Tag: M.W=250-300

Isidor, Marie S.; Dong, Wentao; Servin-Uribe, Rogelio I.; Villarroel, Julia; Altintas, Ali; Ayala-Sumuano, J. Tonatiuh; Varela-Echavarria, Alfredo; Barres, Romain; Stephanopoulos, Gregory; Macotela, Yazmin; Emanuelli, Brice published the artcile< Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes>, Computed Properties of 112-63-0, the main research area is insulin resistance glucose white adipocyte.

In obesity, adipose tissue dysfunction resulting from excessive fat accumulation leads to systemic insulin resistance (IR), the underlying alteration of Type 2 Diabetes. The specific pathways dysregulated in dysfunctional adipocytes and the extent to which it affects adipose metabolic functions remain incompletely characterized. We interrogated the transcriptional adaptation to increased adiposity in association with insulin resistance in visceral white adipose tissue from lean men, or men presenting overweight/obesity (BMI from 19 to 33) and discordant for insulin sensitivity. In human adipocytes in vitro, we investigated the direct contribution of IR in altering metabolic gene programming and glucose utilization using 13C-isotopic glucose tracing. We found that gene expression associated with impaired glucose and lipid metabolism and inflammation represented the strongest association with systemic insulin resistance, independently of BMI. In addition, we showed that inducing IR in mature human white adipocytes was sufficient to reprogram the transcriptional profile of genes involved in important metabolic functions such as glycolysis, the pentose phosphate pathway and de novo lipogenesis. Finally, we found that IR induced a rewiring of glucose metabolism, with higher incorporation of glucose into citrate, but not into downstream metabolites within the TCA cycle. Collectively, our data highlight the importance of obesity-derived insulin resistance in impacting the expression of key metabolic genes and impairing the metabolic processes of glucose utilization, and reveal a role for metabolic adaptation in adipose dysfunction in humans.

International Journal of Obesity published new progress about Adipocyte. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balaratnam, Sumirtha; Rhodes, Curran; Bume, Desta Doro; Connelly, Colleen; Lai, Christopher C.; Kelley, James A.; Yazdani, Kamyar; Homan, Philip J.; Incarnato, Danny; Numata, Tomoyuki; Schneekloth, John S. Jr published the artcile< A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites>, Related Products of 112-63-0, the main research area is PreQ metabolite chem probe transcriptome binding site mapping.

The role of metabolite-responsive riboswitches in regulating gene expression in bacteria is well known and makes them useful systems for the study of RNA-small mol. interactions. Here, we study the PreQ1 riboswitch system, assessing sixteen diverse PreQ1-derived probes for their ability to selectively modify the class-I PreQ1 riboswitch aptamer covalently. For the most active probe (11), a diazirine-based photocrosslinking analog of PreQ1, X-ray crystallog. and gel-based competition assays demonstrated the mode of binding of the ligand to the aptamer, and functional assays demonstrated that the probe retains activity against the full riboswitch. Transcriptome-wide mapping using Chem-CLIP revealed a highly selective interaction between the bacterial aptamer and the probe. In addition, a small number of RNA targets in endogenous human transcripts were found to bind specifically to 11, providing evidence for candidate PreQ1 aptamers in human RNA. This work demonstrates a stark influence of linker chem. and structure on the ability of mols. to crosslink RNA, reveals that the PreQ1 aptamer/ligand pair are broadly useful for chem. biol. applications, and provides insights into how PreQ1, which is similar in structure to guanine, interacts with human RNAs.

Nature Communications published new progress about Aptamers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tamura, Yasumitsu; Tsunekawa, Masayoshi; Miyamoto, Tomohisa; Ikeda, Masazumi published the artcile< Syntheses and some properties of 4-acyl-1-methyl-2-azathiabenzene 1-oxides>, COA of Formula: C19H34O2, the main research area is azathiabenzene oxide; thiabenzene aza oxide; thiazine oxide; acylvinylsulfoximine cyclization; sulfoximine acylvinyl cyclization.

4-Acyl-1-methyl-2-azathiabenzene 1-oxides I [R = H, R1 = Me, OEt, R2 = Me; RR1 = (CH2)3, R2 = Me; R = R1 = Me, R2 = H] were prepared by base catalyzed cyclization of N-(2,2-diacylvinyl)dimethylsulfoximines which, in turn, were obtained by the reactions of (MeCO)2C:CHOEt, EtOCH:C(CO2Et)2, MeCOC(:CHOEt)CO2Et, and 2-acetyl-3-methoxy-2-cyclohexen-1-one with dimethylsulfoximine. Comparison of the phys. and chem. properties of the azathiabenzene 1-oxides with those of the corresponding 4-acyl-1-methylthiabenzene 1-oxides II suggests that both the ylidic and betaine like properties of the 2-azathiabenzene 1-oxides are much lower than those of the latter.

Journal of Organic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Yucheng; Hu, Qingcai; Wu, Zongjie; Bi, Wanjun; Chen, Bin; Hao, Zhilong; Wu, Liangyu; Ye, Naixing; Sun, Yun published the artcile< Volatile metabolomics and coexpression network analyses provide insight into the formation of the characteristic cultivar aroma of oolong tea (Camellia sinensis)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Camellia sinensis volatile metabolomics coexpression network analysis.

Finished oolong tea products with distinctly characteristic cultivar aromas generally have higher economic value. To advance our understanding of the aromatic differences between Camellia sinensis cv. Tieguanyin (TGY) and Jinguanyin (JGY) cultivars and their underlying formation mechanism, volatile metabolomics anal., electronic nose (EN) anal., sensory evaluation, and RNA sequencing were performed during this study. The EN and sensorial anal. showed a significant difference in odor characteristics between the two cultivars, which featured sweet floral and fruity aromas and green floral aromas, resp. A metabolomics anal. of tea products showed that linalool (floral, OAV = 50.6) and geraniol (rose-like and sweet, OAV = 1.9) may contribute to the characteristic aroma. The volatile determination at each stage during the oolong tea manufacturing process emphasized that the significant difference in linalool and geraniol contents in fresh leaves from the two cultivars and the increase rate were potential reasons for their characteristic aroma and suggested that the “”Tanqing”” treatment clarified and intensified the characteristic cultivar aroma. A linalool synthase CsLIN with the expected catalytic activity was identified by coexpression network analyses. Collectively, our work pinpoints two key aroma substances within two cultivars and elaborates on the potential cause of characteristic cultivar aroma formation.

LWT–Food Science and Technology published new progress about Camellia sinensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jouandin, Patrick; Marelja, Zvonimir; Shih, Yung-Hsin; Parkhitko, Andrey A.; Dambowsky, Miriam; Asara, John M.; Nemazanyy, Ivan; Dibble, Christian C.; Simons, Matias; Perrimon, Norbert published the artcile< Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting>, COA of Formula: C19H34O2, the main research area is Drosophila TORC1 tissue growth lysosomal cystine fasting mitochondria.

Adaptation to nutrient scarcity involves an orchestrated response of metabolic and signaling pathways to maintain homeostasis. We find that in the fat body of fasting Drosophila, lysosomal export of cystine coordinates remobilization of internal nutrient stores with reactivation of the growth regulator target of rapamycin complex 1 (TORC1). Mechanistically, cystine was reduced to cysteine and metabolized to acetyl-CoA (acetyl-CoA) by promoting CoA metabolism In turn, acetyl-CoA retained carbons from alternative amino acids in the form of tricarboxylic acid cycle intermediates and restricted the availability of building blocks required for growth. This process limited TORC1 reactivation to maintain autophagy and allowed animals to cope with starvation periods. We propose that cysteine metabolism mediates a communication between lysosomes and mitochondria, highlighting how changes in diet divert the fate of an amino acid into a growth suppressive program.

Science (Washington, DC, United States) published new progress about Adipose tissue. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Emad, Ayat M.; Rasheed, Dalia M.; El-Kased, Reham F.; El-Kersh, Dina M. published the artcile< Antioxidant, Antimicrobial Activities and Characterization of Polyphenol-Enriched Extract of Egyptian Celery (Apium graveolens L., Apiaceae) Aerial Parts via UPLC/ESI/TOF-MS>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Apium graveolens antioxidant antimicrobial polyphenol UPLCESITOFMS; Apium graveolens; UPLC/ESI/TOF-MS; antimicrobial; antioxidant; celery.

Medicinal plant extracts are increasingly considered a major source of innovative medications and healthcare products. This study focused on preparing a polyphenol enriched water extract of Egyptian celery “”Apium graveolens L., Apiaceae”” aerial parts (TAE) in an endeavor to accentuate its antioxidant capacity as well as its antimicrobial activity. (TAE) of celery was partitioned against different organic solvents to yield dichloromethane (DCM), Et acetate (EAC), and butanol (BUOH) fractions. (TAE) and the organic fractions thereof besides the remaining mother liquor (ML) were all screened for their antioxidant capacity using various protocols viz. monitoring the reducing amplitudes for ferric ions (FRAP), and radical scavenging potentials of oxygen (ORAC), 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and metal chelation assays. The examination procedure revealed both (TAE) extract and (DCM) fraction, to pertain the highest antioxidant potentials, where the IC50 of the (TAE) using ABTS and metal chelation assays were ca. 34.52 ± 3.25 and 246.6 ± 5.78μg/mL, resp. The (DCM) fraction recorded effective results using the FRAP, ORAC, and DPPH assays ca. 233.47 ± 15.14 and 1076 ± 25.73μM Trolox equivalent/mg sample and an IC50 474.4 ± 19.8μg/mL, resp. Addnl., both (TAE) and (DCM) fraction exerted antimicrobial activities recording inhibition zones (mm) (13.4 ± 1.5) and (12.0 ± 1.0) against Staphylococcus aureus and (11.0 ± 1.2) and (10.0 ± 1.3) against Escherichia coli, resp., with no anti-fungal activity. Min. inhibitory concentration (MIC) of (TAE) and (DCM) fraction were 1250 and 2500μg/mL, resp. UPLC/ESI/TOF-MS unveiled the chem. profile of both (TAE) and (DCM) fraction to encompass a myriad of active polyphenolic constituents including phenylpropanoids, coumarins, apigenin, luteolin, and chrysoeriol conjugates.

Molecules published new progress about Aliphatic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pathan, Javed R.; Sureshan, Kana M. published the artcile< Solvent-Free and Catalyst-Free Synthesis of Cross-Linkable Polyfumaramides via Topochemical Azide-Alkyne Cycloaddition Polymerization>, Product Details of C19H34O2, the main research area is polyfumaramide topochem azide alkyne cycloaddition polymerization.

Unsaturated polymers are important materials having a lot of applications. Among polymers, polyamides possess a prime position due to their thermal and chem. stability. Herein, we report a simple, greener, catalyst-free, and solid-state synthesis of two unsaturated polyamides via a topochem. azide-alkyne cycloaddition reaction. Two designed fumaramide monomers M1 and M2, functionalized with complementary azide and alkyne reactive motifs at the termini, reacted upon heating their crystalline powders and resulted in the formation of triazolyl-linked unsaturated polyfumaramides P1 and P2, resp. We have characterized the reaction using various time-dependent techniques such as NMR, FTIR, PXRD, and DSC measurements. Interestingly, the monomer M1 resulted in 1,5-disubstituted triazole-linked unsaturated polyfumaramide (P1), whereas the monomer M2 polymerized into a polyfumaramide having both 1,4-disubstituted and 1,5-disubstituted triazole linkages (P2). Also, the trans-olefinic bond of both the fumaramide monomers was unaffected in the polymerization process and hence yielded unsaturated polymers having trans-olefin units in the repeating unit. Demonstrating the scope of postsynthetic modification, we have shown that unsaturation can be exploited for crosslinking via a light-induced [2 + 2] cycloaddition reaction. This first report on the solid-state synthesis of unsaturated polyfumaramides will be of great interest.

ACS Sustainable Chemistry & Engineering published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Terenziani, Francesca; Mongin, Olivier; Katan, Claudine; Bhattula, Bharath Kumar Goud; Blanchard-Desce, Mireille published the artcile< Effects of dipolar interactions on linear and nonlinear optical properties of multichromophore assemblies: a case study>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is multichromophore assembly nonlinear optical property effect dipolar interaction.

Interchromophore interactions in flexible multidipolar structures for nonlinear optics were addressed by a combined exptl. and theor. study on two series of one-, two-, and three-chromophore systems in which identical push-pull chromophores are assembled through covalent and flexible linkers in close proximity. The photophys. and nonlinear optical properties (quadratic hyperpolarizability) of the multichromophore systems were investigated and compared to those of the monomeric chromophores. Multimers have larger dipole moments than their monomeric analogs, i.e., the dipolar subchromophores self-orient within the multimeric structures. This effect was found to depend on the intersubchromophore distance in a nontrivial manner, which confirms that mol. engineering of such flexible systems is more complex than in completely geometrically controlled systems. Elec.-field-induced second-harmonic generation (EFISHG) measurements in solution revealed increased figures of merit as compared to the monomeric analog. This effect increases with increasing number and polarity of the individual subchromophores in the nanoassembly and increasing spacing between dipolar subchromophores. Exptl. results are interpreted by a theor. model for interacting polar and polarizable chromophores. The properties of multidipolar assemblies are shown to be related to the relative orientation of chromophores, which is imposed by interchromophore interactions. The supramol. structure is thus a result of self-organization. The proposed theor. model was also used to predict the properties of multichromophore structures made up of more polar and polarizable push-pull chromophores, and showed that stronger interchromophore interactions can heavily affect the individual optical responses. This suggests new routes for engineering highly NLO responsive multichromophore systems.

Chemistry – A European Journal published new progress about Chromophores. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maji, Biswajit; Vedachalan, Seenuvasan; Ge, Xin; Cai, Shuting; Liu, Xue-Wei published the artcile< N-Heterocyclic Carbene-Mediated Oxidative Esterification of Aldehydes: Ester Formation and Mechanistic Studies>, Quality Control of 112-63-0, the main research area is heterocyclic carbene oxidative esterification aldehyde ester mechanistic.

An unexpected N-heterocyclic carbene-catalyzed esterification of α,β-unsaturated aldehydes including aromatic aldehydes with reactive cinnamyl bromides in the presence of air oxygen or MnO2 as an oxidant is described. In the presence of oxygen, halogenated and electron-deficient aldehydes react smoothly to furnish esters in good yields. Great efforts were made on mechanistic studies to deduce a plausible mechanism, based on the exptl. results and isotopic labeling experiment

Journal of Organic Chemistry published new progress about Allylic halides Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent) (bromides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Dongyi; Yang, Fan; Shang, Wei; Zhao, Zhiming; Shen, Junyi; Cai, Hui published the artcile< Paeoniflorin-loaded pH-sensitive liposomes alleviate synovial inflammation by altering macrophage polarity via STAT signaling>, Computed Properties of 112-63-0, the main research area is paeoniflorin liposome synovial inflammation macrophage polarity STAT signaling; Liposome; Macrophages; Paeoniflorin; Rheumatoid arthritis; STAT signaling.

Macrophage polarization plays a prominent role in the pathogenesis of rheumatoid arthritis (RA) and could be regulated by natural extracts paeoniflorin (Pae) but with low bioavailability. In the present study, Pae-loaded liposomes (Pae-LS) with co-conjugation of folate and PEG were prepared for the improvement of therapeutic benefits. We evaluated biophys. characterizations of Pae-LS and macrophage uptake of liposomes, as well as gain insight into whether Pae-LS can improve synovial inflammation in CIA rats and how Pae-LS promoted RAW 264.7 macrophages phenotype switch. We found that Pae-LS showed phys. stability, sustained release, long circulation, pH-responsive properties, and higher uptake by active macrophages than free Pae. Furthermore, Pae-LS could repress STAT1 phosphorylation to reduce the levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and iNOS expression, as well as lead to a marked increase in anti-inflammatory cytokine (IL-10) and CD206 levels via elevated p-STAT6. In contrast to free Pae, Pae-LS treatment was more effective in alleviating synovial inflammation and hyperplasia in the ankle joint of CIA rats. Our study revealed Pae-LS could effectively suppress synovial inflammation of CIA rats by regulating macrophage polarization via STAT signaling and had the potential for RA treatment as liposome delivery carriers systems.

International Immunopharmacology published new progress about Carriers (drug delivery). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics