Tag: M.W=250-300

Zhang, Yue; Li, Kun; Gao, Wei; Liu, Xiaoyu; Yuan, Haolin; Tang, Liangfu; Fan, Zhijin published the artcile< Tandem Synthesis of 1,2,3-Thiadiazoles with 3,4-Dichloroisothiazoles and Hydrazines under External Oxidant- and Sulfur-free Conditions>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thiadiazole preparation; dichloroisothiazole ketone hydrazine tandem nucleophilic addition intramol rearrangement.

1,2,3-Thiadiazoles are among the most important heterocyclic motifs with wide applications in natural products and medicinal chem. Herein, authors disclosed a tandem reaction for the synthesis of structurally diverse 1,2,3-thiadiazoles from 3,4-dichloroisothiazol-5-ketones and hydrazines. This method is characterized by free of external oxidants or sulfur requirements, mild reaction conditions, broad substrate scope and easy purification

Organic Letters published new progress about Hydrazines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lei, Tao; Wei, Si-Meng; Feng, Ke; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published the artcile< Borylation of Diazonium Salts by Highly Emissive and Crystalline Carbon Dots in Water>, Quality Control of 112-63-0, the main research area is diazonium salt borylation crystalline carbon dot water green catalyst; boronic ester preparation photocatalyst mechanism; borylation; carbon dots; emission; photochemistry; photoredox chemistry.

Efficient borylation reaction of diazonium salts in water is realized for the first time by using easily prepared, highly emissive and crystalline carbon dots. Electron-donating and electron-withdrawing groups on diazonium salts were well tolerated with moderate to good conversion efficiency. Compared with widely used metal complexes, organic dyes and quantum dots, the approach presented herein uses carbon dots, which are nontoxic and possess good biol. and medicinal compatibility and high reactivity. Therefore, this approach presents a new prospective use for carbon dots in green chem.

ChemSusChem published new progress about Absorption spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ram, Ram N.; Kumar, Neeraj; Kumar Gupta, Dharmendra published the artcile< Substrate-Controlled Diastereoselective Synthesis of Sugar-Based Chlorinated Perhydrofuro[2,3-b]pyrans via Copper(I)-Catalyzed Radical Cyclization>, Synthetic Route of 4098-06-0, the main research area is Ferrier rearrangement chloroethanol acetal glucal cyclization glycoside disaccharide preparation; crystal structure disaccharide stereoselective cyclization copper catalyzed hydrofuropyran chlorinated.

The work describes the first copper(I) chloride/2,2′-bipyridine-catalyzed atom transfer radical cyclization (ATRC) of unsaturated carbohydrate-derived chloroacetals to generate chlorinated perhydrofuro[2,3-b]pyrans via an effective diastereoselective route. Various glycals (glucal, galactal and lactal) underwent the Ferrier rearrangement with 2,2,2-trichloroethanols to give acetal precursors stereoselectively, R-selective with galactal in contrast to S-selective with glucal. The radical cyclization of the Ferrier products occurred smoothly to afford cis-fused bicyclic products with the transfer of the chlorine atom at the non-anomeric carbon in the cyclized radical intermediate predominantly from the equatorial direction. The carbohydrate templates controlled the stereochem. of both Ferrier rearrangement and ATRC steps. The stereo-structures of the products were also supported by single crystal X-ray diffraction crystallog. The products possess biol. important structural segments such as a glycosidic linkage, a fused bicyclic acetal unit and a chlorosugar unit which are potential sources for biol. studies and further synthetic elaborations.

Advanced Synthesis & Catalysis published new progress about Bicyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morgan, H.; Taylor, D. M.; D’Silva, C. published the artcile< Surface plasmon resonance studies of chemisorbed biotin-streptavidin multilayers>, Formula: C19H34O2, the main research area is surface plasmon resonance spectroscopy protein; immobilization biotin bisbiotin streptavidin gold.

Surface plasmon resonance spectroscopy has been used to confirm that a monolayer of biotin may be immobilized by chemisorption onto evaporated gold films and subsequently used to bind a monolayer of streptavidin. As expected, the strong affinity of the protein for the biotin ligand ensures that the binding of the protein layer is highly specific. No non-specific binding occurs to the biotinylated gold surface: the protein layer is resistant to washing in 1M NaCl. It is suggested that multilayer structures may be assembled by chemisorption of successive protein monolayers using a bifunctional bisbiotin ligand for connecting individual layers.

Thin Solid Films published new progress about Chemisorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hapuarachchige, Sudath; Montano, Gilbert; Ramesh, Chinnasamy; Rodriguez, Delany; Henson, Lauren H.; Williams, Casey C.; Kadavakkollu, Samuel; Johnson, Dennis L.; Shuster, Charles B.; Arterburn, Jeffrey B. published the artcile< Design and Synthesis of a New Class of Membrane-Permeable Triazaborolopyridinium Fluorescent Probes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is synthesis membrane permeable triazaborolopyridinium fluorescent probe.

A new class of fluorescent triazaborolopyridinium compounds was synthesized from hydrazones of 2-hydrazinylpyridine (HPY) and evaluated as potential dyes for live-cell imaging applications. The HPY dyes are small, their absorption/emission properties are tunable through variation of pyridyl or hydrazone substituents, and they offer favorable photophys. characteristics featuring large Stokes shifts and general insensitivity to solvent or pH. The stability, neutral charge, cell membrane permeability, and favorable relative influences on the water solubility of HPY conjugates are complementary to existing fluorescent dyes and offer advantages for the development of receptor-targeted small-mol. probes. This potential was assessed through the development of a new class of cysteine-derived HPY-conjugate imaging agents for the kinesin spindle protein (KSP) that is expressed in the cytoplasm during mitosis and is a promising chemotherapeutic target. Conjugates possessing the neutral HPY or charged Alexa Fluor dyes that function as potent, selective allosteric inhibitors of the KSP motor were compared using biochem. and cell-based phenotypic assays and live-cell imaging. These results demonstrate the effectiveness of the HPY dye moiety as a component of probes for an intracellular protein target and highlight the importance of dye structure in determining the pathway of cell entry and the overall performance of small-mol. conjugates as imaging agents.

Journal of the American Chemical Society published new progress about Allosterism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sake, Cara L.; Metcalf, Alexander J.; Meagher, Michelle; Di Paola, Jorge; Neeves, Keith B.; Boyle, Nanette R. published the artcile< Isotopically nonstationary 13C metabolic flux analysis in resting and activated human platelets>, Related Products of 112-63-0, the main research area is isotopically nonstationary metabolic flux platelet thrombin; Blood platelets; Metabolic flux analysis; Metabolomics; Thrombin.

Platelet metabolism is linked to platelet hyper- and hypoactivity in numerous human diseases. Developing a detailed understanding of the link between metabolic shifts and platelet activation state is integral to improving human health. Here, we show the first application of isotopically nonstationary 13C metabolic flux anal. to quant. measure carbon fluxes in both resting and thrombin activated platelets. Metabolic flux anal. results show that resting platelets primarily metabolize glucose to lactate via glycolysis, while acetate is oxidized to fuel the tricarboxylic acid cycle. Upon activation with thrombin, a potent platelet agonist, platelets increase their uptake of glucose 3-fold. This results in an absolute increase in flux throughout central metabolism, but when compared to resting platelets they redistribute carbon dramatically. Activated platelets decrease relative flux to the oxidative pentose phosphate pathway and TCA cycle from glucose and increase relative flux to lactate. These results provide the first report of reaction-level carbon fluxes in platelets and allow us to distinguish metabolic fluxes with much higher resolution than previous studies.

Metabolic Engineering published new progress about Analysis (isotopically nonstationary 13C metabolic flux). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Spicer, Julie A.; Miller, Christian K.; O’Connor, Patrick D.; Jose, Jiney; Huttunen, Kristiina M.; Jaiswal, Jagdish K.; Denny, William A.; Akhlaghi, Hedieh; Browne, Kylie A.; Trapani, Joseph A. published the artcile< Substituted arylsulphonamides as inhibitors of perforin-mediated lysis>, Quality Control of 112-63-0, the main research area is arylsulfonamide perforin mediated lysis inhibitor structure activity Immunosuppressive; Arylsulphonamide; Bioisostere; Immunosuppressant; Perforin; Perforin inhibitor.

The structure-activity relationships for a series of arylsulfonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however, inappropriate activity has also been implicated in certain auto-immune and therapy-induced conditions such as allograft rejection and graft vs. host disease. Since perforin is expressed exclusively by cells of the immune system, inhibition of this protein would be a highly selective strategy for the immunosuppressive treatment of these disorders. Compounds from this series were demonstrated to be potent inhibitors of the lytic action of both isolated recombinant perforin and perforin secreted by natural killer cells in vitro. Several potent and soluble examples were assessed for in vivo pharmacokinetic properties and found to be suitable for progression to an in vivo model of transplant rejection.

European Journal of Medicinal Chemistry published new progress about Arenesulfonamides Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Zhong-Yan; Zhao, Yu-Lei; Zhou, Jian published the artcile< Sequential Au(I)/chiral tertiary amine catalysis: a tandem C-H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles>, Product Details of C19H34O2, the main research area is diazooxindole anisole diazooxindole gold chiral amine tandem Michael addition; quaternary oxindole enantioselective diastereoselective preparation.

An unprecedented sequential Au(I)/bifunctional tertiary amine catalysis was reported, which enabled a tandem C-H functionalization of weak nucleophiles (anisoles or thiophenes) and asym. Michael addition for the highly enantioselective synthesis of quaternary oxindoles from diazooxindoles and nitroenynes.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenynes Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mala, Zaneta A.; Janicki, Mikolaj J.; Niedzwiecka, Natalia H.; Gora, Robert W.; Konieczny, Krzysztof A.; Kowalczyk, Rafal published the artcile< Stereoselectivity Enhancement During the Generation of Three Contiguous Stereocenters in Tetrahydrothiophenes>, Application of C19H34O2, the main research area is enantioselective diastereoselective sulfa Michael intramol aldol cascade mercaptoacetaldehyde enynone; thiophene tetrahydro enantioselective diastereoselective synthesis.

Application of carefully designed Cinchona alkaloid based squaramides resulted in the formation of three contiguous stereocenters in enantio- and diastereoselective Sulfa-Michael/intramol. aldol reactions cascade [e.g., I + II → III (62%, 96% ee, 20:1 d.r.)]. Increase of the temperature to 333 K in reaction of mercaptoacetic aldehyde and various en-ynones allowed the rise of the reaction rate while not affecting the enantioselectivity nor diastereoselectivity. Stereoselectivity was dependent on the structure of the hydrogen-bonding unit, thus revealing the importance of weak interactions in the formation of the multifunctional tetrahydrothiophenes. Kohn-Sham D. Functional Theory results suggest that a perfect fit of the electrophile and squaramide via tailored (+)N-H hydrogen bonding and π-π stacking interactions were the main factors of the chirality transfer.

ChemCatChem published new progress about Aldol addition, stereoselective (intramol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Xiao; Zhao, Na; Li, Zhibo published the artcile< Stereoselective Ring-Opening Polymerization of rac-Lactide Catalyzed by Squaramide Derived Organocatalysts at Room Temperature>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lactide stereoselective squaramide organocatalyst ring opening polymerization.

Substantial progresses have been made toward the development of metal-free catalysts for stereoselective ring-opening polymerization (ROP) of rac-lactide. Yet the discovery of organic catalysts effective at ambient temperature remains a major challenge. Here, the bifunctional H-bonding catalyst SQ-1 containing a basic tertiary amine and squaramide motif proved to be good candidate for the stereoselective ROP of rac-lactide at room temperature, yielding stereoregular polylactide with controlled mol. weights (up to 21.1 kg/mol) and high tacticity (PiESC up to 0.88). Furthermore, binary H-bonding catalytic system consisting of squaramides (SQ-2 to SQ-6) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) could efficiently promote the ROP of rac-lactide at room temperature within short reaction time. Among them, the most bulky squaramide SQ-2 exhibited the best stereoselectivity towards the ROP of rac-lactide without transesterification side reactions during the polymerization process. The resulting polylactides were proved to have controlled mol. weights as high as 22.2 kg/mol and narrow distributions (1.10-1.24).

Chinese Journal of Chemistry published new progress about Glass transition temperature. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics