Tag: M.W=250-300

Aiken, Stuart published the artcileAn intramolecular, Pd-mediated α-arylation route to 4-aryl-2-naphthols, Recommanded Product: Methyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate, the publication is Tetrahedron Letters (2015), 56(33), 4840-4842, database is CAplus.

1-Aryl-1-(2-bromophenyl)but-2-yn-1-ols, obtained from the addition of prop-1-yn-1-yllithium to 2-bromobenzophenones, readily rearrange to 4-aryl-4-(2-bromophenyl)but-3-en-2-ones upon treatment with TFA. Subsequent intramol. Pd-mediated α-arylation of these but-3-en-2-ones gave 4-aryl-2-naphthols which were smoothly transformed into photochromic naphthopyrans.

Tetrahedron Letters published new progress about 956229-86-0. 956229-86-0 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronic acid and ester, name is Methyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate, and the molecular formula is C15H21BO4, Recommanded Product: Methyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sharma, Shilpa published the artcilePolyaspartic acid, 2-acrylamido-2-Methyl propane sulfonic acid and sodium alginate based biocompatible stimuli responsive polymer gel for controlled release of GHK-Cu peptide for wound healing, Safety of Trimethylolpropane triacrylate, the publication is Journal of Biomaterials Applications (2022), 37(1), 132-150, database is CAplus and MEDLINE.

Stimuli responsive polymer based on Polyaspartic acid, 2-Acrylamido-2-methylpropane sulfonic acid and sodium alginate (NaAlg) were synthesized using two crosslinkers Ethylene glycol dimethacrylate (EGDMA) and TMPTA (Trimethylolpropane triacrylate). The polymers were standardized and optimized to obtain a polymer with maximum swelling in distilled water, saline, glucose and solutions of varying pH. The synthesized polymer swelled well in distilled water, glucose solution and acidic- alk. medium. The biocompatibility of the polymer was evaluated for blood compatibility and protein adsorption. The polymer with maximum swelling property was used for peptide release studies. The polymer was further used to study the peptide encapsulation and release efficiency of the polymeric material which was confirmed by FTIR, Scanning Emission Microscope and EDX. The encapsulation efficiency of the polymer for encapsulating (glycyl-l-histidyl-l-lysine-copper) GHK-Cu was observed to be 55.26% and peptide release of 51.84% was observed for Ethylene glycol dimethacrylate based polymer after 24 h whereas for Trimethylolpropane triacrylate based polymer the encapsulation efficiency was observed to be 49.6% and release was 39.01%. The EGDMA based polymer was further examined under in vivo studies in order to evaluate the efficiency of the synthesized polymer. The in vivo studies include wound closure, histopathol. anal., biochem. and toxicity assay. The material has shown promising results for both in vivo and in vitro studies.

Journal of Biomaterials Applications published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C14H17FN4O3, Safety of Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Furber, Mark published the artcileDiscovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I, Safety of (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(24), 7702-7706, database is CAplus and MEDLINE.

The discovery of potent small mol. dual antagonists of the human CCR3 and H₁ receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting from a CCR1 lead compound, led to compound 20 with potent dual CCR3/H₁ activity and in vitro metabolic stability.

Bioorganic & Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Safety of (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Zhenhua; Gorski, Bartosz; Leonori, Daniele published the artcile< Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki-Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons>, Quality Control of 112-63-0, the main research area is alkyl iodide aryl organoboron copper catalyst Suzuki Miyaura coupling; aryl alkane preparation.

A mechanistically distinct approach to achieve Suzuki-Miyaura-type cross-couplings between alkyl iodides and aryl organoborons was reported. This process required a copper catalyst but, in contrast with previous approaches based on palladium and nickel systems, does not utilizes the metal for the activation of the alkyl electrophile. Instead, this strategy exploited the halogen-atom transfer ability of α-aminoalkyl radicals to convert secondary alkyl iodides into the corresponding alkyl radicals that then were coupled with aryl, vinyl, alkynyl, benzyl and allyl boronate species. These novel coupling reactions feature simple set up and conditions (1 h at room temperature) and facilitate access to privileged motifs targeted by the pharmaceutical sector.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia-Garcia, Amalia; Oyarzabal, Itziar; Cepeda, Javier; Seco, Jose M.; Garcia-Valdivia, Antonio A.; Gomez-Ruiz, Santiago; Salinas-Castillo, Alfonso; Choquesillo-Lazarte, Duane; Rodriguez-Dieguez, Antonio published the artcile< Slow relaxation of magnetization and luminescence properties of a novel dysprosium and pyrene-1,3,6,8-tetrasulfonate based MOF {[Dy4(μ-pytet)(μ4-pytet)2(DMF)20(H2O)2]·4DMF·4H2O}n (1).>, Synthetic Route of 112-63-0, the main research area is dysprosium pyrenetetrasulfonate MOF preparation crystal structure magnetic relaxation luminescence.

The authors report the formation of a novel multifunctional metal-organic framework (MOF) based on Dy(III) ions using pyrene-1,3,6,8-tetrasulfonate (pytet)4- as a ligand, synthesized using a soft hydrothermal route. This material shows a two-dimensional network with small channels along a crystallog. axis and displays intense photoluminescence properties in the solid state at room temperature due to the pyrene derivative ligand. The magnetic properties of this 2-dimensional-MOF are also accomplished, confirming slightly frequency-dependent out of phase signals under an applied field of 1000 Oe.

New Journal of Chemistry published new progress about Color. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lemieux, Robert P.; Schuster, Gary B. published the artcile< Photochemistry of axially chiral (arylmethylene)cycloalkanes: a search for suitable photoswitchable liquid crystalline materials>, Quality Control of 112-63-0, the main research area is arylmethylenecycloalkane photochem liquid crystal optical switch; optical absorption CD arylmethylenecycloalkane; photoracemization axially chiral arylmethylenecycloalkane.

A series of chiral (arylmethylene)cycloalkanes was synthesized in racemic and optically active form to examine their suitability for incorporation in a liquid crystal-based optical switch. Irradiation of these compounds with UV light leads to their rapid photoracemization and, in some cases, their simultaneous destruction. The absorption spectra and CD spectra of these optically active compounds were determined Chiral exciton coupling theory proves to be a good guide for predicting the magnitude of Δε and gλ (the Kuhn anisotropy factor). Addition of the optically active (arylmethylene)cycloalkanes to nematic liquid crystal materials induces cholesteric behavior. The helical twisting power (βM) was determined for each compound, and a limit of 90 μm was established for the detection of a long-pitch cholesteric liquid crystal. Irradiation of the cholesteric liquid crystals formed by addition of the optically active (arylmethylene)cycloalkanes induces the transition to a compensated nematic phase that is readily sensed by optical microscopy.

Journal of Organic Chemistry published new progress about Circular dichroism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lei; Ni, Qijian; Bluemel, Marcus; Shu, Tao; Raabe, Gerhard; Enders, Dieter published the artcile< NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides>, Synthetic Route of 112-63-0, the main research area is succinimide preparation enantioselective diastereoselective; ketoamide aldehyde cycloaddition heterocyclic carbene catalyst; N-heterocyclic carbenes; asymmetric synthesis; ketoamides; organocatalysis; succinimides.

The efficient asym. synthesis of highly substituted succinimides (3R/3S,4R) I (R = 2-ClC6H4, 4-H3COC6H4, 3-thienyl, etc.; R1 = CH3, 4-H3CC6H4, 2-furyl; R2 = C6H5, 3-ClC6H4, 4-H3COC6H4, 2-(methoxycarbonyl)-3-thienyl) from α,β-unsaturated aldehydes and α-ketoamides via N-heterocyclic carbene (NHC) catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles II (X = C6H5, 4-H3COC6H4; Y = C6H5, 2-furyl; Z = C6H5, 2-(methoxycarbonyl)-3-thienyl) and provides easy access to assemble a wide range of succinimides I from simple starting materials.

Chemistry – A European Journal published new progress about [3+2] Cycloaddition reaction, stereoselective ((3+2)). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Detert, Heiner; Sugiono, Erli published the artcile< Synthesis and electronic spectra of substituted oligo(phenylenevinylene)s>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oligophenylenevinylene preparation UV fluorescence.

A series of substituted oligo(p-phenylenevinylene)s (OPVs) with five benzene rings was prepared via PO-activated olefinations and Knoevenagel condensations. The central ring is substituted with two octyloxy groups to ensure good solubility of the OPVs and the lateral styrene units carry further substituents, with either electron-accepting or donating character and also combinations thereof. The spectral features of these OPVs are dominated by the basic chromophore; further auxochrome groups on the lateral rings (meta and para positions) shift the absorption and emission spectra only slightly to longer wavelengths. Significant bathochromic shifts (absorption ca 20 nm, emission ca 40 nm) are observed for OPVs with cyano groups on the terminal vinylene segments. The absorption spectra are independent of the concentration and solvatochromism is very small. The OPVs are photochem. stable to near-UV irradiation (366 nm) in neutral solution, whereas mid-UV irradiation (254 nm) causes decomposition of the chromophore. The presence of traces of acids or amines leads to different photochem. pathways.

Journal of Physical Organic Chemistry published new progress about Fluorescence. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Srinivasulu, Vunnam; Janda, Kim D.; Abu-Yousef, Imad A.; O’Connor, Matthew John; Al-Tel, Taleb H. published the artcile< A modular CuI-L-proline catalyzed one-pot route for the rapid access of constrained and privileged hetero-atom-linked medium-sized ring systems>, Formula: C19H34O2, the main research area is benzodiazepinone benzodiazocinone benzooxazocinone benzothiazapine benzothiazine indole preparation.

An efficient CuI-L-proline catalyzed one-pot synthesis was developed to generate a collection of skeletally diverse heterocyclic ring systems with sizes ranging from 6 to 9. A salient feature of this design strategy was its modular synthetic utility using an SN2 reaction followed by a microwave assisted CuI-L-proline hetero-arylation, which has granted access to a series of heterocyclic frameworks, including: benzo[e]pyrrolo[1,2-a][1,4]diazepin e.g. I, benzo[e]pyrrolo[1,2-a][1,4]diazocin, benzo[e]pyrido[1,2-a][1,4]diazocinones, dibenzo[b,f][1,5]diazoninones, dihydrodibenzo[b,e][1,4]thiazepine, dibenzo[b,e][1,4]thiazocine and benzo[6,7][1,4]diazepino[1,2-a]indole. Moreover, the synthetic procedures described allows rapid entries to synthetically challenging medium-sized heterocyclic systems with good overall yields.

Tetrahedron published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takaya, Jun; Ito, Shisei; Nomoto, Hironori; Saito, Narumasa; Kirai, Naohiro; Iwasawa, Nobuharu published the artcile< Fluorine-controlled C-H borylation of arenes catalyzed by a PSiN-pincer platinum complex>, Application In Synthesis of 112-63-0, the main research area is fluorine controlled carbon hydrogen borylation arene catalyst; phosphorus silicon nitrogen pincer platinum complex catalyzed regioselective borylation; arylboronic ester regioselective synthesis; crystal mol structure phosphorus silicon nitrogen pincer platinum complex.

An efficient, regioselective synthesis of fluorine-substituted arylboronic esters was achieved through fluorine-controlled C-H borylation of arenes with diboron catalyzed by a PSiN-platinum complex. The promising utility of the PSiN-platinum catalyst and its unique regioselectivity were demonstrated for the first time, which would complement the well-developed Ir-catalyzed C-H borylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics