Tag: M.W=250-300

Cao, Xianting; Zhong, Haizhen A.; Zhang, Pengfei; Zheng, Hui published the artcile< The simple system of fixing CO2 to synthesize benzimidazolones at atmospheric pressure>, SDS of cas: 112-63-0, the main research area is carbondioxde benzimidazolone pressure catalysts.

A simple chem. fixation of CO2 at atm. pressure to make valuable benzimidazolones derivates via the o-phenylene-diamines carbonylation reaction catalyzed by DBU/S was developed. Different reaction conditions were examined and optimized. A series of benzimidazolones derivatives were synthesized using NMP as solvent at 413K with excellent yields (80-94%). Various substrates were employed and the results suggested the wide application of our method. The quantum mechanics calculations demonstrated that the complexation of DBU with sulfur significantly enhanced the reaction. This protocol rovides a novel approach of fixing CO2 at atm. pressure into a series of 2-benzimidazolones derivates.

Journal of CO2 Utilization published new progress about Catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shultz, Zachary; Shan, Chuan; Wojtas, Lukasz; Lopchuk, Justin M. published the artcile< A modular approach for the installation of functionalized phosphonates to heterocycles>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phosphonate heterocycle preparation.

Phosphonic acids and esters are pervasive throughout the discovery sciences, from medicine and agriculture, to materials and asym. synthesis. The ability to install and construct mol. architecture containing phosphonic functionality has led to the development of new medicines and catalyst systems in the field of organo- and organometallic catalysis. To continue the advancement in the field, improved synthetic access to phosphorous-containing motifs is required. In particular, heterocyclic phosphonates and their acid derivatives are so far underdeveloped. The method described herein provides a robust and operationally simple procedure for the installation of various phosphonates to a wide range of electrophilic heterocycles.

ARKIVOC (Gainesville, FL, United States) published new progress about Heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Lei published the artcile< Robust thiol-branched all-solid-state polymer electrolyte featuring high ionic conductivity for lithium-metal batteries>, Formula: C19H34O2, the main research area is solid state polymer electrolyte lithium metal battery.

The high energy d. of lithium metal batteries (LMBs) causes great attention of researchers. However, side effects of liquid electrolytes and dendrite growth problem limit the development of LMBs. Solid electrolytes with high ionic conductivity, good film-forming ability, and compatible interface with electrodes are highly desired yet remain to be explored. Herein, we design and fabricate a thiol-branched all-solid-state polymer electrolyte (SPE) with high ionic conductivity (1.09 x 10-4 S cm-1, 40°C) and good film-forming ability for the first time. The SPE is prepared via covalently crosslinking hyperbranched poly(glycidol) (chem. decorated by -SH, named as HPG-SH) and trimethylolpropane propoxylate triacrylate through multiple -C-S-C bonds. Specifically, the HPG is synthesized by anionic polymerization, followed by esterification reaction of HPG with mercaptoacetic acid to obtain HPG-SH. The SPE also exhibits an impressive lithium-ion transference number (0.31). Such design and prepare strategy makes the Li/SPE/LiFePO4 cell successfully cycle and the capacity reaches 145 mAh g-1 with average coulombic efficiency close to 100% over 70 cycles at low temperature This work offers a new perspective to design high-performance SPEs at the mol. level.

Ionics published new progress about Anionic polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fei, Yan-Qing; Shi, Ru-Ting; Zhou, Yang-Fan; Wu, Jin-Ze; Song, Zhi published the artcile< Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway>, Synthetic Route of 112-63-0, the main research area is mannose anticancer agent Wnt beta catenin glioma; Glioma; MGMT; Mannose; Temozolomide; Wnt/β-catenin pathway.

Temozolomide (TMZ) is generally applied for glioma treatment, while drug resistance of TMZ limits its therapeutic efficacy. Mannose exerts evident anti-tumor effect. We intended to investigate whether mannose enhanced TMZ sensitivity to glioma and examined the underlying mechanism. MTT and clone formation assays were performed to detect cell viability and proliferation. Cell apoptosis was measured by flow cytometry. The protein and gene expression levels were detected by Western blot and qRT-PCR assays. Xenograft glioma model was established to explore the influence of mannose in vivo. Mannose inhibited glioma cell growth, which was facilitated by knockdown of phosphomannose isomerase (PMI) while reversed by overexpression of PMI. Mannose enhanced the sensitivity of glioma cells to TMZ, indicated by the further inhibited cell viability and colony formation and the aggravated cell apoptosis, which was reversed by overexpression of O6-methylguanine DNA methyltransferase (MGMT). Furthermore, mannose and TMZ inhibited MGMT expression and Wnt/β-catenin activation. Moreover, activating Wnt/β-catenin pathway blocked anti-proliferative effect induced by mannose and TMZ, which was further suppressed by overexpressed MGMT. Mannose inhibited glioma growth, suppressed Ki67 and downregulated MGMT and β-catenin in vivo. Mannose inhibited MGMT to enhance sensitivity of glioma cells to TMZ, with Wnt/β-catenin pathway involvement. Our data suggested that mannose could be an innovative agent to improve glioma treatment, particularly in TMZ-resistant glioma with high MGMT.

Neurochemistry International published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jaffett, Victor A.; Nerurkar, Alok; Cao, Xufeng; Guzei, Ilia A.; Golden, Jennifer E. published the artcile< Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi-Mumm and regiospecific quinazolinone rearrangements>, Electric Literature of 112-63-0, the main research area is arylamidine stereoselective preparation; azidobenzoic acid isocyanide aldehyde bismethylaminoethane Ugi Mumm regiospecific rearrangement.

An efficient four-step, six-transformation protocol was developed to afford bioactive N-alkyl- or N-arylamide (E)-arylamidines I (R1 = Cy, 4-OMeC6H4, i-Pr, etc.; R2 = i-Pr, i-Bu, H, etc.; R3 = H, 5-CH3, 5-F, etc.) featuring strategic amidine C3 modifications which were inaccessible or low yielding by previous methods. This synthetic approach, exemplified with 24 amidines and requiring only a single purification, highlights a multicomponent Ugi-Mumm rearrangement to afford highly diversified quinazolinones which undergo regiospecific rearrangement to afford new amidines. The method extensively broadens the structural scope of this new class of trisubstituted amidines and demonstrates the tolerance of regional C3 amidine steric bulk, visualized with X-ray crystallog. anal.

Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Deborah Y.; Tom, Martin C.; Wei, Wei; Tewari, Surabhi; Ahluwalia, Manmeet S.; Yu, Jennifer S.; Chao, Samuel T.; Suh, John H.; Peereboom, David; Stevens, Glen H. J.; Barnett, Gene H.; Angelov, Lilyana; Mohammadi, Alireza M.; Hogan, Thomas; Kissel, Courtney; Lapin, Brittany; Schuermeyer, Isabel; Parsons, Michael W.; Naugle, Richard; Murphy, Erin S. published the artcile< Quality of life following concurrent temozolomide-based chemoradiation therapy or observation in low-grade glioma>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is quality life following concurrent temozolomide based chemoradiation therapy; Chemoradiation; EQ-5D; Low grade glioma; PHQ-9; Quality of life; Temozolomide.

Low-grade glioma (LGG) exhibits longer median survival than high-grade brain tumors, and thus impact of our therapies on patient quality of life remains a crucial consideration. This study evaluated the effects of concurrent temozolomide-based chemoradiation (RT + TMZ) or observation on quality of life (QOL) in patients with low-grade glioma. We completed a retrospective cross-sectional study of adults with LGG who underwent surgery with known mol. classification from 1980 to 2018. Postoperatively, patients were either observed or received adjuvant concurrent temozolomide-based chemoradiation. EQ-5D and PHQ-9 depression screen were completed before outpatient visits every 2-3 mo. Baseline score was defined as ± 30 days within initial operation. Of the 63 patients (mean age 44 ± 17 years, 51% female) with baseline EQ-5D or PHQ-9 depression screen data and at least one follow-up measure, 30 (48%) were observed and 33 (52%) received RT + TMZ. No significant decline was seen in EQ-5D or PHQ-9 scores at 3, 6, 9, 12, and 24 mo compared to baseline scores for all patients. At each time point, there was no significant difference between those who were observed or received adjuvant therapy. The linear mixed model estimating PHQ-9 value or EQ-5D index demonstrated that there was no significant difference in PHQ-9 or EQ-5D index between treatment groups (p = 0.42 and p = 0.54, resp.) or time points (p = 0.24 and p = 0.99, resp.). Our study found no significant decline in patient QOL or depression scores as assessed by patient- reported outcome measures for patients with low-grade glioma up to 2 years following surgery. We found no difference between RT + TMZ compared to observation during this time frame. Addnl. follow-up can help identify the longer-term impact of treatment strategy on patient experience.

Journal of Neuro-Oncology published new progress about Astrocytoma (mol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Suri, Deepa; Kothari, Seema; Banerji, Kalyan K. published the artcile< Kinetics and mechanism of the oxidation of formic and oxalic acids by pyridinium hydrobromide perbromide>, Reference of 112-63-0, the main research area is oxidation formic acid pyridinium hydrobromide perbromide; oxalic acid oxidation pyridinium hydrobromide perbromide; kinetics mechanism oxidation carboxylic acid; LFER Grunwald Winstein solvent effect.

Oxidation of formic and oxalic acids by pyridinium hydrobromide perbromide proceeds via acyclic and cyclic intermediates resp. to give carbon dioxide.

Journal of Chemical Research, Synopses published new progress about Isotope effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Winkler, Dirk F. H.; McGeer, Patrick L. published the artcile< Protein labeling and biotinylation of peptides during spot synthesis using biotin p-nitrophenyl ester (biotin-ONp)>, Application In Synthesis of 112-63-0, the main research area is protein labeling biotinylation peptide MALDI TOF mass spectrometry.

Biotin-labeled peptides are used for numerous biochem. and microbiol. applications. Due to the strong affinity of biotin to streptavidin, the detection of biotinylated mols. is very sensitive. A powerful technique for parallel synthesis and high-throughput screening of peptides is the spot synthesis. One example for the use of spot synthesis is the screening of biotinylated peptides synthesized on cellulose membranes, which is particularly favorable for the investigation of protease cleavage sites. Addnl., in combination with biotinylated protein samples, the spot technique can be used for investigations of peptide-protein and protein-protein interactions. Here, we present our results of the use biotin p-nitrophenyl ester (biotin-ONp) in spot synthesis and as a reagent for biotin-labeling of protein samples.

Proteomics published new progress about Biotinylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pardieu, Bryann; Pasanisi, Justine; Ling, Frank; Dal Bello, Reinaldo; Penneroux, Justine; Su, Angela; Joudinaud, Romane; Chat, Laureen; Wu, Hsin Chieh; Duchmann, Matthieu; Sodaro, Gaetano; Chauvel, Clementine; Castelli, Florence A.; Vasseur, Loic; Pacchiardi, Kim; Belloucif, Yannis; Laiguillon, Marie-Charlotte; Meduri, Eshwar; Vaganay, Camille; Alexe, Gabriela; Berrou, Jeannig; Benaksas, Chaima; Forget, Antoine; Braun, Thorsten; Gardin, Claude; Raffoux, Emmanuel; Clappier, Emmanuelle; Ades, Lionel; de The, Hugues; Fenaille, Francois; Huntly, Brian J.; Stegmaier, Kimberly; Dombret, Herve; Fenouille, Nina; Lobry, Camille; Puissant, Alexandre; Itzykson, Raphael published the artcile< Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia>, Reference of 347174-05-4, the main research area is cystine acute myeloid leukemia therapy.

By querying metabolic pathways associated with leukemic stemness and survival in multiple AML datasets, we nominated SLC7A11 encoding the xCT cystine importer as a putative AML dependency. Genetic and chem. inhibition of SLC7A11 impaired the viability and clonogenic capacity of AML cell lines in a cysteine-dependent manner. Sulfasalazine, a broadly available drug with xCT inhibitory activity, had anti-leukemic activity against primary AML samples in ex vivo cultures. Multiple metabolic pathways were impacted upon xCT inhibition, resulting in depletion of glutathione pools in leukemic cells and oxidative stress-dependent cell death, only in part through ferroptosis. Higher expression of cysteine metabolism genes and greater cystine dependency was noted in NPM1-mutated AMLs. Among eight anti-leukemic drugs, the anthracycline daunorubicin was identified as the top synergistic agent in combination with sulfasalazine in vitro. Addition of sulfasalazine at a clin. relevant concentration significantly augmented the anti-leukemic activity of a daunorubicin-cytarabine combination in a panel of 45 primary samples enriched in NPM1-mutated AML. These results were confirmed in vivo in a patient-derived xenograft model. Collectively, our results nominate cystine import as a druggable target in AML and raise the possibility to repurpose sulfasalazine for the treatment of AML, notably in combination with chemotherapy.

Leukemia published new progress about Acute myeloid leukemia. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Reference of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Basarab, Gregory S.; Brassil, Patrick; Doig, Peter; Galullo, Vincent; Haimes, Howard B.; Kern, Gunther; Kutschke, Amy; McNulty, John; Schuck, Virna J. A.; Stone, Gregory; Gowravaram, Madhusudhan published the artcile< Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization>, Electric Literature of 112-63-0, the main research area is benzisoxazole spiropyrimidinetrione preparation DNA gyrase inhibitor scaffold SAR.

The compounds described herein with a spirocyclic architecture fused to a benzisoxazole ring represent a new class of antibacterial agents that operate by inhibition of DNA gyrase as corroborated in an enzyme assay and by the inhibition of precursor thymidine into DNA during cell growth. Activity resided in the configurationally lowest energy (2S,4R,4aR) diastereomer. Highly active compounds against Staphylococcus aureus had sufficiently high solubility, high plasma protein free fraction, and favorable pharmacokinetics to suggest that in vivo efficacy could be demonstrated, which was realized with compound I in S. aureus mouse infection models. A high drug exposure NOEL on oral dosing in the rat suggested that a high therapeutic margin could be achieved. Importantly, I was not cross-resistant with other DNA gyrase inhibitors such as fluoroquinolone and aminocoumarin antibacterials. Hence, this class shows considerable promise for the treatment of infections caused by multidrug resistant bacteria, including S. aureus.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics