Tag: M.W=250-300

Hys, Vasyl Y.; Milokhov, Demyd S.; Volovenko, Olesya B.; Konovalova, Irina S.; Shishkina, Svitlana V.; Volovenko, Yulian M. published the artcile< Synthetic Approach to Fused Azasultams with 1,2,4-Thiadiazepine Framework>, Synthetic Route of 112-63-0, the main research area is fused azasultam thiadiazepine preparation; azole pyrrole carboxylate sulfonamide heterocyclization.

Synthetic approach to fused azasultams with 1,2,4-thiadiazepine framework via base promoted protocols has been developed. 1H-Azole-2-carboxylates and N-(chloromethyl)-N-methylmethanesulfonamide were used as ambiphilic building blocks in the one-pot and two-step reaction sequences. Chem. behavior of the obtained azasultams in reactions with amines, hydrazine, DMFDMA, and NaBH4 was investigated. An enamino ketone derived from an azasultam was exploited in the synthesis of new pyrazole and pyrimidine heterocycles.

Synthesis published new progress about Condensation reaction (sulfa-Dieckmann). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giese, B.; Kopping, B.; Gobel, T.; Dickhaut, J.; Thoma, G.; Kulicke, K. J.; Trach, F. published the artcile< Radical cyclization reactions>, COA of Formula: C19H34O2, the main research area is review Reactions; review Radical; review Cyclization.

A review of the article Radical cyclization reactions.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia-Urricelqui, Ane; de Cozar, Abel; Campano, Teresa E.; Mielgo, Antonia; Palomo, Claudio published the artcile< syn-Selective Michael Reaction of α-Branched Aryl Acetaldehydes with Nitroolefins Promoted by Squaric Amino Acid Derived Bifunctional Broensted Bases>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stereoselective Michael aryl acetaldehyde nitroolefin bifunctional cinchona squaric peptide.

Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different α-Me arylacetaldehydes react with β-aromatic and β-alkyl nitroolefins to afford the Michael adducts in high enantioselectivity and syn-selectivity. NMR experiments and DFT calculations predict the reaction to occur through the intermediacy of E-enolate. The interaction between the substrates and the catalyst follows Papai’s model, wherein an intramol. H-bond interaction in the catalyst between the NH group of one of the tert-leucines and the squaramide oxygen seems to be key for discrimination of the corresponding reaction transition states. Thus, e.g., 2-phenylpropanal + (E)-4-chloro-β-nitrostyrene → I (84%, 95:5 dr, 94% ee).

European Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (γ-nitro). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Meng; Hu, Jun; Zhu, Yuejie; Wang, Xianqing; Zeng, Shumin; Hong, Yijiang; Zhao, Guang published the artcile< Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos>, Application of C15H22N2O2, the main research area is Zebrafish embryos ferroptosis apoptosis selenomethionine; L-selenomethionine; ROS; apoptosis; ferroptosis; microphthalmia.

Selenium is an essential trace element for humans and other vertebrates, playing an important role in antioxidant defense, neurobiol. and reproduction However, the toxicity of excessive selenium has not been thoroughly evaluated, especially for the visual system of vertebrates. In this study, fertilized zebrafish embryos were treated with 0.5μM L-selenomethionine to investigate how excessive selenium alters zebrafish eye development. Selenium-stressed zebrafish embryos showed microphthalmia and altered expression of genes required for retinal neurogenesis. Moreover, ectopic proliferation, disrupted mitochondrial morphol., elevated ROS-induced oxidative stress, apoptosis and ferroptosis were observed in selenium-stressed embryos. Two antioxidants-reduced glutathione (GSH) and N-acetylcysteine (NAC)-and the ferroptosis inhibitor ferrostatin (Fer-1) were unable to rescue selenium-induced eye defects, but the ferroptosis and apoptosis activator cisplatin (CDDP) was able to improve microphthalmia and the expression of retina-specific genes in selenium-stressed embryos. In summary, our results reveal that ferroptosis and apoptosis might play a key role in selenium-induced defects of embryonic eye development. The findings not only provide new insights into selenium-induced cellular damage and death, but also important implications for studying the association between excessive selenium and ocular diseases in the future.

International Journal of Molecular Sciences published new progress about Antioxidants. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghanbari Moheb Seraj, Rahele; Tohidfar, Masoud; Azimzadeh Irani, Maryam; Esmaeilzadeh-Salestani, Keyvan; Moradian, Toktam; Ahmadikhah, Asadollah; Behnamian, Mahdi published the artcile< Metabolomics analysis of milk thistle lipids to identify drought-tolerant genes>, HPLC of Formula: 112-63-0, the main research area is Silybum metabolomics lipids drought stress FATA2 CYP86A1 PXG3.

Milk thistle is an oil and medicinal crop known as an alternative oil crop with a high level of unsaturated fatty acids, which makes it a favorable edible oil for use in food production To evaluate the importance of Milk thistle lipids in drought tolerance, an experiment was performed in field conditions under three different water deficit levels (Field capacity (FC), 70% FC and 40% FC). After harvesting seeds of the plant, their oily and methanolic extracts were isolated, and subsequently, types and amounts of lipids were measured using GC-MS. Genes and enzymes engaged in biosynthesizing of these lipids were identified and their expression in Arabidopsis was investigated under similar conditions. The results showed that content of almost all measured lipids of milk thistle decreased under severe drought stress, but genes (belonged to Arabidopsis), which were involved in their biosynthetic pathway showed different expression patterns. Genes biosynthesizing lipids, which had significant amounts were selected and their gene and metabolic network were established. Two networks were correlated, and for each pathway, their lipids and resp. biosynthesizing genes were grouped together. Four up-regulated genes including PXG3, LOX2, CYP710A1, PAL and 4 down-regulated genes including FATA2, CYP86A1, LACS3, PLA2-ALPHA were selected. The expression of these eight genes in milk thistle was similar to Arabidopsis under drought stress. Thus, PXG3, PAL, LOX2 and CYP86A1 genes that increased expression were selected for protein anal. Due to the lack of protein structure of these genes in the milk thistle, modeling homol. was performed for them. The results of mol. docking showed that the four proteins CYP86A1, LOX2, PAL and PXG3 bind to ligands HEM, 11O, ACT and LIG, resp. HEM ligand was involved in production of secondary metabolites and dehydration tolerance, and HEM binding site remained conserved in various plants. CA ligands were involved in synthesis of cuticles and waxes. Overall, this study confirmed the importance of lipids in drought stress tolerance in milk thistle.

Scientific Reports published new progress about Arabidopsis thaliana. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pang, Xinlong; Chen, Chao; Su, Xiang; Li, Ming; Wen, Lirong published the artcile< Diverse Tandem Cyclization Reactions of o-Cyanoanilines and Diaryliodonium Salts with Copper Catalyst for the Construction of Quinazolinimine and Acridine Scaffolds>, Application In Synthesis of 112-63-0, the main research area is cyanoaniline diaryliodonium salt copper cyclization catalyst; quinazolinimine preparation; diaryliodonium salt cyanoaniline copper intramol electrophilic substitution catalyst; acridine preparation.

Two cyclization modes are realized to produce different nitrogen-containing heterocycles, i.e., quinazolin-4(3H)-imines, e.g., I, and acridines, e.g., II, by assembling o-cyanoanilines and diaryliodonium salts via tandem reaction pathways.

Organic Letters published new progress about Acridines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sharif, Mariam; Anjum, Irfan; Shabbir, Arham; Mushtaq, Muhammad Naveed published the artcile< Anti-asthmatic effect of Juglans regia Linn. in mice>, Application of C19H34O2, the main research area is Juglans allergic asthma antiasthmatic phytochems.

Plants are considered as an essential source to treat different diseases. In traditional system of medicine, Juglans regia (J. regia) has been used in curing sinusitis and cough. The aim of the present study was to evaluate the anti-asthmatic activity of J. regia in ovalbumin-induced allergic asthmatic BALB/c mice. The mice were sensitized i.p. and subsequently challenged with ovalbumin (intranasal) to induce allergic asthma. Mice were treated with methanolic, n-hexane and Et acetate extracts of J. regia and methylprednisolone for 7 consecutive days, along with intranasal challenge. The total and differential leukocyte counts in blood, bronchoalveolar lavage fluid (balf) and lung wet/dry ratio were determined GC-MS anal. was also performed. The results showed that Et acetate extract of J. regia significantly reduced inflammatory cells count in both blood and balf more significantly. Lung wet/dry weight ratio was reduced in asthmatic mice treated with the different extracts of J. regia. Serum IgE antibodies level was also significantly decreased in extracts treated groups. GC-MS anal. of all three extracts of J. regia showed the presence of various phytochems. responsible for its anti-inflammatory and anti-asthmatic activity. The results of the present study validated the traditional use of J. regia in respiratory disorders like asthma and sinusitis.

Pakistan Journal of Pharmaceutical Sciences published new progress about Allergic asthma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Minghe; Li, Lin; Huang, Ming; Tan, Yao; Shang, Ye; Meng, Xianghui; Pang, Yafen; Xu, Hong; Zhao, Xin; Lei, Wei; Chang, Yanxu; Wang, Yi; Zhang, Deqin; Zhang, Boli; Li, Yuhong published the artcile< Sanye tablet ameliorates insulin resistance and dysregulated lipid metabolism in high-fat diet-induced obese mice>, Application In Synthesis of 112-63-0, the main research area is Sanye tablet insulin lipid metabolism lipidomics proteomics; HFD; SYT; insulin resistance; lipidomics; proteomics.

Sanye Tablet (SYT) is a patent prescription widely used in treating T2D and pre-diabetes, especially T2D comorbid with hypertriglyceridemia, for many years in China. However, the underlying mechanism that accounts for the anti-diabetic potential of SYT by regulating lipid-related intermediates remains to be elucidated. This study aimed to investigate the mechanism of SYT on lipid metabolism and insulin sensitivity in high-fat diet (HFD)-induced obese mice by means of combining lipidomics and proteomics. The obese mice models were developed via HFD feeding for 20 consecutive weeks. Mice in the treatment group were given metformin and SYT resp., and the effects of SYT on body weight, blood glucose, insulin sensitivity, fat accumulation in the organs, and pathol. changes in the liver were monitored. Lipid metabolism was examined by lipidomics. Further determination of signaling pathways was detected by proteomics. The biol. contributions of the compounds detected in SYT′s chem. fingerprint were predicted by network pharmacol. SYT treatment reduced body weight, inhibited viscera and hepatic steatosis lipid accumulation, and prevented insulin resistance. Furthermore, it was found that circulatory inflammatory cytokines were reduced by SYT treatment. In addition, lipidomics anal. indicated that SYT targets lipid intermediates, including diacylglycerol (DAG) and Ceramide (Cer). Mechanistically, SYT pos. affected these lipid intermediates by suppressing liver lipogenesis via downregulation of SREBP1/ACC and the JAK/STAT signaling pathway. Our results predicted that astragalin and rosmarinic acid might regulate the JAK-STAT pathway by targeting PIM2 and STAT1, resp., while paeoniflorin and rosmarinic acid were likely to regulate inflammatory responses by targeting TNFα, IL-6, and IL-4 during T2D. Overall, our study provides supportive evidence for the mechanism of SYT′s therapeutic effect on dysregulated lipid metabolism in diabesity.

Frontiers in Pharmacology published new progress about Antiinflammatory cytokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Le Marechal, Jean-Francois published the artcile< Bromination of alkenes: between chemical and pedagogical improvements>, Electric Literature of 112-63-0, the main research area is bromination alkene pedagogical.

The bromination of stilbene is used to illustrate some chem. concepts that are difficult for student comprehension. The mechanism of trans-stilbene bromination by pyridinium tribromide is compared to that by bromine. The solvent effect on the reaction stereochem. is also discussed. The use of binary phase diagrams is used to discuss the racemate of the reaction products.

BUP published new progress about Alkenes Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Kenji; Takaishi, Hideo published the artcile< Synthetic microbial chemistry. XXII. Synthesis of monocerin, an antifungal, insecticidal and phytotoxic heptaketide metabolite of Exserohilum monoceras>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is monocerin total synthesis.

Both the naturally occurring enantiomer I and the racemate of monocerin were synthesized for the first time.

Tetrahedron published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics