Tag: M.W=250-300

Weng, Wei-Zhao; Gao, Yin-He; Zhang, Xue; Liu, Yan-Hua; Shen, Ying-Jie; Zhu, Yan-Ping; Sun, Yuan-Yuan; Meng, Qing-Guo; Wu, An-Xin published the artcile< Oxidative C(sp3)-H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines>, Electric Literature of 112-63-0, the main research area is triazolopyridine quinoline preparation; quinoline hydrazinyl pyridine oxidative cyclization.

An oxidative [4 + 1] annulation used to prepare 1,2,4-triazolo[4,3-a]pyridines e.g., I in the presence of I2-DMSO were described. This protocol enables synthesis of triazolo[4,3-a]pyridine-quinoline linked diheterocycles I via a direct oxidative functionalization of sp3 C-H bonds of 2-methyl-azaheteroarenes e.g., 2-methylquinoline. The reaction shows a wide substrate scope and good functional group tolerance.

Organic & Biomolecular Chemistry published new progress about C-H bond activation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Xiaoliang; Yan, Dayun; Lin, Li; Sherman, Jonathan H.; Peters, Katherine B.; Keir, Stephen T.; Keidar, Michael published the artcile< Cold Plasma Discharge Tube Enhances Antitumoral Efficacy of Temozolomide>, Computed Properties of 112-63-0, the main research area is temozolomide plasma discharge tube antitumor glioblastoma drug sensitization; Temozolomide; antitumor; drug-sensitization; glioblastoma; plasma discharge tube.

Glioblastoma (GBM) is a fatal human brain tumor with a low survival rate. Temozolomide (TMZ) has been widely used in GBM therapy with noticeable side effects. Cold plasma is an ionized gas that is generated near room temperature Here, we demonstrated the enhancement therapeutic efficacy of TMZ via using a cold plasma source based on nonequilibrium plasma in a sealed glass tube, named a radial cold plasma discharge tube (PDT). The PDT affected glioblastoma cells’ function just by its electromagnetic (EM) emission rather than any chem. factors in the plasma. The PDT selectively increased the cytotoxicity of TMZ on two typical glioblastoma cell lines, U87MG and A172, compared with normal astrocyte cell line hTERT/E6/E7 to some extent. Furthermore, on the basis of a patient-derived xenograft model, our preliminary in vivo studies demonstrated the drastically improved mean survival days of the tumor-barrier mice by more than 100% compared to control. The PDT is not only independent of continuous helium supply but is also capable of resisting the interference of environmental changes. Thus, the PDT was a stable and low-cost cold atm. plasma source. In short, this study is the first to demonstrate the promising application of PDTs in GBM therapy as a noninvasive and portable modality.

ACS Applied Bio Materials published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jianqiang; Gu, Wenjing; Ma, Ning; Fan, Xiaoye; Ci, Xinxin published the artcile< Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is leonurine cisplatin ferroptosis acute kidney injury Nrf signalling pathway; Nrf2; cisplatin-induced acute kidney injury; ferroptosis; leonurine.

Evidence indicates that ferroptosis plays a key role in acute kidney injury induced by cisplatin. The Nrf2/NRF2 pathway regulates oxidative stress, lipid peroxidation and pos. regulates cisplatin-induced acute kidney injury, but its effect along with the alkaloid leonurine, found in motherwort, on ferroptosis after such acute kidney injury remains unclear. The anti-ferroptotic effects of Nrf2 and leonurine were assessed in a mouse model of cisplatin-induced acute kidney injury. In vitro, the effects of leonurine on erastin- and RSL3-induced HK-2 human PTEC ferroptosis were examined Nrf2 deletion induced ferroptosis-related protein expression and iron accumulation in vivo, aggravating cisplatin-induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis in vitro, being abolished in siNrf2-treated cells. Moreover, leonurine potently inhibited cisplatin-induced renal damage, as assessed by of serum creatinine, blood urea nitrogen, kidney injury mol.-1 and NGAL. Importantly, leonurine activated the Nrf2 antioxidative pathway and preventing changes in ferroptosis-related morphol. and biochem. indicators, malondialdehyde level, SOD and GSH depletion, and GPX4 and xCT down-regulation, in cisplatin-induced acute kidney injury. Nrf2 KO mice were more susceptible to ferroptosis after cisplatin-induced acute kidney injury than control mice. The protective effects of leonurine on acute kidney injury and ferroptosis were largely abolished in Nrf2 KO mice. These data suggest that renal protective effects of Nrf2 activation on cisplatin-induced acute kidney injury are achieved, at least partially, by inhibiting lipid peroxide-mediated ferroptosis, highlighting the potential of leonurine in acute kidney injury treatment.

British Journal of Pharmacology published new progress about Acute kidney injury. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zou, Ying; Fahmi, Nour Eddine; Vialas, Corine; Miller, Guy M.; Hecht, Sidney M. published the artcile< Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin>, Formula: C12H24N2O4, the main research area is deamido bleomycin A2 total synthesis; demethyl deamido bleomycin A2 total synthesis; aglycon deamido bleomycin A2 total synthesis; DNA relaxation cleavage deamido bleomycin A2.

This work describes the synthesis of deamido-demethyl-bleomycin A2, I (R = SMe) and deamido-bleomycin A2, I (R = SMe2), as well as their resp. aglycons. Amino ester II was the key intermediate for I. Synthetic deamido-bleomycin A2 was shown to be identical to the product formed by treatment of bleomycin A2 (BLM-A2) with bleomycin hydrolase, as judged by reversed-phase HPLC anal. and 1H NMR spectroscopy. Deamido-bleomycin A2 was found to retain significant DNA cleavage activity in DNA plasmid relaxation assays and had the same sequence selectivity of DNA cleavage as bleomycin A2. The most significant alteration of function noted in this study was a reduction in the ability of deamido-bleomycin A2 to mediate double-strand DNA cleavage, relative to that produced by BLM-A2.

Journal of the American Chemical Society published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Formula: C12H24N2O4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diaz-Sanchez, Blanca R.; Iglesias-Arteaga, Martin A.; Melgar-Fernandez, Roberto; Juaristi, Eusebio published the artcile< Synthesis of 2-Substituted-5-halo-2,3-dihydro-4(H)-pyrimidin-4-ones and Their Derivatization Utilizing the Sonogashira Coupling Reaction in the Enantioselective Synthesis of α-Substituted β-Amino Acids>, Formula: C19H34O2, the main research area is pyrimidinone dihydro derivative preparation enantioselective conversion beta amino acid; crystal structure dihydropyrimidinone; mol structure dihydropyrimidinone.

A convenient, one-pot procedure for the synthesis of 1-benzoyl-2(S)-substituted-5-iodo-2,3-dihydropyrimidin-4(1H)-ones by tandem decarboxylation/β-iodination of the corresponding 6-carboxy-perhydropyrimidin-4-ones was developed. Several 1-benzoyl-2(S)-substituted-5-bromo-2,3-dihydropyrimidin-4(1H)-ones were readily prepared by bromination of 1-benzoyl-2(S)-substituted-2,3-dihydropyrimidin-4(1H)-ones. Subsequently, Sonogashira coupling of the halogenated heterocyclic enones with various terminal alkynes produced 1-benzoyl-2(S)-isopropyl-5-alkynyl-2,3-dihydropyrimidin-4(1H)-ones in good yields. Hydrogenation of the unsaturated C-C moieties in a Sonogashira product followed by acid hydrolysis afforded a highly enantioenriched α-substituted β-amino acid (S)-2-(aminomethyl)-4-phenylbutanoic acid. The crystal and mol. structures of 1-benzoyl-2(S)-phenyl-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-bromo-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-phenylethynyl-2,3-dihydropyrimidin-4(1H)-one were determined by x-ray crystallog.

Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kahveci, Zafer; Sekizkardes, Ali K.; Arvapally, Ravi K.; Wilder, Logan; El-Kaderi, Hani M. published the artcile< Highly porous photoluminescent diazaborole-linked polymers: synthesis, characterization, and application to selective gas adsorption>, Product Details of C19H34O2, the main research area is porous photoluminescent diazaborolelinked polymer gas adsorption optical property.

The formation of boron-nitrogen (B-N) bonds has been widely explored for the synthesis of small mols., oligomers, or linear polymers; however, its use in constructing porous organic frameworks remains very scarce. In this study, three highly porous diazaborole-linked polymers (DBLPs) have been synthesized by condensation reactions using 2,3,6,7,14,15-hexaaminotriptycene and aryl boronic acids. DBLPs are microporous and exhibit high Brunauer-Emmett-Teller surface area (730-986 m2 g-1) which enable their use in small gas storage and separation At ambient pressure, the amorphous polymers show high CO2 (DBLP-4: 4.5 mmol g-1 at 273 K) and H2 (DBLP-3: 2.13 wt% at 77 K) uptake while their physicochem. nature leads to high CO2/N2 (35-42) and moderate CO2/CH4 (4.9-6.2) selectivity. The electronic impact of integrating diazaborole moieties into the backbone of these polymers was investigated for DBLP-4 which exhibits green emission with a broad peak ranging from 350 to 680 nm upon excitation with 340 nm in DMF without photobleaching. This study demonstrates the effectiveness of B-N formation in targeting highly porous frameworks with promising optical properties.

Polymer Chemistry published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramar, Thangeswaran; Subbaiah, Murugaiah A. M.; Ilangovan, Andivelu published the artcile< Orchestrating a β-Hydride Elimination Pathway in Palladium(II)-Catalyzed Arylation/Alkenylation of Cyclopropanols Using Organoboron Reagents>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is enone preparation diastereoselective chemoselective; cyclopropanol organoboronic reagent arylation alkenylation palladium catalyst.

The scope of chemoselective β-hydride elimination in the context of arylation/alkenylation of homoenolates RC(O)CH=CHR1 (R = 4-methoxyphenyl, 2,3-dihydro-1,4-benzodioxin-6-yl, cyclohexyl, naphthalen-2-yl, etc.; R1 = Ph, 2H-1,3-benzodioxol-4-yl, naphthalen-2-yl, etc.) from cyclopropanol precursors I using organoboronic reagents R1B(OH)2/R1BO2C2(CH3)4 as transmetalation coupling partners was examined The reaction optimization paradigm revealed a simple ligand-free Pd(II) catalytic system to be most efficient under open air conditions. The preparative scope, which was investigated with examples, supported the applicability of this reaction to a wide range of substrates tolerating a variety of functional groups while delivering β-substituted enone and dienone derivatives in 62-95% yields.

Journal of Organic Chemistry published new progress about Alkenylation catalysts, stereoselective (chemoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kanimozhi, S.; Prithviraj, Elumalai; Sumathy, Govindarajan published the artcile< Phytochemical and GC-MS analysis of Sphaeranthus amaranthoides Burm>, Electric Literature of 112-63-0, the main research area is Sphaeranthus amaranthoide burm phytochem GC MS analysis.

To isolate and evaluate the phytochem. constituents of Sphaeranthus amaranthoides using GC-MS. Preliminary phytochem. screening of the extract was carried out according to the standard method described by Brindha et al. GC-MS anal. was performed on the methanolic extract of S. amaranthoides to find out the chem. constituents. Phytochem. screening revealed the presence of steroids, alkaloids, sugars, phenolics, flavonoids, saponins, tannins, and amino acids to a spotted degree. GC-MS results revealed the presence of 15 different phytocompounds, viz., 3,4-Xylyl, 3,5-di-tert-butylbenzoate, n-Hexadecanoic acid, , 17.beta. -Hydroxy-6-oxo-4,5-secoandrostan-4-oic acid, 3-Cyclopenten-1-one, 3-hydroxy-2-(1-hydroxy-3-methylbutylidene)-5-(3-methyl-2-butenylidene)-5, 17.beta. -Hydroxy-6-oxo-4,5-secoandrostan-4-oic acid Me ester 6, Indan, 6-tert-butyl-4-ethyl-1,1-dimethyl -7, 9,12-Octadecadienoic acid (Z,Z)-, Me ester 10(E),12(Z)-Conjugated linoleic acid, 9-Octadecenoic acid, (E)-Octadecanoic acid, 9.12-Octadecadienoic acid (Z, Z)-, 2,3-dihydroxypropyl ester,1,8, 11-Heptadecatriene, (Z,Z)-, 11-Methyltricosane, Nonane, 5-butyl-, 1,3-Benzenedicarboxylic acid, bis (2-ethylhexyl) ester etc. The presence of various bioactive compounds confirms the application of Sphaeranthus amaranthoides for various diseases by means of a herbal system of treatments.

Natural Volatiles & Essential Oils published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effenberger, Franz; Stelzer, Uwe published the artcile< Enzyme-catalyzed reactions. 15. Preparation of (R)-2-(sulfonyloxy) nitriles and their reactions with acetates. Inversion of the configuration of optically active cyanohydrins>, Synthetic Route of 112-63-0, the main research area is nitrile sulfonyloxy preparation transacylation; acetoxy nitrile preparation enzymic deacetylation; cyanohydrin configuration inversion.

(R)-R1SO3CHRCN (I, R = Pr, CH2CHMe2, CH2CH2SMe, cyclohexyl, cyclohexenyl; R1 = 4-MeC6H4, Me, CF3) were obtained in high optical purity by sulfonylation of (R)-HOCHRCN. In contrast to I, (R)-R1SO3CHPhCN (II) are unstable at higher temperature I react at room temperature with alkali acetates in a typical SN2 manner to give (S)-AcOCHRCN in high optical purity. Under these reaction conditions, II partly racemize and decompose Hydrolysis of (S)-AcOCHRCN gave (S)-I.

Chemische Berichte published new progress about Configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nikpassand, Mohammad; Fekri, Leila Zare published the artcile< An In Situ Procedure; Grinding Synthesis of 4H-benzo[h]chromene-3- carbonitriles Using DBU-hydrobromide-perbromide>, HPLC of Formula: 112-63-0, the main research area is carbonitrile hydrobromide perbromide.

Background: A clean and environmentally benign route to 4H-benzo[h]chromene-3- carbonitriles has been developed via three-component condensation reaction of various benzyl alcs., malononitrile and 1-naphthol using DBU-hydrobromide-perbromide as an efficient oxidizing reagent at room temperature

Methodol.: The present methodol. offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environmental consequences.

Conclusion: All of synthesized compounds were characterized by IR, NMR and elemental analyses.

Current Green Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics