Tag: M.W=250-300

Lewinski, Piotr; Kaluzynski, Krzysztof; Pretula, Julia; Mielniczak, Grazyna; Penczek, Stanislaw published the artcile< Catalysis in polymerization of cyclic esters. Catalyst and initiator in one molecule. Polymerization of lactide>, Related Products of 112-63-0, the main research area is lactide ring opening polymerization catalyst.

Poly(L-lactide) (PLA) was synthesized with initiator and catalyst in one mol. (CINICAT): 5-ethyl-2-hydroxy-5-hydroxymethyl-1,3,2-dioxaphosphorinane-2-oxide (GM). Polymerizations were conducted at the relatively high temperature (170-190°C) because of the low basicity of LA. Nevertheless, the studied processes were found to be living/controlled, no side reactions were determined and only PLA with fragments of GM as the end-groups were detected. PLA with Mn up to ∼40·103 g/mol. Kinetic studies indicated second order dependence of the rate of polymerization on the initial concentration of the CINICAT. This result is suggesting activation of the monomer and propagation with two independent macromols.

Journal of Catalysis published new progress about Cationic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Skupinska, Krystyna A.; McEachern, Ernest J.; Skerlj, Renato T.; Bridger, Gary J. published the artcile< Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines>, Reference of 112-63-0, the main research area is aminotetrahydroquinoline aminotetrahydroisoquinoline preparation; hydrogenation acetamidoquinoline acetamidoisoquinoline; hydrolysis acetamidotetrahydroquinoline; regioselective reduction quinoline derivative.

A method to prepare amino-substituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The yields of the products are good when the acetamido substituent is present on the pyridine ring and moderate with the acetamido substituent on the benzene ring. This method has also been applied to the regioselective reduction of quinoline substrates bearing other substituents (R = OMe, CO2Me, Ph).

Journal of Organic Chemistry published new progress about Hydrogenation, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Di; Ma, Lixue; Wu, Mengna; Wang, Xiaoyu; Xu, Lei; Yu, Qiaoru; Wang, Changyuan published the artcile< Effect of microbial communities on the quality characteristics of northeast soybean paste: Correlation between microorganisms and metabolites>, Computed Properties of 112-63-0, the main research area is soybean paste microorganism metabolite microbial community.

To systematically explore the impact of microbial community composition on the quality characteristics of northeast soybean paste, the microbial community structure was determined by high-throughput sequencing technol. and the flavor substance, free amino acid (FAA) and biogenic amine (BA) contents were determined by HS-SPME-GC-MS and HPLC. Furthermore, the correlation between microorganisms and metabolites was investigated. The results indicated that the core bacteria mainly included Tetragenococcus, Bacillus and Lactobacillus; Candida_f__norank, Wickerhamomyces and Aspergillus were the dominant fungi. A total of 139 flavor compounds were detected in all samples, and decamethylcyclopentasiloxane, isoamyl phenylacetate and octamethylcyclotetrasiloxane accounted for the highest proportion. A total of 24 FAAs were detected in the soybean paste. Pantoea, Kroppenstedtia and Kocuria were significantly pos. correlated with most FAAs (p < 0.05). Addnl. 5 BAs were detected in the soybean paste, and the contents of BAs in Y4 were highest, which was affected by different microbes. This study provided relevant information for the microbial community composition and metabolites of northeast soybean paste, which was of great significance for understanding the characteristics and safety of soybean paste. LWT--Food Science and Technology published new progress about Acaulium. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Yunxia; Chen, Hansen; Tsoi, Bun; Wang, Qi; Shen, Jiangang published the artcile< Danggui-Shaoyao-San (DSS) ameliorates cerebral ischemia-reperfusion injury via activating SIRT1 signaling and inhibiting NADPH oxidases>, Electric Literature of 112-63-0, the main research area is DSS cerebral ischemia reperfusion injury SIRT signaling NADPH oxidase; Danggui-Shaoyao-San; SIRT1; oxidative stress; peroxynitrite; stroke.

Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurol. health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reperfusion. Both ethanol extract and aqueous extract of DSS (12 g/kg) were orally administrated into the rats at 30 min prior to MCAO ischemic onset. We found that 1 ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurol. deficit scores in the post-ischemic stroke rats; 2 Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3 Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4 Ethanol extract of DSS significantly down-regulated the expression of p67phox but has no effect on p47phox and iNOS statistically. 5 Ethanol extract of DSS significantly up-regulated the expression of SIRT1 in the cortex and striatum of the postischemic brains; 6 Co-treatment of EX527, a SIRT1 inhibitor, abolished the DSS’s neuroprotective effects. Taken together, DSS could attenuate oxidative/nitrosative stress and inhibit neuronal apoptosis against cerebral ischemic-reperfusion injury via SIRT1-dependent manner.

Frontiers in Pharmacology published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Wenjuan; Yu, Huizhu; Zhu, Xiaoquan; Li, Haoran published the artcile< A luminescence europium Metal-organic coordination polymer for Room-Temperature X-ray detection>, Quality Control of 112-63-0, the main research area is preparation europium pyrenetetrasulfonate coordination polymer xray detection luminescence scintillator.

A novel Eu ions-based metal-organic coordination polymer (MOCP) named Eu(1,3,6,8-PTS)(H2O)7·4H2OHbipy (1) (PTS = pyrenetetrasulfonic acid) was prepared, and its structure, stability, photoluminescence and scintillation properties were systematically investigated. Compound 1 gives a peculiar snake-shaped chain structure with the aid of π-π stacking effect of 4,4′-bipyridine auxiliary template. An efficient and stable light emission was detected under x-ray irradiation, which presents an excellent linear response to X-ray dose. Also, this compound demonstrates high radiation stability, illustrating its potential as a scintillator for x-ray detection. This work not only provides guidance for the design and fabrication of sulfonic ligand derived MOCPs with Eu (III) ions coordination, but also demonstrates the potential of MOCPs scintillators for x-ray detection technol.

Inorganic Chemistry Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Di; Chang, Shiquan; Li, Xin; Shi, Huimei; Jing, Bei; Chen, Zhenni; Lin, Yi; Zheng, Yachun; Qian, Guoqiang; Pan, Yuwei; Zhao, Guoping published the artcile< Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis>, SDS of cas: 112-63-0, the main research area is mecobalamin neuroprotectant sciatic nerve chronic constriction injury; Schwann cells; TLR4/NF-kB; chronic constriction injury; chronic neuralgia; paeoniflorin; sciatica.

Therapeutic drugs of chronic neuralgia have a high risk of addiction, making it crucial to identify novel drugs for chronic neuralgia. This study aimed to explore the therapeutic effect of paeoniflorin on chronic sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including the sham operation group, chronic constriction injury (CCI) group, mecobalamin group, and paeoniflorin group. The therapeutic effect and mechanism of paeoniflorin were evaluated via rat and cell experiments Mech., hot, or cold hyperalgesia was induced in the rats after CCI operation, while paeoniflorin relieved chronic neuralgia. Besides, paeoniflorin decreased the levels of IL1, IL6, TNF-α, CRP, and LPS and increased the level of IL10 in serum. As for the sciatic nerve, the number of inflammatory cells was decreased, and Schwann cells were present after paeoniflorin treatment, and paeoniflorin promoted the recovery of nerve structure. In cell experiments, LPS induced Schwann cell apoptosis via the TLR4/NF-kB pathway. And paeoniflorin attenuated LPS-induced Schwann cell apoptosis by decreasing the levels of TLR4, p-NF-kB, caspase3, cleaved-caspase3, and cleaved-caspase7. Overall, these results suggest that paeoniflorin alleviates chronic sciatica by decreasing inflammatory factor levels and promotes the repair of damaged nerves by reducing Schwann cell apoptosis.

Phytotherapy Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toshima, Hiroaki; Saito, Masatoshi; Yoshihara, Teruhiko published the artcile< Total synthesis of (+)-(2S,3R)-Piscidic acid via catalytic asymmetric dihydroxylation of a trisubstituted olefin>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is catalysis asym dihydroxylation trisubstituted olefin; piscidic acid total synthesis; asymmetric dihydroxylation; catalytic asymmetric synthesis; piscidic acid.

(+)-(2S,3R)-Piscidic acid was efficiently synthesized with high optical purity (90% e.e.) via Sharpless catalytic asym. dihydroxylation of a trisubstituted olefin in only 6 steps from com. available 4-hydroxyphenyl-pyruvic acid as the starting material. The reaction proceeded with high optical purity by using the chiral ligands, dihydroquinidine 2,5-diphenyl-4,6-pyrimidinediyl diether or dihydroquinidine 1,4-anthraquinonediyl diether.

Bioscience, Biotechnology, and Biochemistry published new progress about Dihydroxylation (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Junwei; Su, Jun published the artcile< Alterations of the Gut Microbiome in Recurrent Malignant Gliomas Patients Received Bevacizumab and Temozolomide Combination Treatment and Temozolomide Monotherapy>, Synthetic Route of 112-63-0, the main research area is bevacizumab temozolomide gut microbiome alteration recurrent malignant glioma human; 16S rRNA gene; Bevacizumab; Gut microbiota; Recurrent malignant glioma; Temozolomide.

This case-control study explored compositions of gut microbiome in recurrent malignant gliomas patients who had received bevacizumab and Temozolomide combination treatment and Temozolomide monotherapy. We investigated gut microbiota communities in feces of 29 recurrent malignant gliomas patients received combination treatment with bevacizumab and Temozolomide (Group 1) and monotherapy with Temozolomide alone (Group 2). We took advantage of the high-throughput Illumina Miseq sequencing technol. by targeting the third and fourth hypervariable (V3-V4) regions of the 16S rRNA (rRNA) gene. We found that the structures and richness of the fecal microbiota in Group 1 were different from Group 2 with LEfSe anal. The fecal microbiota in both Group 1 and Group 2 were mainly composed by Firmicutes, Proteobacteria, Bacteroidetes and Actinobacteria. However, Group 1 patients had higher relative abundance of Firmicutes, Bacteroidetes, Actinobacteria and lower relative abundance of Bacteroidetes and Cyanobacteria in their fecal microbiota than that in Group 2 patients. To evaluate bevacizumab involved post-treatment state of the fecal microbiota profile, we used random forest predictive model and ensembled decision trees with an AUC of 0.54. This study confirmed that the gut microbiota was different in recurrent malignant gliomas patients received the combination therapy of bevacizumab and Temozolomide compared with Temozolomide monotherapy. Our discover can help better understand the influence of bevacizumab related treatment on recurrent malignant gliomas patients. Therefore, this finding may also support the potentially therapeutic options for recurrent malignant gliomas patients such as fecal microbiota transplant.

Indian Journal of Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bruns, Robert F.; Watson, Ian A. published the artcile< Rules for Identifying Potentially Reactive or Promiscuous Compounds>, Computed Properties of 112-63-0, the main research area is reactive promiscuous compound screening.

This article describes a set of 275 rules, developed over an 18-yr period, used to identify compounds that may interfere with biol. assays, allowing their removal from screening sets. Reasons for rejection include reactivity (e.g., acyl halides), interference with assay measurements (fluorescence, absorbance, quenching), activities that damage proteins (oxidizers, detergents), instability (e.g., latent aldehydes), and lack of druggability (e.g., compounds lacking both oxygen and nitrogen). The structural queries were profiled for frequency of occurrence in druglike and nondruglike compound sets and were extensively reviewed by a panel of experienced medicinal chemists. As a means of profiling the rules and as a filter in its own right, an index of biol. promiscuity was developed. The 584 gene targets with screening data at Lilly were assigned to 17 subfamilies, and the number of subfamilies at which a compound was active was used as a promiscuity index. For certain compounds, promiscuous activity disappeared after sample repurifn., indicating interference from occult contaminants. Because this type of interference is not amenable to substructure search, a “”nuisance list”” was developed to flag interfering compounds that passed the substructure rules.

Journal of Medicinal Chemistry published new progress about Acid halides Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Zhen; Zhou, Teng; Qi, Zhiwen; Sundmacher, Kai published the artcile< Computer-aided screening of deep eutectic solvent systems for the associative extraction of α-tocopherol from deodorizer distillate>, Application In Synthesis of 112-63-0, the main research area is tocopherol deodorizer distillate eutectic solvent system extraction.

This work presents a computer-aided framework for the screening of deep eutectic solvent (DES) systems by using the α-tocopherol extraction from methylated oil deodorizer distillates (MODD) as an example of practical relevance. Taking advantage of the differences in the hydrogen bond donating abilities of α-tocopherol and methyllinoleate (model compounds in MODD), the DES screening task is to select suitable components that can achieve the associative extraction of α-tocopherol by in situ DES formation at high selectivity against methyllinoleate. The COSMO-RS model is employed in the DES screening for two purposes: (1) The solid-liquid equilibrium between α-tocopherol and each candidate component are calculated to check the potential for DES formation and identify the existence of a proper liquid window. (2) The infinite dilution capacity and selectivity of different components for the α-tocopherol/methyllinoleate extraction are predicted to estimate their potential for the separation task. The components preselected by COSMO-RS evaluation are further examined regarding other phys. as well as environmental, health, and safety (EHS) properties.

Computer-Aided Chemical Engineering published new progress about Deep eutectic solvents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics