Tag: M.W=250-300

Huang, Ning; Ding, Xuesong; Kim, Jangbae; Ihee, Hyotcherl; Jiang, Donglin published the artcile< A Photoresponsive Smart Covalent Organic Framework>, Related Products of 112-63-0, the main research area is anthracene covalent organic framework photoinduced cycloaddition reaction; anthracene; covalent organic frameworks; photoresponsive materials; porous polymer; smart materials.

Ordered π-columnar structures found in covalent organic frameworks (COFs) render them attractive as smart materials. However, external-stimuli-responsive COFs have not been explored. Here we report the design and synthesis of a photoresponsive COF with anthracene units as the photoresponsive π-building blocks. The COF is switchable upon photoirradiation to yield a concavo-convex polygon skeleton through the interlayer [4π+4π] cycloaddition of anthracene units stacked in the π-columns. This cycloaddition reaction is thermally reversible; heating resets the anthracene layers and regenerates the COF. These external-stimuli-induced structural transformations are accompanied by profound changes in properties, including gas adsorption, π-electronic function, and luminescence. The results suggest that COFs are useful for designing smart porous materials with properties that are controllable by external stimuli.

Angewandte Chemie, International Edition published new progress about Covalent organic frameworks. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kubisch, Christin; Ochsenreither, Katrin published the artcile< Valorization of a Pyrolytic Aqueous Condensate and Its Main Components for L-Malic Acid Production with Aspergillus oryzae DSM 1863>, Application In Synthesis of 112-63-0, the main research area is Aspergillus malic acid valorization pyrolytic aqueous condensate.

Pyrolytic aqueous condensate (PAC) might serve as a cost-effective substrate for microbial malic acid production, as it is an unused side stream of the fast pyrolysis of lignocellulosic biomass that contains acetol and acetate as potential carbon sources. In the present study, shake flask cultures were performed to evaluate the suitability of acetol and its combination with acetate as substrates for growth and L-malate production with the filamentous fungus Aspergillus oryzae. Acetol concentrations of up to 40 g/L were shown to be utilized for fungal growth. In combination with acetate, co-metabolization of both substrates for biomass and malate formation was observed, although the maximum tolerated acetol concentration decreased to 20 g/L. Furthermore, malate production on PAC detoxified by a combination of rotary evaporation, overliming and activated carbon treatment was studied. In shake flasks, cultivation using 100% PAC resulted in the production of 3.37 ± 0.61 g/L malate, which was considerably improved by pH adjustment up to 9.77 ± 0.55 g/L. A successful scale-up to 0.5-L bioreactors was conducted, achieving comparable yields and productivities to the shake flask cultures. Accordingly, fungal malate production using PAC was successfully demonstrated, paving the way for a bio-based production of the acid.

Fermentation published new progress about Aspergillus oryzae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Tengteng; Lv, Shujie; Zhang, Wei; Tang, Yanan; Chang, Hong; Hu, Zihan; Fang, Liang; Du, Jiaojiao; Wu, Sifan; Yang, Xinli; Guo, Yangfu; Guo, Ruihan; Ge, Zongrui; Wang, Lei; Zhang, Caiyun; Wang, Rulin; Chen, Weidong published the artcile< PF-PLC micelles ameliorate cholestatic liver injury via regulating TLR4/MyD88/NF-κB and PXR/CAR/UGT1A1 signaling pathways in EE-induced rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is 17α-ethynylestradiol; CAR; Cholestasis liver injury; MyD88; NF-κB pathway; PF-PLC micelles; PXR; TLR4; UGT1A1.

Paeoniflorin (PF) has a certain therapeutic effect on cholestasis liver injury. To further improve the bioavailability of PF and play its pharmacol. role in liver protection, PF-phospholipid complex micelles (PF-PLC micelles) were prepared based on our previous research on PF-PLC. The protective effects of PF and PF-PLC micelles on cholestasis liver injury induced by 17α-ethynylestradiol (EE) were compared, and the possible mechanisms were further explored. Herein, we showed that PF-PLC micelles effectively improved liver function, alleviated liver pathol. damage, and localized infiltration of inflammatory cells. Mechanism studies indicated that PF-PLC micelles treatment could suppress the TLR4/MyD88/NF-κB pathway, and further reduce the levels of pro-inflammatory factors. Meanwhile, our exptl. results demonstrated that the beneficial effect of PF-PLC micelles on EE-induced cholestasis may be achieved by the upregulation of nuclear receptors and metabolic enzymes (PXR/CAR/UGT1A1). All these results indicate that PF-PLC micelles have great potential in the treatment of cholestatic liver disease.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Lyu; Chen, Yanlu; Lin, Leyu; Schlarb, Alois K.; Li, Yue; Shi, Xinyan published the artcile< Architecture of covalent bonds between filament layers to enhance performance of 3D printing biodegradable polymer blends>, Synthetic Route of 112-63-0, the main research area is biodegradable polymer blend three dimensional printing covalent bond filament.

Generally, the filament layer adhesion in articles 3D printed by Fused Deposition Modeling (FDM, one of 3D printing method) is completely provided by the diffusion and entanglement of mol. chains between adjacent layers. However, the poor layer adhesion and strong anisotropy in FDM due to the difficult movement of polymer chains and the complex thermal history during 3D printing have turned to be the main factors restricting the development of FDM. In this paper, poly (lactic acid)/poly (butylene adipate terephthalate)/poly (lactic acid) grafted glycidyl methacrylate biodegradable blend (PLA/PBAT/PLA-g-GMA, PLA-g-GMA was a self-made compatibilizer) was used as the matrix. A low mol. weight three-armed PLA (noted as U-PLA) was synthesized by ring opening polymerization of lactide which was initiated by trimethylolpropane (TMP) and end capping with double bonds. Then, U-PLA and phenylbis (2,4,6-trimethylbenzoyl) phosphine oxide (XBPO) was added in the matrix. The rheol. results found that U-PLA acted as a low mol. weight plasticizer to promote the fluidity of the matrix during 3D printing process. On the other hand, compared with polymer chains in matrix, U-PLA was more prone to cross interlayer motion, resulting in stronger phys. entanglements. With UV irradiation, XBPO was triggered to release free radicals and initiated crosslinking at terminal double bonds of U-PLA which rich concentrated between adjacent layers. Mol. dynamics and exptl. results showed that with increase of U-PLA, the interlayer bonding strength of FDM specimens increased significantly. The maximum tensile strength of 3D printing specimens increased by 82.5% (printing direction at 90°). This work clearly showed that with UV irradiation covalent bonds were successfully architected between filament layers of FDM specimens.

Polymer Testing published new progress about Biodegradable plastics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sui, Meng; Chen, Yong; Li, Fashe; Wang, Wenchao; Shen, Jiaxu published the artcile< Study on the mechanism of auto-oxidation of Jatropha biodiesel and the oxidative cleavage of C-C bond>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biodiesel methyl linoleate hexanal oxidation Jatropha.

Jatropha biodiesel was obtained according to the continuous preparation process which included vapor esterification – transesterification – methanol steam distillation Accelerated oxidation of small Jatropha biodiesel was obtained by the Rancimat method. GC-MS and liquid phase micro-extraction were used to study and analyze the components in the oxidation process of Jatropha curcas biodiesel. The electronic effects of the related reactants and products were calculated by d. functional theory, followed by the deduction of the related chem. reaction paths. Exptl. investigation shows that Me linoleate is the main factor affecting the oxidation stability of the Jatropha biodiesel. The main volatile products at the initial stages of the oxidation of Me linoleate are hexanal, Me octanoate, styrene, and 2-heptenal. The cis/trans-3-octyl-oxiranyl octanoic acid Me ester (18.03% yield) is produced by the reaction of peroxy acid and Me oleate during the oxidation of Me oleate. The hydrogen extraction reaction is difficult to occur, and the oxidation reaction energy barrier is relatively high due to the relatively large bond energy of the C-H bond in the Me stearate mol. In this manuscript, the auto-oxidation mechanism of the biodiesel fatty acid Me esters at the initial stage of oxidation, the path of oxidative cleavage of the C-C bond of Jatropha biodiesel and the formation process of ethylene oxide structure are obtained through DFT calculation and anal. of the oxidation products.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Chunxian; Preiss, Laura; Wang, Bin; Fu, Lei; Wen, Hui; Zhang, Xiang; Cui, Huaqing; Meier, Thomas; Yin, Dali published the artcile< Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds>, Category: esters-buliding-blocks, the main research area is quinoline dimethylaminomethyl phenyl preparation antitubercular activity; ATP synthase; Mycobacterium tuberculosis; bedaquiline; multidrug resistance; pulmonary tuberculosis.

Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chem. synthesis and compound optimization are rather difficult and expensive. This study describes the structural simplification of bedaquiline while preserving antitubercular activity. The compound’s structure was split into fragments and reassembled in various combinations while replacing the two chiral carbon atoms with an achiral linkage instead. Four series of analogs were designed; these candidates retained their potent antitubercular activity at sub-microgram per mL concentrations against both sensitive and multidrug-resistant (MDR) Mycobacterium tuberculosis strains. Six out of the top nine MIC-ranked candidates were found to inhibit mycobacterial ATP synthesis activity with IC50 values between 20 and 40 μm, one had IC50>66 μm, and two showed no inhibition, despite their antitubercular activity. These results provide a basis for the development of chem. less complex, lower-cost bedaquiline derivatives and describe the identification of two derivatives with antitubercular activity against non-ATP synthase related targets.

ChemMedChem published new progress about ATPase inhibitors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lloyd, David G.; Hughes, Rosario B.; Zisterer, Daniela M.; Williams, D. Clive; Fattorusso, Caterina; Catalanotti, Bruno; Campiani, Giuseppe; Meegan, Mary J. published the artcile< Benzoxepin-Derived Estrogen Receptor Modulators: A Novel Molecular Scaffold for the Estrogen Receptor>, SDS of cas: 112-63-0, the main research area is benzoxepin derivative estrogen receptor modulator antitumor breast cancer.

The authors present and examine the efficacy of a novel benzoxepin-based scaffold for modulation of the human estrogen receptor. Receptor tolerance of this new mol. scaffold is examined through presentation of exptl. determined antiproliferative effects on human MCF-7 breast tumor cells and measured binding affinities. The effect of functional group substitution on the benzoxepin scaffold is explored through a brief computational structure-activity relationship investigation with mol. simulation.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Sha; Jiang, Mingchen; Yan, Shuxia; Liang, Miaomiao; Wang, Wei; Yuan, Bin; Xu, Qiuyue published the artcile< Network pharmacology-based, experimental identification of the effects of paeoniflorin on major depressive disorder>, Application of C19H34O2, the main research area is major depressive disorder paeoniflorin; experimental verification; major depressive disorder; network pharmacology; paeoniflorin; treatment targets.

Major depressive disorder (MDD) is one of the most common psychiatric disorders, the diagnosis, treatment of MDD are major clin. issues. However, there is a lack of effective biomarkers, drugs diagnosis, therapeutics of MDD. In the present study, bioinformatics anal. combined with an exptl. verification strategy was used to identify biomarkers, paeoniflorin targets for MDD diagnosis, treatment. Based on network pharmacol., we obtained potential targets, pathways of paeoniflorin as an antidepressant through multiple databases. We then constructed a protein-protein interaction network, performed enrichment analyses. According to the results, we performed in vivo, in vitro exptl. validation. The results showed that paeoniflorin may exert an antidepressant effect by regulating cell inflammation, synaptic function, NF-κB signaling pathway, intestinal inflammation. NPM1, HSPA8, HSPA5, HNRNPU, TNF are the targets of paeoniflorin treatment. In addition, we demonstrated that paeoniflorin inhibits inflammatory cytokine production via the p38MAPK/NF-κB pathway, has neuroprotective effects on the synaptic structure. Our findings provide valuable evidence for the diagnosis, treatment of MDD.

Frontiers in Pharmacology published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jin, Yue; Liu, Huiling; Yang, Meihua; Chen, Jianmin published the artcile< Adaptability of hplc method to determination of aflatoxins content in traditional chinese medicine>, Formula: C19H34O2, the main research area is aflatoxin determination HPLC Chinese medicine.

The HPLC for determining the content of aflatoxins in traditional Chinese medicine was presented. Two affinity chromatog. columns: AflaTest P and EASI-Extract AFLATOXIN and three common columns: LiChrospher100 RP-18e column, phenomenex Luna C18 column, and phenomenex Luna Phenyl-Hexyl column were used and compared. The pyridinium bromide perbromide solution was used as derivatizing agent. The loads for both affinity chromatog. columns were sufficient for determination of aflatoxins content in traditional Chinese medicine based on the “”green trade standards of importing and exporting medicinal plants and preparations”” (WM2-2001). Based on the results of reproducibility tests on the resolution and peak area, the three common columns were suitable for IAC purification and post-column derivatization HPLC of determining aflatoxins content in traditional Chinese medicine.

Zhongguo Zhongyao Zazhi published new progress about Aflatoxins Role: ADV (Adverse Effect, Including Toxicity), ANT (Analyte), BIOL (Biological Study), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baltina, Lidia; Sapozhnikova, Tatyana; Makara, Nina; Gabdrakhmanova, Svetlana; Baltina, Lia; Kondratenko, Rimma published the artcile< Paeoniflorin benzoates: synthesis and influence on learning and memory of aged rats in the passive avoidance task>, Application In Synthesis of 112-63-0, the main research area is paeoniflorin benzoate preparation learning memory age Alzheimer’s; Paeoniflorin; benzoates; passive avoidance task; rats.

Paeoniflorin per-O-benzoates with the preserved pinane structure and rearranged aglycon , containing C4 = O function, were obtained and their influence on learning and memory of aged rats was studied in the passive avoidance task. It was found that the chem. modification of paeoniflorin affected the cognitive functions of aged rats. The introduction of C4 = O function into the pinane part of benzoate led to the improvement in learning process and preservation of the memory trace in aged rats as compared to the natural glycoside. This compound can be considered as the promising for further studies on in vivo models of disorders characteristic for Alzheimer’s disease.

Natural Product Research published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics