Tag: M.W=250-300

He, Yuan; Lou, Jiang; Wu, Kaikai; Wang, Hongmei; Yu, Zhengkun published the artcile< Copper-Catalyzed Radical C-C Bond Cleavage and [4+1] Annulation Cascade of Cycloketone Oxime Esters with Enaminothiones>, Application In Synthesis of 112-63-0, the main research area is thiophene cyanoalkyl amino derivative synthesis; ring cleavage annulation cascade cycloketone oxime ester enamino thione; copper catalyzed radical carbon carbon bond cleavage annulation cascade.

Carbon-carbon bond formation is among the most important reactions in organic synthesis. Reconstruction of a carbon-carbon bond through ring-opening C-C bond cleavage of a strained carbocycle usually occurs via a thermodynamically preferable pathway. However, carbon-carbon bond formation through thermodynamically less favorable C-C bond cleavage has seldom been documented. Herein, we disclose an unusual C-C bond cleavage of cycloketone oxime esters for [4+1] annulation. Under anaerobic copper(I) catalysis, cycloketone oxime esters underwent regioselective, thermodynamically less favorable radical C-C bond cleavage followed by annulation with enaminothiones; i.e., α-thioxo ketene N,S-acetals efficiently affording 2-cyanoalkyl-aminothiophene derivatives Cyclobutanone, -pentanone, -hexanone, and -heptanone oxime esters could act as the effective C1 building blocks in the annulation reaction. An iminyl radical mechanism is proposed for the rare C-C bond cleavage/[4+1] annulation cascade.

Journal of Organic Chemistry published new progress about [4+1] Cycloaddition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Young, Nicholas; Hobbs, Mark; Rahnama, Fahimeh; Shi, Jinyang; Briggs, Simon published the artcile< An observational study of high- and low-abundance anti-retroviral resistance mutations among treatment-naive people living with HIV in New Zealand between 2012 and 2017>, Category: esters-buliding-blocks, the main research area is DRM HIV infection; Australasia; HIV infection; anti-HIV agent; anti-retroviral agent; high-throughput nucleotide sequencing; integrase inhibitor.

HIV resistance genotyping detects drug resistance mutations (DRMs) in ≥20% of circulating virus within an infected individual (high-abundance DRMs). Deep sequencing also detects DRMs in smaller viral subpopulations (low-abundance DRMs), although these are of uncertain importance. In this retrospective anal. of 292 treatment-naive patients, high-abundance DRMs were present in 30/292 (10%) patients, but only one (0.3%) had resistance to first-line anti-retrovirals. Low-abundance DRMs were present in 36/247 (15%) patients, but none who received anti-retrovirals for which these were present had virol. failure. These findings demonstrate that starting first-line therapy in treatment-naive patients need not be delayed while awaiting resistance testing.

Internal Medicine Journal published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Butin, Noemie; Berges, Cecilia; Portais, Jean-Charles; Bellvert, Floriant published the artcile< An optimization method for untargeted MS-based isotopic tracing investigations of metabolism>, Category: esters-buliding-blocks, the main research area is isotopic iquid chromatog mass spectrometry metabolism computer software; Isotope labelling experiments; LC/MS; Parameter optimization; Untargeted analysis.

Stable isotope tracer studies are increasingly applied to explore metabolism from the detailed anal. of tracer incorporation into metabolites. Untargeted LC/MS approaches have recently emerged and provide potent methods for expanding the dimension and complexity of the metabolic networks that can be investigated. A number of software tools have been developed to process the highly complex MS data collected in such studies; however, a method to optimize the extraction of valuable isotopic data is lacking. To develop and validate a method to optimize automated data processing for untargeted MS-based isotopic tracing investigations of metabolism The method is based on the application of a suitable reference material to rationally perform parameter optimization throughout the complete data processing workflow. It was applied in the context of 13C-labeling experiments and with two different software, namely geoRge and X13CMS. It was illustrated with the study of a E. coli mutant impaired for central metabolism The optimization methodol. provided significant gain in the number and quality of extracted isotopic data, independently of the software considered. Pascal triangle samples are well suited for such purpose since they allow both the identification of anal. issues and optimization of data processing at the same time. The proposed method maximizes the biol. value of untargeted MS-based isotopic tracing investigations by revealing the full metabolic information that is encoded in the labeling patterns of metabolites.

Metabolomics published new progress about Computer program (geoRge, X13CMS). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boyles, David C.; Curran, Timothy T.; Greene, Derek; Macikenas, Dainius; Parlett, Roger V. published the artcile< Novel, base-promoted reaction of N-alkoxycarbonyl-O-(halo-substituted 4-nitrophenyl)hydroxylamines>, Synthetic Route of 112-63-0, the main research area is alkoxycarbonyl hydroxyaniline preparation; nitrophenyl alkoxycarbonyl hydroxylamine base reaction.

The base-promoted reactions of N-alkoxycarbonyl-O-(nitrophenyl)hydroxylamines which contain a halogen attached to the aromatic ring were described. The reaction is promoted under mild conditions (NaHCO3 or K2CO3) and provides N-alkoxycarbonyl-N-hydroxyaniline. In a crossover experiment, some scrambling was observed which suggests that the reaction is inter- and intramol. in nature. N-Boc-(2,6-dichloro-4-nitrophenyl)hydroxylamine was also found to N-Boc aminate Bn2NH to form the protected hydrazine in modest yield. For example, treatment of (2,6-dichloro-4-nitrophenoxy)carbamic acid 1,1-dimethylethyl ester with sodium hydrogen carbonate gave an N-hydroxyaniline derivative, i.e., (2,6-dichloro-4-nitrophenyl)hydroxycarbamic acid 1,1-dimethylethyl ester (I). Further reaction of I with N-(phenylmethyl)benzenemethanamine gave 2,2-bis(phenylmethyl)hydrazinecarboxylic acid 1,1-dimethylethyl ester.

Tetrahedron Letters published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ucar, Mualla Balaban; Ucar, Gunes published the artcile< Characterization of methanol extracts from Quercus hartwissiana wood and bark>, Formula: C19H34O2, the main research area is Quercus wood bark.

The MeOH extracts of wood and bark from Quercus hartwissiana have been investigated by GC-MS after derivatization, as well as by classical spectroscopic methods. The results for the free compounds revealed that ellagic acid, catechin, gallic acid, quercitol, and also long chain fatty acids, sugars, and sitosterol were the essential compounds in wood and bark, most of them being present in differing amounts The results for the free compounds revealed that ellagic acid, catechin, gallic acid, quercitol, and also long chain fatty acids, sugars, and sitosterol were the essential compounds in wood and bark, most of them being present in differing amounts Amounting to 1/4th to 1/3rd of the free compounds, the bark had the highest catechin content. While the content of sugars, such as fructose and glucose, increased in sapwood and bark extracts remarkably, the amounts of these compounds decreased in extracts of heartwood. The profile of the bound compounds contained sugars (i.e., arabinose, xylose, and, above all, glucose), ellagic and gallic acids, quercitols, and inositols. Compared with the composition of free compounds, the hydrolyzed extracts showed relatively higher amounts of sugars, especially glucose, gallic acid and quercitol.

Chemistry of Natural Compounds published new progress about Bark. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Labbe, Gerrit; Sannen, Ingrid; Dehaen, Wim published the artcile< Synthesis of fused dihydro-1,2,4-thiadiazolimines from cyano-substituted azides and acyl isothiocyanates>, Reference of 112-63-0, the main research area is fused hydrothiadiazolimine; cyano substituted azide cycloaddition acyl isothiocyanate; mechanism cycloaddition acyl isothiocyanate.

Organic azides, bearing a nitrile function at the γ- or δ-position, react with acyl isothiocyanates to give fused dihydro-1,2,4-thiadiazolimines. Representative examples are given. In the case of 2-NCC6H4CH2N3 and BzNCS, the formation of I is accompanied by two side products, II and III. Mechanisms are presented to explain the formation of the products.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagleniec, Damian; Wilczek, Marcin; Romanski, Jan published the artcile< Tripodal, squaramide-based ion pair receptor for effective extraction of sulfate salt>, Computed Properties of 112-63-0, the main research area is tripodal squaramide based ion pair receptor preparation; ion pair receptors; squaramide; sulfate extraction; tripodal receptors.

Combining three features-the high affinity of squaramides toward anions, cooperation in ion pair binding and preorganization of the binding domains in the tripodal platform-led to the effective receptor I [R1R2 = O(CH2CH2O)5]. The lack of at least one of these key elements caused a lower affinity toward ion pairs. Receptor I [R1R2 = O(CH2CH2O)5] was found to form an intramol. network in wet chloroform, which changed into inorganic-organic associates after contact with ions and allowed salts to be extracted from an aqueous to an organic phase. The disparity in the binding mode of I [R1R2 = O(CH2CH2O)5] with sulfates and with other monovalent anions led to the selective extraction of extremely hydrated sulfate anions in the presence of more lipophilic salts, thus overcoming the Hofmeister series.

Molecules published new progress about Crown ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Desch, Karl Heinz published the artcile< Fungicide finishing of synthetic fabrics>, Application In Synthesis of 112-63-0, the main research area is Antibac MF fungicide synthetic fiber; benzimidazolecarbamic acid methyl ester fungicide; acrylic fiber fungicide.

The fungicidal finishing of acrylic awnings with Antibac MF (I) [5805-53-8], a benzimidazolecarbamic acid Me ester, is described. The oral toxicity of I is low and I controls a wide variety of fungi. Fungicidal compositions containing I are durable and weather-resistant.

Deutscher Faerber-Kalender published new progress about Acrylic fibers Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gloaguen, Celine; Voisin-Chiret, Anne Sophie; Sopkova-de Oliveira Santos, Jana; Fogha, Jade; Gautier, Fabien; De Giorgi, Marcella; Burzicki, Gregory; Perato, Serge; Petigny-Lechartier, Cecile; Simonin-Le Jeune, Karin; Brotin, Emilie; Goux, Didier; N’Diaye, Monique; Lambert, Bernard; Louis, Marie-Helene; Ligat, Laetitia; Lopez, Frederic; Juin, Philippe; Bureau, Ronan; Rault, Sylvain; Poulain, Laurent published the artcile< First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies>, Related Products of 112-63-0, the main research area is oligopyridine preparation Mcl1 ovary cancer sensitization BclxL siRNA.

Apoptosis control defects such as the deregulation of Bcl-2 family member expression are frequently involved in chemoresistance. In ovarian carcinoma, we previously demonstrated that Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. In this context, we designed and synthesized oligopyridines potentially targeting the Mcl-1 hydrophobic pocket, evaluated their capacity to inhibit Mcl-1 in live cells, and implemented a functional screening assay to evaluate their ability to sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. We established structure-activity relationships and focused our attention on MR29072, named Pyridoclax. Surface plasmon resonance assay demonstrated that pyridoclax directly binds to Mcl-1. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fu, Yu; Van Oosterwijck, Chantal; Vandendriessche, Annelies; Kowalczuk-Bleja, Agnieszka; Zhang, Xi; Dworak, Andrzej; Dehaen, Wim; Smet, Mario published the artcile< Hyperbranched Poly(arylene oxindole)s with a Degree of Branching of 100% for the Construction of Nanocontainers by Orthogonal Modification>, Computed Properties of 112-63-0, the main research area is polycondensation hyperbranched polyarylene oxindole synthesis functionalization modification; functionalized hyperbranched polyarylene oxindole hydrophobic hydrophilic dye encapsulation.

Hyperbranched polymers with a degree of branching of 100% were prepared and converted into different types of unimol. micelle-like structures. The polymers were obtained by acid catalyzed polycondensation of an isatin-based AB2 monomer, prepared without using toxic organometal reagents or extensive chromatog. purification The molar masses as determined by SEC relative to linear PS standards were strongly underestimated as compared to absolute data determined by MALLS. This could be accounted for by the densely branched structure and the formation of intramol. hydrogen bonds. The hyperbranched scaffolds were converted into unimol. micelle-like structures in two ways. In a first approach, long alkyl chains were introduced at the terminal units and carboxyl groups at the dendritic units. The resulting macromols. were soluble in apolar solvents and able to bind polar dyes. Alternatively, the terminal units could be converted into quaternary ammonium salts, leading to water-soluble macromols. binding apolar BODIPY dyes.

Macromolecules (Washington, DC, United States) published new progress about Branched polymers, hyperbranched dendritic polymers Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation) (aromatic polyether-polyketone-, oxindole-containing). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics