Tag: M.W=250-300

Zhao, Guozhong; Li, Jingjing; Zheng, Fuping; Yao, Yunping published the artcile< The fermentation properties and microbial diversity of soy sauce fermented by germinated soybean>, Related Products of 112-63-0, the main research area is soy sauce fermentation germinated soybean microbial diversity; antioxidant activity; flavor components; gamma-aminobutyric acid; germinated soybean sauce; microbial diversity.

The quality of com. soy sauce is variable at present. Tech. work is needed to improve the quality and flavor of soy sauce, especially in China. Material is a factor for influencing soy sauce characters in fermentation Germinated soybean sauce (fermented by germinated soybean) had a gamma aminobutyric acid (GABA) concentration of 6.83μg mL-1, whereas a control (a soy sauce fermented by soybean) had a GABA concentration of less than 2.42μg mL-1. Germinated soybean sauce also contained significantly higher levels of isoflavones, total polyphenol, and amino acid nitrogen than the control soy sauce. Microbial diversity results showed that Bacillus was the dominant bacteria in germinated soy sauce compared with the control. Aldehydes, alcs., esters, and phenols were the major flavor components of germinated soybean sauce. A soy sauce with high levels of GABA, isoflavones, and total polyphenol was developed using germinated soybean. Stenotrophomonas, the typical pathogen found in the control, was reduced dramatically and replaced by Bacillus during fermentation with the germinated soybean. The germinated soybean sauce exhibited a better aroma and taste than the control. Soy sauce fermented by soybeans that germinated for 48 h exhibited greater advantages than soy sauce that germinated for 24 and 72 h. 2020 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Rong-Hua; Liu, Chen-Guang; Zhang, Ze; Xing, Mei-Qi; Han, Yu-Mo; Zhou, Tao; Wang, Xin-Yue; Wang, Chen published the artcile< Metabolomics analysis of Semen Cuscutae protection of kidney deficient model rats using ultra high-performance liquid chromatography-quadrupole time-of-flight Mass Spectrometry>, Application In Synthesis of 112-63-0, the main research area is metabolomics semen cuscutae liquid chromatog mass spectrometry; Kidney yang deficiency syndrome; Metabolomics; Semen Cuscutae; UPLC-QTOF/MS.

The traditional Chinese medicine syndrome “”Kidney yang deficiency”” is a kind of chronic kidney disease. With the development of society, the incidence of chronic kidney disease is increasing year by year, which also brings great economic pressure to people. Semen Cuscutae is an important traditional Chinese medicine to tonify liver and kidney, mainly used to tonify deficiency of liver and kidney, spleen and kidney deficiency and diarrhea. Although there are a lot of research at the mol. and cellular level to study the Semen Cuscutae on the treatment of Kidney yang deficiency syndrome, but there’s no comprehensive research complete with metabolomics method from plasma, feces and urine metabolites aspects. The purpose of this study is to find the potential differential biomarkers of the Kidney yang deficiency model and blank group rats in plasma, urine and feces, and to investigate the mechanism of Semen Cuscutae in the treatment of Kidney yang deficiency syndrome. In this study, ultra high-performance liquid chromatog.-quadrupole time-of-flight Mass Spectrometry (UPLC-QTOF/MS) was used to identify potential biomarkers. Through the anal. of metabolic profiles of plasma, urine, and feces, as well as multivariate statistical anal. and pathway anal., the therapeutic mechanism of Semen Cuscutae for Kidney yang deficiency syndrome was described. The results showed that there were 69 differential metabolites in plasma, 93 differential metabolites in feces and 62 differential metabolites in urine, and the changes of the levels of these biomarkers showed that Semen Cuscutae had a good therapeutic effect on Kidney yang deficiency syndrome. Through the anal. of the channel, the metabolite changes mainly affected the steroid hormone biosynthesis, arachidonic acid metabolism, primary bile acid biosynthesis, sheath lipid metabolism and biosynthesis of tyrosine, phenylalanine metabolism, retinol metabolism,taurine and hypotaurine metabolism, lysine degradation and vitamin B6 metabolism, tryptophan metabolism, terpenoid backbone biosynthesis and starch and sucrose metabolism Therefore, the results suggested that Semen Cuscutae could exert a good therapeutic effect by reversing the levels of some biomarkers.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Shaojian; Zhu, Jianhua; Wu, Bencheng; Ma, Rui; Chang, Yuechun; Li, Xiaohui; Wei, Yuqing; Yu, Liujie published the artcile< Green synthesis of ester base oil with high viscosity - Part I: Catalyst preparation, characterization, evaluation, and mechanism analysis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is green ester base oil lubricant viscosity catalyst preparation.

High viscosity ester base oil, as an eco-friendly lubricant base oil with high performance, can significantly reduce the friction, wear, and energy consumption of large machinery. However, there is less research on the preparation of heterogeneous catalysts for synthesis of high viscosity ester oil. In this work, Sn/Zr mixed oxide catalysts were prepared for the green synthesis of ester base oil with high viscosity. This approach gets rid of addnl. template, surfactant, organic solvent, sulfur, nitrogen, phosphorus, and halogen, thereby avoiding the potential environmental pollution. A superior powd. catalyst MO-Sn8Zr-9.0-160-18 was developed with optimized Sn/Zr molar ratio, pH, hydrothermal temperature, and hydrothermal time of 8:1, 9.0, 160°, and 18 h, resp. Results of catalyst characterization indicated that the developed catalysts were mesoporous materials with hydrophobic properties, allowing for free diffusion of macromols., adsorption of reactants, and desorption of water. Addnl., the sp. surface area, pore volume, pore diameter, and surface hydrophobicity of catalyst were enhanced by doping Zr, so the catalysts with higher [Sn/Zr]ICP/[Sn/Zr]XPS exhibited better catalytic activity. Preformed catalyst was prepared by simple mech. mixing method to achieve better catalyst separation The sp. surface area, acid amount, and acid strength of catalyst were indeed improved significantly after catalyst molding. By programmed heating, the preformed catalyst achieved a maximum carboxyl conversion of 97.2%. Moreover, spent catalyst could be reactivated via solvent washing, drying, calcination, and hydrogen reduction, exhibiting good reusability.

Fuel published new progress about Base oils. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gidik, Betul published the artcile< Antioxidant, Antimicrobial Activities and Fatty Acid Compositions of Wild Berberis spp. by Different Techniques Combined with Chemometrics (PCA and HCA)>, Product Details of C19H34O2, the main research area is berberis medicinal plant ferric reducing antioxidant phenolic flavonoid content; HCA; PCA; bioactivity; industrial crops; medicinal plants; wild fruits.

Interest in medicinal plants and fruits has increased in recent years due to people beginning to consume natural foods. This study aims to investigate the total phenolic flavonoid content, antioxidant activity, condensed tannin content, oil content, and fatty acid compositions of five local breeds of Berberis spp. from Bayburt, Turkey, and their antioxidant and antimicrobial activities. The fatty acid composition of samples was performed with gas chromatog.-mass spectrometry (GC-MS), and the total fatty acid content of samples was between 6.12% and 8.60%. The main fatty acids in Berberis spp. samples were α-linolenic acid (32.85-37.88%) and linoleic acid (30.98-34.28%) followed by oleic acid (12.85-19.56%). Two antioxidant assays produced similar results, demonstrating that extracts of wild B. vulgaris L. had the highest ferric reducing antioxidant power (FRAP) (621.02μmol FeSO4.7H2O/g) and 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) (0.10 SC50 mg/mL) values. According to principal component anal. (PCA), four components were determined In addition, two main groups were determined according to hierarchical cluster anal. (HCA), and wild and culture of B. vulgaris L. were in different subgroups. This is the first original report about the fatty acid composition and oil content of Berberis spp. grown in Bayburt, Turkey. The obtained results indicate that B. integerrima Bunge and B. vulgaris, which have especially remarkable fatty acid content, antioxidant, and antimicrobial activity, could be potential sources for these properties in different areas of use.

Molecules published new progress about Antimalarials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhi-Wen; Liu, Yan-Qiu; Zhu, Yu-Chao; Wu, Jie-Ying published the artcile< 4-(4-Nitrostyryl)-N,N-diphenylaniline>, Formula: C19H34O2, the main research area is crystal structure Nitrostyryldiphenylaniline; mol structure hydrogen bond Nitrostyryldiphenylaniline.

In the triarylamine group of the title compound, C26H20N2O2, the N atom adopts an approx. trigonal-planar geometry, lying 0.046 (5) Å from the plane P defined by its three neighboring C atoms; the benzene and two terminal Ph rings are twisted by 37.4(1), 31.4(1) and 47.8(1)°, resp. from plane P. In the trans-stilbene fragment, the two benzene rings form a dihedral angle of 31.3 (1)°. In the crystal, weak intermol. C-H···O interactions link the mols. into ribbons in [100]. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Fang-Fang; Ma, Jian-Fang; Song, Shu-Yan; Yang, Jin; Liu, Ying-Ying; Su, Zhong-Min published the artcile< Influence of Neutral Ligands on the Structures of Silver(I) Sulfonates>, Electric Literature of 112-63-0, the main research area is silver sulfonate pyrazine picoline hexamethylenetetramine complex preparation structure; crystal structure silver sulfonate pyrazine picoline hexamethylenetetramine complex.

This article represents a systematical examination of the structures of Ag(I) sulfonates incorporating neutral ligands. To survey the influence of the properties of neutral ligands on the structures of Ag(I) sulfonates, three kinds of sulfonate anions (L1 = 1-naphthalenesulfonate, L2 = p-toluenesulfonate, and L3 = 1,3,6,8-pyrenetetrasulfonate) and three kinds of neutral ligands (pyrazine, Pyr, a divergent bidentate ligand; hexamethylenetetramine, hmt, a divergent tetradentate ligand; and β-picoline, Pic, a monodentate ligand) were selected for study, and five novel Ag(I) sulfonates containing neutral ligands were synthesized: [Ag(L1)(Pyr)]·H2O (1), Ag(L2)(Pyr) (2), Ag4(L3)(Pyr)4(H2O)2 (3), [Ag(L1)(hmt)]·H2O (4), and Ag(L1)(Pic)2 (5). The crystal structures were determined by single-crystal x-ray diffraction, and these compounds show a variety of structures with different dimensionalities. Also, the luminescent properties of compounds 2, 4 and 5 are also discussed.

Inorganic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nasrin, Suaad; Islam, Mohammad Nazmul; Tayab, Mohammed Abu; Nasrin, Mst. Samima; Siddique, Abu Bakar Md.; Emran, Talha Bin; Reza, A. S. M. Ali published the artcile< Chemical profiles and pharmacological insights of Anisomeles indica Kuntze: An experimental chemico-biological interaction>, Reference of 112-63-0, the main research area is Anisomeles human blood diarrhea phytochem antidepressive antidiarrheal thrombolytic antiinflammatory; Anisomeles indica; Anti-depression; Anti-inflammatory; Antidiarrheal; MeOH-AI; Thrombolytic.

Anisomeles indica (L.) Kuntze is an ethnomedicinally important plant that has long been used in traditional medicine to treat a variety of ailments, including dyspepsia, abdominal pain, colic, allergies, inflammation, and rheumatic arthritis. However, the scientific framework underlying these medicinal properties is not well known. This study aimed to investigate the antidepressive, antidiarrheal, thrombolytic, and anti-inflammatory potential of a methanol extract of A. indica (MeOH-AI). The potential bioactive compounds in the MeOH-AI were identified using gas chromatog.-mass spectrometry (GC-MS), and antidepressant activities were evaluated using the tail suspension test (TST) and forced swim test (FST). Antidiarrheal effects were also assayed in castor oil-induced diarrhea and gastrointestinal motility studies. The anti-inflammatory activities were explored by examining the effects on protein inhibition and denaturation in heat- and hypotonic solution-induced hemolysis assays. The thrombolytic activity was evaluated using the clot lysis test in human blood. BIOVIA and Schrodinger Maestro (v11.1) were applied for docking anal. to determine binding interactions, and the absorption, distribution, metabolisms, excretion/toxicity (ADME/T) properties of bioactive compounds were explored using a web-based method. The GC-MS anal. of MeOH-AI revealed the presence of several bioactive compounds MeOH-AI administration resulted in significant (p < 0.01) reductions in the immobility times for both the FST and TST compared with those in the control group. MeOH-AI also induced significant (p < 0.01) reductions in castor oil-induced diarrhea severity and gastrointestinal motility in a mouse model. In addition, the in vitro anti-inflammatory and thrombolytic activity studies produced remarkable responses. The binding assay showed that 4-dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine interacts favorably with monoamine oxidase and serotonin and M3 muscarinic acetylcholine receptors, displaying good pharmacokinetic properties, which may mediate the effects of MeOH-AI on depression and diarrhea. Overall, the research findings indicated that MeOH-AI has significant antidepressant, antidiarrheal, and anti-inflammatory effects and may represent an alternative source of novel therapeutic factors. Biomedicine & Pharmacotherapy published new progress about 5-HT3 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Campolo, Michela; Casili, Giovanna; Lanza, Marika; Filippone, Alessia; Paterniti, Irene; Cuzzocrea, Salvatore; Esposito, Emanuela published the artcile< Multiple mechanisms of dimethyl fumarate in amyloid β-induced neurotoxicity in human neuronal cells>, Electric Literature of 112-63-0, the main research area is dimethyl fumarate neuroprotectant neurotoxicity Alzheimer disease; Alzheimer’s disease; Nf-kB; Nrf2; dimethyl fumarate; oxidative stress; tau hyper-phosphorylation.

Alzheimer disease (AD) is characterized by a complex heterogeneity of pathol. changes, and any therapeutic approach categorically requires a multi-targeted way. It has been demonstrated that together with the hallmarks of the disease such as neurofibrillary tangles and senile plaques, oxidative and inflammatory stress covered an important role. Di-Me fumarate (DMF) is an orally bioavailable Me ester of fumaric acid and activator of Nrf2 with potential neuroprotective and immunomodulating activities. Therefore, the aim of the present work was to evaluate the potential beneficial effects of DMF, compared with its active metabolite monomethyl fumarate (MMF) (both at 30μM) in an in vitro Alzheimer’s model using SH-SY5Y human neuroblastoma cell lines stimulated with amyloid-beta (Aβ). Moreover, the effect of DMF, compared with MMF, was evaluate by an ex vivo model using organotypic hippocampal slice cultures stimulated with Aβ1-42 (1μg/mL), to better understand its action in a pathol. setting. In both models, DMF pre-treatment (30μM) preserved cellular viability from Aβ stimulation, reducing tau hyper-phosphorylation, much more efficiently then MMF (30μM). Moreover, DMF was able to induce an activation of manganese superoxide dismutase (MnSOD) and heme-oxygenase-1 (HO-1), decreasing the severity of oxidative stress. Our results showed important multi-protective effects of DMF pre-treatment from Aβ stimulation both in in vitro and ex vivo models, highlighting an Nrf2/NF-κB-dependent mechanism, which could provide a valuable support to the therapies for neurodegenerative diseases today.

Journal of Cellular and Molecular Medicine published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scherschinski, Lea; Prem, Markus; Kremenetskaia, Irina; Tinhofer, Ingeborg; Vajkoczy, Peter; Karbe, Anna-Gila; Onken, Julia Sophie published the artcile< Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma>, Related Products of 112-63-0, the main research area is glioblastoma receptor tyrosine kinase temozolomide radiation; R428; RTK-AXL; glioblastoma multiforme; post-translational receptor modification; radiation; temozolomide; tyrosine kinase inhibitor (TKI).

The receptor tyrosine kinase AXL (RTK-AXL) is implicated in therapy resistance and tumor progression in glioblastoma multiforme (GBM). Here, we investigated therapy-induced receptor modifications and how endogenous RTK-AXL expression and RTK-AXL inhibition contribute to therapy resistance in GBM. GBM cell lines U118MG and SF126 were exposed to temozolomide (TMZ) and radiation (RTX). Receptor modifications in response to therapy were investigated on protein and mRNA levels. TMZ-resistant and RTK-AXL overexpressing cell lines were exposed to increasing doses of TMZ and RTX, with and without RTK-AXL tyrosine kinase inhibitor (TKI). Colorimetric microtiter (MTT) assay and colony formation assay (CFA) were used to assess cell viability. Results showed that the RTK-AXL shedding product, C-terminal AXL (CT-AXL), rises in response to repeated TMZ doses and under hypoxia, acts as a surrogate marker for radio-resistance. Endogenous RTX-AXL overexpression leads to therapy resistance, whereas combination therapy of TZM and RTX with TKI R428 significantly increases therapeutic effects. This data proves the role of RTK-AXL in acquired and intrinsic therapy resistance. By demonstrating that therapy resistance may be overcome by combining AXL TKI with standard treatments, we have provided a rationale for future study designs investigating AXL TKIs in GBM.

International Journal of Molecular Sciences published new progress about Animal cell line (SF126). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia-Gallego, Sandra; Andren, Oliver C. J.; Malkoch, Michael published the artcile< Accelerated Chemoselective Reactions to Sequence-Controlled Heterolayered Dendrimers>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sequence controlled heterolayered dendrimer synthesis chemoselective reaction.

Chemoselective reactions are a highly desirable approach to generate well-defined functional macromols. Their extraordinary efficiency and selectivity enable the development of flawless structures, such as dendrimers, with unprecedented structure-to-property capacity but with typically tedious synthetic protocols. Here we demonstrate the potency of chemoselective reactions to accomplish sequence-controlled heterolayered dendrimers. An accurate accelerated design of bis-MPA monomers with orthogonally complementary moieties and a wisely selected chem. toolbox generated highly complex monodisperse dendrimers through simplified protocols. The versatility of the strategy was proved by obtaining different dendritic families with different properties after altering the order of addition of the monomers. Moreover, we evaluated the feasibility of the one-pot approach toward these heterolayered dendrimers as proof-of-concept.

Journal of the American Chemical Society published new progress about 1,3-Dipolar cycloaddition reaction (CuAAC). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics