Tag: M.W=250-300

Wang, Jiao; Song, Yan; Hwarari, Delight T.; Liang, Xin-hao; Ding, Jian-hao; Yan, Meng-wen; Wu, Fu-an; Wang, Jun; Sheng, Sheng published the artcile< Fatty acid synthases and desaturases are essential for the biosynthesis of α-linolenic acid and metamorphosis in a major mulberry pest, Glyphodes pyloalis walker ( Lepidoptera: Pyralidae )>, SDS of cas: 112-63-0, the main research area is fatty acid synthase desaturase linolenic metamorphosis Glyphodes; Glyphodes pyloalis; desaturases; fatty acid synthases; mulberry trees; α-linolenic acid.

Alpha linolenic acid is an essential unsaturated fatty acid in organisms. However, there is a large gap between α-linolenic acid accumulation and its synthesis mechanism in insects. Fatty acid synthases (FASs) and desaturases (Desats) are vital enzymes required for the synthesis of unsaturated fatty acids. The pupae of Glyphodes pyloalis (Lepidoptera: Pyralidae), which is a destructive pest of mulberry trees, contain the highest level of α-linolenic acid compared to other life-history stages. To further explore the synthesis mechanism of α-linolenic acid in G. pyloalis pupae, author constructed a pupal transcriptome dataset and identified 106 genes related to fatty acid metabolism from it. Among these, two fatty acid synthases (GpylFAS) and five desaturases (GpylDesat) were identified. A qRT-PCR validation revealed that GpylFAS1 and GpylDesat1, 2, 3, 5 were expressed highest at pupal stages. Furthermore, the content of α-linolenic acid decreased significantly after silencing GpylFAS1 and GpylDesat5, resp. Besides, knocking down GpylFAS1 or GpylDesat5 resulted in more malformed pupae and adults, as well as lower emergence rates. Meanwhile, silencing GpylFAS1 or GpylDesat5 affected the expressions of the other GpylFASs and GpylDesats. The present results illustrate the pivotal function of FASs and Desats in α-linolenic acid biosynthesis and metamorphosis in insects. Authors research also broadens the sources of unsaturated fatty acids, especially for α-linolenic acid from insects, and provides novel insights for the management of mulberry insect pests from the perspective of utilization rather than control.

Pest Management Science published new progress about Acyl carrier proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Tong; Meng, Qian; Lin, Lan; Yang, Li; Zhao, Wenjiao; Sun, Dequn published the artcile< Self-assembled dehydropeptide nanocarrier as a delivery system for antitumor drug temozolomide>, Formula: C19H34O2, the main research area is glioblastoma cell antitumor dehydropeptide nanocarrier temozolomide; Dehydropeptide; Drug delivery; Nanocarrier; Self-assembly; Temozolomide.

Stable mol. conformation and intermol. forces are essential for peptide self-assembly. In this study, one novel dehydropeptide (DDP) monomer (Boc-(Z)Cα,b-ΔPhe-Gly-NHMe, DDP 1) was prepared; its conformation was confirmed to be more stable than the normal peptide 2 by NMR (NMR) and X-ray crystal diffraction experiments DDP 1 was self-assembled to one novel dehydropeptide nanomaterial (DDPN 1). Fourier transform IR (FTIR) spectroscopy results showed that hydrogen bonding was the main driving force of self-assembly. Electron microscope images displayed that the DDPN 1 fibers were longer and more stable than peptide 2 nanomaterials. Results of cell activity and enzyme hydrolysis proved that DDPN 1 had excellent biocompatibility and resistance to the enzymic hydrolysis of protease K. Therefore, the DDPN 1 was used to load the antitumor drug temozolomide (TMZ). Due to intermol. hydrogen bonds formed between TMZ and DDPN 1, TMZ-loaded DDPN 1 had a high percent entrapment efficiency (EE) of 83.72 ± 4.30% (n = 8) and a percent drug loading efficiency (LE) of 6.70 ± 0.34% (n = 8), and the half-life of TMZ-loaded DDPN 1 was 2.5-3 times longer than that of TMZ at pH 7. The in vitro cell viability results revealed that TMZ-loaded DDPN 1 exhibited higher antitumor activity (IC50 = 552.1 μM) against U118-MG than that of TMZ (IC50 = 1980.1 μM), possibly because that U118-MG cells uptook more TMZ from TMZ-loaded DDPN 1 than from free TMZ directly. This study is expected to inspire the design of biocompatible nanocarriers applied for anti-enzymic hydrolysis in drug delivery systems.

Bioorganic Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Horia, Raymond; Nguyen, Dan-Thien; Eng, Alex Yong Sheng; Seh, Zhi Wei published the artcile< Using a Chloride-Free Magnesium Battery Electrolyte to Form a Robust Anode-Electrolyte Nanointerface>, Quality Control of 112-63-0, the main research area is chloride magnesium battery electrolyte robust anode electrolyte nanointerface; chloride-free electrolyte; magnesium battery electrolyte; magnesium bis(hexamethyldisilazide); rechargeable magnesium battery; tetrabutylammonium borohydride.

Magnesium bis(hexamethyldisilazide) (Mg(HMDS)2)-based electrolytes are compelling candidates for rechargeable magnesium batteries due to their high compatibility with magnesium metal anode. However, the usual combination of Mg(HMDS)2 with chloride salts limits their practical application due to severe corrosion of cell components and low anodic stability. Herein, we report for the first time, a chloride-free Mg(HMDS)2-based electrolyte in 1,2-dimethoxyethane. By chem. controlling the moisture content using tetrabutylammonium borohydride as a moisture scavenger, the electrolyte demonstrates outstanding electrochem. performance in magnesium plating/stripping, with an average Coulombic efficiency of 98.3% over 150 cycles, and is noncorrosive to cell components. Surface anal. and depth profiling of the magnesium metal anode reveals the formation of a robust solid electrolyte interphase at the anode-electrolyte nanointerface, which allows magnesium plating/stripping to occur reversibly. The electrolyte also demonstrates good compatibility with a copper sulfide nanomaterial cathode, which exhibits a high initial discharge capacity of 261.5 mAh g-1.

Nano Letters published new progress about Abstraction reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nguyen, Xuan B.; Nakano, Yuji; Duggan, Nisharnthi M.; Scott, Lydia; Breugst, Martin; Lupton, David W. published the artcile< N-Heterocyclic Carbene Catalyzed (5+1) Annulations Exploiting a Vinyl Dianion Synthon Strategy>, HPLC of Formula: 112-63-0, the main research area is acrylate tethered divinyl ketone NHC catalyst diastereoselective cycloisomerization annulation; hexahydroindene tetralin stereoselective preparation vinyl dianion synthon; enonyl unsaturated ester NHC catalyst dimerization cycloisomerization annulation; cyclohexanone stereoselective preparation vinyl dianion synthon; N-heterocyclic carbenes; enantioselectivity; homoenolates; organocatalysis; synthons.

Direct polarity inversion of conjugate acceptors provides a valuable entry to homoenolates. N-heterocyclic carbene (NHC) catalyzed reactions, in which β-unsubstituted conjugate acceptors undergo homoenolate formation and C-C bond formation twice, have been developed. Specifically, the all-carbon (5+1) annulations give a range of mono- and bicyclic cyclohexanones (31 examples). In the first family of annulations, β-unsubstituted acrylates tethered to a divinyl ketone undergo cycloisomerization, providing hexahydroindenes and tetralins. In the second, partially untethered substrates undergo an intermol. (5+1) annulation involving dimerization followed by cycloisomerization. While enantioselectivity was not possible with the former, the latter proved viable, allowing cyclohexanones to be produced with high levels of enantiopurity (most >95:5 e.r.) and exclusive diastereoselectivity (>20:1 d.r.). Derivatizations and mechanistic studies are also reported.

Angewandte Chemie, International Edition published new progress about Cyclization catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Snider, Barry B.; Vo, Nha Huu; Foxman, Bruce M. published the artcile< Manganese(III)-based oxidative fragmentation-cyclization reactions of unsaturated cyclobutanols>, Synthetic Route of 112-63-0, the main research area is oxidative fragmentation cyclization unsaturated cyclobutanol; manganese acetate oxidation unsaturated cyclobutanol.

Allylic cyclobutanols, e.g., I, are oxidatively fragmented by Mn(OAc)3.2H2O in EtOH to give tertiary radicals. These tertiary radicals undergo both 6-endo-cyclization to the α,β-unsaturated ketone to afford α-keto radicals, and 5-exo-cyclization to provide β-keto cyclopentylmethyl radicals. The α-keto radicals produced by 6-endo-cyclization are reduced to ketones or dimerize. The β-keto radicals formed by 5-exo-cyclization are oxidized by Cu(OAc)2 to yield methylenecyclopentanones and rearrange to give 3-oxocyclohexyl radicals that are oxidized by Cu(OAc)2 to afford cyclohexenones. Thus, oxidation of I with 2 equiv Mn(OAc)3.2H2O and 1 equiv Cu(OAc)2 in EtOH for 1 h at reflux affords 22% methylenecyclopentanone II, 1.5% cyclohexenone III, and 44% tricyclic enone IV. Acetylenic cyclobutanols are oxidatively fragmented by Mn(OAc)3.2H2O in EtOH to provide tertiary radicals that cyclize to give α-keto vinyl radicals, which abstract a hydrogen atom to yield methylenecyclopentanones. Pentenylcyclobutanol V is oxidatively fragmented by Mn(OAc)3.2H2O to afford a tertiary radical which cyclizes to furnish cyclopentylmethyl radicals, which are oxidized by Cu(OAc)2 to methylenecyclopentane VI and an isomer.

Journal of Organic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kobayashi, Nagao published the artcile< Lid-type inclusion of pyrene-1,3,6,8-tetrasulfonate anion by β-cyclodextrin>, Reference of 112-63-0, the main research area is inclusion lid type pyrenetetrasulfonate cyclodextrin; pyrenetetrasulfonate inclusion beta cyclodextrin.

UV absorption and induced CD studies have indicated a new type of inclusion behavior (‘lid-type’) in cyclodextrin-arene 1:1 host-guest complexes exemplified by the pyrene-1,3,6,8-tetrasulfonate-β-cyclodextrin complex.

Journal of the Chemical Society, Chemical Communications published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kisel, V. M.; Potikha, L. M.; Kovtunenko, V. A. published the artcile< Condensed isoquinolines. Part 9. Alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is isoquinoquinazolinone benzyl halide alkylation; spiroisoquinoquinazolinindane preparation; diazadibenzopleiadene preparation.

The alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one proceeds at N(6) or C(7) depending on the type of alkylating agent and reaction conditions. C(7)-alkylation occurs in the presence of base. The secondary alkylation of the 7-alkyl derivatives occurs at the same position under these conditions. Depending on the conditions, the reaction with ortho-xylylene dibromide leads to spiro[5H-isoquino-[2,3-a]quinazolin-7(12H),2′-indane]-5-one or 11-oxo-4b,5,10,16-tetrahydro-11H-10a-azonia-15b-azadibenzo[a,e]pleiadene bromide.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Qiangjun; Yin, Changlong; Li, Yongwei; Yang, Zhe; Tian, Zongying published the artcile< Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism>, Product Details of C19H34O2, the main research area is peimine paeoniflorin hepatoprotectant CYP3A4 Pgp pharmacokinetic interaction; CYP3A4; Drug–drug interaction; P-gp; transport.

Peimine and paeoniflorin can be combined for the treatment of cough in paediatrics. The interaction during the co-administration could dramatically affect the bioavailability of drugs. The interaction between peimine and paeoniflorin was investigated in this study. The pharmacokinetics of paeoniflorin (20 mg/kg) with or without the coadministration of peimine (5 mg/kg for 10 days before paeoniflorin) was orally investigated in Sprague-Dawley rats (n = 6). The group without the peimine was set as the control group. The metabolic stability of paeoniflorin was studied in rat liver with microsomes. The effect of peimine on the absorption of paeoniflorin was investigated with Caco-2 cell monolayers. The Cmax (244.98 ± 10.95 vs. 139.18 ± 15.14μg/L) and AUC(0-t) (3295.92 ± 263.02 vs. 139.18 ± 15.14 h·μg/L) of paeoniflorin was increased by peimine. The t1/2 was prolonged from 5.33 ± 1.65 to 14.21 ± 4.97 h and the clearance was decreased from 15.43 ± 1.75 to 4.12 ± 0.57 L/h/kg. Consistently, peimine increased the metabolic stability of paeoniflorin with rat liver microsomes with the increased t1/2 (56.78 ± 2.62 vs. 26.33 ± 3.15 min) and the decreased intrinsic clearance (24.42 ± 3.78 vs. 52.64 ± 4.47μL/min/mg protein). Moreover, the transportation of paeoniflorin was also inhibited by peimine as the efflux ratio decreased from 3.06 to 1.63. Peimine increased the systemic exposure of paeoniflorin through inhibiting the activity of CYP3A4 and P-gp. These results provide a reference for further in vivo studies in a broader population.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Combination chemotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shao, Yuewen; Ba, Shuaijie; Sun, Kai; Gao, Guoming; Fan, Mengjiao; Wang, Junzhe; Fan, Huailin; Zhang, Lijun; Hu, Xun published the artcile< Selective production of valerolactone or 1,4-pentanediol from levulinic acid/esters over Co-based catalyst and importance of synergy of hydrogenation sites and acidic sites>, Quality Control of 112-63-0, the main research area is magnesium cobalt catalyst ethyl levulinate hydrogenation valerolactone pentanediol.

γ-Valerolactone (GVL) or 1,4-pentanediol (1,4-PDO) are the value-added chems., selectivities of which from conversion of levulinic acid/ester depend on balanced distribution of metallic sites and other active sites of the catalysts. In this study, Co-based catalysts with various precursors of LDH structures were synthesized to investigate the roles of hydrogenation, acidic and basic sites in the formation of GVL and 1,4-PDO from Et levulinate (EL). The results indicated that Al in Co-Mg-Al or Co-Al created acidic sites and facilitated cobalt dispersion by developing porous structures and strong interaction with Co species. Kinetic study indicated that the conversion of GVL controlled the formation rate of 1,4-PDO from EL. The superior catalytic activity and recyclability were observed over Co-Mg-Al and Co-Al catalysts, with the selectivity of both of GVL and 1,4-PDO reaching 98%, which was equivalent or superior to noble-metal based catalysts. Bronsted acidic sites in catalyst could facilitate the lactonization of Et 4-hydroxyvalerate to GVL and the ring-opening of GVL to 1,4-PDO, by cooperating with hydrogenation sites. Lewis acidic sites improved the adsorption of substrates and reaction intermediates, accelerating the ring-opening of GVL. The synergy between acidic sites together with hydrogenation sites was the key for achieving the excellent catalytic performance.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Hydrogenation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xiaolong; Jin, Yujuan; Wang, Bohua; Tian, Huafeng; Weng, Yunxuan published the artcile< Reinforcing and Toughening Modification of PPC/PBS Blends Compatibilized with Epoxy Terminated Hyperbranched Polymers>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is epoxy terminated hyperbranched polyester PPC PBS blend preparation property.

Polypropylene carbonate (PPC)/polybutylene succinate (PBS) blends were prepared by melt-blending with terminal epoxy-based hyperbranched polymers (EHBP) as modifier. The thermal properties, mech. properties, rheol. properties and fracture morphol. were characterized by dynamic thermomech. analyzer, thermogravimetric analyzer, electronic universal testing machine, rotating rheometer and scanning electron microscope. Upon addition of EHBP, the difference between the glass transition temperature of PPC and PBS became smaller, indicating the compatibility of PPC and PBS were improved by EHBP. Furthermore, by adding 0.5phr of EHBP, the impact strength increased from 9.55 to 17.31 kJ/m2, the elongation at break increased from 136.29 to 204.39%, and the tensile strength increased from 10.00 to 16.84 MPa. The fracture surface of the PPC/PBS blends became rough with the increase of EHBP, even with large filamentous structures and tiny holes, which further demonstrated that EHBP acted as an excellent toughening effect on PPC/PBS. Gel content anal. confirmed that both phys. and chem. micro-crosslinking were formed after incorporation of EHBP.

Journal of Polymers and the Environment published new progress about Branched polymer chains. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics