Yang, Xiaonan; Guo, Xiaoyun; Miao, Jianhua; Li, Li; Lei, Ming published the artcile< Metabolic and Transcriptomic Analyses Reveal the Effects of Ethephon on Taraxacum kok-saghyz Rodin>, Related Products of 112-63-0, the main research area is Taraxacum ethephon transcriptomic analyses; Taraxacum kok-saghyz Rodin; metabolomics; transcriptomics.

The roots of Taraxacum kok-saghyz Rodin (TKS) are well-known and valued for their rubber-producing ability. Therefore, research on the anal. and detection of metabolites from the roots of TKS have been reported in previous studies. However, all of these studies have the shortcoming of focusing on only the rubber of TKS, without profiling the other metabolites in a systematic and comprehensive way. Here, the primary and secondary metabolites from the leaves of TKS were investigated using UPLC-ESI-MS/MS, and a total of 229 metabolites were characterized. Carboxylic acid derivatives, fatty acyls, phenols, and organooxygen compounds were found to be the major metabolites of TKS. The transcriptome data indicated that ribosomal, glycolysis/gluconeogenesis, phenylpropanoid biosynthesis, and linoleic acid metabolism genes were significantly differentially expressed. This study is the first to report the differences in the metabolic and transcriptome profiles of TKS leaves under exogenous ethephon spray, which improves our understanding of the main metabolites and their mol. mechanisms in TKS leaves.

Molecules published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Keith, D. Jamin; Townsend, Steven D. published the artcile< Total Synthesis of the Congested, Bisphosphorylated Morganella morganii Zwitterionic Trisaccharide Repeating Unit>, Safety of (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is zwitterionic polysaccharide immune response phosphoglycerol phosphocholine oligosaccharide; oligosaccharide Morganella Morganii trisaccharide repeating unit Zwitterionic phosphorylated glycosylation.

Zwitterionic polysaccharides (ZPS) activate T-cell-dependent immune responses by major histocompatibility complex class II presentation. Herein, we report the first synthesis of a Morganella morganii ZPS repeating unit as an enabling tool in the synthesis of novel ZPS materials. The repeating unit incorporates a 1,2-cis-α-glycosidic bond; the problematic 1,2-trans-galactosidic bond, Gal-β(1→3)-GalNAc; and phosphoglycerol and phosphocholine residues which have not been previously observed together as functional groups on the same oligosaccharide. The successful third generation approach leverages a first in class glycosylation of a phosphoglycerol functionalized acceptor. To install the phosphocholine unit, a highly effective phosphocholine donor was synthesized.

Journal of the American Chemical Society published new progress about Glycosylation. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Safety of (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toda, Fumio; Schmeyers, Jens published the artcile< Selective solid-state bromination of anilines and phenols>, COA of Formula: C19H34O2, the main research area is aniline solid state bromination; phenol solid state bromination.

Environmentally benign solid-state bromination of anilines and phenols with gaseous Br2 and solid bromination reagents is described. In most cases the reactions proceeded in the absence of solvents with higher yields and selectivity than in solution

Green Chemistry published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crich, David; Eustace, K. Angeline; Fortt, Simon M.; Ritchie, Timothy J. published the artcile< Acyl radical cyclizations in synthesis. Part 2. Further substituent effects on the mode and efficiency of cyclization of 6-heptenoyl radicals>, Quality Control of 112-63-0, the main research area is cyclization heptenoyl radical; selenol ester cyclization stereochem.

In an attempt to determine the factor affecting exo/endo- selectivity in the cyclization of 6-heptenoyl radicals various heteroatom substituted selenol esters were prepared and reacted with tributyltin hydride. The incorporation of a 7-phenylthio moiety results in clean, high yielding, cyclization in the exo- mode. Evidence is given for the reversibility of 6-heptenoyl radical cyclizations.

Tetrahedron published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dove, Stefan published the artcile< Picolinic acids as inhibitors of dopamine β-monooxygenase: QSAR and putative binding site>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dopamine monooxygenase picolinic acid derivative inhibitor QSAR.

Dopamine β-monooxygenase (DBM, EC 1.14.17.1) catalyzes the oxidation of dopamine into (R)-noradrenaline. DBM inhibitors may act as antihypertensive drugs. A series of 22 picolinic acids substituted in 4- and 5-position was previously synthesized and tested for inhibition of DBM from bovine adrenal medulla. The QSAR of these compounds were investigated by Hansch anal. and comparative mol. field anal. (CoMFA). The correlation of pI50 values with electronic (nucleophilic substituent constant σp-, oxygen net charges and HOMO energy calculated by AMPAC-AM1), hydrophobic (π values of R4) and steric descriptors (molar refraction and Sterimol parameters of R5) indicated that a more neg. charged carboxylate moiety, more lipophilic R4 groups as well as wider bulk and higher molar refraction of 5-substituents increase DBM inhibition. The CoMFA approach generally reproduced these QSAR in terms of steric and electrostatic field variables, the latter restricted to the carboxylate area. To predict a putative binding site, dopamine and fusaric acid were docked into a partial homol. model of DBM derived from a crystal structure of peptidylglycine α-hydroxylating monooxygenase (EC 1.14.17.3). The inhibitor is suggested to interact by its carboxylate group with the copper site CuB and the protonated amino group of dopamine according to the uncompetitive type of inhibition. R4 points to a tyrosine side chain. R5 protrudes into the fringe of the catalytic crevice. It may “”freeze”” to the solvated surface of polar amino acids and addnl. contact an isoleucine residue. Taken together, the model explains the QSAR results by corresponding types of interaction.

Archiv der Pharmazie (Weinheim, Germany) published new progress about QSAR (quantitative structure-activity relationship) (dopamine β-monooxygenase inhibition). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics