Tag: M.W=250-300

Wang, Xuerui; Yin, Zequn; Cao, Peichang; Zheng, Shihong; Chen, Yuanli; Yu, Maoyun; Liao, Chenzhong; Zhang, Zhongyuan; Duan, Yajun; Han, Jihong; Zhang, Shuang; Yang, Xiaoxiao published the artcile< NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines>, COA of Formula: C19H34O2, the main research area is NaoXinTong capsule ameliorate memory deficit regulating inflammatory cytokine; Alzheimer’s disease; Apoptosis; Cognitive impairment; NaoXinTong Capsule; Neuroinflammation.

Alzheimer’ s disease (AD) is the most common neurodegenerative disease in aging population. Neuroinflammation, hyperphosphorylated Tau (p-Tau) and the imbalance between production and clearance of β-amyloid peptide (Aβ) are the major causes for AD development. NaoXinTong Capsule (NXT), a traditional Chinese medicine, is wildly used for treatment of cardiovascular and cerebrovascular diseases. Hence, we used the double transgenic mice expressing chimeric human amyloid precursor protein and mutant human presenilin 1 (APP/PS1) and HT-22 cells to determine the neuroprotective effects of NXT in AD development and the involved mechanisms. The 3-mo-old APP/PS1 mice were randomly divided into 3 groups and received following treatment: Control group, mice were fed normal chow; NXT groups, mice were fed normal chow containing NXT at a normal and a high dose, resp. While the age-matched C57BL/6J mice fed normal chow were used as the normal control. The NXT treatment was lasted for 5 mo. We found that NXT treatment improved spatial memory impairment and cognitive decline in APP/PS1 mice by decreasing p-Tau levels and Aβ accumulation in the brain. Mechanistically, we observed that NXT inhibited neuron atrophy and apoptosis by downregulating inflammatory cytokines, interleukin 1β (IL-1β), IL-6 and tumor necrosis factor α (TNF-α), and inflammation mediators, nuclear factor κB (NF-κB) and toll-like receptor 4 (TLR4) in the brain. Consistently, NXT blocked L-glutamic acid-induced reactive oxygen species production, inflammation and apoptosis in HT-22 cells partially by inhibiting TLR4/NF-κB/IL-1β signaling pathway. Our study demonstrates that NXT ameliorates AD by reducing p-Tau, Aβ accumulation, inflammation and neuron apoptosis via regulation of TLR4-mediated inflammatory system. It also suggests the potential application of NXT for AD treatment.

Biomedicine & Pharmacotherapy published new progress about Achyranthes bidentata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lokman NolHakim, Muhammad Amirrul Hakim; Shohaimi, Norshahidatul Akmar Mohd; Mokhtar, Wan Nur Aini Wan; Ibrahim, Mohd Lokman; Abdullah, Rose Fadzilah published the artcile< Immobilization of Potassium-Based Heterogeneous Catalyst over Alumina Beads and Powder Support in the Transesterification of Waste Cooking Oil>, Formula: C19H34O2, the main research area is immobilization potassium heterogeneous catalyst alumina transesterification waste cooking oil.

In this work, the beads and powder potassium hydroxide (KOH) and potassium carbonate (K2CO3) supported on alumina oxide (Al2O3) were successfully prepared via incipient wetness impregnation technique. Herein, the perforated hydrophilic materials (PHM) made from low-d. polyethylene (LDPE) was used as the catalyst reactor bed. The prepared catalysts were investigated using TGA, XRD, BET, SEM-EDX, TPD, FTIR while spent catalysts were analyzed using XRF and ICP-AES to study its deactivation mechanism. The catalytic performance of beads and powder KOH/Al2O3 and K2CO3/Al2O3 catalysts were evaluated via transesterification of waste cooking oil (WCO) to biodiesel. It was found that the optimum conditions for transesterification reaction were 1:12 of oil-to-methanol molar ratio and 5 weight% of catalyst at 65°C. As a result, the mesoporous size of beads KOH/Al2O3 and K2CO3/Al2O3 catalysts yielded 86.8% and 77.3% at 2 h’ reaction time of fatty acids Me ester (FAME), resp. It was revealed that the utilization of PHM for beads K2CO3/Al2O3 increase the reusability of the catalyst up to 7 cycles. Furthermore, the FAME produced was confirmed by the gas chromatog.-mass spectroscopic technique. From this finding, beads KOH/Al2O3 and K2CO3/Al2O3 catalysts showed a promising performance to convert WCO to FAME or known as biodiesel.

Catalysts published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Huifang; Lu, Qun; Liu, Rui published the artcile< Widely targeted metabolomics analysis reveals the effect of fermentation on the chemical composition of bee pollen>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolomics analysis fermentation chem composition bee pollen; Bee pollen; Differential metabolites analysis; ESI-Q-TRAP-MS/MS; Fermentation; Phenolamides.

Microbial fermentation can break the bee pollen wall. However, the global profiling of bee pollen metabolites under fermentation remains unclear. This study aims to comprehensively elucidate the changes in the composition of bee pollen after microbial fermentation Ultra-performance liquid chromatog.-electron spray ionization-mass spectrometry (UPLC-ESI-MS) based on widely targeted metabolomics anal. was used to compare the chem. composition of unfermented bee pollen (UBP) and fermented bee pollen (FBP). Among the 890 metabolites detected, a total of 668 differential metabolites (classified into 17 categories) were identified between UBP and FBP. Fermentation significantly increased the contents of primary metabolites such as 74 amino acids and derivatives, 42 polyunsaturated fatty acids and 66 organic acids, as well as some secondary metabolites such as 38 phenolic acids, 80 flavone aglycons and 22 phenolamides. The results indicate that fermentation is a promising strategy to improve the nutritional value of bee pollen.

Food Chemistry published new progress about Aglycons Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yan, Bin; Han, Dehui; Boissiere, Olivier; Ayotte, Patrick; Zhao, Yue published the artcile< Manipulation of block copolymer vesicles using CO2: dissociation or ""breathing"">, Reference of 112-63-0, the main research area is diblock copolymer vesicle carbon dioxide dissociation swelling.

We demonstrate a general way to prepare CO2-responsive block copolymer (BCP) vesicles by employing poly(N,N’-diethylaminoethylmethacrylate) (PDEAEMA) as the hydrophobic block. Two amphiphilic BCPs containing either poly(N,N’-dimethylacrylamide) (PDMA) or poly(ethylene oxide) (PEO) as the hydrophilic block and either PDEAEMA or P(DEAEMA-co-CMA) (photo-crosslinkable PDEAEMA containing a number of coumarin side groups) as the hydrophobic block were synthesized and used to prepare vesicles in aqueous solutions These vesicles exhibit very good responsiveness to gas stimuli. On the one hand, upon CO2 bubbling, PDMA-b-PDEAEMA vesicles display morphol. changes that range from expansion to complete dissociation, which is thought to be determined by the protonation degree of the DEAEMA unit in the vesicle membrane. On the other hand, PEO-b-P(DEAEMA-co-CMA) vesicles whose membrane is crosslinked through coumarin dimerization can undergo reversible expansion and contraction under alternating passage of CO2 and argon (Ar) in solution; the extent of such vesicle “”breathing”” can be controlled by adjusting the degree of dimerization of coumarin within the vesicle membrane. Finally, pyrene-1,3,6,8-tetrasulfonic acid tetrasodium salt was used as a model drug, allowing its CO2-controllable release from these two vesicle types to be investigated.

Soft Matter published new progress about Dimerization (of coumarin-containing block). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pazy, Yael; Raboy, Bilha; Matto, Meirav; Bayer, Edward A.; Wilchek, Meir; Livnah, Oded published the artcile< Structure-based rational design of streptavidin mutants with pseudo-catalytic activity>, Application of C19H34O2, the main research area is design streptavidin hydrolysis catalyst.

Introduction of enzymic activity into proteins or other types of polymers by rational design is a major objective in the life sciences. To date, relatively low levels of enzymic activity could be introduced into antibodies by using transition-state analogs of haptens. In the present study, the authors identify the structural elements that contribute to the observed hydrolytic activity in egg white avidin, which promote the cleavage of active biotin esters (notably biotinyl p-nitrophenyl ester). The latter elements were then incorporated into bacterial streptavidin via genetic engineering. The streptavidin mol. was thus converted from a protector to an enhancer of hydrolysis of biotin esters. The conversion was accomplished by the combined replacement of a “”lid-like loop”” (L3,4) and a leucine-to-arginine point mutation in streptavidin. Interestingly, neither of these elements play a direct role in the hydrolytic reaction. The latter features were thus shown to be responsible for enhanced substrate hydrolysis. This work indicates that structural and noncatalytic elements of a protein can be modified to promote the induced fit of a substrate for subsequent interaction with either a catalytic residue or water mols. This approach complements the conventional design of active sites that involves direct modifications of catalytic residues.

Journal of Biological Chemistry published new progress about Avidins Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bi, Jingjing; Tan, Qiang; Wu, Hao; Liu, Qingfeng; Zhang, Guisheng published the artcile< Rhodium-Catalyzed Denitrogenative Trans-annulation of N-Sulfonyl-1,2,3-triazoles with Glycals Giving Pyrroline-Fused N-Glycosides>, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is crystal structure aminoglycoside stereoselective cyclization sulfonyl triazole glycal; stereoselective cyclization aminoglycoside preparation rhodium catalyzed sulfonyl triazole glycal; aminoglycoside preparation rhodium catalyzed annulation sulfonyl triazole pyrroline glycoside.

Described here is a selective synthesis of 2,3-dihydropyrrole-fused N-glycosides through rhodium-catalyzed denitrogenation trans-annulation of N-sulfonyl-1,2,3-triazoles with glycals. A series of pyrroline-fused N-glycosides are afforded in moderate to excellent yields with exclusive regioselectivity and stereoselectivity. Functional application of such a resultant product by oxidative addition and epoxidation is also explored. Notably, the treatment of a pyrroline-fused N-glycoside (3a) with TMSOTf efficiently leads to an interesting unexpected C-nucleoside I via a TMSOTf-inducing ring opening/acetyl migration/ring closing reaction sequence.

Organic Letters published new progress about Aminoglycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bohne, C.; Abuin, E. B.; Scaiano, J. C. published the artcile< Triplet-triplet annihilation of pyrene derivatives as mobility probes in sodium 1,4-bis(2-ethylhexyl)sulfosuccinate/water/isooctane reversed micelles>, Electric Literature of 112-63-0, the main research area is micelle Aerosol OT pyrene fluorescence probe; triplet annihilation pyrene probe AOT micelle; reverse micelle interaction pyrene probe mobility.

Triplet-triplet annihilation (TTA) of pyrene probe mols. was used as a probe to study mobility of AOT reversed micelles in the microsecond time domain. Inter- and intramicellar processes can be differentiated by using different probe-to-micelle concentration ratios. The TTA for micelles containing only 1 pyrene mol. occurs with a rate constant of ∼1/3 the value for the diffusion controlled limit and it is ascribed to an intermicellar process in which the collision of triplets does not require the contact of water cores of the 2 micelles. The delayed fluorescence excimer-to-monomer (E/M) intensity ratio resulting from TTA is much lower than the one observed in homogeneous solution, indicating that the microenvironment for triplet-triplet encounter is more rigid when compared to solutions The TTA from micelles containing >1 probe (multiple occupancy) show initially a higher E/M intensity ratio for the delayed emission than the one observed for intermicellar processes, indicating that when 2 pyrenes are in the same micelle a more favorable geometry for excimer formation exists in the triplet-triplet encounter complex. A decrease with time of the E/M intensity ratio is observed under multiple occupancy conditions.

Langmuir published new progress about Diffusion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Hichul; El-Khoury, Victoria; Schulte, Nadine; Zhan, Tianzuo; Betge, Johannes; Cousin, Loic; Felli, Emanuele; Pessaux, Patrick; Ogier, Arnaud; Opitz, Oliver; Ku, Bosung; Ebert, Matthias P.; Kwon, Yong-Jun published the artcile< Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid>, Product Details of C19H34O2, the main research area is human metastatic lung atypical carcinoid spheroid bevacizumab capecitabine; Personalized functional profiling; antiangiogenic therapy; drug screening; lung carcinoid; neuroendocrine tumors; personalized medicine; pharmacotyping; precision medicine; spheroids.

Lung carcinoids are neuroendocrine tumors representing 1 to 2% of lung cancers. This study outlines the case of a patient with a metastatic lung atypical carcinoid who presented with a pleural effusion and progression of liver metastases after developing resistance to conventional treatments. Personalized functional profiling (PFP), i.e. drug screening, was performed in ex-vivo spheroids obtained from the patient liver metastasis to identify potential therapeutic options. The drug screening results revealed cediranib, an antiangiogenic drug, as a hit drug for this patient, from a library of 66 Food and Drug Administration (FDA)-approved and investigational drugs. Based on the PFP results and the reported evidence of clin. efficacy of bevacizumab and capecitabine combination in gastro-intestinal neuroendocrine tumors, this combination was given to the patient. Four months later, the pleural effusion and pleura carcinosis regressed and the liver metastasis did not progress. The patient experienced 2 years of a stable disease under the PFP-guided personalized treatment.

Cancer Biology & Therapy published new progress about Antiangiogenic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schultz, Terry W.; Hewitt, Mark; Netzeva, Tatiana I.; Cronin, Mark T. D. published the artcile< Assessing applicability domains of toxicological QSARs: definition, confidence in predicted values, and the role of mechanisms of action>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is modeling predictive toxicity QSAR Tetrahymena aromatic compound.

There are many issues relating to the use of Quant. Structure – Activity Relationships (QSARs) to make predictions for regulatory purposes. Among those issues, characterization of models and the development of suitable tools to determine applicability domains rank as the more important. With regard to aquatic toxicol., QSARs for acute effects (e.g., IGC50-1) often take the form of a hydrophobic [i.e., Logarithm of the 1-Octanol/Water Partition Coefficient (log P)]-electrophilic [e.g., Maximum Acceptor Superdelocalizability (Amax)]-dependent, regression-based model. In this study, the applicability domain of a model for the toxicity of aromatic compounds to Tetrahymena pyriformis [log (IGC50-1) = 0.545(0.015) log P + 16.2(0.62) Amax-5.91(0.20); n = 384, r2 (adj) = 0.859, r2(pred) = 0.856, s = 0.275, F = 1163, Pr > F = 0.0001] was assessed. The structural and physicochem. domains of the model were characterized using two test sets of toxicity data (one prescreened to be within the descriptor space and structural domain of the training set and the other to be outside the structural domain of the training set). For test set compounds inside the domain of the model, there was no relationship between absolute residue values for predictions and hydrophobicity; however, there was a linear relationship between absolute residue values and electrophilicity. It was concluded that predictivity in the region of the domain associated with higher electrophilicity, greater potency, and derivatives containing both halo- and nitro-groups is poorer than elsewhere in the domain, and therefore less confidence should be given to those values. Compounds in this region of the domain of the model are associated with the soft-, or pro-electrophilic mechanisms of toxic action. For the second test set, i.e., derivatives outside the structural domain, an examination of absolute residue values revealed that the observed toxicity is typically in excess of that predicted, especially for compounds in the structural space(s) of well-known electrophilic mechanisms of reactive toxicity. Caution is therefore urged in using statistical approaches to account for, and apply confidence to predictions from the applicability domain. An appreciation of the mechanism of toxicity appears to be critical to the determination of the most likely applicability domain.

QSAR & Combinatorial Science published new progress about Aquatic toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Han-Ming; Jia, Wen-Qiang; Liang, Zhi-Qin; Ye, Song published the artcile< N-Heterocyclic carbene-catalyzed [3+3] cyclocondensation of bromoenals and ketimines: highly enantioselective synthesis of dihydropyridinones>, Reference of 112-63-0, the main research area is benzoisothiazolopyridinone pyridinone dihydro enantioselective synthesis; enal bromo enantioselective cyclocondensation ketimine triazolium salt catalyst.

The N-heterocyclic carbene-catalyzed enantioselective [3+3] cyclocondensation of bromoenals and cyclic/acyclic ketimines gives the corresponding chiral dihydropyridinones I (R1 = n-Pr, Ph, 3-ClC6H4, 4-MeC6H4, etc.; R2 = H, n-Pr, Ph) and II (R1 = Ph, 4-ClC6H4, 2-MeOC6H4, etc.; R2 = H, Me; R3 = Ph, 2-ClC6H4, thiophen-2-yl, etc.) in high yields with high enantioselectivity.

Asian Journal of Organic Chemistry published new progress about Aldehydes, halo Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics