Tag: M.W=250-300

Alsubaiei, Sana Razhan M.; Alfawaz, Hanan A.; Amina, Musarat; Al Musayeib, Nawal M.; El-Ansary, Afaf; Ahamad, Syed Rizwan; Noman, Omar M.; Maini, Jaber A. published the artcile< Comparative chemical profiling and biological potential of essential oils of petal, choke, and heart parts of Cynara scolymus L. head>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cynara essential oil petal choke heart part antibacterial antioxidant.

The essential oil and macroelemental composition of different parts of flower bud (petal, choke, and heart) of Cynara scolymus L. were explored and compared using gas chromatog. mass spectrometry (GC-MS) and inductively coupled plasma mass spectrometry (ICP-MS). Overall, 62 organic components were detected in the flower bud based on mass spectra characteristics and retention indexes. The essential oil extracted from the petals, choke, and bud showed the presence of thirty-one, twenty-one, and twenty-one compounds, resp., with linoleic acid and palmitic acid as the major components. 21 components were identified in the oil of the petals, comprising 94.45% of the total oil, in which linoleic acid Me ester, palmitic acid Me ester, octadecanoic acid Me ester, O-α-d-glucopyranoside, and heptyl oct-3-yl ester were the major constituents. Twenty-one compounds, representing 89.13% of the total oil, were detected in the choke oil. Linoleic acid Me ester, palmitic acid Me ester, and 2-methyl-1-hexadecanol were the main components. However, the edible heart oil contains twenty compounds, comprising 86.84% of the total oil. Cyclopropane butanoic acid, linoleic acid, Me ester, and palmitic acid were the major constituents. The anal. executed by ICP-MS revealed the presence of significant amounts of various inorganic elements in all the three samples. The extracted essential oils were tested for antibacterial, antioxidant, and anticancer activities. The results showed that the oil extracted from the petals of C. scolymus flower bud displayed the highest antibacterial, antioxidant, anti-inflammatory, and anticancer effects, as compared to choke and heart oils.

Journal of Chemistry published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xingkuan; Fang, Xinqiang; Chi, Yonggui Robin published the artcile< cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity>, Reference of 112-63-0, the main research area is enal imine cyclization heterocyclic carbene; cyclic ketone stereoselective preparation; heterocyclic carbene stereoselective cyclization catalyst.

The first successful generation of cis-homoenolate equivalent from cis-enals under the catalysis of N-heterocyclic carbenes (NHCs) has been realized. The cis-homoenolate intermediates undergo effective reactions with α,β-unsaturated imines to afford chiral cyclic ketone products, e.g., I and II. Compared to the trans-enals, cis-enals show different stereoselectivities and new reactivity patterns.

Chemical Science published new progress about Cyclic ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

dos Santos Pedroso-Fidelis, Giulia; de Melo, Maria Eduarda; Possato, Jonathann Correa; Fernandes, Bruna Barros; De Pieri, Ellen; Cercena, Rodrigo; Dal-Bo, Alexandre Goncalves; Feuser, Paulo Emilio; Machado-de-Avila, Ricardo Andrez published the artcile< Temozolomide associated to gold nanoparticles promoted a synergic effect and apoptosis when exposed to melanoma cells>, Application In Synthesis of 112-63-0, the main research area is temozolomide gold nanoparticle synergic effect apoptosis melanoma.

Temozolomide (TMZ) is prescribed primarily because of its known ability to cross the blood-brain barrier, being a potentially chemotherapic drug for cancer treatment. However, it has dose-limiting hemotoxicity and rapid hydrolysis, which limits its anti-tumor efficacy. On the other hand, recent studies have shown that gold nanoparticles (GNPs) with their biocompatibility and cytotoxic potential in tumor cells can be combined with chemotherapy leading to an improvement in the existing treatment. Thus, this work aimed to evaluate the cytotoxic effects of TMZ associated with GNPs (T-GNPs) on B16F10 cells. Different GNPs were successfully synthesized, and the results showed that there was an electrostatic interaction between TMZ and GNPs, not changing their physicochem. properties. TMZ associated with GNPs exposed on B16F10 cells presented a cytotoxic effect even more pronounced than free TMZ. In addition, different T-GNPs did not induced cytotoxic effect on non-tumor cells (NIH3T3 and red blood cells). A synergism between TMZ and GNPs was observed, inducing B16F10 cell death by apoptosis.

Journal of Nanoparticle Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Guoming; Lv, Mingxuan; Shao, Yuewen; Gao, Guanggang; Zhao, Hui; Zhang, Shu; Wang, Yi; Duan, Ran; Chen, Qifeng; Hu, Xun published the artcile< Crystal facet-dependent activity of h-WO3 for selective conversion of furfuryl alcohol to ethyl levulinate>, Computed Properties of 112-63-0, the main research area is crystal facet WO3 furfuryl alc ethyl levulinate.

The use of WO3 as an acid catalyst has received extensive attention in recent years. However, the correlation between the catalytic activity and the predominantly exposed surface with varied acidic sites needs further understanding. Herein, the effects of the Bronsted and Lewis acid sites of different crystal facets of WO3 on the catalytic conversion of furfuryl alc. (FA) to Et levulinate (EL) in ethanol were investigated in detail. A yield of EL up to 93.3% over WO3 with the (110) facet exposed was achieved at 170°C, while FA was mainly converted to polymers over (001) faceted nanosheets and nanobelts with exposed (002) and (100) facets. This was attributed to the different distribution of the acidic sites on different exposed crystal facets. The (110) faceted WO3 possessed abundant and strong Bronsted acid sites, which favored the conversion of FA to EL, while the (100) faceted WO3 with stronger Lewis acid sites and weaker Bronsted acid sites mainly led to the formation of polymers. In addition, the (110) faceted WO3 showed excellent sustainability in comparison with the (100) faceted counterpart.

Physical Chemistry Chemical Physics published new progress about Crystal morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Veteska, Marek; Pospisil, Miroslav; Melanova, Klara; Benes, Ludvik; Zima, Vitezslav published the artcile< Structure analysis of hydrotalcite intercalated with pyrenetetrasulfonate; experiments and molecular modelling>, Product Details of C19H34O2, the main research area is pyrenetetrasulfonate hydrotalcite intercalated structure.

The structure of pyrenetetrasulfonate intercalated with hydrotalcite, having the formula [Zn0.68Al0.32(OH)2][(C16H6O12S4)0.08·xH2O], was proposed based on mol. simulations combined with exptl. data (X-ray powder diffraction, thermogravimetry). Calculations were done for samples kept at various relative humidities (0%, 84%, 98%). The appropriate models were selected from comparison of calculated and measured diffraction patterns. Modeling revealed the arrangement of pyrenetetrasulfonate anions, and the positions and the amount of water mols. in the interlayer space of the host structure. The results confirmed a large variability in the arrangement of the guest species. In the sample without water mols. (0% RH), pyrenetetrasulfonate anions formed a layer at the center of the interlayer distance. For the sample kept at 84% RH, the anions formed two layers at the thirds of the interlayer. For the sample kept at 98% RH, the anions became tilted with respect to the layered double hydroxides (LDH) layers and are less organized. Water mols. were arranged in three distinct planes: one in the middle and two at the quarters of interlayer distance. The number of water mols. obtained by the modeling basically agrees with the water content as measured by thermogravimetry.

Journal of Molecular Modeling published new progress about Intercalation compounds Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Napolitano, Gaetana; Fasciolo, Gianluca; Magnacca, Nunzia; Goglia, Fernando; Lombardi, Assunta; Venditti, Paola published the artcile< Oxidative damage and mitochondrial functionality in hearts from KO UCP3 mice housed at thermoneutrality>, Synthetic Route of 112-63-0, the main research area is UCP oxidative damage heart mitochondria thermoneutrality phosphorylation; Calnexin; EIF2α; GRP78 BIP; Heart; Hsp 60; Mitochondrial complexes; Oxidative stress; Oxygen consumption; Thermoneutrality; UCP3.

The antioxidant role of mitochondrial uncoupling protein 3 (UCP3) is controversial. This work aimed to investigate the effects of UCP3 on the heart of mice housed at thermoneutral temperature, an exptl. condition that avoids the effects of thermoregulation on mitochondrial activity and redox homeostasis, preventing the alterations related to these processes from confusing the results caused by the lack of UCP3. WT and KO UCP3 mice were acclimatized at 30°C for 4 wk and hearts were used to evaluate metabolic capacity and redox state. Tissue and mitochondrial respiration, the activities of the mitochondrial complexes, and the protein expression of mitochondrial complexes markers furnished information on mitochondrial functionality. The levels of lipid and protein oxidative damage markers, the activity of antioxidant enzymes, the reactive oxygen species levels, and the susceptibility to in vitro Fe-ascorbate-induced oxidative stress furnished information on redox state. UCP3 ablation reduced tissue and mitochondrial respiratory capacities, not affecting the mitochondrial content. In KO UCP3 mice, the mitochondrial complexes activities were lower than in WT without changes in their content. These effects were accompanied by an increase in the level of oxidative stress markers, ROS content, and in vitro susceptibility to oxidative stress, notwithstanding that the activities of antioxidant enzymes were not affected by UCP3 ablation. Such modifications are also associated with enhanced activation/phosphorylation of EIF2α, a marker of integrated stress response and endoplasmic reticulum stress (GRP778 BIP). The lack of UCP3 makes the heart more prone to oxidative insult by reducing oxygen consumption and increasing ROS. Our results demonstrate that UCP3 helps the cell to preserve mitochondrial function by mitigating oxidative stress.

Journal of Physiology and Biochemistry published new progress about Ablation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Jingqing; Feng, Xinyu; Dai, Xinyu; Peng, Gang; Guo, Zhirui; Liu, Zhengxia; Wang, Min; Guo, Wenjun; Zhang, Peng; Li, Yuntao published the artcile< TMZ magnetic temperature-sensitive liposomes-mediated magnetothermal chemotherapy induces pyroptosis in glioblastoma>, Application of C19H34O2, the main research area is temozolomide liposome pyroptosis glioblastoma magnetic temperature magnetothermal chemotherapy; Glioblastoma; Pyroptosis; Temozolomide; Temperature-sensitive liposomes.

Glioblastoma (GBM) is the most fatal and common type of primary malignant tumors in central nervous system. Chemotherapy drugs are difficult to reach the encephalic region effectively due to blood-brain barrier (BBB), but functional nanoparticle drug carriers can help to solve the problem. Herein, we developed a controllable drug carrier called temozolomide magnetic temperature-sensitive liposomes (TMZ/Fe-TSL) to investigate its feasibility and mol. mechanisms on GBM. Our research found TMZ/Fe-TSL exposed to alternating magnetic field (AMF) could induce significantly GBM cell death and promote the production of ROS. It also showed that the expression of NLRP3, CASP1 and N-GSDMD was upregulated compared to the control group, while the expression of CASP3 showed a reverse change. The results indicated that TMZ/Fe-TSL exposed to the AMF was capable of inducing GBM cells death. And the way and mechanisms of cell death may involve in ROS and pyroptosis, but not apoptosis.

Nanomedicine (New York, NY, United States) published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Linwei; Liu, Wei; Zhao, Liang-Liang; Zhang, Zengyu; Yan, Xiaoyu published the artcile< Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is deuteriodifluoromethyl arene preparation; difluoromethylarene deuteration.

The budding deuteriodifluoromethyl group (CF2D) is a potentially significant functional group in medicinal chem. Herein, authors investigated t-BuOK-catalyzed H/D exchange reaction of difluoromethylarenes in DMSO-d6 solution The method provides excellent deuterium incorporation at the difluoromethyl group. Meanwhile, the effect of a trace amount of D2O in DMSO-d6 solution on the deuteration reaction was also investigated.

Journal of Organic Chemistry published new progress about Aralkyl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (deuterio). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kalu-Uka, Godwin Mong; Kumar, Sandeep; Kalu-Uka, Abraham Chinedu; Vikram, Shruti; Okorafor, Okore Okay; Kigozi, Moses; Ihekweme, Gina Odochi; Onwualu, Azikiwe Peter published the artcile< Prospects for biodiesel production from Macrotermes nigeriensis: Process optimization and characterization of biodiesel properties>, Category: esters-buliding-blocks, the main research area is biodiesel production macrotermes nigeriensis process optimization.

The use of insects as feedstock for biodiesel production has sparsely been studied and very little is known of the fuel properties and engine performance of insect biodiesel. In this study, biodiesel was initially produced from an insect feedstock M. nigeriensis, then its physicochem. properties were characterized. The biodiesel was produced via the three-step process of lipid extraction, acid esterification (1 wt% H2SO4) and alk. transesterification (0.5 wt% NaOH). The optimal reaction time, temperature and methanol-oil molar ratio for the acid-esterification process resulted in a free fatty acid conversion of 96.58%. The volumetric yield, fatty acid Me esters content and physicochem. properties of M. nigeriensis biodiesel were analyzed using various anal. equipment such as the GC-HRMS, and 1H NMR. Anal. of the production process showed that 86.54 vol% biodiesel was obtained from M. nigeriensis oil. Further anal. showed that the biodiesel contained 96.72% fatty acid Me esters. The composition of the fatty acid Me esters was found to be 48% saturated esters and 52% monosatd. esters. The biodiesel d. (841 kg m-3), viscosity (2.32 mm2 s-1), flash point (125°C), pour point (-15°C), cetane number (51.4), higher heating value (41.8 MJ kg-1) and acid value (0.44 mgKOH.g-1) were in compliance with the ASTM D6751 standards One of the important results to highlight is the remarkably low viscosity of the biodiesel, which is attributed to the high concentration of monounsaturated fatty acid Me esters. Lower viscosity of fuel helps to improve fuel atomization and combustion efficiency, and hence lower emissions. The absence of polyunsaturated fatty acid esters also indicates that the biodiesel will have good oxidation stability.

Biomass and Bioenergy published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gwak, Joo-Han; Awala, Samuel Imisi; Nguyen, Ngoc-Loi; Yu, Woon-Jong; Yang, Hae-Young; von Bergen, Martin; Jehmlich, Nico; Kits, K. Dimitri; Loy, Alexander; Dunfield, Peter F.; Dahl, Christiane; Hyun, Jung-Ho; Rhee, Sung-Keun published the artcile< Sulfur and methane oxidation by a single microorganism>, Application In Synthesis of 112-63-0, the main research area is Methylovirgula growth methanotrophy thiotrophy sulfur methane oxidation; facultative methanotrophy; mixotrophy; thiotrophy; wetland.

Natural and anthropogenic wetlands are major sources of the atm. greenhouse gas methane. Methane emissions from wetlands are mitigated by methanotrophic bacteria at the oxic-anoxic interface, a zone of intense redox cycling of carbon, sulfur, and nitrogen compounds Here, we report on the isolation of an aerobic methanotrophic bacterium, ′Methylovirgula thiovorans′ strain HY1, which possesses metabolic capabilities never before found in any methanotroph. Most notably, strain HY1 is the first bacterium shown to aerobically oxidize both methane and reduced sulfur compounds for growth. Genomic and proteomic analyses showed that soluble methane monooxygenase and XoxF-type alc. dehydrogenases are responsible for methane and methanol oxidation, resp. Various pathways for respiratory sulfur oxidation were present, including the Sox-rDsr pathway and the S4I system. Strain HY1 employed the Calvin-Benson-Bassham cycle for CO2 fixation during chemolithoautotrophic growth on reduced sulfur compounds Proteomic and microrespirometry analyses showed that the metabolic pathways for methane and thiosulfate oxidation were induced in the presence of the resp. substrates. Methane and thiosulfate could therefore be independently or simultaneously oxidized. The discovery of this versatile bacterium demonstrates that methanotrophy and thiotrophy are compatible in a single microorganism and underpins the intimate interactions of methane and sulfur cycles in oxic-anoxic interface environments.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics