Tag: M.W=250-300

Fernandez-Alvarez, Ana J.; Thomas, Maria Gabriela; Pascual, Malena L.; Habif, Martin; Pimentel, Jeronimo; Corbat, Agustin A.; Pessoa, Joao P.; La Spina, Pablo E.; Boscaglia, Lara; Plessis, Anne; Carmo-Fonseca, Maria; Grecco, Hernan E.; Casado, Marta; Boccaccio, Graciela L. published the artcile< Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondrial function>, Category: esters-buliding-blocks, the main research area is smaug membrane less organelle AMPK mTOR affect mitochondrial function; AMPK; Membrane-less organelles; Metformin; Mitochondria; Processing bodies; Smaug; UQCRC1.

Smaug is a conserved translational regulator that binds numerous mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs form cytosolic membrane-less organelles (MLOs) in several organisms and cell types. We have performed single-mol. fluorescence in situ hybridization (FISH) assays that revealed that SDHB and UQCRC1 mRNAs associate with Smaug1 bodies in U2OS cells. Loss of function of Smaug1 and Smaug2 (also known as SAMD4A and SAMD4B, resp.) affected both mitochondrial respiration and morphol. of the mitochondrial network. Phenotype rescue by Smaug1 transfection depends on the presence of its RNA-binding domain. Moreover, we identified specific Smaug1 domains involved in MLO formation, and found that impaired Smaug1 MLO condensation correlates with mitochondrial defects. Mitochondrial complex I inhibition upon exposure to rotenone, but not strong mitochondrial uncoupling upon exposure to CCCP, rapidly induced the dissolution of Smaug1 MLOs. Metformin and rapamycin elicited similar effects, which were blocked by pharmacol. inhibition of AMP-activated protein kinase (AMPK). Finally, we found that Smaug1 MLO dissolution weakens the interaction with target mRNAs, thus enabling their release. We propose that mitochondrial respiration and the AMPK-mTOR balance controls the condensation and dissolution of Smaug1 MLOs, thus regulating nuclear mRNAs that encode key mitochondrial proteins.

Journal of Cell Science published new progress about Cell morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Murphy, Nicie Conley; Compton, Robert N.; Pagni, Richard M. published the artcile< Effect of Chiral and Achiral Perturbations on the Crystallization of 4,4'-Dimethylchalcone from Ethyl Acetate>, HPLC of Formula: 112-63-0, the main research area is beta radiolysis polarized light effect crystallization methylchalcone; optical activity achiral mol manipulation synthetic photochem method; chiral achiral perturbation effect crystallization methylchalcone Et acetate.

4,4′-Dimethylchalcone is an achiral mol. that crystallizes from Et acetate in the chiral space group P212121. The authors report the effect of β-radiolysis and circularly and linearly polarized light on the crystallization of 4,4′-dimethylchalcone from Et acetate. Exposure of the evaporating solution to energetic β-particles from a Sr-90 source generated a random distribution of (+) and (-) crystals. Irradiation of the evaporating solution by intense right- or left-circularly polarized light (1064 nm) from a Nd:YAG laser afforded results that were comparable to the results of the β-radiolysis experiments Linearly polarized light (LPL), on the other hand, had a profound influence on the distribution of crystals, yielding in this instance a large bifurcation of (+) and (-) crystals. A likely cause of this outcome may be due to the optical Kerr effect. The anisotropic polarizability of the chalcone mol. causes a preferential alignment in the direction of the E field when using LPL. This mol. alignment results in a sizable enantiomeric excess. Circularly polarized light does not produce the alignment of the chalcone and thus has no effect on the asym. induction. This alignment offers an opportunity for chirally autocatalytic secondary nucleation to occur, which is then able to amplify small initial asymmetry in the number of (+) and (-) crystals. The chirality of the chalcone crystals was determined via their reaction in water with pyridinium tribromide to yield the chiral compound erythro-1,2-dibromo-4,4′-dimethylchalcone, thus allowing the chirality of the crystal to be propagated to mol. chirality.

Crystal Growth & Design published new progress about Chirality. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yan; Kong, Xiao; Yang, Xiaoyin; Zhu, Lixian; Liang, Rongrong; Luo, Xin; Zhang, Liang; Hopkins, David L.; Mao, Yanwei; Zhang, Yimin published the artcile< Effect of energy metabolism and proteolysis on the toughness of intermediate ultimate pH beef>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is longissimus lumborum beef energy metabolism toughness pH; Beef; Intermediate pH(u); Targeted metabolomics; Tenderness.

The objective of this study was to identify the tenderness and energy metabolism attributes in normal ultimate pH (pHu, 5.4-5.8, NpHu), intermediate pHu (5.8-6.2, IpHu) and high pHu (> 6.2, HpHu) Longissimus lumborum from beef. During 21 days of aging, the IpHu group exhibited a higher Warner-Bratzler shear force, lower activity of μ-calpain, and a higher content of heat shock protein 27 and greater protein oxidation Metabolomics anal. revealed that 24 differential metabolites were detected during the first 24 h postmortem between pH groups, and these were mainly the products of glycolysis, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. The relatively higher ATP content in the IpHu group could delay tenderization by being used as key substrate for protein phosphorylation. In addition, the relationship between guanosine triphosphate, diphosphate and monophosphate, and beef tenderness was worthy to be verified in the future study.

Meat Science published new progress about Beef. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagashima, Yuki; Takita, Ryo; Yoshida, Kengo; Hirano, Keiichi; Uchiyama, Masanobu published the artcile< Design, Generation, and Synthetic Application of Borylzincate: Borylation of Aryl Halides and Borylzincation of Benzynes/Terminal Alkyne>, Electric Literature of 112-63-0, the main research area is borylzincate formation mol structure calculation; borylation aryl halide borylzincation benzyne terminal alkyne; zinc catalyzed borylation aryl halide.

Borylzincate was generated in situ from dialkylzinc, diboron, and metal alkoxide. Model DFT calculations showed that although the formation of boryl-zinc-ate is kinetically favorable, it is thermodynamically unfavorable. Therefore, we designed a successive reaction sequence that would provide a compensating energy gain. This enabled Zn-catalyzed borylation of aryl halides and boryl-zincation of benzynes and terminal alkyne from diborons without the need for any cocatalyst.

Journal of the American Chemical Society published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manjunathan, Pandian; Shanbhag, Dhanush Y.; Vinu, Ajayan; Shanbhag, Ganapati V. published the artcile< Recognizing soft templates as stimulators in multivariate modulation of tin phosphate and its application in catalysis for alkyl levulinate synthesis>, Electric Literature of 112-63-0, the main research area is tin phosphate catalysis alkyl levulinate.

Catalyst synthesis is an art where an inefficient material can be remarkably converted into a highly active and selective catalyst by adopting a suitable synthetic strategy to tune its properties during synthesis. The underlying principle of the strategy presented here is the integration of tailoring the structural and chem. behavior of tin phosphates with tuned catalytic active centers directed by employing different structure directing agents (SDAs) and the attempt to understand this in detail. It is demonstrated how soft templates can be effectively used for their so far unknown utilization of tuning the active sites in phosphate containing catalysts. We found that, by using an appropriate synthesis strategy, it is possible to tune and control explicitly both the catalyst morphol. and the nature of active sites at the same time. The 31P MAS NMR study revealed that employing SDAs in the synthesis strongly influenced the nature and amount of phosphate species in addition to porosity. The resultant different nanostructured SnPO catalysts were investigated for one-pot synthesis of alkyl levulinates via alcoholysis of furfuryl alc. Among the catalysts, SnPO-P123 exhibited greater Bu levulinate yield via alcoholysis of furfuryl alc. with n-butanol and the study was extended to synthesize different alkyl levulinates. Importantly, the active sites in the SnPO-P123 catalyst responsible for the reaction were elucidated by a study using 2,6-lutidine as a basic probe mol. This study therefore provides an avenue for rational design and construction of highly efficient and robust nanostructured SnPO catalysts to produce alkyl levulinates selectively.

Catalysis Science & Technology published new progress about Alcoholysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Navarre, Laure; Martinez, Remi; Genet, Jean-Pierre; Darses, Sylvain published the artcile< Access to enantioenriched α-amino esters via rhodium-catalyzed 1,4-addition/enantioselective protonation>, HPLC of Formula: 112-63-0, the main research area is amino acid ester asym preparation; aryltrifluoroborate amino acrylate conjugate addition protonation rhodium.

Conjugate addition of potassium trifluoro(organo)borates to dehydroalanine derivatives, mediated by a chiral rhodium catalyst and in situ enantioselective protonation, afforded straightforward access to a variety of protected α-amino esters with high yields and enantiomeric excesses up to 95%. Among the tested chiral ligands and proton sources, Binap, in combination with guaiacol (2-methoxyphenol), an inexpensive and nontoxic phenol, afforded the highest asym. inductions. Organostannanes have also shown to participate in this reaction. By a fine-tuning of the ester moiety, and using Difluorophos as chiral ligand, increased levels of enantioselectivity, generally close to 95%, were achieved. Deuterium labeling experiments revealed, and DFT calculation supported, an unusual mechanism involving a hydride transfer from the amido substituent to the α carbon explaining the high levels of enantioselectivity attained in controlling this α chiral center.

Journal of the American Chemical Society published new progress about Amino acid esters Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Xing Hong; Yang, Qiang; Hui, Qun; Wang, Min published the artcile< First-principles calculations of molecular adsorption on the surface of two-dimensional BCOH>, HPLC of Formula: 112-63-0, the main research area is benzenetriboronic acid mol adsorption electronic property.

A two-dimensional structure by the dehydration reaction of 1,3,5-benzenetriboronic acid (shorted as BCOH) is investigated. BCOH is dynamically and thermally stable. It is an indirect semiconductor possessing a band gap of 3.83 eV. The adsorption behavior of CO, CO2, H2, H2O, NH3, NO and NO2 on BCOH are mainly investigated. The results show that most of the gas mols. prefer to adsorb at the interval sites (I1 or I3). The adsorption energies of NO and NO2 are lower than the other mols., revealing that NO and NO2 have better adsorption affinity on BCOH. Except NO and NO2, the band gaps are slightly changed with the mol. adsorption. When NO or NO2 is adsorbed on BCOH, the band gap becomes zero, revealing that a semiconductor-to-metal transition occurs and the conductivity is improved a lot. Thus, BCOH may provide promising potentials for the detection of nitrogen oxides (NO or NO2).

Chemical Physics published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tang, Xuyuan; Li, Xiuyi; Zhang, Dongyan; Han, Wei published the artcile< Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2>, Reference of 347174-05-4, the main research area is ferroptosis astragaloside IV Sirt1 Nrf2 mitochondrial damage; AS-IV; DR; RPE; astragaloside-IV; diabetic retinopathy; retinal pigment epithelial.

Astragaloside-IV (AS-IV) (C41H68O14) is a high-purity natural product extracted from Astragalus, which has demonstrated biol. activities. However, the effect of AS-IV on retinal pigment epithelial (RPE) cells in diabetic retinopathy (DR) remains unclear. In this study, high glucose (HG) was shown to promote ARPE-19 RPE cell death, increase the contents of reactive oxygen species (ROS) and oxidized glutathione (GSSG), and enhance lipid peroxidation d. of mitochondrial membrane. In contrast, AS-IV decreased glutathione (GSH) content, mitochondria size and ridge. Addition of iron death inhibitor Ferrostatin-1 (Fer-1) to RPE cells decreased cell dead rate, thus indicating that HG-induced mitochondrial damage occurred due to ferroptosis. AS-IV alleviated HG-induced RPE cell damage. Furthermore, HG decreased levels of silent information regulator 1 (Sirt1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the nucleus of RPE cells; AS-IV could alleviate these effects and increased expression of glutathione peroxidase 4 (GPX4), glutamate cysteine ligase (GCLM) and glutamate cysteine ligase catalytic subunit (GCLC), which are Nrf2 downstream genes. Mechanistically, AS-IV was shown to alleviate the effects of HG by increasing mir-138-5p expression in RPE cells and promoting expression of Sirt1 and Nrf2 in the nucleus. Transfection of mir-138-5p agonist inhibited the regulatory effects of AS-IV on Sirt1 and Nrf2, accompanied by decreased GPX4, GCLM and GCLC levels, and restoration of ferroptosis-related changes. Collectively, HG increased ferroptosis rate in RPE cells. In addition, AS-IV inhibited miR-138-5p expression, subsequently increasing Sirt1/Nrf2 activity and cellular antioxidant capacity to alleviate ferroptosis, resulting decreased cell death, which potentially inhibits the DR pathol. process.

Bioengineered published new progress about Antioxidants. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Reference of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Figueroa-Diaz, Andrea Belen; Carlos-Hernandez, Salvador; Diaz-Jimenez, Lourdes published the artcile< Crude glycerol/guishe based catalysts for biodiesel production: conforming a guishe biorefinery>, Reference of 112-63-0, the main research area is glycerol guishe catalyst biodiesel production.

Biodiesel production imposes some challenges, such as the crude glycerol management and cleaning requirements of biodiesel produced by homogeneous transesterification. Heterogeneous catalysts based on residual biomass have been proposed to tackle these challenges; in addition, biomass revalorization is fundamental for biorefineries development. In this research, two organic wastes (crude glycerol and guise) are used to synthesize carbonaceous catalysts. Four catalysts, with different crude glycerol/guishe proportions, were prepared by pyrolysis at 800 and 900°C, followed by a chem. functionalization with H2SO4. SEM (SEM), Fourier transform IR spectroscopy (FT-IR), and thermal gravimetric anal. (TGA) were used to characterize the catalysts. The performance of the catalysts was evaluated in a soybean oil transesterification reaction. The crude glycerol/guishe based catalysts lead to similar biodiesel yields than the obtained with a conventional homogeneous catalyst (CH3NaO). The catalyst identified as BS-25-8 (a mixture of 25% guishe and 75% crude glycerol, pyrolyzed at 800°C and sulfonated), in a proportion of 1 wt%, achieved the highest fatty acid Me esters (FAME) yield (99%) in the transesterification reaction, even surpassing the performance of the CH3NaO (yield of 93%).

Catalysts published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bakeev, K. N.; MacKnight, William J. published the artcile< Fluorescent molecular probe technique for assessing the interaction between sulfonated polystyrene and poly(ethylacrylate-co-4-vinylpyridine) ionomers in tetrahydrofuran>, Application of C19H34O2, the main research area is sulfonated polystyrene interaction copolymer THF; ethyl acrylate vinylpyridine copolymer interaction; ionomer interaction THF fluorescent probe.

The interaction between sulfonated polystyrene (I) and Et acrylate-4-vinylpyridine copolymer (II) ionomers was studied over a wide concentration range in THF using a fluorescent mol. probe (1,3,6,8-pyrenetetrasulfonic acid tetra-Na salt) technique. The acid-base interaction between the sulfonate groups of I and the pyridine groups of II and the miscibility of these ionomers are evident for 4.5 and 7.8 mol% pyridine group content in II, and are not detectable for II with 1.7 mol% pyridine groups. Concentration-dependent excimer fluorescence from I-II mixtures indicates the occurrence of polar interactions as a result of proton transfer from the styrenesulfonic acid groups to the pyridine groups. These interactions are clearly evident at high concentrations and are controlled by the high-mol.-weight II component.

Macromolecules published new progress about Chemical chains. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics